Rituximab (monoclonal anti-CD20 antibody) induced posterior reversible encephalopathy syndrome (PRES): A case report and literature review by Praveen K. Sharma, MD, Sanjaykanth Balachandar, MBBS, Michael Antony Vikram, MBBS, Pujitha Duvooru Sukumar, MD

“…Clinicians should maintain a high index of suspicion for PRES in patients receiving monoclonal anti-CD20 antibody therapies, immunosuppressants, and corticosteroids, facilitating timely diagnosis and intervention to prevent potentially life-threatening complications. …”
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Trends in Survival for Adult Organ Transplantation by Grant Patrick, BS, Brian Hickner, MD, Karthik Goli, BS, Liam D. Ferreira, MBA, John Goss, MD, Abbas Rana, MD

“…Continued advancements in allocation policy, immunosuppression, and improved care of patients on the waitlist may contribute to further progress in outcomes of all organs, but the increasing discrepancy in supply and demand of donor kidneys is alarming and has impeded the progress of kidney intent-to-treat survival.…”
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Dexamethasone Coanalgesic Administration in Steroid Naïve and Steroid Non-Naïve Patients for the Prevention of Pain Flares after Palliative Radiotherapy for Bone Metastases by Dimitar G. Tonev, Silvia A. Lalova, Elena P. Petkova-Lungova, Nikolay V. Timenov, Gabriela M. Radeva, Todor G. Kundurzhiev

“…Lower dose 4 mg dexamethasone was revealed as a moderate analgesic agent in steroid naïve patients with no side effects, whereas in steroid non-naïve patients the predominantly higher dose 8 mg dexamethasone had minimal impact on pain flares prevention at the expense of more pronounced immunosuppression (P = 0.039). Conclusions. Irrespective of the supporting evidence of dexamethasone potential for prevention of RT-induced pain flare, our data failed to reveal its efficacy in the real practice world (a case mix of uncomplicated and complicated bone metastases). …”
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SDF-1α Facilitates Mesenchymal Stem Cells to Induce Regulatory B Cell Differentiation from Patients with Immune Thrombocytopenia by Zhe Chen, Shufen Zhou, Jianyun Li, Hui Li, Can Huang, Qin Guo, Tiantian Zhang, Bingya Yang, Chuanqing Tu, Chengshan Guo

“…Mesenchymal stem cells (MSCs) have been demonstrated in the ability to induce immunosuppression, and stromal cell-derived factor-1α (SDF-1α) plays an important role in the migration and survival of MSCs. …”
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Effectiveness and Safety of Dupilumab and Tralokinumab for Treating Atopic Dermatitis and Pruritic Skin Disorders in Oncological Patients: A Narrative Review by Lauletta G, Potestio L, Patruno C, De Lucia M, Napolitano M

“…The management of these conditions in patients with a history or with concomitant cancer presents unique challenges, as traditional systemic therapies may pose risks due to their immunosuppressive effects. In recent years, biologic agents such as dupilumab and tralokinumab have emerged as promising treatments for AD, offering targeted modulation of the immune response with potentially fewer systemic side effects. …”
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Azathioprine Hypersensitivity Syndrome during Treatment of Severe Interstitial Lung Disease with Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis by Eri Nakano, Tomohiko Asakawa, Mea Asou, Eri Nohara, Tomoyuki Seki, Makoto Araki

“…The diagnosis of azathioprine hypersensitivity is often delayed because of the difficulty in identifying the relationship between immunosuppressive agents and hypersensitivity and in distinguishing this from infection or relapse of the primary disease. …”
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Synergic Renoprotective Effects of Combined ASC Therapy with RAAS Blockade in Experimental Advanced CKD by Marina P. C. Maires, Krislley R. Pereira, Everidiene K. V. B. Silva, Victor H. R. Souza, Flavio Teles, Paulyana F. Barbosa, Margoth R. Garnica, Felipe M. Ornellas, Irene L. Noronha, Camilla Fanelli

“…The treatments currently employed to control CKD progression are limited and mainly based on the pharmacological inhibition of RAAS, associated with diuretics and immunosuppressive drugs. However, this conservative management promotes only partial deceleration of CKD evolution and does not completely avoid the progression of the disease and the loss of renal function, which motivates the medical and scientific community to investigate new therapeutic approaches to detain renal inflammation/fibrosis and CKD progression. …”
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A literature review of recent advances in gastric cancer treatment: exploring the cross-talk between targeted therapies by Reza Panahizadeh, Padideh Panahi, Vahid Asghariazar, Shima Makaremi, Ghasem Noorkhajavi, Elham Safarzadeh

