An Unusual Case of Systemic Lupus Erythematosus and Hemophagocytic Syndrome by Saika Sharmeen, Nazia Hussain

“…Hemophagocytic syndrome (HS) or hemophagocytic lymphohistiocytosis (HLH) is an immune mediated phenomenon that can occur in the setting of an autoimmune disease, chronic immunosuppression, malignancy, or infection. It has been more commonly described in the pediatric population and less commonly in adults. …”
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A Case of Oral Histoplasmosis Concomitant with Pulmonary Tuberculosis by Silas Antonio Juvencio de Freitas Filho, Natália Galvão Garcia, Mário César de Souza, Denise Tostes Oliveira

“…The human immunodeficiency virus (HIV) infection test was negative. The immunosuppression caused by tuberculosis in our patient probably had an important role in the development of intraoral lesions of histoplasmosis. …”
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Burkholderia Gladioli – A Predictor of Poor Outcome in Cystic Fibrosis Patients Who Receive Lung Transplants? A Case of Locally Invasive Rhinosinusitis and Persistent Bacteremia in... by Bradley S Quon, James D Reid, Patrick Wong, Pearce G Wilcox, Amin Javer, Jennifer M Wilson, Robert D Levy

“…A case involving a lung transplant recipient with cystic fibrosis who ultimately died as a result of severe rhinosinusitis due to B gladioli infection in the context of postlung transplant immunosuppression is reported.…”
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COVID-19 infection, quarantine, and sleep disorders: literature review by E. Sakalauskaitė-Juodeikienė

“…In this article, the author reviews sleep changes caused by viral infection and provides evidence that sleep deprivation acts as a significant factor in functional immunosuppression. The author reviews recent scientific literature suggesting that the administration of melatonin and melatonin receptor agonists for patients with COVID-19 infection treated in the intensive care unit can reduce prevalence of delirium and improve sleep quality, protect patients from “cytokine storm” and improve acute lung injury. …”
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Pregnancy Following Liver Transplantation: Review of Outcomes and Recommendations for Management by Kuljit S Parhar, Paul S Gibson, Carla S Coffin

“…Several key issues that are noted when counselling patients who are considering pregnancy following liver transplantation include the optimal timing of pregnancy, optimal contraception methods and the management of immunosuppression during pregnancy. The present review summarizes the most recent literature so that the clinician may address these issues with their patient and enable them to make informed decisions about pregnancy planning. …”
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A Rare Case of Pseudomonas aeruginosa-Associated Diarrhea in a Cirrhotic Patient by Malcolm Chapman, Atul Lodh, Joven Tristeza, Alexander Yang

“…This case is unique as our patient does not have a history of recent antibiotic use or prior history of immunosuppression. However, immune dysfunction in cirrhosis results in defects in both innate and acquired immunity, thus predisposing our patient to PsA-associated diarrhea. …”
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Platelet‐activating factor: a potential therapeutic target to improve cancer immunotherapy by Qi Yan, Hemn Mohammadpour

“…Recent findings by Dahal et al. reveal that platelet‐activating factor (PAF), a lipid mediator elevated in the TME, contributes to the differentiation of neutrophils into immunosuppressive neutrophils. They showed that inhibiting PAF signaling reduces MDSC‐mediated immunosuppression, thereby enhancing cytotoxic T‐cell activity. …”
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Dendritic Cell-Based Approaches for Therapeutic Immune Regulation in Solid-Organ Transplantation by Giuseppe Vassalli

“…To avoid immune rejection, allograft recipients require drug-based immunosuppression, which has significant toxicity. An emerging approach is adoptive transfer of immunoregulatory cells. …”
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Pneumatosis Intestinalis and Pneumoperitoneum After Lung Transplantation: Single-Center Experience and Systematic Review by Hiroshi Kagawa, Masashi Furukawa, Ernest G. Chan, Matthew Morrell, Pablo G. Sanchez

“…Mechanical ventilation, tracheostomy, gastrointestinal procedure, CMV infection, Clostridium difficile (C. difficile) infection, and immunosuppression can be the risk factors, and the management includes laparotomy or conservative management. …”
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Cells of the Innate and Adaptive Immune Systems in Kaposi’s Sarcoma by Owen Ngalamika, Sody Munsaka

“…The different forms of KS including HIV-associated KS, iatrogenic (immunosuppression-related) KS, and classical KS in elderly males suggest that immune cell dysregulation is among the key components in promoting KS development in KSHV-infected individuals. …”
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A 47-Year-Old Stem Cell Transplant Recipient with Fever, Cough and Chest Pain by Omar S Salh, Omar N Nadhem, Sanket R Thakore, Ruba A Halloush, Faisal A Khasawneh

