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361
Ticam2 ablation facilitates monocyte exhaustion recovery after sepsis
Published 2025-01-01“…Abstract Sepsis is a leading cause of death worldwide, with most patient mortality stemming from lingering immunosuppression in sepsis survivors. This is due in part to immune dysfunction resulting from monocyte exhaustion, a phenotype of reduced antigen presentation, altered CD14/CD16 inflammatory subtypes, and disrupted cytokine production. …”
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362
Identifying RBBP7 as a Promising Diagnostic Biomarker for BK Virus-Associated Nephropathy
Published 2022-01-01“…BK virus-associated nephropathy (BKVN) remains a major infectious complication due to powerful immunosuppression in kidney transplant recipients, and its histologic appearance can mimic rejection, leading to diagnostic and treatment dilemmas thus molecular diagnostic methods would be beneficial. …”
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363
Tuberculous Osteomyelitis of the Scapular Spine Revealing HIV-1 Infection
Published 2024-12-01“…This rare form of tuberculosis with an exceptional site revealed a HIV infection with profound immunosuppression. The patient was initiated on anti-tubercular treatment according to Moroccan recommendations.…”
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364
The impact of KRAS mutations on the tumour microenvironment and treatment response in non-small cell lung cancer
Published 2024-12-01“…KRAS-G12C, KRAS-G12V, and KRAS-G12D mutations may enhance NSCLC drug resistance through immunosuppression.…”
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365
Late Onset Graft Plasmacytoma-Like PTLD Presenting as Acute Hyperglycemia in a Kidney-Pancreas Transplant Recipient
Published 2019-01-01“…We report the case of a 54-year-old simultaneous pancreas-kidney transplant recipient (immunosuppression: OKT3, methylprednisolone, cyclosporine, and azathioprine), diagnosed with an IgG-kappa monoclonal gammopathy of undetermined significance eighteen years after transplant. …”
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366
Experimental Porcine Toxoplasma gondii Infection as a Representative Model for Human Toxoplasmosis
Published 2017-01-01“…In addition, the severe immunosuppression during acute infection described in mice does not occur in the experimentally infected ones. …”
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367
Systemic and Nonrenal Adverse Effects Occurring in Renal Transplant Patients Treated with mTOR Inhibitors
Published 2013-01-01“…The mammalian target of rapamycin inhibitors (mTOR-I), sirolimus and everolimus, are immunosuppressive drugs largely used in renal transplantation. …”
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368
Ruxolitinib Associated Tuberculosis Presenting as a Neck Lump
Published 2015-01-01“…It was hypothesized that use of Ruxolitinib through its selective inhibition of Janus-activated kinases 1 and 2 resulted in immunosuppression and miliary tuberculosis in this patient. …”
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369
A Novel In Situ Dendritic Cell Vaccine Triggered by Rose Bengal Enhances Adaptive Antitumour Immunity
Published 2022-01-01“…However, overcoming immune tolerance and immunosuppression in the tumour microenvironment (TME) is still a great challenge. …”
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370
Viral and Nonviral Engineering of Natural Killer Cells as Emerging Adoptive Cancer Immunotherapies
Published 2018-01-01“…Clinical responses to adoptive NK-based immunotherapy have been thwarted, however, by the profound immunosuppression induced by the tumor microenvironment, particularly severe in the context of solid tumors. …”
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371
Repeated CMV Infection in a Heart Transplantation Patient
Published 2012-01-01“…The patient received different treatments against CMV and the immunosuppression was changed several times. Finally, everolimus was introduced instead of cyclosporine, and mycophenolate mofetil was withdrawn. …”
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372
Immunotherapy for Hepatocellular Carcinoma: Current Advances and Future Expectations
Published 2018-01-01“…Here, we briefly introduce the mechanism of immunosuppression in hepatocellular carcinoma and summarize the rationale of the four major immunotherapeutic approaches with their current advances.…”
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373
Decoding the mechanisms behind second primary cancers
Published 2025-01-01“…This review summarizes recent studies on the mechanisms of SPCs, including the roles of genomic changes after first primary cancer (FPC) treatments, stromal cell phenotypic and metabolic changes, hormone levels and receptor expression, immunosuppression, aberrant gene methylation, EGFR signaling, and cell-free DNA in SPC development. …”
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374
Fatal Multiorgan Failure Associated with Disseminated Herpes Simplex Virus-1 Infection: A Case Report
Published 2012-01-01“…Autopsy revealed a predominantly retroperitoneal diffuse large B-cell lymphoma as the suspected origin of immunosuppression underlying herpes simplex dissemination.…”
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375
Insights into CSF-1/CSF-1R signaling: the role of macrophage in radiotherapy
Published 2025-02-01“…Furthermore, inhibition of CSF-1/CSF-1R signaling combined with radiotherapy has been extensively studied to reduce immunosuppression and promote abscopal effect. In addition, cumulative evidence demonstrated that M2 phenotype macrophage is dominant in tissue fibrosis and the inhibition of CSF-1/CSF-1R signaling pathway ameliorated pulmonary fibrosis, including radiation-induced lung fibrosis. …”
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376
Cytokine Patterns in Brain Tumour Progression
Published 2013-01-01“…The body’s response to cancer has many parallels with inflammation and repair; the inflammatory cells and cytokines present in tumours are more likely to contribute to tumour growth, progression, and immunosuppression, rather than in building an effective antitumour defence. …”
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377
The Role of Beta HPV Types and HPV-Associated Inflammatory Processes in Cutaneous Squamous Cell Carcinoma
Published 2020-01-01“…Dysregulation of the immune system (chronic inflammation and immunosuppression), environmental factors (ultraviolet radiation), and genetic factors are the most important cofactors involved in beta HPV-related carcinogenesis. …”
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378
A Very Rare Case: HPV-Negative Vulvar Cancer in an Adolescent
Published 2018-01-01“…These patients have usually risk factors such as human papillomavirus (HPV) infection and immunosuppression. Herein, we present a case of invasive squamous vulvar cancer in an 18-year-old patient without any risk factor. …”
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379
The Challenges of Distinguishing Different Causes of TMA in a Pregnant Kidney Transplant Recipient
Published 2024-01-01“…TMA disorders are well-recognised in kidney transplant recipients, often due to an underlying genetic predisposition related to complement dysregulation, or de novo due to infection, immunosuppression toxicity, or antibody-mediated rejection. …”
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380
Lymphomatoid Granulomatosis Treated Successfully with Rituximab in a Renal Transplant Patient
Published 2011-01-01“…Here, we describe LYG in a 70-year-old renal allograft recipient who, 4 years after transplantation, on tacrolimus and mycophenolate mofetil and prednisone maintenance immunosuppression, complained of low-grade fever, persistent headache and gait disturbance. …”
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