A Decade of Experience Using mTor Inhibitors in Liver Transplantation by Jeffrey Campsen, Michael A. Zimmerman, Susan Mandell, Maria Kaplan, Igal Kam

“…Patients that received SRL as primary immunosuppression had 50% less rejection compared to controls.…”
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Anaesthesia affects immune function and impact on long-term cancer prognosis: A review by Kisdyanti Yuniar Melissa, Suandika Made, Rahmawati Arni Nur

“…Anti-tumour immunity is compromised by local and systemic immunosuppression, which may ultimately contribute to tumor survival and the long-term prognosis of cancer patients. …”
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Effect of innate and induced immunity on infectious bursal disease pathogenesis by A. N. Semina

“…In case of IBD, the immunosuppression is both direct consequence of specific target-cell infection and indirect consequence of the interactions occurring in the bird’s immune network. …”
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Adjuvant Ciprofloxacin for Persistent BK Polyomavirus Infection in Kidney Transplant Recipients by David Arroyo, Sindhu Chandran, Parsia A. Vagefi, David Wojciechowski

“…BK virus (BKV) infection is a common complication following kidney transplantation. Immunosuppression reduction is the cornerstone of treatment while adjuvant drugs have been tried in small uncontrolled studies. …”
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Whole blood ratio of CDK1/CX3CR1 mRNA expression combined to lactate refines the prediction of ICU mortality in septic patients in the Sepsis-3 era: a proof-of-concept study by Marie-Angélique Cazalis, Marie-Angélique Cazalis, Louis Kreitmann, Louis Kreitmann, Guillaume Monneret, Guillaume Monneret, Alexandre Pachot, Alexandre Pachot, Karen Brengel-Pesce, Karen Brengel-Pesce, Jean-François Llitjos, Jean-François Llitjos, Jean-François Llitjos

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Insights into the Roles of B Cells in Patients with Sepsis by Xijie Dong, Hao Tu, Shuang Qin, Xiangjun Bai, Fan Yang, Zhanfei Li

“…Dysfunction of B cells, along with aggravated immunosuppression, are closely related to poor prognosis. …”
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Homeostatic T Cell Proliferation after Islet Transplantation by Paolo Monti, Lorenzo Piemonti

“…Pancreatic islet transplantation in patients with type 1 diabetes mellitus is performed under immunosuppression to avoid alloreactive T cell responses and to control the reactivation of autoreactive memory T cells. …”
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Molecular Mechanisms of Immunomodulation Properties of Mesenchymal Stromal Cells: A New Insight into the Role of ICAM-1 by Yury Rubtsov, Кirill Goryunov, Аndrey Romanov, Yulia Suzdaltseva, George Sharonov, Vsevolod Tkachuk

“…ICAM-1 is involved in the control of T cell activation leading to immunosuppression or modest stimulation depending on the T cell status. …”
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CNS Vasculitis Associated with Waldenström Macroglobulinemia by Tanawan Riangwiwat, Chris Y. Wu, Alberto S. Santos-Ocampo, Randal J. Liu, Aaron M. McMurtray, Beau K. Nakamoto

“…To our knowledge, CNS vasculitis in a WM patient, in the absence of cryoglobulins, has not been reported. Immunosuppression is the preferred treatment.…”
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Hydroxychloroquine Effects on TLR Signalling: Underexposed but Unneglectable in COVID-19 by Aliede E. in ‘t Veld, Manon A. A. Jansen, Luuk C. A. Ciere, Matthijs Moerland

“…We argue that the clinical effect of prophylactic or therapeutic HCQ treatment in COVID-19 depends on the balance between inhibition of viral replication, immunosuppression, and off-target side effects, and that the outcome is probably dependent on disease stage and disease severity. …”
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Absence of Rejection in a Facial Allograft Recipient with a Positive Flow Crossmatch 24 Months after Induction with Rabbit Anti-Thymocyte Globulin and Anti-CD20 Monoclonal Antibody by Bruce E. Gelb, J. Rodrigo Diaz-Siso, Natalie M. Plana, Adam Jacoby, William J. Rifkin, Kimberly S. Khouri, Daniel J. Ceradini, Eduardo D. Rodriguez

