Identification of Crotonylation Metabolism Signature Predicting Overall Survival for Clear Cell Renal Cell Carcinoma by Jie Zheng, Yingqing Liu, Kai Wei, Jiewu Shi, Lin Li, Xuefeng Jiang, Lingsong Tao

“…KAT2A shows strong associations with clinical factors and the immunosuppressive environment, suggesting potential for innovative immunotherapies in ccRCC treatment.…”
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Investigation of possible predictive factors, clinical characteristics, and treatment in vascular Behçet's disease: real-life data from a single center by Abdulvahap Kahveci, Zeycan Kübra Cevval

“…Although immunosuppressive drugs represent the cornerstone of treatment for vasculo-Behçet's disease, most patients had also received anticoagulant therapy following the initial attack.…”
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Lived experiences for individuals with cystic fibrosis who have undergone lung transplantation: a qualitative study by Ulrika Skogeland, Isabelle de Monestrol, Terezia Pincikova, Tove Godskesen

“…Participants highlighted the importance of taking immunosuppressive medications as prescribed, even though the regimen was complicated and these medications had side effects. …”
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New treatment options for generalized myasthenia gravis by Antanas Vaitkus, J. Čiauškaitė, M. Malakauskaitė, M. Baublytė

“…Four treatment strategies are used in clinical practice: symptomatic, immunosuppressive, immunomodulatory, and surgical treatment, which can help control the disease but are not equally effective for all patients. …”
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Diagnostic Difficulties in Woman with Crohn’s Disease, Ascites, and Elevated Value of Serum CA125 Antigen by Maria Kłopocka, Ariel Liebert, Joanna Bielińska, Marcin Manerowski

“…This issue is particularly important in patients treated with immunosuppressants and biological agents. The discussion focused on the usefulness of CA125 (cancer antigen 125, mucin 16) serum level estimation in clinical practice and draws attention to the possible reasons for the increase of its value which is not associated to ovarian cancer.…”
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A Survey of Canadian Gastroenterologists about the Use of Methotrexate in Patients with Crohn’s Disease by Nilesh Chande, Terry Ponich, James Gregor

“…BACKGROUND: Methotrexate (MTX) is effective in remission induction and maintenance in steroid-dependent Crohn's disease (CD), but is often considered to be a second-line immunosuppressive agent, to be used in cases of failure or intolerance to azathioprine (AZA) or 6-mercaptopurine (6-MP). …”
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Advances in CAR T cell therapy: antigen selection, modifications, and current trials for solid tumors by Safwaan H. Khan, Safwaan H. Khan, Yeonjoo Choi, Mysore Veena, Mysore Veena, John K. Lee, John K. Lee, Daniel Sanghoon Shin, Daniel Sanghoon Shin

“…However, the extension of these successes to solid tumors remains limited due to several intrinsic challenges, including antigen heterogeneity and immunosuppressive tumor microenvironments. In this review, we provide a comprehensive overview of recent advances in CAR T cell therapy aimed at overcoming these obstacles. …”
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Autoimmune pulmonary alveolar proteinosis developed during treatment for systemic sclerosis: a case report by Tomoki Kozono, Kentaro Tanaka, Tomoko Yagi, Kazuto Kamikawaji, Masaki Watanabe, Azusa Iwanaga, Minako Hamada, Yoshifusa Koreeda, Hiromasa Inoue, Ikkou Higashimoto

“…Conclusion In patients with interstitial lung shadows who do not improve with immunosuppressive treatment, PAP is one of the differential diagnoses that should be considered. …”
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Hypoxia-tolerant polymeric photosensitizer prodrug for cancer photo-immunotherapy by Jie Yu, Jiayan Wu, Jingsheng Huang, Cheng Xu, Mengke Xu, Clarence Zhi Han Koh, Kanyi Pu, Yan Zhang

“…Abstract Although photodynamic immunotherapy represents a promising therapeutic approach against malignant tumors, its efficacy is often hampered by the hypoxia and immunosuppressive conditions within the tumor microenvironment (TME) following photodynamic therapy (PDT). …”
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Efficacy and safety of telitacicept in IgA nephropathy: a real-world study by Lingqiu Dong, Dandan Yang, Aiya Qin, Siqing Wang, Yi Tang, Jiaxing Tan, Wei Qin

“…Telitacicept reduced median proteinuria by 0.72 g/d (54.6%) from baseline, compared with a reduction of 0.18 g/d (20%) in the supportive treatment group and 1.12 g/d (72.1%) in the immunosuppressive treatment group. Preserved eGFR levels were observed in the telitacicept group, whereas eGFR levels decreased in the other two groups. …”
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Massive pulmonary thromboembolism in a pediatric patient with eosinophilic granulomatosis with polyangiitis: a case-based review emphasizing management by Batuhan Küçükali, Merve Yazol, Çisem Yıldız, Büşra Acun, Nuran Belder, Nihal Karaçayır, Merve Kutlar, Pelin Esmeray Şenol, Zühre Kaya, Deniz Gezgin Yıldırım, Sevcan A. Bakkaloğlu

