Size effect-based improved antioxidant activity of selenium nanoparticles regulating Anti-PI3K-mTOR and Ras-MEK pathways for treating spinal cord injury to avoid hormone shock-induced immunosuppression by Peixin Liu, Xiaodong Liu, Zihao Wu, Kui Shen, Zhaofeng Li, Xiaowei Li, Qifeng Wu, Leung Chan, Zhong Zhang, Yutong Wu, Liwen Liu, Tianfeng Chen, Yi Qin

“…Selenium nanoparticles have demonstrated significant antioxidative and anti-inflammatory properties via a non-immunosuppressive pathway; however, their clinical application has been limited by their inadequate stability and functionality to cross the blood-spinal cord barrier (BSCB). …”
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Ophthalmological manifestations in inflammatory bowel disease under the watchful eye of a gastroenterologist from a tertiary centre by Konrad Lewandowski, Magdalena Kaniewska, Katarzyna Karłowicz, Martyna Więcek, Edyta Tulewicz-Marti, Piotr Celmer, Małgorzata Frankowska, Joanna Sempińska-Szewczyk, Grażyna Rydzewska

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Idiopathic Retroperitoneal Fibrosis-Related Hydronephrosis: Evaluation of Comprehensive Management and Prediction of Inflammatory Markers for Stent-Free Outcomes by Huang Z, Liu Y, Xiao Y, Hu H, Xu T

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DRUG-INDUCED GINGIVAL OVERGROWTHS: AN INSIGHT INTO MOLECULAR MECHANISMS by Gabriel Rotundu, Diana Tatarciuc, Bogdan Amărioarei, Dana Budală, Ruxandra Stan, Oana Butnaru, Alexandra Mârțu, Liliana Păsărin, Ionut Luchian

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Anti-HMGB1 Monoclonal Antibody Ameliorates Immunosuppression after Peripheral Tissue Trauma: Attenuated T-Lymphocyte Response and Increased Splenic CD11b+Gr-1+ Myeloid-Derived Suppressor Cells Require HMGB1 by Xiangcai Ruan, Sophie S. Darwiche, Changchun Cai, Melanie J. Scott, Hans-Christoph Pape, Timothy R. Billiar

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Age-related immunosenescence and Epstein–Barr virus-positive mucocutaneous ulcer presenting as oral cancer: a case report by Jiayuan Ye, Shengqiang Ji, Zhouxiao Wu, Genhua Ma, Jing Chen, Shimin Wu, Yilian Xie

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Reviewing the current diagnostic and treatment approaches for myocarditis – analysis of literature by Damian Zys, Maciej Wojszczyk, Julia Ryniecka, Witold Czyż, Julia Kacperczyk, Marta Chuncia-Ileczko, Michalina Wójcikiewicz, Filip Arczewski, Karol Dziedzic, Julia Kulbacka

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Incidence and risk factors for Graves’ orbitopathy in patients who underwent anti-inflammatory and immunosuppressive treatment during medical treatment for Graves’ disease: investigation of 1,553 cases with newly diagnosed Graves’ disease and proposal of a predictive score by Natsuko Watanabe, Jaeduk Yoshimura Noh, Ai Kozaki, Ran Yoshimura, Ai Yoshihara, Nami Suzuki, Masako Matsumoto, Miho Fukushita, Aya Kinoshita, Azusa Aida, Hideyuki Imai, Shigenori Hiruma, Toshu Inoue, Kosuke Inoue, Kiminori Sugino, Koichi Ito

“…Appropriate administration of anti-inflammatory and immunosuppressive treatment (AIIST) is important for patients with Graves’ orbitopathy (GO). …”
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Subtle‐but‐smouldering myocardial injury after immune checkpoint inhibitor treatment accompanied by amyloid deposits by Mizuki Ida, Shiro Nakamori, Shinya Yamamoto, Seimi Watanabe, Kyoko Imanaka‐Yoshida, Masaki Ishida, Hajime Sakuma, Keiichi Yamanaka, Kaoru Dohi

