CMV Ileitis: To Treat or Not to Treat? Implications of Initiating Biologic Therapy for Concurrent Crohn’s Disease by Kendra T. Stilwell, Jason Estes, Maria T. Kurtz, James M. Francis, David T. Lynch, Anish A. Patel

“…Conversely, recent data suggests that spontaneous resolution occurs less frequently than previously believed; furthermore, mortality rate in immunocompetent individuals is similar to that of the immunosuppressed. We present a case of a 43-year-old male who was simultaneously diagnosed with CMV ileitis and Crohn’s Disease. …”
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The Efficacy of Adalimumab Treatment in Pediatric Non-Infectious Uveitis: A Retrospective Cohort Study by Kübra Özdemir Yalçınsoy, Osman Özen, Yasemin Özdamar Erol, Pınar Çakar Özdal

“…Objectives: To evaluate the clinical features of pediatric non-infectious uveitis (NIU) patients treated with adalimumab (ADA) and the efficacy of ADA in patients unresponsive to conventional immunosuppressive therapy. Materials and Methods: The records of 91 NIU patients aged ≤16 years who received ADA therapy were evaluated retrospectively. …”
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Blocking the CD39/CD73 pathway synergizes with anti-CD20 bispecific antibody in nodal B-cell lymphoma by Carsten Müller-Tidow, Peter Dreger, Joseph Kauer, Wolfgang Huber, Clara Kolbe, Berit Brinkmann, Sascha Dietrich, Tobias Roider

“…CD39 catalyzes—together with CD73—the hydrolysis of immunogenic ATP into immunosuppressive adenosine and thus actively promotes an immunosuppressive micromilieu. …”
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Impact of Herpesvirus Detection via Metagenomic Next-Generation Sequencing in Patients with Lower Respiratory Tract Infections by Zhang H, Zhang X, Zheng Y, Gu X, Fu Z, Gai W, Wang H

“…Additionally, the HD group tended to have longer hospital stays compared to non-HD group, especially in immunosuppressed patients. Furthermore, in immunocompetent patients, there were significant differences in α diversity and β diversity between the HD group and non-HD group, but such differences were not observed in immunosuppressed patients.Conclusion: The presence of herpesvirus in patients with non-critical LRTI is associated with longer hospital stays and alterations in the lung’s microbial composition. …”
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The effect of conditioned media on the cellular proliferation of pancreatic cancer cells, pancreatic stellate cells, and myeloid-derived suppressor cells by Y. Chong, S. Samsudin, D. Bahrani, C. Chang, A. Masamune, S. Ng, N. Ismail, K. Ho

“…Objective: Pancreatic cancer has remained one of the most devastating diseases over the past two decades, with minimal improvements in survival rates. Its highly immunosuppressive tumour microenvironment is driven by secreted proteins, such as cytokines and growth factors, which promote the differentiation of immunosuppressive cells and influence cellular proliferation and migration. …”
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Study of antifungal susceptibility pattern of various Candida species with reference to conventional and automated methods in a tertiary care hospital by Paulami De, Rehena Sarkar, Raja Ray, Kumkum Bhattacharyya, Hasina Banu, Hirak Jyoti Raj

“…Introduction: The incidence of Candida infections is on the rise with the increase in number of immuno-compromised patients due to excessive use of immunosuppressive drugs as well as the use of medical and surgical interventions. …”
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The clinical significance of T cell infiltration and immune checkpoint expression in central nervous system germ cell tumors by Jiajun Zhou, Jiajun Zhou, Wenhao An, Lei Guan, Lei Guan, Jinyu Shi, Qiaozhen Qin, Shuai Zhong, Zheng Huang, Rui Liu, Chenxing Wu, Zhong Ma, Xueling Qi, Xiaoxia Jiang, Yan Wang, Shouwei Li

“…The results also highlighted the strong immunosuppressive nature of the CNS GCTs’ tumor microenvironment. …”
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Invasive Aspergillosis in the Intensive Care Unit by Anna Zubovskaia, Jose A. Vazquez

“…Invasive aspergillosis (IA) is a fungal infection, which has traditionally been associated with neutropenia and immunosuppressive therapies. Our understanding of invasive aspergillosis has been evolving and, in the past few decades, IA among ICU patients has been recognized as a common infection and has become more widely recognized. …”
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Critical Care Management for Novel 2019 SARS-CoV-2 and HCoV-NL63 Coinfection in a Young Immunocompromised Patient: A Chicago Experience by Alejandro Sanchez-Nadales, Miguel Treminio-Quezada, Hasan Abad, Jessica Navarro-Motta, Pamela Contreras-Chavez, Anil Kachru, Chae Chu

