Colonization of a Central Venous Catheter by the Hyaline Fungus Fusarium solani Species Complex: A Case Report and SEM Imaging by Alberto Colombo, Giuseppe Maccari, Terenzio Congiu, Petra Basso, Andreina Baj, Antonio Toniolo

“…The incidence of opportunistic infections by filamentous fungi is increasing partly due to the widespread use of central venous catheters (CVC), indwelling medical devices, and antineoplastic/immunosuppressive drugs. The case of a 13-year-old boy under treatment for acute lymphoblastic leukemia is presented. …”
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Rhino-Orbito-Cerebral Mucormycosis: Two Cases with Amaurosis as Presentation, Medical Surgical Management and Follow-Up by Carmen Navarro-Perea, Ignacio Cañas-Zamarra, Enrique Mencía-Gutiérrez, Enrique Revilla-Sánchez, María-Dolores Lago-Llinás, Silvia Pérez-Trigo, Álvaro Bengoa-González

“…Purpose: Mucormycosis is an infection caused by fungi to the class Zygomycetes that usually appears in immunosuppressed patients. Diagnostic confirmation is often delayed, with fatal prognosis in cases in which treatment is not rapidly established. …”
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The Fate of the Tumor in the Hands of Microenvironment: Role of TAMs and mTOR Pathway by Danilo Figueiredo Soave, Marina Pacheco Miguel, Fernanda Dias Tomé, Liliana Borges de Menezes, Patrícia Resende Alo Nagib, Mara Rúbia Nunes Celes

“…Currently, it is believed that macrophages related to tumoral microenvironment present an “M2-like” feature promoting an immunosuppressive microenvironment enhancing tumoral angiogenesis, growth, and metastasis. …”
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A germline FLT3 variant in aplastic anemia by Lemchukwu C. Amaeshi, Amalia A. Sofianidi, Aditi Shastri, Mendel Goldfinger, Marina Konopleva, Amit K. Verma, Mark Chaitowitz, Ioannis Mantzaris

“…Herein, we report the first to our knowledge, and unusual case of a germline, gain-of-function, FLT3 variant in a patient with severe AA treated successfully with immunosuppressive therapy. Although a proposed link between dysregulated FLT3 signaling and autoimmunity has been described and could be speculated in the case of AA, it is currently unknown whether a pathogenetic connection between an activating germline FLT3 variant and AA truly exists and whether the mutation signifies a lifelong risk of disease recurrence and/or clonal evolution. …”
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Polymeric immunogel prevents tumor recurrence and metastasis by dual activation of innate and adaptive immunity by Guanyu Jin, Hao Liu, Zi Mei, Qionghua Jin, Sheng Ma, Lanqing Wang, Yuanzhen Su, Letian Lv, Zijuan Wang, Huicong Zhou, Mingqiang Li, Zehuan Huang, Xuesi Chen, Shixian Lv

“…Tumor recurrence and metastasis after surgery are important factors affecting patient survival. The immunosuppressed tumor microenvironment after surgery reduces the ability of the immune system to clear residual tumor cells, thus increasing the risk of recurrence and metastasis. …”
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Orbital Metastasis of Breast Cancer Mimicking Invasive Fungal Rhinosinusitis by Mayara Tabai, Igor Moreira Hazboun, Emerson Taro Inoue Sakuma, Marcelo Hamilton Sampaio, Eulalia Sakano

“…She was using prednisone in immunosuppressive doses for a year and had breast cancer treated three years earlier. …”
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Large Granular Lymphocytic Leukemia: A Report of Response to Rituximab by Uroosa Ibrahim, Sara Parylo, Shiksha Kedia, Shafinaz Hussein, Jean Paul Atallah

“…Large granular lymphocytic (LGL) leukemia is a rare form of low grade leukemia characterized by large cytotoxic T cells or natural killer cells on morphological examination. Immunosuppressive therapy is employed as first-line therapy. …”
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Cholesterol Targeted Catalytic Hydrogel Fueled by Tumor Debris can Enhance Microwave Ablation Therapy and Anti‐Tumor Immune Response by Lin Shen, Zhijuan Yang, Yi Zhong, Yanran Bi, Junchao Yu, Qinwei Lu, Yanping Su, Xiaoxiao Chen, Zhongwei Zhao, Gaofeng Shu, Minjiang Chen, Liang Cheng, Liangzhu Feng, Chenying Lu, Zhuang Liu, Jiansong Ji

“…Abstract The immunosuppressive residual tumor microenvironment (IRTM) is a key factor in the high recurrence and metastasis rates of hepatocellular carcinoma (HCC) after microwave ablation (MWA). …”
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Switching Stable Kidney Transplant Recipients to a Generic Tacrolimus Is Feasible and Safe, but It Must Be Monitored by Fernando González, René López, Elizabeth Arriagada, René Carrasco, Natalia Gallardo, Eduardo Lorca

“…Tacrolimus is the primary immunosuppressive drug used in kidney transplant patients. …”
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Strongyloides Colitis as a Harmful Mimicker of Inflammatory Bowel Disease by Julio Poveda, Farah El-Sharkawy, Leopoldo R. Arosemena, Monica T. Garcia-Buitrago, Claudia P. Rojas

