Site-Specific Immunosuppression in Vascularized Composite Allotransplantation: Prospects and Potential by Jonas T. Schnider, Matthias Weinstock, Jan A. Plock, Mario G. Solari, Raman Venkataramanan, Xin Xiao Zheng, Vijay S. Gorantla

“…Logically, antirejection drugs, biologics, or other agents delivered locally to the VCA may reduce the need for systemic immunosuppression with its adverse effects. …”
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Combination Immunosuppressive Therapy in Primary Autoimmune Inner Ear Disease in Pregnancy by Saikrishna Ananthapadmanabhan, Joe Jabbour, David Brown, Vanaja Sivapathasingam

“…It is an otologic emergency requiring a multidisciplinary approach to management to commence immunosuppressive therapy. This can be achieved using steroids, immunomodulators, plasmapheresis, intravenous immunoglobulin, or biologic agents. …”
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The Feasibility of Percutaneous Dilatational Tracheostomy in Immunosuppressed ICU Patients with or without Thrombocytopenia by Marianne Angelberger, Michaela Barnikel, Alessia Fraccaroli, Johanna Tischer, Sofía Antón, Alexandra Pawlikowski, Mark op den Winkel, Hans Joachim Stemmler, Stephanie-Susanne Stecher

“…Percutaneous dilatational tracheostomy (PDT) has become the preferred method in several intensive care units (ICUs), but data on PDT performed in immunosuppressed and thrombocytopenic patients are scarce. …”
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Is renal biopsy always necessary to start immunosuppressive therapy in lupus nephritis? by Vasudevan Chelliah, V Balaraman, S Ilango, S Ramesh, V Kannan Bhaba, D Shivakumar

“…Thus it might be argued that immunosuppressive therapy (steroids and mycophenolate mofetil) may be started without renal biopsy in a known SLE patient with laboratory evidence of LN and positive serology; however, robust studies are required.…”
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Regulation of Stress-Induced Immunosuppression in the Context of Neuroendocrine, Cytokine, and Cellular Processes by Evgenii Balakin, Ksenia Yurku, Mark Ivanov, Alexander Izotov, Valeriya Nakhod, Vasiliy Pustovoyt

Subjects: “…stress-induced immunosuppression…”
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Spatial transcriptomics deciphers the immunosuppressive microenvironment in colorectal cancer with tumour thrombus by Heming Ge, Zhengda Pei, Zhongyi Zhou, Qian Pei, Cenap Güngör, Linyi Zheng, Wei Liu, Fengyuan Li, Jingxuan Zhou, Yao Xiang, Haiping Pei, Yuqiang Li, Wenxue Liu

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Onychomycosis in Psoriatic Patients with Nail Disorders: Aetiological Agents and Immunosuppressive Therapy by Núbia Carvalho Pena de Oliveira Praeiro Alves, Tomaz de Aquino Moreira, Lucivânia Duarte Silva Malvino, José Joaquim Rodrigues, Roberto Ranza, Lúcio Borges de Araújo, Reginaldo dos Santos Pedroso

“…Six patients (15.78%) were not using immunosuppressive therapy, and the others were using methotrexate, etanercept, adalimumab, infliximab, secukinumab, or golimumab, in monotherapy or in combination with other drugs. …”
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Successful Renal Transplantation between Identical Twins with Very Brief Immunosuppression by Idris Yakubu, Abdolreza Haririan, Stephen Bartlett, Tracy Sparkes

“…Renal transplantation between monozygous identical twins provides an opportunity to utilize minimal immunosuppression to maintain stable allograft function, thereby alleviating the toxicities of immunosuppressive therapy. …”
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Neutropenic Enterocolitis in a Pediatric Heart Transplant Recipient on Multiple Immunosuppressants by Emily E. Miller, Leigh Christopher Reardon

“…Fortunately, this patient improved with bowel rest, fluids, antibiotics, and alteration of her immunosuppressive regimen. However, NE can be fatal, and thus it is an important condition to consider, even in patients without leukemia or on chemotherapeutic regimens.…”
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Immunosuppression and Outcomes in Patients with Cutaneous Squamous Cell Carcinoma of the Head and Neck by Doriana Iancu, Ana Fulga, Doina Vesa, Iuliu Fulga, Dana Tutunaru, Andrei Zenovia, Alin Ionut Piraianu, Elena Stamate, Corina Sterian, Florentin Dimofte, Mihail Alexandru Badea, Alin Laurentiu Tatu

Subjects: “…immunosuppression…”
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Immunosuppression Induced by Chronic Inflammation and the Progression to Oral Squamous Cell Carcinoma by Yujuan Sun, Nan Liu, Xiaobing Guan, Hongru Wu, Zheng Sun, Hui Zeng

