The Role of Gut Microbiota in Tumor Immunotherapy by Miao Wu, Jiawei Bai, Chengtai Ma, Jie Wei, Xianjin Du

“…Some bacteria help fight tumors by activating immunity, while some bacteria mediate immunosuppression to help cancer cells escape from the immune system. …”
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Microglia-secreted TNF-α affects differentiation efficiency and viability of pluripotent stem cell-derived human dopaminergic precursors. by Shirley D Wenker, María Isabel Farias, Victoria Gradaschi, Corina Garcia, Juan Beauquis, María Celeste Leal, Carina Ferrari, Xianmin Zeng, Fernando J Pitossi

“…We first observed that transplanted human dopaminergic precursors into the striatum of immunosuppressed rats elicited an early and sustained activation of astroglial and microglial cells after 15 days' post-transplant. …”
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A Case of De Novo Antiglomerular Basement Membrane Disease Presenting during Pregnancy by F. A. K. Lodhi, T. Akcan, J. N. Mojarrab, S. Sajjad, R. Blonsky

“…Fetal safety should be considered and risks thoroughly discussed with the patient when choosing an immunosuppressive regimen for this condition.…”
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Ticam2 ablation facilitates monocyte exhaustion recovery after sepsis by Blake A. Caldwell, Susanti Ie, Amy Lucas, Liwu Li

“…Abstract Sepsis is a leading cause of death worldwide, with most patient mortality stemming from lingering immunosuppression in sepsis survivors. This is due in part to immune dysfunction resulting from monocyte exhaustion, a phenotype of reduced antigen presentation, altered CD14/CD16 inflammatory subtypes, and disrupted cytokine production. …”
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Identifying RBBP7 as a Promising Diagnostic Biomarker for BK Virus-Associated Nephropathy by Yicun Wang, Yuxuan Wang, Di Zhang, Hao Zhang, Wei Wang, Xiaopeng Hu

“…BK virus-associated nephropathy (BKVN) remains a major infectious complication due to powerful immunosuppression in kidney transplant recipients, and its histologic appearance can mimic rejection, leading to diagnostic and treatment dilemmas thus molecular diagnostic methods would be beneficial. …”
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Tuberculous Osteomyelitis of the Scapular Spine Revealing HIV-1 Infection by Khaoula Idsaid, Malika Idalene, Khadija Danaoui, Wiam Ait Driss, Rania Elfargani, Nabila Soraa, Noura Tassi

“…This rare form of tuberculosis with an exceptional site revealed a HIV infection with profound immunosuppression. The patient was initiated on anti-tubercular treatment according to Moroccan recommendations.…”
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The impact of KRAS mutations on the tumour microenvironment and treatment response in non-small cell lung cancer by Guomin Gu, Chunling Liu, Yan Yang, Yan Zhao, Xiaodan Zhu, Gang Sun

“…KRAS-G12C, KRAS-G12V, and KRAS-G12D mutations may enhance NSCLC drug resistance through immunosuppression.…”
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Late Onset Graft Plasmacytoma-Like PTLD Presenting as Acute Hyperglycemia in a Kidney-Pancreas Transplant Recipient by P. Ventura-Aguiar, M. T. Cibeira, A. Martinez, M. Cuatrecasas, M. Aymerich, J. Ferrer, J. Blade, F. Diekmann, M. J. Ricart

“…We report the case of a 54-year-old simultaneous pancreas-kidney transplant recipient (immunosuppression: OKT3, methylprednisolone, cyclosporine, and azathioprine), diagnosed with an IgG-kappa monoclonal gammopathy of undetermined significance eighteen years after transplant. …”
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Experimental Porcine Toxoplasma gondii Infection as a Representative Model for Human Toxoplasmosis by Julia Nau, Silvia Kathrin Eller, Johannes Wenning, Katrin Henrike Spekker-Bosker, Horst Schroten, Christian Schwerk, Andrea Hotop, Uwe Groß, Walter Däubener

“…In addition, the severe immunosuppression during acute infection described in mice does not occur in the experimentally infected ones. …”
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Listeria monocytogenes and Staphylococcus aureus coinfection in a patient with multiple myeloma: Case report by Roberta Vaikutyte-Ramanauskiene, Danguole Vaznaisiene

“…Conclusion: In conclusion, this case emphasizes the intersection of hematological malignancy, chemotherapy-related immunosuppression, and subsequent severe disseminated bacterial infections and coinfections. …”
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Systemic and Nonrenal Adverse Effects Occurring in Renal Transplant Patients Treated with mTOR Inhibitors by Gianluigi Zaza, Paola Tomei, Paolo Ria, Simona Granata, Luigino Boschiero, Antonio Lupo