“…It was diagnosed to be post-transplant lymphoproliferative disorder, a potential sequela of immunosuppression and a very difficult entity to treat in profoundly immunosuppressed patients.…”
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Emerging Implications for Extracellular Matrix-Based Technologies in Vascularized Composite Allotransplantation by Ricardo Londono, Vijay S. Gorantla, Stephen F. Badylak

“…Despite recent progress in vascularized composite allotransplantation (VCA), limitations including complex, high dose immunosuppression regimens, lifelong risk of toxicity from immunosuppressants, acute and most critically chronic graft rejection, and suboptimal nerve regeneration remain particularly challenging obstacles restricting clinical progress. …”
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Concomitant Cytomegalovirus Viraemia in Multisystem Inflammatory Syndrome in Adults (MIS-A) following COVID-19 by Benjamin Valente-Acosta, Francisco Moreno-Sánchez, Yvette Neme-Yunes, Sara López-Rueda, Irma Hoyo-Ulloa, Mónica Garcia-Gutierrez

“…Cytomegalovirus (CMV) viraemia is associated primarily with immunosuppression. In COVID-19 patients, it has been reported in severe and critical cases. …”
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Refractory Epistaxis due to Severe Factor V Deficiency with Inhibitor by Elizabeth S. John, Minesh D. Patel, Julio Hajdenberg

“…We describe a complicated case of an elderly patient with severe factor V deficiency with high inhibitor titer refractory to FEIBA (anti-inhibitor coagulation complex) treated with NovoSeven concurrently with cyclosporine immunosuppression and Rituxan. Given that there are no consensus guidelines on treatment, this case offers important insight into the therapeutic approaches that can be used to treat such patients.…”
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Intravenous immunoglobulin for mortality and inflammatory status in patients with sepsis: a retrospective database study by Hayabusa Takano, Hayabusa Takano, Naoki Kanda, Naoki Kanda, Yuji Wakimoto, Hiroyuki Ohbe, Kensuke Nakamura, Kensuke Nakamura

“…Moreover, IVIG may favorably affect sepsis-induced immunosuppression like persistent inflammation, immunosuppression, and catabolism syndrome (PICS).MethodsThis study was a retrospective cohort study using inpatient claims database provided by Medical Data Vision, which included approximately 190,000 episodes of intensive care unit admissions in Japanese acute care hospitals between April 2008 and September 2021. …”
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The effect of GM-CSF and predictors of treatment outcome in pediatric septic shock patients by Zhen-Hao Yu, Gui-Xiang Tian, Yao-Dong Wang, Ting-Yan Liu, Peng Shi, Jia-Yun Ying, Wei-Ming Chen, Yu-Feng Zhou, Guo-Ping Lu, Cai-Yan Zhang

“…Abstract Background Pediatric septic shock is a critical condition associated with high mortality rates, largely due to sepsis-induced immunosuppression. Granulocyte-macrophage colony-stimulating factor (GM-CSF) has been explored as a therapeutic intervention to counteract this immunosuppression. …”
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Leiomyoma in a Renal Allograft by Yan Jun Li, Amila Rohan Siriwardana, James Lawrence Penn Symons, Gordon Francis O’Neill, Min Ru Qiu, Timothy John Furlong

“…The patient was converted to everolimus for posttransplant immunosuppression management and there was no sign of progression over a year.…”
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Unveiling the complex double-edged sword role of exosomes in nasopharyngeal carcinoma by Xueyan Huang, Yuedi Tang

“…Exosomes could serve as biomarkers and therapeutic agents, as well as the molecular mechanisms by which they promote cell growth, angiogenesis, metastasis, immunosuppression, radiation resistance, and chemotherapy resistance in NPC. …”
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Current Bioengineering Methods for Whole Kidney Regeneration by Shuichiro Yamanaka, Takashi Yokoo

“…Kidney regeneration is likely to provide an inexhaustible source of tissues and organs for immunosuppression-free transplantation. It is currently garnering considerable attention and might replace kidney dialysis as the ultimate therapeutic strategy for renal failure. …”
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A delay-differential equation model of HIV related cancer--immune system dynamics by Urszula Foryś, Jan Poleszczuk

“…It is therefore of great importance to understand links between HIV related immunosuppression and cancer prognosis. In the paper we present a simple model of HIV related cancer - immune system interactions in vivo which takes into account a delay describing the time needed by CD$4^+$ T lymphocyte to regenerate after eliminating a cancer cell. …”
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