Crusted Demodicosis in an Immunocompetent Pediatric Patient by Guillermo Antonio Guerrero-González, Maira Elizabeth Herz-Ruelas, Minerva Gómez-Flores, Jorge Ocampo-Candiani

“…The development of symptoms in this patient could be secondary to local immunosuppression caused by the chronic use of topical steroids.…”
Get full text

Macrophage Activation Syndrome/Secondary Hemophagocytic Lymphohistiocytosis in Adult‐Onset Still's Disease: An Uncommon Initial Presentation in a Young Nepalese Female: A Case Repo... by Kanchan Bishwakarma, Kajal Bishwakarma, Sunil Bogati, Saket Jha

“…HLH may be due to immunosuppression, infections, cancer, or autoimmune diseases with fever and cytopenia. …”
Get full text

Improved Medication Adherence with the Use of Extended-Release Tacrolimus in Liver Transplant Recipients: A Pilot Randomized Controlled Trial by Manisha Verma, Radi Zaki, Johnathan Sadeh, John P. Knorr, Mark Gallagher, Afshin Parsikia, Victor Navarro

“…Nonadherence to immunosuppression in liver transplant recipients (LTRs) leads to deterioration in health outcomes. …”
Get full text

Trends in Survival for Adult Organ Transplantation by Grant Patrick, BS, Brian Hickner, MD, Karthik Goli, BS, Liam D. Ferreira, MBA, John Goss, MD, Abbas Rana, MD

“…Continued advancements in allocation policy, immunosuppression, and improved care of patients on the waitlist may contribute to further progress in outcomes of all organs, but the increasing discrepancy in supply and demand of donor kidneys is alarming and has impeded the progress of kidney intent-to-treat survival.…”
Get full text

Everolimus in Heart Transplantation: An Update by Stephan W. Hirt, Christoph Bara, Markus J. Barten, Tobias Deuse, Andreas O. Doesch, Ingo Kaczmarek, Uwe Schulz, Jörg Stypmann, Assad Haneya, Hans B. Lehmkuhl

“…Unless there are special considerations to take into account, all de novo heart transplant patients can be regarded as potential candidates for immunosuppression with everolimus and reduced-exposure calcineurin inhibitor therapy. …”
Get full text

Dexamethasone Coanalgesic Administration in Steroid Naïve and Steroid Non-Naïve Patients for the Prevention of Pain Flares after Palliative Radiotherapy for Bone Metastases by Dimitar G. Tonev, Silvia A. Lalova, Elena P. Petkova-Lungova, Nikolay V. Timenov, Gabriela M. Radeva, Todor G. Kundurzhiev

“…Lower dose 4 mg dexamethasone was revealed as a moderate analgesic agent in steroid naïve patients with no side effects, whereas in steroid non-naïve patients the predominantly higher dose 8 mg dexamethasone had minimal impact on pain flares prevention at the expense of more pronounced immunosuppression (P = 0.039). Conclusions. Irrespective of the supporting evidence of dexamethasone potential for prevention of RT-induced pain flare, our data failed to reveal its efficacy in the real practice world (a case mix of uncomplicated and complicated bone metastases). …”
Get full text

Mdivi-1 Protects CD4+ T Cells against Apoptosis via Balancing Mitochondrial Fusion-Fission and Preventing the Induction of Endoplasmic Reticulum Stress in Sepsis by You Wu, Yong-Ming Yao, He-Liang Ke, Lan Ying, Yao Wu, Guang-Ju Zhao, Zhong-Qiu Lu

“…Apoptosis of CD4+ T cells plays a central role in the progression of sepsis because it is associated with subsequent immunosuppression and the lack of specific treatment. Thus, developing therapeutic strategies to attenuate the apoptosis of CD4+ T cells in sepsis is critical. …”
Get full text

SDF-1α Facilitates Mesenchymal Stem Cells to Induce Regulatory B Cell Differentiation from Patients with Immune Thrombocytopenia by Zhe Chen, Shufen Zhou, Jianyun Li, Hui Li, Can Huang, Qin Guo, Tiantian Zhang, Bingya Yang, Chuanqing Tu, Chengshan Guo

“…Mesenchymal stem cells (MSCs) have been demonstrated in the ability to induce immunosuppression, and stromal cell-derived factor-1α (SDF-1α) plays an important role in the migration and survival of MSCs. …”
Get full text

Severe Symptomatic Primary CMV Infection in Inflammatory Bowel Disease Patients with Low Population Seroprevalence by Catherine Rowan, Ciaran Judge, Mary D. Cannon, Garret Cullen, Hugh E. Mulcahy, Elizabeth Ryan, Cillian F. De Gascun, Glen A. Doherty

“…Primary cytomegalovirus infection can cause a severe illness in IBD patients, particularly those receiving immunosuppression. In areas where adult CMV seroprevalence is low, evidence of CMV should be sought in IBD patients presenting with any febrile systemic illness.…”
Get full text

<i>Vibrio vulnificus</i>—A Review with a Special Focus on Sepsis by Marcello Candelli, Marta Sacco Fernandez, Cristina Triunfo, Andrea Piccioni, Veronica Ojetti, Francesco Franceschi, Giulia Pignataro

“…High-risk populations include individuals with underlying conditions such as chronic liver disease, diabetes, or immunosuppression, which heighten susceptibility to severe outcomes. …”
Get full text

