Lutein Suppresses the Maturation and Function of Bone Marrow-Derived Dendritic Cells by Seulah Choi, Tae Sung Kim, Hui Xuan Lim

“…These results demonstrated that lutein may exhibit immunosuppressive activity by inhibiting the phenotypic and functional maturation of DCs, and provide new evidence for the value of lutein in the search for novel therapeutic agents in the treatment of inflammatory diseases. …”
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Intra-Abdominal Localisation of a Buschke-Lowenstein Tumour: Case Presentation and Review of the Literature by N. E. Wester, E. M. Hutten, C. Krikke, Robert A. Pol

“…Treatment was impeded by cachexia, an immunosuppressive state after kidney transplantation and difficulties in establishing a reliable diagnose. …”
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Everolimus for Compassionate Use in Multiple Basal Cell Carcinomas by Laura Eibenschutz, Delia Colombo, Caterina Catricalà

“…Everolimus is an inhibitor of the mammalian target of rapamycin (mTOR) and has been shown to have antineoplastic activity in addition to its use as an immunosuppressive agent for the prevention of organ transplant rejection. …”
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Successful Outcome of a Corticodependent Henoch-Schönlein Purpura Adult with Rituximab by Taylor Pindi Sala, Jean-Marie Michot, Renaud Snanoudj, Marion Dollat, Emmanuel Estève, Bernadette Marie, Yacine Taoufik, Jean-François Delfraissy, Thierry Lazure, Olivier Lambotte

“…Eight years after the transplantation, while taking combined immunosuppressive therapy with tacrolimus and azathioprine indicated for the prevention against transplant rejection, she developed a Henoch-Schönlein purpura. …”
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Biometallic ions and derivatives: a new direction for cancer immunotherapy by Lin Zhao, Yajun Gui, Jing Cai, Xiangying Deng

“…In addition, biometallic ions and derivatives can directly inhibit tumor cell progression and offer the possibility of effectively overcoming the limitations of current cancer immunotherapy by promoting immune responses and reducing immunosuppressive signals. This review explores the role and potential application prospects of biometallic ions in cancer immunotherapy, providing new ideas for future clinical application of metal ions as part of cancer immunotherapy and helping to guide the development of more effective and safe therapeutic regimens.…”
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Atypical Vascular Involvement in a Case of Behçet's Disease by Alejandro Rodríguez Morata, Ana Hidalgo Conde, Carlos de la Cruz Cosme, Susana Gómez Ramírez, Rafael Gómez Medialdea

“…The pseudoaneurysm was successfully treated, we performed an iliofemoral bypass, and we treated it with steroids and immunosuppressive therapy. Conclusions. These rare clinical manifestations highlight the importance of considering BD in young patients, even in usual cases of vascular intervention, whether arterial or venous in nature.…”
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New Diagnostics for Fungal Infections in Transplant Infectious Disease: A Systematic Review by Apurva Akkad, Neha Nanda

“…Fungal infections are common in highly immunosuppressed, solid organ transplant recipients. They can be quite difficult to diagnose in a timely manner; thus, we present a review of current studies focusing on broad categories of molecular diagnostics, i.e., metagenomic sequencing, magnetic resonance, and gas chromatography mass spectrometry. …”
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Risk Factors for Tuberculosis by Padmanesan Narasimhan, James Wood, Chandini Raina MacIntyre, Dilip Mathai

“…Along with well-established risk factors (such as human immunodeficiency virus (HIV), malnutrition, and young age), emerging variables such as diabetes, indoor air pollution, alcohol, use of immunosuppressive drugs, and tobacco smoke play a significant role at both the individual and population level. …”
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The Successful Use of Infliximab in a Relapsing Case of Susac’s Syndrome by Suran L. Fernando, Therese Boyle, Annika Smith, John D.E. Parratt

“…We present such a case of Susac’s syndrome that was also refractory to conventionally prescribed combination of immunosuppressive treatments including high-dose potent corticosteroids, intravenous cyclophosphamide, methotrexate, plasma exchange, rituximab, and mycophenolate. …”
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Immunotherapy of Cancer: Reprogramming Tumor-Immune Crosstalk by Kyle K. Payne, Amir A. Toor, Xiang-Yang Wang, Masoud H. Manjili

“…These include weak immunogenicity of the tumor, as well as immunosuppressive mechanisms which prevent effective antitumor immune responses. …”
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Harnessing nanoparticles for reshaping tumor immune microenvironment of hepatocellular carcinoma by JinSong Li, GuanBo Zhang, Gang Li, Jie Zhang, Zhi Yang, Lin Yang, ShiJie Jiang, JiaXing Wang

“…However, acquired resistance and the tumor immunosuppressive microenvironment (TIME) significantly hinder its clinical application. …”
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Bilateral Ureteral Stenosis with Hydronephrosis as First Manifestation of Granulomatosis with Polyangiitis (Wegener’s Granulomatosis): A Case Report and Review of the Literature by Joelle Suillot, Jürg Bollmann, Samuel Rotman, Eric Descombes