“…Herein, we document a pediatric EGPA patient with deep venous thrombosis presenting with massive pulmonary thromboembolism during a relapse, treated with immunosuppressive and anticoagulant therapy to raise awareness among clinicians. …”
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Th1/Th2 cytokines and ICAM–1 levels post-liver transplant do not predict early rejection by E. Granot, A. Tarcsafalvi, S. Emre, P. Sheiner, S. Guy, M. E. Schwartz, P. Boros, C. M. Miller

“…Levels of IFN-γ, IL–4 and their ratios did not correlate with rejection or immunosuppressive therapy. Thus, Th1/Th2 cytokine monitoring during the first week post-transplant does not predict early rejection and immunosuppressive therapy is the predominant factor affecting ICAM and sIL–2R levels after liver transplantation.…”
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Inhalable nanovesicles loaded with a STING agonist enhance CAR-T cell activity against solid tumors in the lung by Tianchuan Zhu, Yuchen Xiao, Zhenxing Chen, Hanxi Ding, Shoudeng Chen, Guanmin Jiang, Xi Huang

“…Abstract Suppression of chimeric antigen receptor-modified T (CAR-T) cells by the immunosuppressive tumor microenvironment remains a major barrier to their efficacy against solid tumors. …”
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Activatable Sulfur Dioxide Nanosonosensitizer Enables Precisely Controllable Sono‐Gaseous Checkpoint Trimodal Therapy for Orthotopic Hepatocellular Carcinoma by Jing Liang, Guangwen Cheng, Luping Qiu, Liyun Xue, Huning Xu, Xiaohui Qiao, Na Guo, Huijing Xiang, Yu Chen, Hong Ding

“…The activity of Aza‐DNBS NPs is initially silenced, and the sonodynamic, gaseous, and immunosuppressive TME reprogramming activities are precisely awakened under US irradiation. …”
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Hepatic Kaposi Sarcoma after Kidney Transplantation: A Case Report by Seunghyeon Roh, Myoung Seok Lee, Siwon Jang, Min Hoan Moon, Joon Koo Han

“…We report a rare case of de novo hepatic Kaposi’s sarcoma manifesting as an ill-defined infiltrative lesion in the left lobe of the liver in a patient who was immunosuppressed for 9 months after a kidney transplantation using ultrasonography, CT, MRI, and fluorodeoxyglucose-PET.…”
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The Incidence and Risk Factors for Lower Limb Skin Graft Failure by Sumeet Reddy, Falah El-Haddawi, Michael Fancourt, Glenn Farrant, William Gilkison, Nigel Henderson, Stephen Kyle, Damien Mosquera

“…One-third of lower limb skin grafts went on to fail with increased BMI, peripheral vascular disease, and immunosuppressant medication use identified as significant risk factors.…”
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Fulminant necrotising fasciitis complicating upper limb arteriovenous fistula access for haemodialysis by Sri Satyavathi Davulury, Vinod Bhan

“…It is known to occur in drug abusers, immunosuppressed individuals, malignancy, renal failure and in malnourished individuals. …”
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Idiopathic CD4 lymphocytopenia: An uncommon but fatal cause of Pneumocystis pneumonia by Julia Schearer, Christopher Merrick

“…In those without previously identified risk factors, maintaining an index of suspicion for this diagnosis with search for underlying immunosuppressive cause is of utmost importance. Here, we present a case of fatal PCP in a patient without a known history of immunocompromise subsequently diagnosed with idiopathic CD4 lymphocytopenia (ICL) with an absolute CD4+ T-cell count of 7 cells/uL.…”
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Fatal Hepatocellular Carcinoma in a Patient with Occult Hepatitis B Virus Infection following the Administration of R-CHOP for Diffuse Large B-Cell Lymphoma by Vincenzo Pitini, Massimo Rizzo, Carmela Arrigo, Patrizia Mondello, Giuseppe Altavilla

“…Like overt HBV infection, OBI can be associated with the integration of HBV sequences into the host genome and has a substantial clinical relevance for patients who are severely immunosuppressed for long durations. We present the case of a patient with a diffuse large B-cell non-Hodgkin lymphoma and OBI who developed a hepatocellular carcinoma with a fulminant clinical course following the administration of rituximab plus CHOP.…”
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Successful Therapy of Refractory Erythema Nodosum Associated with Crohn's Disease Using Potassium Iodide by John K Marshall, E Jan Irvine

“…While mild skin involvement often responds to conservative management, severe or refractory cases may require systemic corticosteroid or immunosuppressive therapy. …”
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