Immunomodulatory Effects of Hemagglutinin- (HA-) Modified A20 B-Cell Lymphoma Expanded as a Brain Tumor on Adoptively Transferred HA-Specific CD4+ T Cells by Valentin P. Shichkin, Roman M. Moriev

“…Our data support an idea about sufficient role of both the tumor-specific and -nonspecific mechanisms inducing immunosuppression in cancer patients.…”
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Pneumonia Severity Index in the Immunocompromised by Kevin M Sanders, Theodore K Marras, Charles KN Chan

“…BACKGROUND: The pneumonia severity index (PSI) accounts for many comorbidities, but not immunosuppression.…”
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An unmet need: Pancreatic beta cell replacement by F Mohamed, C Adams, B Mansfield

“…In SA, only a few pancreas transplants have been performed, primarily because of surgical risks and the need for immunosuppression. Islet transplantation is an alternative but faces limitations due to donor scarcity and immunosuppression requirements. …”
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Monomorphic Ventricular Tachycardia as a Presentation of Giant Cell Myocarditis by Michael H. Chiu, Cvetan Trpkov, Saman Rezazedeh, Derek S. Chew

“…She was treated with combined immunosuppressive therapy as well as guideline-directed medical therapy. …”
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Neoantigen mRNA vaccines and A2A receptor antagonism: A strategy to enhance T cell immunity by Saber Imani, Parham Jabbarzadeh Kaboli, Ali Babaeizad, Mazaher Maghsoudloo

“…By targeting A2AR, this approach reduces TME-induced immunosuppression, enhances DC activation, and improves neo-antigen presentation. …”
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A Challenging Twist in Pulmonary Renal Syndrome by Rajaie Namas, Bernard Rubin, Wamidh Adwar, Alireza Meysami

“…Prompt cessation of hydralazine may be sufficient to reverse disease activity but immunosuppression may be needed.…”
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Divergent Effects of <i>Circoviridae</i> Capsid Proteins on Type I Interferon Signaling by Anon H. Kosaka, Chen-Yu Huang, Zih-Ying Lu, Hua-Zhen Hsing, Amonrat Choonnasard, Rissar Siringo Ringo, Kuo Pin Chuang, Akatsuki Saito

“…Additionally, beak and feather disease virus in parrots, canine circovirus in dogs, and columbid circovirus (pigeon circovirus) in racing pigeons induce immunosuppression, followed by secondary infections in these hosts. …”
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Dermatological Manifestations in Immunocompromised Pediatric Patients on Chemotherapy: A Cross-sectional, Observational Study by Tulika Rai, Rajendra Kumar Mahawar, Priyanka Aggarwal

“…Background: Pediatric patients on chemotherapy suffer from various dermatoses due to immunosuppression or due to cutaneous adverse effects of chemotherapy. …”
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Prior Exposure to Immunosuppressors Sensitizes Retinal Microglia and Accelerates Optic Nerve Regeneration in Zebrafish by Ilse Bollaerts, Jessie Van houcke, An Beckers, Kim Lemmens, Sophie Vanhunsel, Lies De Groef, Lieve Moons

“…We first demonstrated that systemic immunosuppression with dexamethasone (dex) impedes regeneration after optic nerve injury. …”
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Small Bowel Transplantation: Current Clinical Status by David Sigalet

“…With recent refinements in immunosuppression techniques, the first successful reports of small bowel transplantation in humans have now been made, increasing interest in bowel transplantation among clinicians and patients alike. …”
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Emicizumab in two patients with acquired haemophilia A – case report by Zhao Milly, Kartika Thomas, Witenko Corey, Snead Jessica, DeSancho Maria T, Ciolek Alana

“…Patients with acquired haemophilia A (PwAHA) can present with severe bleeding and may require lengthy treatment with bypassing agents and immunosuppression. We present two cases of the implementation of emicizumab in PwAHA. …”
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Mechanisms and Mediators of Inflammation: Potential Models for Skin Rejection and Targeted Therapy in Vascularized Composite Allotransplantation by Theresa Hautz, Dolores Wolfram, Johanna Grahammer, Ravi Starzl, Christoph Krapf, Johann Pratschke, W. P. Andrew Lee, Gerald Brandacher, Stefan Schneeberger

