COVID-19 infection, quarantine, and sleep disorders: literature review by E. Sakalauskaitė-Juodeikienė

“…In this article, the author reviews sleep changes caused by viral infection and provides evidence that sleep deprivation acts as a significant factor in functional immunosuppression. The author reviews recent scientific literature suggesting that the administration of melatonin and melatonin receptor agonists for patients with COVID-19 infection treated in the intensive care unit can reduce prevalence of delirium and improve sleep quality, protect patients from “cytokine storm” and improve acute lung injury. …”
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Pregnancy Following Liver Transplantation: Review of Outcomes and Recommendations for Management by Kuljit S Parhar, Paul S Gibson, Carla S Coffin

“…Several key issues that are noted when counselling patients who are considering pregnancy following liver transplantation include the optimal timing of pregnancy, optimal contraception methods and the management of immunosuppression during pregnancy. The present review summarizes the most recent literature so that the clinician may address these issues with their patient and enable them to make informed decisions about pregnancy planning. …”
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Dendritic Cell-Based Approaches for Therapeutic Immune Regulation in Solid-Organ Transplantation by Giuseppe Vassalli

“…To avoid immune rejection, allograft recipients require drug-based immunosuppression, which has significant toxicity. An emerging approach is adoptive transfer of immunoregulatory cells. …”
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Pneumatosis Intestinalis and Pneumoperitoneum After Lung Transplantation: Single-Center Experience and Systematic Review by Hiroshi Kagawa, Masashi Furukawa, Ernest G. Chan, Matthew Morrell, Pablo G. Sanchez

“…Mechanical ventilation, tracheostomy, gastrointestinal procedure, CMV infection, Clostridium difficile (C. difficile) infection, and immunosuppression can be the risk factors, and the management includes laparotomy or conservative management. …”
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Cells of the Innate and Adaptive Immune Systems in Kaposi’s Sarcoma by Owen Ngalamika, Sody Munsaka

“…The different forms of KS including HIV-associated KS, iatrogenic (immunosuppression-related) KS, and classical KS in elderly males suggest that immune cell dysregulation is among the key components in promoting KS development in KSHV-infected individuals. …”
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A 47-Year-Old Stem Cell Transplant Recipient with Fever, Cough and Chest Pain by Omar S Salh, Omar N Nadhem, Sanket R Thakore, Ruba A Halloush, Faisal A Khasawneh

“…It was diagnosed to be post-transplant lymphoproliferative disorder, a potential sequela of immunosuppression and a very difficult entity to treat in profoundly immunosuppressed patients.…”
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Emerging Implications for Extracellular Matrix-Based Technologies in Vascularized Composite Allotransplantation by Ricardo Londono, Vijay S. Gorantla, Stephen F. Badylak

“…Despite recent progress in vascularized composite allotransplantation (VCA), limitations including complex, high dose immunosuppression regimens, lifelong risk of toxicity from immunosuppressants, acute and most critically chronic graft rejection, and suboptimal nerve regeneration remain particularly challenging obstacles restricting clinical progress. …”
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Concomitant Cytomegalovirus Viraemia in Multisystem Inflammatory Syndrome in Adults (MIS-A) following COVID-19 by Benjamin Valente-Acosta, Francisco Moreno-Sánchez, Yvette Neme-Yunes, Sara López-Rueda, Irma Hoyo-Ulloa, Mónica Garcia-Gutierrez

“…Cytomegalovirus (CMV) viraemia is associated primarily with immunosuppression. In COVID-19 patients, it has been reported in severe and critical cases. …”
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Refractory Epistaxis due to Severe Factor V Deficiency with Inhibitor by Elizabeth S. John, Minesh D. Patel, Julio Hajdenberg

“…We describe a complicated case of an elderly patient with severe factor V deficiency with high inhibitor titer refractory to FEIBA (anti-inhibitor coagulation complex) treated with NovoSeven concurrently with cyclosporine immunosuppression and Rituxan. Given that there are no consensus guidelines on treatment, this case offers important insight into the therapeutic approaches that can be used to treat such patients.…”
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The effect of GM-CSF and predictors of treatment outcome in pediatric septic shock patients by Zhen-Hao Yu, Gui-Xiang Tian, Yao-Dong Wang, Ting-Yan Liu, Peng Shi, Jia-Yun Ying, Wei-Ming Chen, Yu-Feng Zhou, Guo-Ping Lu, Cai-Yan Zhang

