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641
Review on the Relationship between Human Polyomaviruses-Associated Tumors and Host Immune System
Published 2012-01-01“…To date, at least nine members of the Polyomaviridae family have been identified, some of them playing an etiological role in malignancies in immunosuppressed patients. Here, we describe the biology of human polyomaviruses, their nonmalignant and malignant potentials ability, and their relationship with the host immune response.…”
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642
Iatrogenic T-Cell Lymphoma with Associated Hemophagocytic Lymphohistiocyotsis in a Patient with Long-Standing Rheumatoid Arthritis
Published 2018-01-01“…Patients with rheumatoid arthritis are at increased risk of hematological malignancies, especially when exposed to immunosuppressive therapy. The mechanisms of lymphomagenesis remain poorly understood but factors implicated include high disease activity, exposure to antitumoral necrosis factor medications, and Epstein–Barr virus infection. …”
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643
Bullous pemphigoid as a diagnostic and therapeutic challenge with a wide spectrum of dermatological symptoms
Published 2025-01-01“…The treatment involves the use of topical or systemic glucocorticosteroids (GCS) and, in challenging cases, immunosuppressive drugs. In a 74-year-old patient with internistic and psychiatric burdens, and oral lesions present for the several past months. …”
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644
Updates in the management of connective tissue disease-associated interstitial lung disease
Published 2021-01-01“…Insights into the pathology of these diseases and the associated lung involvement have resulted in the emergence of several immunosuppressive, antifibrotic, and small molecules as alternatives in CTD-ILD. …”
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645
A Rare Case of Meningitis Caused by Alcaligenes faecalis in an Immunocompetent Patient
Published 2022-01-01“…The first cases of infections caused by this microorganism, such as pneumonia, soft tissue infections, urinary tract infections, bacteremia, and meningitis, date back more than 40 years and are almost entirely in newborns and immunosuppressed hosts. Optimal antibiotic therapy for A. faecalis has not been well established in the literature. …”
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646
Tacrolimus Toxicity due to Biliary Obstruction in a Combined Kidney and Liver Transplant Recipient
Published 2017-01-01“…The immunosuppressant tacrolimus has a narrow therapeutic window, necessitating therapeutic drug monitoring to maintain efficacy and minimise toxicity. …”
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647
Systemic Lupus Erythematosus with Multiple Autoimmune Disease Presented with Extensive Peripheral Gangrene
Published 2020-01-01“…Although SLE gangrene may respond to immunosuppressants, it has a high risk of complications that can end up with amputations.…”
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648
Management of Metachronous Bilateral Testis Cancer in a Patient with Pre-B Cell ALL
Published 2015-01-01“…We discuss the management of bilateral testis masses in a young patient with a hematologic malignancy as well as the role of immunosuppressive chemotherapy in developing a second cancer. …”
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649
New Onset Granulomatosis with Polyangiitis Associated with COVID-19
Published 2021-01-01“…Symptoms often overlap between the two diseases, and while there is no current cure for COVID-19, rapid immunosuppressive initiation can be lifesaving for patients with GPA. …”
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650
Therapeutic drug monitoring for triazoles: A needs assessment review and recommendations from a Canadian perspective
Published 2014-01-01“…Invasive fungal infections cause significant morbidity and mortality in patients with concomitant underlying immunosuppressive diseases. The recent addition of new triazoles to the antifungal armamentarium has allowed for extended-spectrum activity and flexibility of administration. …”
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651
Cerebral Wegener’s Granuloma: Surgery Mandatory for Diagnosis and Treatment
Published 2013-01-01“…The importance of a surgery in case of localized WG has been emphasized, in order to confirm the diagnosis and to avoid additional medicaments, like antiepileptic drugs, potentially harmful in immunosuppressed patients.…”
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652
Cotrimoxazole-Induced Hypoglycaemia in a Patient with Churg-Strauss Syndrome
Published 2013-01-01“…Cotrimoxazole is a commonly used antimicrobial agent which is traditionally indicated in the management of pneumocystis infection of which HIV and immunosuppressed individuals are at high risk. Furthermore, it can be used on the long term for prophylactic indications. …”
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653
Successful Use of Posaconazole to Treat Invasive Cutaneous Fungal Infection in a Liver Transplant Patient on Sirolimus
Published 2012-01-01“…The high morbidity and mortality associated with these infections necessitates urgent therapy with antifungal drugs; however, the interaction between these drugs and immunosuppressive therapies can be a major limitation because of drug toxicity. …”
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654
Sporadic inclusion body myositis in the rheumatology clinic
Published 2020-01-01“…., glucocorticoid, and immunosuppressive/immunomodulatory/immunobiological drugs). …”
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655
Successful Treatment of Hemophagocytic Lymphohistiocytosis Associated with Lupus Nephritis by Using Mycophenolate Mofetil
Published 2017-01-01“…HLH associated with autoimmune diseases is often refractory to corticosteroid treatment; thus, additional immunosuppressive drugs, such as cyclosporine, cyclophosphamide, or tacrolimus, are required. …”
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656
Severe Respiratory Distress in a Child with Pulmonary Idiopathic Hemosiderosis Initially Presenting with Iron-Deficiency Anemia
Published 2015-01-01“…The suspicion of IPH led to the use of immunosuppressive therapy with high dose of corticosteroids with rapid improvement in clinical condition and discharge from hospital.…”
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657
Harnessing amino acid pathways to influence myeloid cell function in tumor immunity
Published 2025-02-01“…Within the tumor microenvironment, amino acid metabolism plays a crucial role in mediating the immunosuppressive functions of myeloid cells, contributing to tumor progression. …”
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658
Improving CD3 bispecific antibody therapy in solid tumors using combination strategies
Published 2025-02-01“…Despite these recent advances, the success of CD3 bsAbs in solid cancer has been hampered by hurdles like limited intratumoral T cell numbers, immunosuppressive tumor microenvironments (TME), and poor memory T-cell induction. …”
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659
A Case of Systemic Lupus Erythematosus Presenting as Guillain-Barré Syndrome
Published 2015-01-01“…We are reporting a rare case of Miller-Fisher (MFS) variant of Guillain-Barré syndrome (GBS) as the first manifestation of SLE in a 41-year-old female who progressed to flaccid paralysis with no neurological improvement with initial immunosuppressive therapy, plasmapheresis, and first cycle of intravenous immunoglobulin (IVIG) but with remarkable and complete recovery after the second 5-day course of IVIG.…”
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660
Diagnosis and Management of Interstitial Lung Disease in Patients with Connective Tissue Diseases
Published 2021-01-01“…In the absence of guidelines regarding how CTD-ILDs should be treated, clinicians face difficult decisions on when to use immunosuppressant and anti-fibrotic therapies. The importance of a multidisciplinary and individualized approach to the diagnosis and management of CTD-ILD is highlighted in the three case studies that we describe in this article.…”
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