A Case Report of Premalignant Plasma Cell Dyscrasia-Induced Renal Failure in a 31-Year-Old Female by Ayrton Bangolo, Mahabuba Akhter, Amer Jarri, Manpreet Kaur, Ali Atoot, Parul Jandir, Mahmood Ibrahim, Lochana Manandhar, Adam Atoot

“…Herein, we present a 31-year-old female with past medical history of lupus nephritis who presented with signs of volume overload and worsening renal function despite adequate immunosuppressive therapy. Renal biopsy revealed heavy and light chain deposition consistent with MGRS. …”
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Management of Uveitis-Related Choroidal Neovascularization: From the Pathogenesis to the Therapy by Enzo D’Ambrosio, Paolo Tortorella, Ludovico Iannetti

“…Also we reported the success rate of single studies concerning the therapies of choroidal neovascularization secondary to uveitis during the last decade: photodynamic therapy, intravitreal bevacizumab, and intravitreal ranibizumab, besides steroidal and immunosuppressive therapy. Hereby a standardization of the therapeutic approach is proposed.…”
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Ultrasound Presentation of a Disseminated Fetal and Neonatal Rhabdoid Tumor by Yolaine Joueidi, Aline Rousselin, Céline Rozel, Philippe Loget, Dominique Ranchere Vince, Sylvie Odent, Franck Bourdeaut, Vincent Lavoue, Maela Le Lous

“…This is a case report of a disseminated fetal rhabdoid tumor discovered at 32 weeks of gestation in a 29-year-old woman on immunosuppressive therapy. The mother consulted for a decrease in fetal movement. …”
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Targeted SPP1 Inhibition of Tumor‐Associated Myeloid Cells Effectively Decreases Tumor Sizes by Benan Kartal, Christopher S. Garris, Hyung Shik Kim, Rainer H. Kohler, Jasmine Carrothers, Elias A. Halabi, Yoshiko Iwamoto, Anne‐Gaëlle Goubet, Yuxuan Xie, Pratyaksha Wirapati, Mikaël J. Pittet, Ralph Weissleder

“…Abstract Secreted phosphosprotein 1 (SPP1)High tumor‐associated macrophages (TAM) are abundant tumor myeloid cells that are immunosuppressive, pro‐tumorigenic, and have a highly negative prognostic factor. …”
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Invasive Mucormycosis Induced Pneumopericardium: A Rare Cause of Pneumopericardium in an Immunocompromised Patient by Sana Khan, Muhammad Waqar Elahi, Waqas Ullah, Hafez Mohammad Ammar Abdullah, Ejaz Ahmad, Mayar Al Mohajer, Aneela Majeed

“…He had a past surgical history of renal transplant for renal cell carcinoma and was on dual immunosuppressive therapy, that is, mycophenolate and tacrolimus. …”
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Retroviral and Lentiviral Vectors for the Induction of Immunological Tolerance by Inès Dufait, Therese Liechtenstein, Alessio Lanna, Christopher Bricogne, Roberta Laranga, Antonella Padella, Karine Breckpot, David Escors

“…Thus, three main approaches have been undertaken to induce immunological tolerance; delivery of potent immunosuppressive cytokines and other molecules, modification of intracellular signalling pathways in dendritic cells, and de-targeting transgene expression from dendritic cells using microRNA technology. …”
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Review and Clinical Perspectives for the Use of Infliximab in Ulcerative Colitis by Remo Panaccione, Richard N Fedorak, Guy Aumais, Edmond-Jean Bernard, Charles N Bernstein, Alain Bitton, Ken Croitoru, Levinus A Dieleman, Robert Enns, Brian G Feagan, Denis Franchimont, Gordon R Greenberg, Anne-Marie Griffiths, John K Marshall, Pierre Pare, Sunil Patel, Robert Penner, Craig Render, Ernest Seidman, A Hillary Steinhart

“…Although the etiology of ulcerative colitis (UC) differs from that of Crohn’s disease, randomized controlled trials have demonstrated that infliximab is also beneficial for the treatment of moderate to severe UC in patients who are either intolerant of or refractory to immunosuppressant agents or steroids, or those who are steroid-dependent. …”
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The Infection Returns: A Case of Pulmonary Sporotrichosis Relapse after Chemotherapy by Samid M. Farooqui, Houssein Youness

“…This case highlights the importance of considering past fungal infections, albeit cured, in patients initiating immunosuppressive therapy.…”
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Intravenous Immunoglobulin and Mycophenolate Mofetil for Long-Standing Sensory Neuronopathy in Sjögren's Syndrome by Maria Giovanna Danieli, Lucia Pettinari, Ramona Morariu, Fernando Monteforte, Francesco Logullo

“…This case documented the efficacy and the safety of the coadministration of intravenous immunoglobulin and mycophenolate mofetil in sensory neuronopathy associated with SS refractory to conventional immunosuppressive therapy.…”
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Bilateral Facial Palsy in Rapidly Progressive Course of Wegener’s Granulomatosis: A Case Report by Anna Roszkowska, Monika Morawska-Kochman, Hanna Temporale, Małgorzata Sikorska-Żuk, Tomasz Kręcicki

