Eales’ Disease: When the Rare Sounds Frequent by Beatriz Oliveira Lopes, Margarida Sena Brízido, Ana Isabel Reis, Margarida Maria Miranda, Susana Morais Pina

“…Therapeutic approach included antituberculosis therapy and systemic steroids, associated or not to immunosuppressive therapy, and retinal scatter photocoagulation in all cases. …”
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Mechanism and Treatment Strategy of Osteoporosis after Transplantation by Lei Song, Xu-Biao Xie, Long-Kai Peng, Shao-Jie Yu, Ya-Ting Peng

“…Bone loss after organ transplant is related to adverse effects of immunosuppressants on bone remodeling and bone quality. …”
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High on Cannabis and Calcineurin Inhibitors: A Word of Warning in an Era of Legalized Marijuana by Naomi Hauser, Tanmay Sahai, Rocco Richards, Todd Roberts

“…Tacrolimus, a potent immunosuppressant medication, acts by inhibiting calcineurin, which eventually leads to inhibition of T-cell activation. …”
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Use of Hyaluronic Acid as Adjuvant in Periodontal Therapy and Healing: a Bibliographic Review by Marcelo Fernando Armijos Briones, Cinthya Lisbeth Sinchiguano Moreano, Coralia de los Ángeles Ortega Medina

“…Hyaluronic acid is a natural non-sulfated polysaccharide of the glycosaminoglycan family, it can cause different responses in the body, the high molecular weight has anti-inflammatory, immunosuppressive and healing effects, while the low molecular weight has proinflammatory properties. …”
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Leprosy with Atypical Skin Lesions Masquerading as Relapsing Polychondritis by Punit Pruthi, Hariharan Munganda, Amit Bangia, Uma Rani, Rajesh Budhiraja, Swapnil Brajpuriya

“…Tissue diagnosis should always be attempted whenever possible in patients presenting with autoimmune features, so that inappropriate therapy with immunosuppressants is avoided.…”
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XMRV Discovery and Prostate Cancer-Related Research by David E. Kang, Michael C. Lee, Jaydip Das Gupta, Eric A. Klein, Robert H. Silverman

“…Subsequent investigations in North America, Europe, Asia, and Africa have either observed or failed to detect XMRV in patients (prostate cancer, chronic fatigue syndrome-myalgic encephalomyelitis (CFS-ME), and immunosuppressed with respiratory tract infections) or normal, healthy, control individuals. …”
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Predictive role of SLC1A5 in neuroblastoma prognosis and immunotherapy by Jian Cheng, Miaomiao Sun, Xiao Dong, Yang Yang, Xiaohan Qin, Xing Zhou, Yongcheng Fu, Yuanyuan Wang, Jingyue Wang, Da Zhang

“…Immune infiltration analysis revealed a more immunosuppressive tumor microenvironment associated with high SLC1A5 expression. …”
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Corticosteroid use beyond 1-year post heart transplantation is associated with worse outcomes: A contemporary analysis of the ISHLT registry by Abhishek Jaiswal, MD, William L. Baker, Pharm.D, Ashwin Pillai, MD, Michelle Kittleson, MD, PhD, Balaphanidhar Mogga, MD, Zeina Jedeon, MD, Caroline Chen, David A. Baran, MD

“…Introduction: Immunosuppressive drugs ensure graft survival in heart transplantation (HT). …”
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Stevens-Johnson syndrome/toxic epidermal necrolysis spectrum for the rheumatologist by Jyoti Ranjan Parida, Saumya Ranjan Tripathy

“…Supportive care is the mainstay of treatment and if not started promptly may result in high mortality and morbidity. Although many immunosuppressive drugs have been tried in treatment, no treatment has proven beneficial except cyclosporine which has been shown to retard the progression of SJS/TEN. …”
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Management of connective tissue disease-associated interstitial lung disease by Keerthi Talari

“…Corticosteroids (except in systemic sclerosis [SSc]-ILD) in combination with immunosuppressants form the mainstay of therapy in CTD-ILD. …”
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Overview of Newer Glucocorticosteroid Preparations for Inflammatory Bowel Disease by R Brattsand

