Strongyloides stercoralis and Organ Transplantation by Bhalaghuru Chokkalingam Mani, Moses Mathur, Heather Clauss, Rene Alvarez, Eman Hamad, Yoshiya Toyoda, Mark Birkenbach, Mustafa Ahmed

“…Infection in the immunocompetent host is usually associated with mild gastrointestinal symptoms. However, in immunosuppressed individuals it has been known to cause a “hyperinfection syndrome” with fatal complications. …”
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Epididymo-Orchitis as a Presenting Feature of Relapsing Polychondritis: A Case Report by Kuljeet Bhamra, Rachel Weerasinghe, Alan Steuer

“…Corticosteroids are the mainstay of treatment but other immunosuppressive drugs can be used in combination with steroids. …”
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Urinary System Manifestation of IgG4-Related Disease: Clinical, Laboratory, Radiological, and Pathological Spectra of a Chinese Single-Centre Study by Fei Teng, Hui Lu, Ke Zheng, Gang Chen, Yubing Wen, Zheng Liu, Linyi Peng, Li Huo, Xiaofeng Zeng, Wen Zhang, Xuemei Li

“…Patients showed good initial response to immunosuppressive treatment but relapses could occur at the maintenance period.…”
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Organ donation in the paediatric intensive care unit: Time for change? by Kristy Xinghan Fu, Sze Lyn Jasmin Jeanette Tan, Ne-Hooi Will Loh

“…To our knowledge, the first solid organ transplantation performed in Singapore in July 1970 involved a kidney from a deceased donor.1 Since then, rapid advancements in both transplant surgery and immunosuppressive medical therapy have enabled solid organ transplantation to better meet the increasing demands of a growing Singapore population with end-organ diseases. …”
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The pivotal image findings of progressive multifocal leukoencephalopathy: A case report by Shou-De Ma, Chih-Wei Wei, Tai-Lin Huang, Chao-Hsin Wu, Shiang-Yu Chang

“…A 60-year-old woman, who was on immunosuppressive therapy, presented with a sudden seizure and was diagnosed with PML based on magnetic resonance imaging (MRI) findings. …”
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Manic-Like Psychosis Associated with Elevated Trough Tacrolimus Blood Concentrations 17 Years after Kidney Transplant by Giuseppe Bersani, Pietropaolo Marino, Giuseppe Valeriani, Valentina Cuoco, Claudia Zitelli, Claudia Melcore, Francesco Saverio Bersani

“…The use of antipsychotics may improve the severity of symptoms; but in order to obtain a complete remission, the reduction in the dose of tacrolimus, or its replacement with alternative immunosuppressant therapies, is recommended.…”
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The hope as social commitment in the processing of tacrolimus by Alessandra Suzin Bertan, Marco Aurélio Cremasco

“… The 2020 year shows the fragility of the human been due to a virus that affects the people dependent of immunosuppressant agents. The aim of this paper it to contextualize the importance of the hope as essential element in chemical design to obtain tacrolimus, and to professionals involved in this research. …”
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Excretory/secretory-products of Echinococcus multilocularis larvae induce apoptosis and tolerogenic properties in dendritic cells in vitro. by Justin Komguep Nono, Katrien Pletinckx, Manfred B Lutz, Klaus Brehm

“…While none of the larvae induced the secretion of pro-inflammatory IL-12p70, the production of immunosuppressive IL-10 was elevated in response to primary cell E/S-products. …”
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Mycophenolate mofetil: an update on its mechanism of action and effect on lymphoid tissue by Anna Krawczyk, Bernard Kravčenia, Tomasz Maślanka

“…IntroductionMycophenolate mofetil (MMF) is an immunosuppressive drug administered in the management of both autoimmune diseases and organ transplantation. …”
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Mesenchymal Stromal Cells Mediate Clinically Unpromising but Favourable Immune Responses in Kidney Transplant Patients by Urvashi Kaundal, Raja Ramachandran, Amit Arora, Deepesh B. Kenwar, Ratti Ram Sharma, Ritambhra Nada, Mukut Minz, Vivekanand Jha, Aruna Rakha

“…Allograft rejection postkidney transplantation (KTx) is a major clinical challenge despite increased access to a healthcare system and improvement in immunosuppressive (IS) drugs. In recent years, mesenchymal stromal cells (MSCs) have aroused considerable interest in field of transplantation due to their immunomodulatory and regenerative properties. …”
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CD73/adenosine dynamics in treatment-induced pneumonitis: balancing efficacy with risks of adverse events in combined radio-immunotherapies by Lena Gockeln, Florian Wirsdörfer, Verena Jendrossek