“…The hydronephrosis and renal function rapidly improved under immunosuppressive therapy with high-dose corticosteroids and intravenous pulse cyclophosphamide. …”
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Infectious scleritis: a review of etiologies, clinical features, and management strategies by Supriya Sharma, Jay U. Sheth, Somasheila I. Murthy, Somasheila I. Murthy

“…A high level of suspicion is required in such cases and risk factors such as with a history of trauma or surgery and worsening or refractory to immunosuppressive medications as these may well be infectious. …”
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Daratumumab for Bortezomib-Refractory Proliferative Glomerulonephritis With Monoclonal Immunoglobulin Deposits in Kidney Allograft: A Case Report by Zewei Chen, Shangxi Fu, Jun Wu, Xiaoling Luo, Zhiguo Mao, Dechao Xu, Xiang Gao

“…Despite treatment with immunosuppressive or clone-targeted chemotherapy, patients with proliferative glomerulonephritis with monoclonal immunoglobulin deposit (PGNMID) frequently progress into end-stage kidney failure, and early recurrence of PGNMID after kidney transplantation is common. …”
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SIRT5 Contributes to Colorectal Cancer Growth by Regulating T Cell Activity by Ke Wang, Zuojian Hu, Cuiping Zhang, Lujie Yang, Li Feng, Pengyuan Yang, Hongxiu Yu

“…An imbalance in the lineages of immunosuppressive Treg cells and the inflammatory Th1 subsets of helper T cells leads to the development of colon cancer. …”
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Posterior Reversible Encephalopathy Syndrome in a Patient with Newly Diagnosed HIV Infection and End Stage Renal Disease by Mohankumar Kurukumbi, Maria I. Castellanos, Amanda K. Crawford, Shreyas D. Gowdar, Annapurni Jayam-Trouth

“…PRES is typically associated with many conditions such as hypertension, uremia, immunosuppressive drugs, and sepsis. This is a case report of a 39-year-old woman with untreated HIV infection and end-stage renal disease (ESRD) who developed PRES with a normal blood pressure and no other known causes of PRES. …”
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Pulmonary Toxoplasmosis Diagnosed on Transbronchial Lung Biopsy in a Mechanically Ventilated Patient by Delyse Garg, Nikhil Madan, Omar Qaqish, Sandhya Nagarakanti, Vipul Patel

“…Invasive toxoplasmosis often manifests as cerebral toxoplasmosis in immunosuppressed patients. In persons living with human immunodeficiency virus (HIV), toxoplasmosis occurs when CD4 counts are very low and is considered an acquired immunodeficiency syndrome (AIDS) defining illness. …”
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Cancer stem cells and tumor-associated macrophages as mates in tumor progression: mechanisms of crosstalk and advanced bioinformatic tools to dissect their phenotypes and interacti... by Francesco Verona, Sebastiano Di Bella, Roberto Schirano, Camilla Manfredi, Francesca Angeloro, Giulia Bozzari, Matilde Todaro, Matilde Todaro, Giuseppe Giannini, Giuseppe Giannini, Giorgio Stassi, Veronica Veschi

“…Among immune cells, macrophages exhibit a more plastic and adaptable phenotype due to their different subpopulations, which are characterized by both immunosuppressive and inflammatory phenotypes. Specifically, tumor-associated macrophages (TAMs) create an immunosuppressive milieu through the production of a plethora of paracrine factors (IL-6, IL-12, TNF-alpha, TGF-beta, CCL1, CCL18) promoting the acquisition by CSCs of a stem-like, invasive and metastatic phenotype. …”
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Cardiogenic Shock: An Unusual Initial Presentation of Churg-Strauss Syndrome by M. Apirami, J. A. Pratheepan, T. Kumanan, M. Guruparan, G. Selvaratnam

“…She was diagnosed as having CSS based on ACR criteria and aggressively treated with immunosuppressants according to her Five-Factor Score and has shown prompt response to therapy. …”
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JC Virus PCR Detection Is Not Infallible: A Fulminant Case of Progressive Multifocal Leukoencephalopathy with False-Negative Cerebrospinal Fluid Studies despite Progressive Clinica... by Mohamed-Ali Babi, William Pendlebury, Steven Braff, Waqar Waheed

“…We describe a case with a false-negative PCR-based analysis for JC virus in cerebrospinal fluid (CSF) in a patient with clinical and radiological findings suggestive of progressive multifocal leukoencephalopathy (PML) who was on chronic immunosuppressive therapy for rheumatoid arthritis. Our patient developed rapidly progressive global decline with clinical and radiographic findings suggestive of PML, but JC virus PCR in CSF was negative. …”
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