Update on the Progress of Musashi-2 in Malignant Tumors by Yiting Niu, Tao Zhou, Yanjun Li

“…This review summarizes the research progress related to MSI2 in recent years, including its occurrence, migration mechanism, and drug resistance, as well as the prospect of developing tumor immunosuppressants and biomarkers.…”
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Regressing Multiple Viral Plaques and Skin Fragility Syndrome in a Cat Coinfected with FcaPV2 and FcaPV3 by Alberto Alberti, Gessica Tore, Alessandra Scagliarini, Laura Gallina, Federica Savini, Chiara Caporali, Francesca Abramo

“…Numerous reports suggest that papillomaviruses (PVs) are involved in their development. Immunosuppressed and immunocompetent cats are both affected, the biological behavior is variable, and the regression is possible but rarely documented. …”
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Determination of anti-COVID-19 IgG and IgM seroprevalence among pregnant women at Pietersburg Hospital, Limpopo Province, South Africa by I Rukasha, S T S Pheeha, M R Lekalakala, P Malope

“…COVID-19 has been a major public health concern globally, leading to a higher mortality rate, especially among immunosuppressed individuals, who include pregnant women, people with HIV and people living with other comorbidities. …”
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Intratympanic administration of dexamethasone attenuates radiation induced damage to middle ear mucosa by Hyuk Chan Kwon, Sup Kim, Sheng Jin, Sun-Ae Shin, Jeong Han Lee, Min Jung Park, Soo Jeong Kim, Yong-Ho Park

“…Dexamethasone (DEX) is widely used in clinical practice because of its immunosuppressive and anti-inflammatory properties. The present study investigated the effects and underlying mechanisms of DEX delivered via intratympanic administration on RTx-induced damage to the middle ear and human middle ear epithelial (HMEE) cells. …”
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Time in therapeutic range of tacrolimus in allogeneic hematopoietic stem cell transplant recipients is associated with acute graft-versus-host disease prophylaxis by Naoki Yoshikawa, Yukina Ehara, Yusei Yamada, Yuki Matsusaki, Kazuya Shimoda, Ryuji Ikeda

“…Abstract Intra-patient variability in immunosuppressive blood drug concentrations is a potential biomarker in managing organ transplant patients. …”
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Retroperitoneal Soft Tissue Sarcoma and Kidney Autotransplantation: A Case Report by S. N. Hakkesteegt, C. A. J. Oudmaijer, L. J. Jeletich, J. Sprakel, H. J. A. N. Kimenai, D. J. Grünhagen

“…Kidney autotransplantation offers a unique solution by preserving renal function in these cases, avoiding the need for dialysis and immunosuppressive therapy. This case report presents a 61‐year‐old female with a large RPS encasing her only functioning kidney. …”
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Cardiovascular disease risk in Korean patients with systemic lupus erythematosus compared to diabetes mellitus and the general population by Jung-Yong Han, Soo-Kyung Cho, Yena Jeon, Gaeun Kang, Sun-Young Jung, Eun Jin Jang, Yoon-Kyoung Sung

“…Advanced age, male gender, and current use of glucocorticoids, immunosuppressive, and anti-platelet agents were associated with increased CVD risk in SLE patients. …”
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Repurposing Drugs for Synergistic Combination Therapies to Counteract Monkeypox Virus Tecovirimat Resistance by Haydar Witwit, Beatrice Cubitt, Roaa Khafaji, Esteban M. Castro, Miguel Goicoechea, Maria M. Lorenzo, Rafael Blasco, Luis Martinez-Sobrido, Juan C. de la Torre

“…In this study we have used vaccinia virus (VACV) as a surrogate of MPXV to assess the antiviral efficacy of combination therapy of TPOXX together with mycophenolate mofetil (MMF), an FDA-approved immunosuppressive agent that we have shown to inhibit VACV and MPXV, or the N-myristoyltransferase (NMT) inhibitor IMP-1088. …”
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In-depth proteomic profiling identifies potentiation of the LPS response by 7-ketocholesterol by Iain R. Phair, Magdalena Sovakova, Noor Alqurashi, Raid B. Nisr, Alison D. McNeilly, Douglas Lamont, Graham Rena

“…In this context, our findings suggest that drugs targeting atherogenic markers induced by 7-KC might be well tolerated, as they will not necessarily be expected to be immunosuppressive.…”
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Isolated Pauci-Immune Pulmonary Capillaritis Associated with Hydrocarbon Inhalation and Marijuana Smoking: An Unusual Case of Severe Hypoxemia by Jason S. Oh, Uni Wong, Divyansh Bajaj, Stella E. Hines

“…He was diagnosed with IPIPC and initiated on immunosuppressive therapy. He was soon liberated from mechanical ventilation and improved to hospital discharge. …”
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Mean Platelet Volume in Ocular Behçet’s Disease by Fatih Mehmet Türkcü, Abdullah Kürşat Cingü, Harun Yüksel, Yasin Çınar, Meltem Akkurt, Muhammed Şahin, Zeynep Özkurt, Alparslan Şahin, İhsan Çaça