“…Biopsies of the colon revealed increased lymphoplasmacytic infiltrate of the lamina propria with eosinophilic microabscesses and presence of larvae, consistent with Strongyloides stercoralis. Immunosuppressive medication was halted. The patient ultimately died a few days later. …”
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The Exposure to Osteoarthritic Synovial Fluid Enhances the Immunomodulatory Profile of Adipose Mesenchymal Stem Cell Secretome by Adriana Cifù, Rossana Domenis, Massimo Pozzi-Mucelli, Paolo Di Benedetto, Araldo Causero, Massimo Moretti, Marta Stevanato, Cinzia Pistis, Pier Camillo Parodi, Martina Fabris, Francesco Curcio

“…Our data show that the exposure of AMSCs to SF activates cells and promotes the release of immunosuppressive factors, which induce macrophage polarization of M0 into the M2-like phenotype and inhibit differentiation of monocytes into mature dendritic cells (mDCs). …”
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Acute Myeloid Leukemia with Basophilic Differentiation Transformed from Myelodysplastic Syndrome by Yasuhiro Tanaka, Atsushi Tanaka, Akiko Hashimoto, Kumiko Hayashi, Isaku Shinzato

“…An 81-year-old man was referred to our department for further examination of intermittent fever and normocytic anemia during immunosuppressive treatment. Chromosomal analysis showed additional abnormalities involving chromosome 7. …”
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Iguratimod prevents renal fibrosis in unilateral ureteral obstruction model mice by suppressing M2 macrophage infiltration and macrophage–myofibroblast transition by Yueyuan Zhou, Zhilan Li, Shenyi Yu, Xuan Wang, Tingting Xie, Weiru Zhang

“…Iguratimod is a novel synthetic, small-molecule immunosuppressive agent used to treat rheumatoid arthritis. …”
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Beyond the icebox: modern strategies in organ preservation for transplantation by Kidus Haile Yemaneberhan, Minseok Kang, Jun Hwan Jang, Jin Hee Kim, Kyeong Sik Kim, Ho Bum Park, Dongho Choi

“…Organ transplantation, a critical treatment for end-stage organ failure, has witnessed significant advancements due to the integration of improved surgical techniques, immunosuppressive therapies, and donor-recipient matching. …”
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WNT11 Promotes immune evasion and resistance to Anti-PD-1 therapy in liver metastasis by Weiliang Jiang, Bingjie Guan, Hongcheng Sun, Yushuai Mi, Sanjun Cai, Rong Wan, Xinxiang Li, Peng Lian, Dawei Li, Senlin Zhao

“…WNT11-overexpressing tumor cells promote immunosuppressive macrophage polarization by inducing IL17D expression via the CAMKII/NF-κB pathway, which result in CD8+ T-cell suppression. …”
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Bibliometric analysis of metformin as an immunomodulator (2013–2024) by Tongyi Zhou, Yunfeng Yu, Liu Li, Xiu Liu, Xiu Liu, Qin Xiang, Rong Yu, Rong Yu

“…Keyword co-occurrence analysis highlighted metformin’s role as an immunomodulator, particularly in the context of the tumor immune microenvironment, immunosuppressive checkpoints, and metformin derivatives. …”
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Immune Privilege and Eye-Derived T-Regulatory Cells by Hiroshi Keino, Shintaro Horie, Sunao Sugita

“…The eye and immune system use strategies to maintain the ocular immune privilege by regulating the innate and adaptive immune response, which includes immunological ignorance, peripheral tolerance to eye-derived antigens, and intraocular immunosuppressive microenvironment. In this review, we summarize current knowledge regarding the molecular mechanism responsible for the development and maintenance of ocular immune privilege via regulatory T cells (Tregs), which are generated by the anterior chamber-associated immune deviation (ACAID), and ocular resident cells including corneal endothelial (CE) cells, ocular pigment epithelial (PE) cells, and aqueous humor. …”
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Attenuation of Autoimmune Phenomena in a Patient with Autoimmune Polyglandular Syndrome Type 1 by Jill D. Jacobson, Julia R. Broussard, Courtney Marsh, Brandon Newell

“…We report on a girl whose disease was progressing rapidly until she began on immunosuppressive agents. A healthy 6-year-old girl with no remarkable medical history presented with new onset hypocalcemic seizures and primary hypoparathyroidism. …”
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Aplastic Anemia Treated with Eltrombopag during Pregnancy by Yuri Suminaga, Yoshitsugu Chigusa, Tadakazu Kondo, Haruko Okamoto, Yosuke Kawamura, Mana Taki, Masaki Mandai, Haruta Mogami

“…A 27-year-old primigravida woman who had a history of aplastic anemia refractory to immunosuppressive therapy and was treated with eltrombopag became pregnant. …”
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Preoperative evaluation of red blood cell distribution width as a promising biomarker for discriminating between benign and malignant breast tumors and assessing breast cancer acti... by Ajay Singh Thakur, Chandrashekhar Indoria, Ruby Sahu, Pratima Kujur, Renuka Gahine

“…The study excluded individuals with inflammatory disorders, pre-neoplastic disease, hematological disorders, or those taking immunosuppressive or anti-inflammatory medications. The RDW values were measured using an automated hematology analyzer. …”
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