“…The mammalian target of rapamycin inhibitors (mTOR-I), sirolimus and everolimus, are immunosuppressive drugs largely used in renal transplantation. …”
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Ruxolitinib Associated Tuberculosis Presenting as a Neck Lump by Eamon Shamil, David Cunningham, Billy L. K. Wong, Piyush Jani

“…It was hypothesized that use of Ruxolitinib through its selective inhibition of Janus-activated kinases 1 and 2 resulted in immunosuppression and miliary tuberculosis in this patient. …”
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A Novel In Situ Dendritic Cell Vaccine Triggered by Rose Bengal Enhances Adaptive Antitumour Immunity by Lanlin Zhang, Jiangyuan Du, Qian Song, Chufan Zhang, Xianghua Wu

“…However, overcoming immune tolerance and immunosuppression in the tumour microenvironment (TME) is still a great challenge. …”
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Viral and Nonviral Engineering of Natural Killer Cells as Emerging Adoptive Cancer Immunotherapies by Sandro Matosevic

“…Clinical responses to adoptive NK-based immunotherapy have been thwarted, however, by the profound immunosuppression induced by the tumor microenvironment, particularly severe in the context of solid tumors. …”
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The Correlation between Oral Candida albicans and Interlukine-23 in Diabetic Patients in Hilla City, Iraq by Huda Reyad Al-Harba, Nebrass Nasir-Alla, Azher Abdulhafidh Jabir

“…Background: Candidiasis is the most common opportunistic fungal infection in the oral cavity. Because of immunosuppression and other physiological changes, diabetes makes people more susceptible to Candida infections. …”
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Repeated CMV Infection in a Heart Transplantation Patient by Josep Melero-Ferrer, Ignacio J. Sanchez-Lazaro, Amparo Navea-Tejerina, Luis Almenar-Bonet, Marino Blanes-Julia, Luis Martinez-Dolz, Antonio Salvador-Sanz

“…The patient received different treatments against CMV and the immunosuppression was changed several times. Finally, everolimus was introduced instead of cyclosporine, and mycophenolate mofetil was withdrawn. …”
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Immunotherapy for Hepatocellular Carcinoma: Current Advances and Future Expectations by Yingjun Xie, Yien Xiang, Jiyao Sheng, Dan Zhang, Xiaoxiao Yao, Yongsheng Yang, Xuewen Zhang

“…Here, we briefly introduce the mechanism of immunosuppression in hepatocellular carcinoma and summarize the rationale of the four major immunotherapeutic approaches with their current advances.…”
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Improved Clinical Outcomes with Appropriate Meropenem De-escalation in Patients with Febrile Neutropenia by Tyler Luu, Austin Fan, Reid Shaw, Hina Dalal, Jenna Adams, Maressa Santarossa, Gail Reid, Stephanie Tsai, Nina M. Clark, Fritzie S. Albarillo

“…Logistic regression model demonstrated positive culture (OR 4.78, P = 0.03), including positive blood culture (OR 8.05, P = 0.003), and GVHD (OR 19.44, P = 0.029), and were associated with high rates of appropriate de-escalation. Immunosuppression (OR 0.22, P = 0.004) was associated with lower rates of appropriate de-escalation. …”
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Decoding the mechanisms behind second primary cancers by Meiyuan Zeng, Anqi Lin, Aimin Jiang, Zhengang Qiu, Hongman Zhang, Shifu Chen, Mingyan Xu, Zaoqu Liu, Quan Cheng, Jian Zhang, Peng Luo

“…This review summarizes recent studies on the mechanisms of SPCs, including the roles of genomic changes after first primary cancer (FPC) treatments, stromal cell phenotypic and metabolic changes, hormone levels and receptor expression, immunosuppression, aberrant gene methylation, EGFR signaling, and cell-free DNA in SPC development. …”
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Fatal Multiorgan Failure Associated with Disseminated Herpes Simplex Virus-1 Infection: A Case Report by Michael Glas, Sigrun Smola, Thorsten Pfuhl, Juliane Pokorny, Rainer M. Bohle, Arno Bücker, Jörn Kamradt, Thomas Volk

“…Autopsy revealed a predominantly retroperitoneal diffuse large B-cell lymphoma as the suspected origin of immunosuppression underlying herpes simplex dissemination.…”
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