“…Abstract Background Pediatric septic shock is a critical condition associated with high mortality rates, largely due to sepsis-induced immunosuppression. Granulocyte-macrophage colony-stimulating factor (GM-CSF) has been explored as a therapeutic intervention to counteract this immunosuppression. …”
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Leiomyoma in a Renal Allograft by Yan Jun Li, Amila Rohan Siriwardana, James Lawrence Penn Symons, Gordon Francis O’Neill, Min Ru Qiu, Timothy John Furlong

“…The patient was converted to everolimus for posttransplant immunosuppression management and there was no sign of progression over a year.…”
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Current Bioengineering Methods for Whole Kidney Regeneration by Shuichiro Yamanaka, Takashi Yokoo

“…Kidney regeneration is likely to provide an inexhaustible source of tissues and organs for immunosuppression-free transplantation. It is currently garnering considerable attention and might replace kidney dialysis as the ultimate therapeutic strategy for renal failure. …”
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A delay-differential equation model of HIV related cancer--immune system dynamics by Urszula Foryś, Jan Poleszczuk

“…It is therefore of great importance to understand links between HIV related immunosuppression and cancer prognosis. In the paper we present a simple model of HIV related cancer - immune system interactions in vivo which takes into account a delay describing the time needed by CD$4^+$ T lymphocyte to regenerate after eliminating a cancer cell. …”
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Hemophagocytic Lymphohistiocytosis in an AIDS Patient with Kaposi Sarcoma: A Treatment Dilemma by Oluwadunni E. Emiloju, Sorab Gupta, Vivian Arguello-Guerra, Claudia Dourado

“…We report this case to highlight the difficulty in managing this patient given the complex interplay of immunosuppression due to AIDS, immune reconstitution following initiation of HAART, and immune overdrive manifesting as HLH.…”
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Mortality Associated with Recurrent Extreme Hyperferritinemia in Critically Ill Adolescents by John Scott Baird

“…Recurrent extreme hyperferritinemia may be a novel biomarker of increased mortality in patients with the syndrome of persistent inflammation, immunosuppression, and catabolism.…”
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Methotrexate-Associated Lymphoproliferative Disorder in a Patient with Psoriasis: A Case Report and Review of the Literature by Carolina Afonso, Adriana Roque, Cátia Almeida, Maria Beatriz Pimentão, Maria José Julião, Rodolfo Silva, Catarina Geraldes, Marília Gomes

“…Iatrogenic immunodeficiency-associated lymphoproliferative disorders (LPDs) are heterogeneous clinicopathological entities developing in patients receiving immunosuppression. Outside the posttransplant setting, methotrexate (MTX), a drug commonly used for the treatment of autoimmune diseases, is an immunosuppressive agent frequently reported to be associated with LPD. …”
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Funding for research on cryptococcal disease: an analysis based on the G-finder report by Iraine Duarte, Marcio L. Rodrigues

“…Abstract Members of the genus Cryptococcus are the causative agents of cryptococcal meningitis, a disease mainly associated with HIV-induced immunosuppression. Patients with cryptococcal meningitis are at a serious risk of death. …”
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Toll-Like Receptor 4 Activation in Cancer Progression and Therapy by Alja Oblak, Roman Jerala

“…While TLR4 activation can promote antitumor immunity, it can also result in increased tumor growth and immunosuppression. Nevertheless, TLR4 engagement by endotoxin as well as by endogenous ligands represents notable contribution to the outcome of different cancer treatments, such as radiation or chemotherapy. …”
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Surgical Management of Right Atrial Mass Associated with a Vascular Access Catheter by David Ferreira, Anthony Le, John Khoo, Paul Nguyen, Manish Jain, Timothy Spicer, Craig Juergens

“…The authors report a case of an atrial mass associated with a tunnelled vascular access catheter in an immunosuppressed haemodialysis patient. In the setting of immunosuppression with fevers, a broad differential for the atrial mass was considered. …”
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Gastrointestinal Cryptococcosis Associated with Intestinal Lymphangiectasia by Fernando Naranjo-Saltos, Alejandro Hallo, Carlos Hallo, Andres Mayancela, Alejandra Rojas

“…This chronic lymph leakage leads to a state of immunosuppression secondary to the loss of humoral and cellular components of the immune system and represents a potential risk factor for opportunistic infections. …”
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