“…In order to further improve therapy outcomes, innovative combinatorial treatment strategies aim to target additional immunosuppressive barriers in the tumor microenvironment such as the CD73/adenosine pathway. …”
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SIGLEC11 promotes M2 macrophage polarization through AKT–mTOR signaling and facilitates the progression of gastric cancer by Chen Li, Yang Lu, Yihao Liu, Minmin Shi, Zhenggang Zhu, Jingxin Yin, Qimeng Shi, Da Fu, Zhenqiang Wang

“…In addition, SIGLEC11+ macrophages accelerate GC progression.Conclusions The abundance of SIGLEC11+ M2-like macrophage-infiltrating tumors may serve as a biomarker for identifying immunosuppressive subtypes of GC. Thus, the potential role of SIGLEC11+ M2 macrophages as therapeutic targets warrants further investigation.…”
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VSIG4+ tumor-associated macrophages mediate neutrophil infiltration and impair antigen-specific immunity in aggressive cancers through epigenetic regulation of SPP1 by Zongfu Pan, Jinming Chen, Tong Xu, Anqi Cai, Bing Han, Ying Li, Ziwen Fang, Dingyi Yu, Shanshan Wang, Junyu Zhou, Yingying Gong, Yulu Che, Xiaozhou Zou, Lei Cheng, Zhuo Tan, Minghua Ge, Ping Huang

“…Abstract V-set and immunoglobulin domain-containing 4 (VSIG4) positive tumor-associated macrophage (VSIG4+ TAM) is an immunosuppressive subpopulation newly identified in aggressive cancers. …”
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Successful Treatment of Disseminated Subcutaneous Panniculitis-Like T-Cell Lymphoma with Single Agent Oral Cyclosporine as a First Line Therapy by Nida Iqbal, Vinod Raina

“…Cyclosporine, an immunosuppressant, has shown good responses in relapsed/refractory SPTL; however its use in first line setting is not well established. …”
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Susac Syndrome and Pregnancy by Yazan Al-Hasan, Justin L. Hoskin, John C. Wolf, Kamala Saha

“…We stress the importance of a multidisciplinary approach, involving both neurology and maternal-fetal medicine, and provide guidance in navigating the various options for immunosuppressive therapy during pregnancy.…”
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Topical Glucocorticoid Use and the Risk of Posttransplant Diabetes by Simon Bøtker, Henrik Birn, Lara Aygen Øzbay

“…Systemically administered glucocorticoids constitute an essential part of the immunosuppressive regimen for transplant recipients, yet their known risks of causing hyperglycemia or posttransplant diabetes require close monitoring and minimisation of use, when possible, to prevent detrimental effects on patient morbidity and graft survival. …”
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Resveratrol and its derivates improve inflammatory bowel disease by targeting gut microbiota and inflammatory signaling pathways by Ming Li, Ping Li, Rongxue Tang, Hui Lu

“…Conventional treatments for IBD include antibiotics, immunosuppressive agents, 5-aminosalicylic acid, steroids and surgery, which have high toxic side effects. …”
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A Challenging Case of Multifocal Mycobacterium marinum Osteoarticular Infection in a Patient with Anorexia Nervosa by Katie Sharff, Zaw Min, Nitin Bhanot

“…Disseminated infection due to Mycobacterium marinum is rare but has been described in immunosuppressed and transplant recipients. We describe a case of multifocal osteoarticular involvement by this pathogen in a patient with anorexia nervosa. …”
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Bartonella Infection in Immunocompromised Hosts: Immunology of Vascular Infection and Vasoproliferation by Mosepele Mosepele, Dana Mazo, Jennifer Cohn

“…This paper will discuss Bartonella's manifestations in immunosuppressed patients and will examine Bartonella's interaction with the immune system including its mechanisms of establishing infection and immune escape. …”
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Paroxysmal Amnesia Attacks due to Hashimoto’s Encephalopathy by Pelin Nar Senol, Aylin Bican Demir, Ibrahim Bora, Mustafa Bakar

“…Although symptoms suggest a nonlesional encephalopathy in most of the cases, sometimes the clinical appearance can be subtle and may not respond to immunosuppressants or immunomodulatory agents. Here we report a case who presented with drowsiness and amnestic complaints associated with paroxysmal electroencephalography (EEG) abnormalities which could be treated only with an antiepileptic drug.…”
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