“…However, postoperative courses of VCA recipients have been complicated by skin rejection, and long-term immunosuppression remains a necessity for allograft survival. …”
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Transplant Tolerance: New Insights and Strategies for Long-Term Allograft Acceptance by Paulina Ruiz, Paula Maldonado, Yessia Hidalgo, Alejandra Gleisner, Daniela Sauma, Cinthia Silva, Juan Jose Saez, Sarah Nuñez, Mario Rosemblatt, Maria Rosa Bono

“…Despite the potential of organ transplantation, the administration of immunosuppressive drugs required for allograft acceptance induces severe immunosuppression in transplanted patients, which leads to serious side effects such as infection with opportunistic pathogens and the occurrence of neoplasias, in addition to the known intrinsic toxicity of these drugs. …”
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Metastatic Urothelial Carcinoma from Transplanted Kidney with Complete Response to an Immune Checkpoint Inhibitor by Ryan S. Chiang, Ashton A. Connor, Brant A. Inman, Wen-Chi Foo, David N. Howell, John F. Madden, Matthew J. Ellis, Aparna S. Rege, Michael R. Harrison

“…She achieved sustained complete remission with transplant nephroureterectomy, retroperitoneal lymphadenectomy, immunosuppression withdrawal, and immunotherapy with pembrolizumab. …”
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The road ahead: emerging therapies for primary IgA nephropathy by Edward J. Filippone, Rakesh Gulati, John L. Farber

“…Sparsentan is indicated for persisting proteinuria. Immunosuppression should be considered for all patients at risk for progression (persisting proteinuria and/or declining eGFR). …”
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Malignant and Noninvasive Skin Tumours in Renal Transplant Recipients by Christopher D. Roche, Joelle S. Dobson, Sion K. Williams, Mara Quante, Joyce Popoola, Jade W. M. Chow

“…Transplant recipients require immunosuppression to prevent graft rejection. This conveys an increased risk of malignancy, particularly skin tumours. …”
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Renal Transplantation in Hepatitis C Positive Patients: A Single Centre Experience by P. R. Shah, A. V. Vanikar, M. R. Gumber, H. V. Patel, V. B. Kute, S. M. Godara, H. L. Trivedi

“…Hepatitis C virus (HCV) infection is an independent risk factor for renal transplantation (RTx). Immunosuppression minimization can render better quality of life to these patients. …”
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Efficacy of Anti-Cancer Immune Responses Elicited Using Tumor-Targeted IL-2 Cytokine and Its Derivatives in Combined Preclinical Therapies by Sahar Balkhi, Giorgia Bilato, Andrea De Lerma Barbaro, Paola Orecchia, Alessandro Poggi, Lorenzo Mortara

“…Also, the use of IL-2 immunocytokines in “in situ” vaccination to relieve the immunosuppression of the TME is discussed.…”
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A Randomized Multicenter Study Comparing a Tacrolimus-Based Protocol with and without Steroids in HCV-Positive Liver Allograft Recipients by Ulf Neumann, Didier Samuel, Pavel Trunečka, Jean Gugenheim, Giorgio Enrico Gerunda, Styrbjörn Friman

“…This randomized study evaluated HCV recurrence in HCV-positive liver allograft recipients using steroid-free immunosuppression. All patients received tacrolimus (TAC) at an initial dose of 0.10–0.15 mg/kg. …”
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Livedoid vasculopathy with mononeuritis multiplex associated with protein S deficiency mimicking systemic vasculitis by Vikramraj K Jain, Krishnamurthy Hegde, Renuka Panchagnula

“…The patient was treated with anticoagulation and immunosuppression after which her symptoms improved. LV can be associated with thrombophilias, fibrinolytic disorders, autoimmune diseases, and malignancy. …”
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