Stevens-Johnson syndrome/toxic epidermal necrolysis spectrum for the rheumatologist by Jyoti Ranjan Parida, Saumya Ranjan Tripathy

“…Supportive care is the mainstay of treatment and if not started promptly may result in high mortality and morbidity. Although many immunosuppressive drugs have been tried in treatment, no treatment has proven beneficial except cyclosporine which has been shown to retard the progression of SJS/TEN. …”
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Management of connective tissue disease-associated interstitial lung disease by Keerthi Talari

“…Corticosteroids (except in systemic sclerosis [SSc]-ILD) in combination with immunosuppressants form the mainstay of therapy in CTD-ILD. …”
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Overview of Newer Glucocorticosteroid Preparations for Inflammatory Bowel Disease by R Brattsand

“…This means that there is a high potential for anti-inflammatory and immunosuppressive actions on rectal and bowel mucosa. The compound is metabolically stable in the bowel compartment, which allows full retention of glucocorticosteroid activity in the target organ. …”
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Pas de Deux: Active Ulcerative Colitis in an HIV-Positive Patient by David C Pearson, Lloyd R Sutherland, Stephan Urbanski

“…It also presents a difficult management problem because the patient has a limited life expectancy and is reluctant to accept colectomy, and further immunosuppressive therapy may be dangerous.…”
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Protein Phosphatase 2A: Role in T Cells and Diseases by Suyasha Roy, Lalit Batra

“…Genetic deletion of PP2A in Tregs disrupts Foxp3 expression due to hyperactivation of mTORC1 signaling which impairs the development and immunosuppressive functions of Tregs. PP2A is important in the induction of Th9 cells and promotes their antitumor functions. …”
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Sensory-Motor Polyneuropathy and Digital Ischemia: A Rare Presentation of Granulomatosis with Polyangiitis by Wasundara Wathurapatha, B. G. A. Rathnamali, Upul Dissanayake

“…She made a good recovery following aggressive immunosuppressive treatment with methylprednisolone and cyclophosphamide and was maintained on prednisolone and azathioprine. …”
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Vasculitic Tibial Mononeuropathy Associated with Inherited Immune Dysregulation: A Review of Tibial Mononeuropathies with Electrodiagnostic Considerations by James Liu, Yue Ding, Sandra Camelo-Piragua, James Richardson

“…She was then started on appropriate immunosuppressive treatment which resulted in significant pain relief and was discharged home. …”
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A Review on the Application of PD-1 Blockade in EBV-Associated Nasopharyngeal Carcinoma Immunotherapy by Jin Bian, Yan Niu, Yanli Ma, Fuhua Chen, Ning Ma

“…Although radiotherapy and chemotherapy are effective treatments for NPC, they have immunosuppressive effects. Immunotherapy has got considerable attention of clinicians for cancer treatment in recent years due to proven success of PD-1/PD-L 1 inhibition in solid tumors trials. …”
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Challenges of Diagnosing Severe Ehrlichiosis in Orthotopic Liver Transplant Recipients by Melissa Parkinson, Spandana Vuyyuru, Jay Patel, Chinelo Animalu

“…We report a case of a 40-year-old male who received an orthotopic liver transplant six months earlier secondary to primary sclerosing cholangitis, on chronic immunosuppressive medication, who presented with complaints of sudden onset fever associated with nausea, vomiting, and diarrhea. …”
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The impact of climate change on the epidemiology of fungal infections: implications for diagnosis, treatment, and public health strategies by Mary E. George, Tonisha T. Gaitor, David B. Cluck, Andrés F. Henao-Martínez, Nicholas R. Sells, Daniel B. Chastain

“…Simultaneously, human factors such as declining immunity, aging populations, and increased use of immunosuppressive therapies are enhancing host susceptibility. …”
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Extrapulmonary sarcoidosis presenting as myositis: A rare case by Niraj Bohania, Sumeet Singla, Jagriti Nahata, Pijush Kanti Nandi, Seema Daksh, S Anuradha

“…Patient showed marked improvement in her symptoms with immunosuppressive therapy. This case is a rare manifestation of extrapulmonary sarcoidosis and emphasizes the role of FDG-PET in diagnosing these cases.…”
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Lutein Suppresses the Maturation and Function of Bone Marrow-Derived Dendritic Cells by Seulah Choi, Tae Sung Kim, Hui Xuan Lim