“…To our knowledge, this is the first report of targeted B cell agents used for induction immunosuppression in skin-containing vascularized composite tissue allotransplantation. …”
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An Interesting Case of Kidney Transplant Recipient with Multiple Concomitant Infections- 10 Years Post Transplantation by Chilaka Rajesh, Utkarsh Mishra, Ankit Jain, T. Jayaprakash, Phaneesh Bharadwaj, Selvin Sundar Rajmani, Nisha Jose, Jeethu Joseph Eapen, Elenjickal Elias John, Santosh Varughese

“…Opportunistic infections or pathogens that reactivate from latent infection in the renal transplant recipients often arise during the peak immunosuppression period and infections such as Pneumocystis jirovecii may arise in the late period of posttransplant. …”
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Glioblastoma Multiforme Stem Cells by Irena Dimov, Deasanka Tasic-Dimov, Irena Conic, Vladisav Stefanovic

“…Therefore, a comprehensive understanding of the mechanisms underlying the GBM-induced immunosuppression is indispensable. This review presents a summary of the present knowledge both on GBMSCs and the GBM, and/or GBMSC-related mechanisms of developing both local and systemic immunosuppression, of which an understanding may lead to the development of the novel and effective therapeutic strategies.…”
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Coinfections increase the risk of HIV acquisition, AIDS progression, and therapy and prophylaxis failure: a review by Robert Root-Bernstein

“…The primary drivers of preexisting immunosuppression and inflammation are non-HIV infections and possibly alloantigen and drug exposures. …”
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Presumed ocular tuberculosis in a developed country: a descriptive retrospective analysis of patients from a tertiary health care centre in the United Kingdom by Mariam M. Boshra, Amira Stylianidies, Hitesh Agrawal

“…Uveitis pattern and presence or absence of disc edema could predict the need for immunosuppression.…”
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The Need for Inducing Tolerance in Vascularized Composite Allotransplantation by Kadiyala V. Ravindra, Hong Xu, Larry D. Bozulic, David D. Song, Suzanne T. Ildstad

“…In order to optimize VCA outcomes, translational studies are needed to develop less toxic immunosuppression and possibly achieve donor-specific tolerance. …”
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Fever, Haematuria, and Acute Graft Dysfunction in Renal Transplant Recipients Secondary to Adenovirus Infection: Two Case Reports by J. Ramírez, I. C. Bostock, A. Martin-Onraët, S. Calleja, A. Sánchez-Cedillo, L. A. Navarro-Vargas, A. L. Noriega-Salas, O. Martínez-Mijangos, N. O. Uribe-Uribe, M. Vilatoba, B. Gabilondo, L. E. Morales-Buenrostro, J. Alberú

“…The viral real-time PCR became negative upon immunosuppression reduction and administration of IVIG; graft function normalized. …”
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Immunomodulatory Effects of Hemagglutinin- (HA-) Modified A20 B-Cell Lymphoma Expanded as a Brain Tumor on Adoptively Transferred HA-Specific CD4+ T Cells by Valentin P. Shichkin, Roman M. Moriev

“…Our data support an idea about sufficient role of both the tumor-specific and -nonspecific mechanisms inducing immunosuppression in cancer patients.…”
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Pneumonia Severity Index in the Immunocompromised by Kevin M Sanders, Theodore K Marras, Charles KN Chan

“…BACKGROUND: The pneumonia severity index (PSI) accounts for many comorbidities, but not immunosuppression.…”
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An unmet need: Pancreatic beta cell replacement by F Mohamed, C Adams, B Mansfield

“…In SA, only a few pancreas transplants have been performed, primarily because of surgical risks and the need for immunosuppression. Islet transplantation is an alternative but faces limitations due to donor scarcity and immunosuppression requirements. …”
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