“…We describe the case of a young, immunosuppressed and critically ill patient with previous Influenza B infection, requiring extracorporeal membrane oxygenation, which was then followed, in the succeeding months, by SARS-CoV-2 infection complicated by severe adult respiratory distress syndrome. …”
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Extensive Morphea Following Adjuvant Radiotherapy for Breast Carcinoma—Case Report by Alexandru Panaitescu, Hannah Nguyen, Laurence Masson-Côté, Carolina Lucena Fernandes

“…., topical tacrolimus or topical corticosteroids), phototherapy, and systemic therapy (i.e., systemic immunosuppressants). We present a case of extensive morphea post RT for breast cancer with 2 years of favorable evolution under systemic therapy.…”
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Two Case Presentations Infected by Trichosporon asahii and Treated with Voriconazole Successfully by Hikmet Gulsah Tanyildiz, Sule Yesil, Sule Toprak, Mehmet Onur Candir, Gurses Sahin

“…Trichosporon asahii is an opportunistic fungus that causes infections in immunosuppressed patients. Neutropenia developing due to malignancies is an important risk factor for fungal infection. …”
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Atypical Kaposi Sarcoma of the Tongue in HIV Positive Tanzanian Female by Elichilia Shao, Flora Ruhangisa, Neema Minja, Kanankira Nnko, Denis Katundu, George Semango, Eva Mbwilo, Amos Mwasamwaja, Kajiru Kilonzo, Isaack Lyaruu

“…This patient was newly diagnosed and had no history of antiretroviral therapy (ART), radiotherapy, or immunosuppressive drugs prior to this admission. Clinically, there were no dermatological features of KS lesions which are purple, red, or brown and which may be flat, raised (plaques), or bumpy (nodules) except for fungating and protruding enlarged tongue which was necrotic. …”
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Simultaneous Penile and Signet Ring Cell Bladder Carcinoma in Renal Transplant Recipient: A First Case by Francesca Manassero, Gianluca Giannarini, Davide Paperini, Andrea Mogorovich, Greta Alí, Ugo Boggi, Cesare Selli

“…This provides the opportunity to initiate appropriate immunosuppressive regimens depending on the tumor type and stage of development. …”
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A Case Report of Purtscher-Like Retinopathy Secondary to Pneumocystis jirovecii Pneumonia in an Immunocompromised Patient by Alastair David Bezzina, Isaac Bertuello

“…To the best of our knowledge, we present the first case of a young adult male, on long-term immunosuppressive therapy following a live-donor kidney transplant, with Purtscher-like retinopathy (PLR) secondary to Pneumocystis jirovecii pneumonia (PCP). …”
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A Case Series of Gastrointestinal Tuberculosis in Renal Transplant Patients by Pedro Azevedo, Cristina Freitas, Hugo Silva, Pedro Aguiar, Pedro Farrajota, Manuela Almeida, Sofia Pedroso, La Salete Martins, Leonídio Dias, José Ramón Vizcaíno, António Castro Henriques, António Cabrita

“…Therapeutic options may be a problem in the context of an immunosuppressed patient, requiring adjustment of maintenance therapy. …”
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Esophageal Involvement in Wegener’s Granulomatosis: A Case Report and Review of the Literature by Glen A Fallows, Sean F Hamilton, Douglas S Taylor, S Bharati Reddy

“…These reports illustrate the need to consider odynophagia as a reflection of disease activity as opposed to complications of immunosuppressive therapy.…”
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Tumor-infiltrating regulatory T cell: A promising therapeutic target in tumor microenvironment by Tianning Huang, Fan Li, Yiming Wang, Jian Gu, Ling Lu, Peifang Wei

“…Regulatory T cell (Tregs) predominantly maintain the immune balance and prevent autoimmunity via their immunosuppressive functions. However, tumor-infiltrating Tregs (TI-Tregs) may mediate tumor immune tolerance in complex tumor microenvironments, resulting in poor prognosis. …”
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RECONSTRUCTION OF AMINO ACID SEQUENCES OF CYCLIC PEPTIDES FROM THEIR MASS SPECTRA by E. S. Fomin

“…Nevertheless, in spite of all efforts, there is little progress in the development of programs able to solve the problem for de novo sequencing of cyclic peptides, which are most effective antibiotics, antitumor agents, immunosuppressants, toxins, and a vast number of nonribosomal peptides with unknown functions. …”
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Disseminated Histoplasmosis with Miliary Histoplasmosis, Neurohistoplasmosis, and Histoplasma capsulatum Bacteremia in Probable Neurosarcoidosis by Peter V. Bui

“…Empiric antimicrobial therapy for a patient with neurosarcoidosis on immunosuppressive agents may need to include antifungal agents.…”
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Control of Herpesvirus Infection in Organ Transplant Recipients by Nina E Tolkoff-Rubin, Robert H Rubin

“…New approaches to controlling these viruses in which pre-emptive therapy is linked to immunosuppressive therapy, and new diagnostic techniques for viral monitoring, hold promise for limiting clinical disease due to these viruses.…”
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