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Adaptive clinical trial of AZD7442 and SARS-CoV-2 vaccination in immunosuppressed patients highly vulnerable to infection with SARS-CoV-2 virus (RAPID-PROTECTION): protocol for a multicentre, interventional open-label, randomised controlled trial by Ernest Choy, Kerenza Hood, Emma Thomas-Jones, Eleanor Barnes, Keith Wilson, Christian H Ottensmeier, Debbie Harris, Adrian Hill, Mark Tuthill, Richard Adams, Catherine Porter, Katie Ewer, Sian Griffin, Rebecca Tangney, Joanne Euden, Shirley Pringle, Lawrence Raisanen, Ruby Ray, Lisette Sheena Nixon, Melanie Varley, Craig Bodman, Paola Cicconi, Vivien Dagley, Steven Knapper

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Repression of the stress granule protein G3BP2 inhibits immune checkpoint molecule PD‐L1 by Yanhong Zhang, Changli Yue, Anna M. Krichevsky, Igor Garkavtsev

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Double-targeted liposomes coated with matrix metallopeptidase-2-responsive polypeptide nanogel for chemotherapy and enhanced immunotherapy against cervical cancer by Zhimin Bai, Yibo Yang, Zutong Cui, Wenming Liang, Xin Zhang, Zihan Zhang, Jianming Sun, Zhiwei Liu, Kun Li, Ming Shi, Jian Li

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The effectiveness of dexamethasone as a combination therapy for COVID-19 by Namazi Nader

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Challenges in ABO-incompatible Renal Transplantation: A Case Report of Acute Antibody-mediated Rejection with Late Graft Thrombosis by Abhishek Pratap Singh, Pankaj Beniwal, Vinay Malhotra

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Autoimmune Hepatitis in Children: The Current State of the Problem by G. V. Volynets, A. I. Khavkin, T. A. Skvortsova, V. V. Matkash

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Exhaustion of CD8pos central memory regulatory T cell differentiation is involved in renal allograft rejection by Florian Kälble, Jonas Leonhard, Jonas Leonhard, Martin Zeier, Oliver Zivanovic, Matthias Schaier, Andrea Steinborn

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Consensus Based Indian Guidelines for the Management of Pemphigus Vulgaris and Pemphigus Foliaceous by Dipankar De, Hitaishi Mehta, Shikha Shah, Kidangazhiathmana Ajithkumar, Shyamanta Barua, Laxmisha Chandrashekar, Manas Chatterjee, Vishal Gupta, Sujay Khandpur, Geeti Khullar, Seetharam Anjaneyulu Kolalapudi, Sheetanshu Kumar, Shekhar Neema, Deepika Pandhi, Shital Poojary, Reena Rai, Murlidhar Rajagopalan, Raghavendra Rao, Bela Shah, Archana Singal, Vishal Thakur, Keshavamurthy Vinay, Ashutosh Aggrawal, Arka De, Soham Mukherjee, Shankar Prinja, Rahul Mahajan, Sanjeev Handa

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A Potential Concept In The Management of Tumors With Modulation of Prostaglandin, Nitric Oxide and Antioxidants by Noori S. Al-Waili

“…Tumors are associated with immunosuppression and anemia. We have hypothesized that the over-production of PGs is responsible for immunosuppression and anemia in conditions associated with increased production of PG such as tumor, and that PG inhibitors might help reversing immunosuppression and anemia, and play a role in eradication and prevention of tumors. …”
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Early Gastric Post-Transplant Lymphoproliferative Disorder and H pylori Detection after Kidney Transplantation: A Case Report and Review of the Literature by CL Nash, LM Price, DA Stewart, F Sepandj, S Yilmaz, A Barama

“…In the era of cyclosporine immunosuppression, the incidence of PTLD affecting the gastrointestinal tract may be increasing in comparison with the incidence seen with the use of older immunosuppression regimens. …”
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Disseminated Histoplasmosis, Pulmonary Tuberculosis, and Cytomegalovirus Disease in a Renal Transplant Recipient after Infection with SARS-CoV-2 by Carvallo-Venegas Mauricio, Fuentes-López Elsa Angélica, Andrade-Ortega Antonio de Jesús, Torres-Baranda José Rodrigo, Carrasco-Carrizosa Aldo, Cerrillos-Gutierrez José Ignacio, Andrade-Sierra Jorge

“…There is no current consensus on the management of immunosuppression during SARS-CoV-2 infection in RTR. Case Presentation. …”
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