“…MPV measurement in ocular BD is not a predictive laboratory test to determine the clinical improvement in early stages following classical immunosuppressive treatment.…”
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Serology of Viral Infections and Tuberculosis Screening in an IBD Population Referred to a Tertiary Centre of Southern Italy by Marco Ardesia, Giuseppe Costantino, Placido Mondello, Angela Alibrandi, Walter Fries

“…With the introduction of more potent immunosuppressive agents in inflammatory bowel disease, prevention of opportunistic infections has become necessary by introducing screening programs. …”
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Phosphodiesterase Inhibitors Suppress Lactobacillus casei Cell-Wall-Induced NF-κB and MAPK Activations and Cell Proliferation through Protein Kinase A—or Exchange Protein Activated... by Takekatsu Saito, Naotoshi Sugimoto, Kunio Ohta, Tohru Shimizu, Kaori Ohtani, Yuko Nakayama, Taichi Nakamura, Yashiaki Hitomi, Hiroyuki Nakamura, Shoichi Koizumi, Akihiro Yachie

“…However, a high mortality rate results from underlying immunosuppressive conditions in patients with Lactobacillus casei bacteremia. …”
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Targeting lipid metabolism: novel insights and therapeutic advances in pancreatic cancer treatment by Yanyan Zhang, Zhichao Yang, Yuchen Liu, Jinjin Pei, Ruojie Li, Yanhui Yang

“…Their accumulation fosters an immunosuppressive tumor microenvironment that supports cancer cell proliferation and metastasis. …”
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Cervical Bone Graft Candida albicans Osteomyelitis: Management Strategies for an Uncommon Infection by Carlo Brembilla, Luigi Andrea Lanterna, Andrea Risso, Giuseppe Bonaldi, Paolo Gritti, Bruno Resmini, Andrea Viscone

“…The factors contributing to its emergence include a growing population of immunosuppressed patients, invasive surgeries, broad-spectrum antibiotics, injection drug users, and alcohol abuse. …”
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A new strategy for the treatment of advanced ovarian cancer: utilizing nanotechnology to regulate the tumor microenvironment by Zixuan Xiong, Yichun Huang, Shulong Cao, Xuqun Huang, Haiyuan Zhang

“…In the immune TME, the immune effector cells such as dendritic cells (DCs), M1-like tumor-associated macrophages (M1-TAMs), and T cells are inhibited. In contrast, immunosuppressive cells such as M2-like tumor-associated macrophages (M2-TAMs), myeloid-derived suppressor cells (MDSCs), and regulatory T cells (Tregs) are activated. …”
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Red flags to suspect inborn errors of immunity in patients with autoimmune diseases by Natalia Vélez, Juliette De Ávila, Jaime Cortés, Nelson Barrero, Leosirlay Rojas, Juan Manuel Bello, Consuelo Romero-Sánchez

“…The principal red flags in autoimmune cytopenias are chronic, recurrent, and refractory cytopenias, recurrent infection, severe infectious complications associated with immunosuppressive treatment, and chronic lymphoproliferation. …”
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The Association of TNF-Alpha Inhibitors and Development of IgA Nephropathy in Patients with Rheumatoid Arthritis and Diabetes by Vedran Premužić, Ivan Padjen, Mislav Cerovec, Marijana Ćorić, Bojan Jelaković, Branimir Anić

“…Discontinuation of anti-TNF-alpha therapy and initiation of immunosuppressive therapy led to improvement in serologic abnormalities and renal function in two patients, while the third patient’s 24-hour proteinuria was only partially reduced, which supports previous reports on TNF-alpha inhibitor induced autoimmunity. …”
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The Potential Role of Regulatory B Cells in Idiopathic Membranous Nephropathy by Zhaocheng Dong, Zhiyuan Liu, Haoran Dai, Wenbin Liu, Zhendong Feng, Qihan Zhao, Yu Gao, Fei Liu, Na Zhang, Xuan Dong, Xiaoshan Zhou, Jieli Du, Guangrui Huang, Xuefei Tian, Baoli Liu

“…Regulatory B cells (Breg) are widely regarded as immunomodulatory cells which play an immunosuppressive role. Breg inhibits pathological autoimmune response by secreting interleukin-10 (IL-10), transforming growth factor-β (TGF-β), and adenosine and through other ways to prevent T cells and other immune cells from expanding. …”
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Long COVID in patients with rheumatologic disease: A single center observational study by Horacio Quinones-Moya, Armando Ocampo-Del Valle, Adolfo Camargo-Coronel, Francisco Javier Jimenez-Balderas, Miriam Berenice Bernal-Enriquez, Pedro Madinabeitia-Rodríguez, Kenia Nahomi Morales-Medino, Cynthia Roque-Ibanez, Mario Raúl Hernandez-Zavala

“…As these patients have immunosuppressive therapy and this syndrome has inflammatory characteristics, we postulate that these patients will have a lower prevalence of sequelae. …”
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