Vitamin D Deficiency Contributes to the Reduction and Impaired Function of Naïve CD45RA+ Regulatory T Cell in Chronic Heart Failure by Yan-hui Ma, Yun-lan Zhou, Chao-yan Yue, Guang-hui Zhang, Lin Deng, Guo-hua Xie, Wei-ping Xu, Li-song Shen

“…Low level of vitamin D receptor (VDR) was detected in CD4+CD45RA+T cell of CHF than control, while 1,25(OH)2D treatment increased the VDR expression to exert its immunosuppression on T cell. The results of this study might provide tangible evidence to our knowledge of the impact of vitamin D supplementation on naïve Tregs, which may offer new means of preventing and treating CHF.…”
Get full text

Hubungan Kadar Limfosit Total dengan Prognosis Penyakit pada Penderita Sirosis Hati di Bagian Penyakit Dalam RSUP Dr. M. Djamil Padang Tahun 2011 by Vyola Regina, Arnelis Arnelis, Zulkarnain Edward

“…In patients with liver cirrhosis is common infections due to immunosuppression. The total lymphocyte count can be used to determine the immune status of patients with liver cirrhosis. …”
Get full text

Successful Tocilizumab Therapy for Macrophage Activation Syndrome Associated with Adult-Onset Still’s Disease: A Case-Based Review by Eri Watanabe, Hitoshi Sugawara, Takeshi Yamashita, Akira Ishii, Aya Oda, Chihiro Terai

“…TCZ initiation after adequate nonselective immunosuppressive therapy, such as methylprednisolone pulse therapy or a prednisolone-based combination of immunosuppressants, can be an effective treatment for AOSD-associated MAS. …”
Get full text

Knockout IL4I1 affects macrophages to improve poor efficacy of CD19 CAR-T combined with PD-1 inhibitor in relapsed/refractory diffuse large B-cell lymphoma by Rui Zhang, Yi Zhang, Hairong Xiao, Qingxi Liu, Mingfeng Zhao

“…IL4I1 expression enhances immunosuppression via the IDO-AHR-Kyn pathway, inhibiting the effectiveness of PD-1 inhibitors combined with CD19 CAR-T. …”
Get full text

Isolation, Molecular Characterisation, and Pathogenicity Analysis of a Novel Recombinant ALV‐J Strain Isolated From Chinese Hetian Chickens by Tianyu Lei, Liyun Zhuang, Tingting Dai, Qun Niu, Yinli Bao, Weiming Lin, Cuiqin Huang, Xintian Zheng

“…ABSTRACT Background Avian leukosis virus subgroup J (ALV‐J) primarily affects poultry, particularly chickens, leading to tumourigenesis and immunosuppression, which results in substantial economic losses. …”
Get full text

Prognostic role of mesangial IgM deposition in IgA nephropathy: a long-term cohort study by Gabriel Stefan, Simona Stancu, Adrian Zugravu, George Terinte-Balcan

“…Treatment with RASI and immunosuppression, and death rates were also comparable. …”
Get full text

Activities of Some Medicinal Plants on the Proliferation and Invasion of Brain Tumor Cell Lines by Saidu I. Ngulde, Umar K. Sandabe, Roger Abounader, Ying Zhang, Isa M. Hussaini

“…Anticancer drugs are often expensive, have narrow spectrum of activities, and are associated with toxicities and side effects such as myelosuppression, immunosuppression, gastrointestinal disturbance, alopecia, skin toxicity, and hepatotoxicity. …”
Get full text

Oral Cancer Stem Cell-Derived Small Extracellular Vesicles Promote M2 Macrophage Polarization and Suppress CD4+ T-Cell Activity by Transferring UCA1 and Targeting LAMC2 by Lan Wu, Sai Ye, Yilin Yao, Chenping Zhang, Wei Liu

“…In conclusion, our results indicated that OSCC-CSC-sEV transfer of UCA1 promotes M2 macrophage polarization via a LAMC2-mediated PI3K/AKT axis, thus facilitating tumor progression and immunosuppression. Our findings provide a new understanding of OSCC-CSC molecular mechanisms and suggest a potential therapeutic strategy for OSCC through targeting CSC-sEVs and M2-TAMs.…”
Get full text

Opioid System and Epithelial–Mesenchymal Transition by Marzena Łazarczyk, Dominik Skiba, Michel-Edwar Mickael, Kinga Jaskuła, Agata Nawrocka, Piotr Religa, Mariusz Sacharczuk

“…Clinicians’ vigilance considering treatment with opioids is necessary, bearing in mind extensive data accumulated over decades that have reported the contribution of opioids to immunosuppression, tumour progression, or impaired tissue regeneration, either following opioid use during surgical tumour resection and post-surgical pain treatment, or as a result of other diseases like diabetes, where chronic wounds healing constitutes a challenge. …”
Get full text

Serum Levels of IL-33 and Correlation with IL-4, IL-17A, and Hypergammaglobulinemia in Patients with Autoimmune Hepatitis by Ma Liang, Zhang Liwen, Zhuang Yun, Ding Yanbo, Chen Jianping

“…The serum levels of IL-33, sST2, Th17 cytokines (IL-17A), Th1 cytokines (IFN-γ, TNF-α), and Th2 cytokines (IL-4) were significantly elevated in AIH patients compared to HCs. Following immunosuppression therapy, serum levels of IL-33 and sST2 were significantly decreased. …”
Get full text