“…The results suggested that the immunosuppression induced by chronic inflammation promotes tumorigenesis in OSCC, rather than initiating it.…”
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Immunosuppression with Antitumour Necrosis Factor Therapy Leading to Strongyloides Hyperinfection Syndrome by Muhammad Farhan Khaliq, Rayan E. Ihle, James Perry

“…Strongyloides stercoralis is an endemic parasitic infection that can remain asymptomatic for years, but it can cause death in immunosuppressed individuals. Here, we present a case of Strongyloides hyperinfection in a 75-year-old male secondary to sepsis and chronic immunosuppression due to TNF-α inhibitors. …”
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Immunosuppressive Role of Myeloid-Derived Suppressor Cells and Therapeutic Targeting in Lung Cancer by Jie Ma, Huaxi Xu, Shengjun Wang

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Does therapy with immunosuppressive drugs improve gastrointestinal symptoms in patients with systemic sclerosis? by Oliver Distler, Cosimo Bruni, Suzana Jordan, Carina Mihai, Muriel Elhai, Rucsandra Dobrota, Alexandru Garaiman, Mike Oliver Becker, Lea Stamm, Sherif Ismail, Norina Zampatti, Aurora Maria Tatu

“…In multivariable linear regression, immunosuppressive therapy during the period of observation and lower baseline GIT scores were significantly associated with lower (better) GIT scores at follow-up.Conclusion Immunosuppressive treatment was associated with lower GIT scores in our cohort, which suggests the potential effects of immunosuppressants on GI manifestations in patients with SSc, requiring confirmation in prospective randomised clinical trials.…”
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Immunosuppressive metabolites in tumoral immune evasion: redundancies, clinical efforts, and pathways forward by David Munn, Maria Rain Jennings, John Blazeck

“…We provide a comprehensive review of the complex networks orchestrated by several of the most potent immunosuppressive metabolites, highlighting the impact of adenosine, kynurenines, prostaglandin E2, and norepinephrine and epinephrine, while discussing completed and ongoing clinical efforts to curtail their impact. …”
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Pure Red Cell Aplasia with Del(20q) Sensitive for Immunosuppressive Treatment by Anh Khoi Vo, Hilde Kollsete Gjelberg, Randi Hovland, Marte Karen Lindstad Brattås, Øystein Bruserud, Håkon Reikvam

“…Treatment of primary, idiopathic PRCA is immunosuppressive therapy. Although it is rare, isolated cytogenetic abnormalities can be seen in PRCA, and abnormal karyotype is associated with poor response to immunosuppressive therapy and poor prognosis. …”
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The Immunosuppressant Fingolimod (FTY720) for the Treatment of Mechanical Force-Induced Abnormal Scars by Masayo Aoki, Akatsuki Kondo, Noriko Matsunaga, Azusa Honda, Yuri Okubo, Kazuaki Takabe, Rei Ogawa

“…Therefore, its local immunosuppressive mechanisms differ from those of conventional immunosuppressive agents. …”
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Pulmonary Mucormycosis in a Patient with Crohn Disease on Immunosuppressive Medications including Infliximab by Alissa J Wright, Theodore Steiner, Ana Maria Bilawich, John C English, C Frank Ryan

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Lactate accumulation promotes immunosuppression and fibrotic transformation of bone marrow microenvironment in myelofibrosis by Mariarita Spampinato, Cesarina Giallongo, Sebastiano Giallongo, Enrico La Spina, Andrea Duminuco, Lucia Longhitano, Rosario Caltabiano, Lucia Salvatorelli, Giuseppe Broggi, Elisabetta P. Pricoco, Vittorio Del Fabro, Ilaria Dulcamare, Antonio Massimo DI Mauro, Alessandra Romano, Francesco Di Raimondo, Giovanni Li Volti, Giuseppe A. Palumbo, Daniele Tibullo

“…Methods To test the involvement of lactate in MF milieu transformation, we measured its levels in MF patients’ sera, eventually finding a massive accumulation of this metabolite, which we showed to promote the expansion of immunosuppressive subsets. Therefore, to assess the significance of its trafficking, we inhibited monocarboxylate transporter 1 (MCT1) by its selective antagonist, AZD3965, eventually finding a mitigation of lactate-mediated immunosuppressive subsets expansion. …”
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Macrophage-inherited exosome excise tumor immunosuppression to expedite immune-activated ferroptosis by Yan Liu, Junjie Liu, Qin Wang, Kun Zhang, Chunyan Zhu, Duo Wang, Guanhua Qiu, Xiaoqi Zhu, Chao Fang

“…Background Immunosuppressive tumor microenvironment (ITM) remains an obstacle that jeopardizes clinical immunotherapy.Methods To address this concern, we have engineered an exosome inherited from M1-pheototype macrophages, which thereby retain functions and ingredients of the parent M1-phenotype macrophages. …”
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