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1021
Efficacy of adalimumab in pediatric non-infectious uveitis with and without anterior segment inflammation
Published 2025-01-01“…Secondary outcomes including best-corrected visual acuity (BCVA), inflammation parameters [anterior chamber cell (ACC), vitreous haze (VH)], retinal nerve fiber layer (RNFL) thickness, fluorescein angiography (FA) scores, as well as systemic immunosuppression therapy (IMT) and glucocorticoid load, were assessed. …”
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1022
Intestinal obstruction caused by disseminated mycobacterium avium complex disease following solid organ transplantation: a case report
Published 2025-01-01“…The patient’s outcome emphasizes the need for vigilance in managing long-term immunosuppressed patients, particularly when they present with atypical infections.…”
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1023
Sinomenine attenuates uremia vascular calcification by miR-143-5p
Published 2025-01-01“…Sinomenine exhibited anti-inflammatory and immunosuppressive effects. Objective of this study was to investigate the effect of sinomenine in vascular calcification and its potential molecular mechanism. …”
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1024
Classification of Nanomaterial Drug Delivery Systems for Inflammatory Bowel Disease
Published 2025-02-01“…Lifelong maintenance therapy may thus be needed to manage these symptoms; however, traditional IBD drugs, such as 5-aminosalicylic acid, glucocorticoids, immunosuppressants, and biological agents, are often associated with problems including poor solubility, instability, and ineffective targeting, as well as causing serious side effects in non-target tissues. …”
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1025
Familial Adenomatous Polyposis and Desmoid Tumor Treated with Multivisceral Transplantation and Kidney Autotransplantation: Case Report and Literature Review
Published 2019-01-01“…The patient received immunosuppressive, antithrombotic, and antibiotic treatment. …”
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1026
Early, Noninvasive Clinical Indicators of Kidney Prognosis in Primary Nephrotic Syndrome: A Retrospective Exploratory Study
Published 2022-01-01“…Univariate Cox proportional hazards regression analysis identified clinical parameters in the 2-month period after initiating immunosuppressive therapy (IST); it predicted 40% reduction in the estimated glomerular filtration rate (eGFR) in 36 patients with primary NS. …”
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1027
Identification of tacrolimus-related genes in familial combined hyperlipidemia and development of a diagnostic model using bioinformatics analysis
Published 2025-02-01“…Given tacrolimus's immunosuppressive impact, the gene expression matrix data obtained from dataset GSE1010 was submitted to CIBERSORT to assess immune cell infiltration outcomes. …”
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1028
An adenoviral vector encoding an inflammation-inducible antagonist, HMGB1 Box A, as a novel therapeutic approach to inflammatory diseases
Published 2025-02-01“…The recombinant protein would be produced and released only in the presence of the inciting stimulus, avoiding immunosuppression or other unwanted side effects that may occur when treating infectious diseases with anti-inflammatory drugs. …”
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1029
Impact of Cyclosporine A on Cognitive Functions and Neuronal Oxidative Stress, Apoptosis and Inflammatory Markers in Rats
Published 2024-07-01“… Cyclosporine A (CYP-A), a potent immunosuppressive agent, significantly impacts organ transplantation and the treatment of autoimmune disorders, and its ability to control autoimmune reactions and prevent organ rejection has made it indispensable in contemporary medicine. …”
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1030
Composite submental flaps in facial reconstructive surgery involving the zygoma and orbit
Published 2020-10-01“…A third case was a 75-year-old immunosuppressed male with a 6.5 cm SCC of the right cheek with invasion of the orbit and zygoma following prior resection as well as high dose radiotherapy. …”
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1031
COVID-19 in the years 2020 to 2022 in Germany: effects of comorbidities and co-medications based on a large-scale database analysis
Published 2025-02-01“…Immunodeficiencies and use of immunosuppressives were strongest risk modifying factors for hospitalization in both study populations. …”
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1032
Effect of cytotoxic CD8+ T-cells secretory proteins on hypoxic pancreatic cancer cells.
Published 2025-01-01“…In pancreatic cancer, the tumor microenvironment is notably hypoxic and exhibits strong immunosuppressive properties. Given that immunotherapy is now approved for pancreatic cancer treatment, further understanding of how pancreatic tumor cell hypoxia influences T-cell cytotoxicityis essential.…”
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1033
Persistent Mortality Risk From Device-related Healthcare-associated Infection in Kidney Transplant Recipients Despite Multifaceted Interventions Action Calls for a Zero-tolerance P...
Published 2025-02-01“…Additional variables associated with increased risk of death included age (HR, 1.03; P < 0.001), baseline immunosuppression (HR based on mycophenolate versus others 0.74; P = 0.02), time since transplantation (HR, 1.003; P < 0.001), platelet count at ICU admission (HR, 0.998; P < 0.001), and sepsis as the reason for ICU admission (HR, 1.67; P < 0.001). …”
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1034
A meta-analysis of whole blood transcriptome reveals genes associated with increased neutrophil activity and T cell suppression in sepsis
Published 2025-01-01“…Dysregulation of immune response, imbalance between pro-inflammatory and anti-inflammatory response, apoptosis, and anti-apoptotic genes were found to be associated with immunosuppression and increased inflammatory reaction during sepsis. …”
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1035
Clinical Outcomes of COVID-19 and Impact on Disease Course in Patients with Inflammatory Bowel Disease
Published 2021-01-01“…Older age, comorbidities, active IBD disease, and systemic corticosteroid, but not immunosuppressive or biological therapy, were associated with severe COVID-19 infection.…”
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1036
Antifungal efficacy of chitosan-mediated fenugreek nanocomposite incorporated in tissue conditioner
Published 2025-03-01“…Introduction: The rough surface of dentures, coupled with xerostomia and immunosuppression, fosters microbial growth and colonization, with Candida albicans being a primary culprit. …”
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1037
Novel protein-based prognostic signature linked to immunotherapeutic efficiency in ovarian cancer
Published 2024-09-01“…Together our findings highlight the importance of a thorough understanding of the immunosuppressive tumor microenvironment in ovarian cancer to guide the development of more effective immunotherapies.…”
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1038
Epithelial cell diversity and immune remodeling in bladder cancer progression: insights from single-cell transcriptomics
Published 2025-01-01“…Furthermore, conventional dendritic cells (DCs) transformed into LAMP3 + DCs, contributing to an immunosuppressive microenvironment and enabling immune evasion. …”
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1039
Achieving Medication‐Free Remission in Patients With Juvenile Dermatomyositis
Published 2025-01-01“…MFR was defined as inactive JDM after discontinuation of all systemic immunosuppressives for ≥6 months, in line with international consensus guidelines for trials of therapies in idiopathic inflammatory myopathies. …”
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1040
Diagnostic performance of the DISQVER metagenomic sequencing tool for the identification of pathogens in febrile neutropenic patients: the ADNEMIA trial
Published 2025-01-01“…Introduction While intensive protocols in onco-haematology have improved survival rates for patients with haematological malignancies, they have also resulted in an increased incidence of infection associated with therapy-induced immunosuppression (including chemotherapy-induced febrile neutropenia; FN). …”
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