Taurine inhibits acute ammonia-induced oxidative stress, immune response, and apoptosis of large yellow croaker (Larimichthys crocea) during keep-live transport by Xin Zhao, Zhenkun Xu, Jun Mei, Jing Xie

“…SOD and GPx activities increased from 3.47 to 13.23 (AM group) to 9.4 and 55.48 (50TAU + AM group), immunosuppression (lysozyme activity increased). In conclusion, taurine may alleviate the adverse effects of ammonia stress on fish physiology. …”
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Lactobacillus gasseri LGV03-derived indole-3-lactic acid ameliorates immune response by activating aryl hydrocarbon receptor by Zikang Zhang, Kangdi Zheng, Zhao Zhang, Longbin Cao, Lizhu Lin, Weimin Sun, Feng Qiu

“…Moreover, the transcriptome sequencing results indicated L. gasseri LGV03 might alleviate vinorelbine-induced immunosuppression in zebrafish. Non-targeted detection and analysis revealed that indole derivatives including phenylacetaldehyde, 3-phenyllactic acid, N-acetylserotonin and indole-3-lactic acid were significantly increased in the lysate and supernatant of L. gasseri LGV03. …”
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Efficacy of adalimumab in pediatric non-infectious uveitis with and without anterior segment inflammation by Chunbo Zhang, Xiaorong Xue, Jinan Xiao, Qiongge Li, Yuyao Zhai, Ying Chen

“…Secondary outcomes including best-corrected visual acuity (BCVA), inflammation parameters [anterior chamber cell (ACC), vitreous haze (VH)], retinal nerve fiber layer (RNFL) thickness, fluorescein angiography (FA) scores, as well as systemic immunosuppression therapy (IMT) and glucocorticoid load, were assessed. …”
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Nocardiosis in Renal Allograft Recipients by Chilaka Rajesh, Athul Thomas, Jeethu Joseph Eapen, Sabina Yusuf, Elenjickal Elias John, Anna T. Valson, Suceena Alexander, Vinoi George David, Joy Sarojini Michael, Santosh Varughese

“…All patients were similarly managed initially with a reduction of immunosuppression and appropriate antibiotics as per culture sensitivity. …”
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Consequences of the Lack of CD73 and Prostatic Acid Phosphatase in the Lymphoid Organs by Gennady G. Yegutkin, Kaisa Auvinen, Marika Karikoski, Pia Rantakari, Heidi Gerke, Kati Elima, Mikael Maksimow, Ileana B. Quintero, Pirkko Vihko, Marko Salmi, Sirpa Jalkanen

“…CD73, ecto-5′-nucleotidase, is the key enzyme catalyzing the conversion of extracellular AMP to adenosine that controls vascular permeability and immunosuppression. Also prostatic acid phosphatase (PAP) possesses ecto-5′-nucleotidase/AMPase activity and is present in leukocytes. …”
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Low regulatory T-cells frequency is associated with graft rejection after small bowel transplantation: Clinical and experimental evidence. by Rodrigo Papa-Gobbi, Pablo Stringa, Maria Virginia Gentilini, Ivana Ivanoff, Mariana Machuca, Nidia Monserrat Arreola, Javier Serradilla, Karla Estefanía-Fernández, Paloma Talayero, María Velayos, Elena Sánchez-Zapardiel, Gabriel Gondolesi, Ane Andrés-Moreno, Martin Rumbo, Francisco Hernández-Oliveros

“…Experimental allogenic-heterotopic small bowel transplantation was performed in rats and animals divided into 3 groups: non-immunosuppressant treatment, rapamycin (2 mg/kg), and tacrolimus (0.6 mg/kg) treatment. …”
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Methicillin-Resistant Staphylococcus aureus Infections in Human Immunodeficiency Virus-Infected Children and Adolescents by George K. Siberry, Toni Frederick, Patricia Emmanuel, Mary E. Paul, Beverly Bohannon, Travis Wheeling, Theresa Barton, Mobeen H. Rathore, Kenneth L. Dominguez

“…Geographic location, black race, and increased VL, but not immunosuppression, were independently associated with MRSA risk.…”
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Prognostic factors of head and neck cutaneous squamous cell carcinoma: a systematic review by Joshua Lubov, Mathilde Labbé, Krystelle Sioufi, Grégoire B. Morand, Michael P. Hier, Manish Khanna, Khalil Sultanem, Alex M. Mlynarek

“…It also suggests that immunosuppressed patients with a high-risk feature on biopsy, such as invasion beyond subcutaneous fat, could possibly benefit from a sentinel lymph node biopsy. …”
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Physician characteristics associated with the referral from general practitioners to dental surgeons and proposal for a referral letter template endorsed by dental surgeons in Fran... by Matthias Lamauviniere, Jan Chrusciel, Cassandre Finot, Adrien Basset, Maximillien Graftieaux, Aline Ohl-Hurtaud, Stéphane Sanchez

“…Standardized referral letters could include the list of items for which interest was confirmed by dental surgeons (including presence of diabetes, immunosuppressants and anticoagulants or antiplatelet agents).…”
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Masticatory muscle changes on magnetic resonance imaging of dogs with Neospora caninum compared to meningoencephalitis of unknown origin by Jessica Zilli, Kathryn Fleming, Chloe Fisher, Chloe Fisher, Tim Sparks, Tom Harcourt-Brown, Edward Ives

“…Treatment of the latter requires immunosuppression, but laboratory test results for infectious agents may take several days to return. …”
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Macrophage Activities in Myocardial Infarction and Heart Failure by Sophia Esi Duncan, Shan Gao, Michael Sarhene, Joel Wake Coffie, Deng Linhua, Xingru Bao, Zhang Jing, Sheng Li, Rui Guo, Jing Su, Guanwei Fan