“…The objective of our report was to describe the unusual course of Wegener’s granulomatosis with the bilateral facial nerve paralysis, which subsided after application of steroids and immunosuppressive therapy in combination with surgical treatment. …”
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Very Early Severe Posttransplant Recurrent Antineutrophil Cytoplasmic Antibody-Associated Glomerulonephritis after Kidney Transplantation: Two Case Reports by Reda Laamech, Hamza Naciri-Bennani, Diane Giovannini, Johan Noble, Bénédicte Janbon, Paolo Malvezzi, Thomas Jouve, Lionel Rostaing

“…We report two cases of extremely rapid recurrent AAV after renal transplantation; both were still ANCA-positive at the time of transplantation, which led us to question the pathogenesis of ANCA antibodies in recurrence in a kidney allograft. Apheresis plus immunosuppressive therapies were ineffective in the first case and the patient became dialysis-dependent, whereas in the second case methylprednisone pulses plus rituximab infusions resulted in long-lasting remission.…”
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HHV8-Negative Primary Effusion Lymphoma of B-Cell Lineage: Two Cases and a Comprehensive Review of the Literature by Neeraj Saini, Ephraim P. Hochberg, Erica A. Linden, Smita Jha, Heinz K. Grohs, Aliyah R. Sohani

“…Primary effusion lymphoma (PEL) is a rare extranodal lymphoma that typically presents in a body cavity in the absence of a detectable tumor mass and that occurs predominantly in immunosuppressed individuals. The neoplastic lymphoid cells are frequently infected with human herpes virus 8 (HHV8), also known as Kaposi sarcoma herpes virus (KSHV). …”
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Voriconazole-induced periostitis in the hand by Gurbinder Singh, Daria Motamedi, Kevin Sweetwood

“…This case report details a 65-year-old male on chronic immunosuppressive and antimicrobial therapy following heart transplant who developed hand pain. …”
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“Almost Bleeding to Death”: The Conundrum of Acquired Amegakaryocytic Thrombocytopenia by Gabrielle Elena Brown, Hani M. Babiker, Carlos L. Cantu, Andrew M. Yeager, Ravitharan Krishnadasan

“…Although standard guidelines have not been established for management of AAT, a few case reports have indicated a response to immunosuppressive treatment. The prompt recognition of this disease entity is essential in view of the substantial risk of morbidity and mortality from excessive bleeding. …”
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Comparative-effectiveness research of COVID-19 treatment: a rapid scoping review by Sharon E Straus, Jesmin Antony, Andrea C Tricco, Rachel Warren, Erin Macdonald, Ba Pham, Milan Patel, Fatemeh Yazdi, Amruta Radhakrishnan, Marco Ghassemi, Patricia Rios, Chantal Williams, Naveeta Ramkissoon, Matthew P Muller, Nazia Darvesh, Gordon V Cormack, Maura R Grossman, Melissa Kampman, Reid Robson

“…The most common therapeutic categories were non-steroidal immunosuppressants (18%), steroids (15%) and antivirals (14%). …”
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Treatment of Inflammatory Bowel Disease in Children by D Grant Gall

“…Prednisone remains the drug of choice in severe ulcerative colitis and active Crohn's disease. The role of immunosuppressive drugs in pediatric patients is unclear. …”
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Epidermodysplasia Verruciformis: A Clinicopathologic Review of Two Cases by Tummidi Santosh, Tanya Sharma, Deepti Joshi, Dinesh Prasad Asati, Sanjeev Vijay Choudhary, Neelkamal Kapoor

“…It can also occur as an acquired entity in patients with immunocompromised status, human immunodeficiency virus (HIV) infection, and immunosuppressant therapy. Hereby, we report two cases of EV, histologically diagnosed on skin punch biopsy, both presented with a clinical history of macular/verrucous lesions in various sun-exposed body regions. …”
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Immune Reactions following Cord Blood Transplantations in Adults by Hiroto Narimatsu

“…Although the incidence of acute and chronic graft versus host disease (GVHD) post-CBT is lower than that following bone marrow transplantation and peripheral blood stem cell transplantation (SCT), the additional immunosuppressive therapy required to treat it could increase the mortality in these patients. …”
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Cerebral Aneurysms: A Rare Feature of Behçet's Disease—A Case Report and Review of the Literature by Samia Younes, Yosra Cherif, Narjes Mokni, Olfa Berriche, Baha Zantour, Amel Boughammoura, Mahbouba Frih-Ayed, Saida Jerbi, Mohamed Habib Sfar

“…The patient underwent two-month systemic high-dose corticosteroids and immunosuppressive therapy associated with severe neurological deficiency upon admission and severe impairment upon discharge. …”
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Reversing NK cell exhaustion: a novel strategy combining immune checkpoint blockade with drug sensitivity enhancement in the treatment of hepatocellular carcinoma by Yuxiang Huang, Hengjian Liao, Jiefu Luo, Huaning Wei, Anling Li, Yujie Lu, Bangde Xiang

“…Combined blockade strategies targeting these immunosuppressive mechanisms, such as the combination of PD-1 inhibitors with other inhibitory pathways (eg. …”
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