“…This means that there is a high potential for anti-inflammatory and immunosuppressive actions on rectal and bowel mucosa. The compound is metabolically stable in the bowel compartment, which allows full retention of glucocorticosteroid activity in the target organ. …”
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Pas de Deux: Active Ulcerative Colitis in an HIV-Positive Patient by David C Pearson, Lloyd R Sutherland, Stephan Urbanski

“…It also presents a difficult management problem because the patient has a limited life expectancy and is reluctant to accept colectomy, and further immunosuppressive therapy may be dangerous.…”
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Protein Phosphatase 2A: Role in T Cells and Diseases by Suyasha Roy, Lalit Batra

“…Genetic deletion of PP2A in Tregs disrupts Foxp3 expression due to hyperactivation of mTORC1 signaling which impairs the development and immunosuppressive functions of Tregs. PP2A is important in the induction of Th9 cells and promotes their antitumor functions. …”
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Seronegative autoimmune hepatitis by A. O. Buyeverov

“…According to available information one can postulate following: 1) clinical vigilance for SAH, especially at liver diseases with high biochemical activity; 2) performing liver biopsies in all cases of unclear diagnosis; 3) application of standard scoring diagnostic system at autoimmune hepatitis; 4) prescription of immunosuppressive therapy at justified suspicion for SAH (at ruling out of the other causes for liver disease). …”
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Sensory-Motor Polyneuropathy and Digital Ischemia: A Rare Presentation of Granulomatosis with Polyangiitis by Wasundara Wathurapatha, B. G. A. Rathnamali, Upul Dissanayake

“…She made a good recovery following aggressive immunosuppressive treatment with methylprednisolone and cyclophosphamide and was maintained on prednisolone and azathioprine. …”
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Vasculitic Tibial Mononeuropathy Associated with Inherited Immune Dysregulation: A Review of Tibial Mononeuropathies with Electrodiagnostic Considerations by James Liu, Yue Ding, Sandra Camelo-Piragua, James Richardson

“…She was then started on appropriate immunosuppressive treatment which resulted in significant pain relief and was discharged home. …”
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A Review on the Application of PD-1 Blockade in EBV-Associated Nasopharyngeal Carcinoma Immunotherapy by Jin Bian, Yan Niu, Yanli Ma, Fuhua Chen, Ning Ma

“…Although radiotherapy and chemotherapy are effective treatments for NPC, they have immunosuppressive effects. Immunotherapy has got considerable attention of clinicians for cancer treatment in recent years due to proven success of PD-1/PD-L 1 inhibition in solid tumors trials. …”
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Challenges of Diagnosing Severe Ehrlichiosis in Orthotopic Liver Transplant Recipients by Melissa Parkinson, Spandana Vuyyuru, Jay Patel, Chinelo Animalu

“…We report a case of a 40-year-old male who received an orthotopic liver transplant six months earlier secondary to primary sclerosing cholangitis, on chronic immunosuppressive medication, who presented with complaints of sudden onset fever associated with nausea, vomiting, and diarrhea. …”
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The impact of climate change on the epidemiology of fungal infections: implications for diagnosis, treatment, and public health strategies by Mary E. George, Tonisha T. Gaitor, David B. Cluck, Andrés F. Henao-Martínez, Nicholas R. Sells, Daniel B. Chastain

“…Simultaneously, human factors such as declining immunity, aging populations, and increased use of immunosuppressive therapies are enhancing host susceptibility. …”
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Extrapulmonary sarcoidosis presenting as myositis: A rare case by Niraj Bohania, Sumeet Singla, Jagriti Nahata, Pijush Kanti Nandi, Seema Daksh, S Anuradha

“…Patient showed marked improvement in her symptoms with immunosuppressive therapy. This case is a rare manifestation of extrapulmonary sarcoidosis and emphasizes the role of FDG-PET in diagnosing these cases.…”
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