“…These results demonstrated that lutein may exhibit immunosuppressive activity by inhibiting the phenotypic and functional maturation of DCs, and provide new evidence for the value of lutein in the search for novel therapeutic agents in the treatment of inflammatory diseases. …”
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Divergent paths of mammary gland involution: unveiling the cellular dynamics in abruptly and gradually involuted mouse models by Sarmila Majumder, Sanjay Mishra, Neelam Shinde, Maria C. Cuitino, Morgan Bauer, Dinesh Ahirwar, Mustafa M. Basree, Vijaya Bharti, Kate Ormiston, Resham Mawalkar, Sara Alsammerai, Gautam Sarathy, Anna E. Vilgelm, Xiaoli Zhang, Ramesh K. Ganju, Bhuvaneswari Ramaswamy

“…Results AI results in rapid cell death, DNA repair response, and immunosuppressive myeloid cells infiltration, leading to a chronically inflamed microenvironment. …”
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Cancer stem cells and tumor-associated macrophages as mates in tumor progression: mechanisms of crosstalk and advanced bioinformatic tools to dissect their phenotypes and interacti... by Francesco Verona, Sebastiano Di Bella, Roberto Schirano, Camilla Manfredi, Francesca Angeloro, Giulia Bozzari, Matilde Todaro, Matilde Todaro, Giuseppe Giannini, Giuseppe Giannini, Giorgio Stassi, Veronica Veschi

“…Among immune cells, macrophages exhibit a more plastic and adaptable phenotype due to their different subpopulations, which are characterized by both immunosuppressive and inflammatory phenotypes. Specifically, tumor-associated macrophages (TAMs) create an immunosuppressive milieu through the production of a plethora of paracrine factors (IL-6, IL-12, TNF-alpha, TGF-beta, CCL1, CCL18) promoting the acquisition by CSCs of a stem-like, invasive and metastatic phenotype. …”
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Cardiogenic Shock: An Unusual Initial Presentation of Churg-Strauss Syndrome by M. Apirami, J. A. Pratheepan, T. Kumanan, M. Guruparan, G. Selvaratnam

“…She was diagnosed as having CSS based on ACR criteria and aggressively treated with immunosuppressants according to her Five-Factor Score and has shown prompt response to therapy. …”
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JC Virus PCR Detection Is Not Infallible: A Fulminant Case of Progressive Multifocal Leukoencephalopathy with False-Negative Cerebrospinal Fluid Studies despite Progressive Clinica... by Mohamed-Ali Babi, William Pendlebury, Steven Braff, Waqar Waheed

“…We describe a case with a false-negative PCR-based analysis for JC virus in cerebrospinal fluid (CSF) in a patient with clinical and radiological findings suggestive of progressive multifocal leukoencephalopathy (PML) who was on chronic immunosuppressive therapy for rheumatoid arthritis. Our patient developed rapidly progressive global decline with clinical and radiographic findings suggestive of PML, but JC virus PCR in CSF was negative. …”
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Regulatory T Cells Resist Cyclosporine-Induced Cell Death via CD44-Mediated Signaling Pathways by Shannon M. Ruppert, Ben A. Falk, S. Alice Long, Paul L. Bollyky

“…Cyclosporine A (CSA) is an immunosuppressive agent that specifically targets T cells and also increases the percentage of pro-tolerogenic CD4+Foxp3+ regulatory T cells (Treg) through unknown mechanisms. …”
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Mitoxantrone Therapy for Acute Posterior Multifocal Placoid Pigment Epitheliopathy with Cerebral Vasculitis by Hélène Massé, Jean-Laurent Guyomard, Dominique Baudet, Jean-François Pinel, Gilles Edan, Jean-François Charlin

“…To report favorable outcome of a case of acute posterior multifocal placoid pigment epitheliopathy (APMPPE) associated with cerebral vasculitis after treatment with immunosuppressive therapy by mitoxantrone. Design. Single case report. …”
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Targeting T helper 17 cells: emerging strategies for overcoming transplant rejection by Young Joon Lee, Mi-La Cho

“…To counteract this, immunosuppressive drugs have been developed to inhibit T cell activity and foster transplant tolerance. …”
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Palpitations, Shortness of Breath, Weakness in Limbs, Edema, and Dyspnea: A Rare Inflammatory Myopathy with Positive Aniti-mitochondrial Antibodies and Cardiac Involvement by LIANG Chunsu, ZHANG Xuchang, ZHANG Ning, KANG Lin, LIU Xiaohong, YU Jiaqi, LIU Yingxian, QIAO Lin, YANG Yanli, ZHAO Xiaoyi, ZHAO Ruijie, NIU Na, YAN Xuelian

“…Treatment involved a combination of glucocorticoids and immunosuppressants, along with resistance exercises for muscle strength and rehabilitation training for lung function, resulting in significant improvement of clinical symptoms. …”
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