“…Also, though inflammation is as a result of adverse HF in patients, but despite the fact that broad immunosuppression therapeutic target has been used in various clinical trials, no positive results have showed up, but rather, the focus on proinflammatory cytokines has proved more benefits in patients with HF. …”
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Precise HER2 Protein Degradation via Peptide‐Conjugated Photodynamic Therapy for Enhanced Breast Cancer Immunotherapy by Changyong Guo, Fei Gao, Guoyuan Wu, Jinqiu Li, Chunquan Sheng, Shipeng He, Honggang Hu

“…Traditional treatments combining the anti‐HER2 antibody trastuzumab with immunotherapy face limitations due to toxicity and tumor microenvironment immunosuppression. This study introduces an innovative strategy combining HER2‐targeting peptides with the photosensitizer (PSs) pyropheophorbide‐a (Pha) via a gelatinase‐cleavable linker, forming self‐assembling nanoparticles. …”
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An adenoviral vector encoding an inflammation-inducible antagonist, HMGB1 Box A, as a novel therapeutic approach to inflammatory diseases by Kari Ann Shirey, John Joseph, Lynda Coughlan, Haye Nijhuis, Alan W. Varley, Jorge C. G. Blanco, Stefanie N. Vogel

“…The recombinant protein would be produced and released only in the presence of the inciting stimulus, avoiding immunosuppression or other unwanted side effects that may occur when treating infectious diseases with anti-inflammatory drugs. …”
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Brincidofovir Use after Foscarnet Crystal Nephropathy in a Kidney Transplant Recipient with Multiresistant Cytomegalovirus Infection by Romain Vial, Christine Zandotti, Sophie Alain, Alexandre Decourt, Noémie Jourde-Chiche, Raj Purgus, Charleric Bornet, Laurent Daniel, Valérie Moal, Tristan Legris

“…Despite a large decrease in immunosuppression, CMV disease was not controlled and a salvage therapy with Brincidofovir (BCV), which is an oral lipid conjugate of cidofovir with limited nephrotoxicity, was attempted. …”
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Persistent Mortality Risk From Device-related Healthcare-associated Infection in Kidney Transplant Recipients Despite Multifaceted Interventions Action Calls for a Zero-tolerance P... by Maria Bethânia Peruzzo, MD, Luana Oliveira Calegari, MSc, Renato Demarchi Foresto, MD, PhD, Helio Tedesco-Silva, MD, PhD, José Medina Pestana, MD, PhD, Lúcio Requião-Moura, MD, PhD

“…Additional variables associated with increased risk of death included age (HR, 1.03; P < 0.001), baseline immunosuppression (HR based on mycophenolate versus others 0.74; P = 0.02), time since transplantation (HR, 1.003; P < 0.001), platelet count at ICU admission (HR, 0.998; P < 0.001), and sepsis as the reason for ICU admission (HR, 1.67; P < 0.001). …”
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A meta-analysis of whole blood transcriptome reveals genes associated with increased neutrophil activity and T cell suppression in sepsis by T. N. Shruthi, Anbazhagan Kolandaswamy, Prabakara Somanna

“…Dysregulation of immune response, imbalance between pro-inflammatory and anti-inflammatory response, apoptosis, and anti-apoptotic genes were found to be associated with immunosuppression and increased inflammatory reaction during sepsis. …”
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Antifungal efficacy of chitosan-mediated fenugreek nanocomposite incorporated in tissue conditioner by Mohika Damle, Ponsekar Abraham Anandapandian, B. Eswaran, Swapnaneel Pradhan, Silvin Joe C J, Shreyas Dhumke

“…Introduction: The rough surface of dentures, coupled with xerostomia and immunosuppression, fosters microbial growth and colonization, with Candida albicans being a primary culprit. …”
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Integrative analysis of ferroptosis in the hypoxic microenvironment of gastric cancer unveils the immune landscape and personalized therapeutic strategies by Xiao Xu, Liangling Fa, Xiaoxiao Sun, Fangfang Yang, Yongrui Liu, Jifu Song, Yongli Zhao, Jigang Dong, Jigang Dong

“…Notably, patients with high ferroptosis-hypoxia risk scores (FHRS) displayed significant levels of hypoxia and epithelial-mesenchymal transition (EMT), which were associated with unfavorable prognosis, increased chemoresistance, and heightened immunosuppression.ConclusionsThis study demonstrates that ferroptosis under hypoxic conditions significantly affects the modulation of the tumor immune microenvironment. …”
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Development of a prognostic model based on four genes related to exhausted CD8+ T cell in triple-negative breast cancer patients: a comprehensive analysis integrating scRNA-seq and... by Yulin Shi, Yang Yu, Jiahan Zhao, Linan Huang, Qingyang Wang, Qi Sun, Lijuan Liu, Changgang Sun

“…T-cell exhaustion (TEX) is a significant risk factor for tumor immunosuppression and invasion. Although improving TEX and enhancing effector function are promising strategies for strengthening immunotherapy, their role in the pathogenesis of TNBC remains unclear. …”
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Diagnostic performance of the DISQVER metagenomic sequencing tool for the identification of pathogens in febrile neutropenic patients: the ADNEMIA trial by Geneviève Héry-Arnaud, Christophe Burucoa, Marie Kempf, David Boutoille, Yohann Foucher, Philippe Lanotte, Maxime Pichon, Stéphane Corvec, Cécile Le Brun, Helene Pailhories

“…Introduction While intensive protocols in onco-haematology have improved survival rates for patients with haematological malignancies, they have also resulted in an increased incidence of infection associated with therapy-induced immunosuppression (including chemotherapy-induced febrile neutropenia; FN). …”
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