“…Challenges include resistance mechanisms, immunosuppressive tumor environments, and inconsistent results from combination therapies. …”
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Hubungan Kadar Limfosit Total dengan Prognosis Penyakit pada Penderita Sirosis Hati di Bagian Penyakit Dalam RSUP Dr. M. Djamil Padang Tahun 2011 by Vyola Regina, Arnelis Arnelis, Zulkarnain Edward

“…In patients with liver cirrhosis is common infections due to immunosuppression. The total lymphocyte count can be used to determine the immune status of patients with liver cirrhosis. …”
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Chronic hepatitis B and risk of kidney involvement by M. V. Mayevskaya, I. N. Tikhonov, V. T. Ivashkin

“…Antiviral therapy is indicated to the most of these patients which potential, at the same time, is limited by initially decreased renal function, nephrotoxicity of some drugs or simultaneous prescription of immunosuppressants after organ transplantation. At development of liver cirrhosis (LC) and its decompensation one more aspect of renal disease at CHB arises i.e. risk of hepatorenal syndrome (HRS) of the 1st or 2nd type that is a poor prognostic marker and requires individual therapeutic approach.Conclusion. …”
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Knockout IL4I1 affects macrophages to improve poor efficacy of CD19 CAR-T combined with PD-1 inhibitor in relapsed/refractory diffuse large B-cell lymphoma by Rui Zhang, Yi Zhang, Hairong Xiao, Qingxi Liu, Mingfeng Zhao

“…IL4I1 expression enhances immunosuppression via the IDO-AHR-Kyn pathway, inhibiting the effectiveness of PD-1 inhibitors combined with CD19 CAR-T. …”
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Isolation, Molecular Characterisation, and Pathogenicity Analysis of a Novel Recombinant ALV‐J Strain Isolated From Chinese Hetian Chickens by Tianyu Lei, Liyun Zhuang, Tingting Dai, Qun Niu, Yinli Bao, Weiming Lin, Cuiqin Huang, Xintian Zheng

“…ABSTRACT Background Avian leukosis virus subgroup J (ALV‐J) primarily affects poultry, particularly chickens, leading to tumourigenesis and immunosuppression, which results in substantial economic losses. …”
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A Comprehensive Comparison of Clinical Presentation and Outcomes of Kidney Transplant Recipients with COVID-19 during Wave 1 versus Wave 2 at a Tertiary Care Center, India by Sanjiv Jasuja, Gaurav Sagar, Anupam Bahl, Neharita Jasuja, Rajesh Chawla, Avdhesh Bansal, Manjit. S. Kanwar, Sudha Kansal, Nikhil Modi, Athar P. Ansari, Viny Kantroo, Purnima Dhar, Chitra Chatterjee, Nitin Ghonge, Samir Tawakley, Shalini Verma

“…Strategies to modify immunosuppressants such as discontinuation of antinucleoside drugs with or without change in calcineurin inhibitors and the use of steroids were similar during both waves. …”
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Perspectives on AI-based recommendations for mask-wearing and COVID-19 vaccination for transplant recipients in the post-COVID-19 era by Oscar A. Garcia Valencia, Charat Thongprayoon, Jing Miao, Jackrapong Bruminhent, Iasmina M. Craici, Wisit Cheungpasitporn

“…In the aftermath of the COVID-19 pandemic, the ongoing necessity for preventive measures such as mask-wearing and vaccination remains particularly critical for organ transplant recipients, a group highly susceptible to infections due to immunosuppressive therapy. Given that many individuals nowadays increasingly utilize Artificial Intelligence (AI), understanding AI perspectives is important. …”
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Inflammatory Choroidal Neovascular Membranes: Clinical Profile, Treatment Effectiveness, and Visual Prognosis by Gonçalo Carrola, Mário Lima-Fontes, Fernando Falcão-Reis, Luís Figueira, Ângela Carneiro

“…Neovascularization was treated with intravitreal anti-VEGF injections (bevacizumab, aflibercept, and ranibizumab), and inflammation with anti-inflammatory/immunosuppressive therapy (oral, intravenous, and/or intravitreal corticosteroids; oral cyclosporine or methotrexate). …”
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Prognostic role of mesangial IgM deposition in IgA nephropathy: a long-term cohort study by Gabriel Stefan, Simona Stancu, Adrian Zugravu, George Terinte-Balcan

“…Treatment with RASI and immunosuppression, and death rates were also comparable. …”
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Activities of Some Medicinal Plants on the Proliferation and Invasion of Brain Tumor Cell Lines by Saidu I. Ngulde, Umar K. Sandabe, Roger Abounader, Ying Zhang, Isa M. Hussaini

“…Anticancer drugs are often expensive, have narrow spectrum of activities, and are associated with toxicities and side effects such as myelosuppression, immunosuppression, gastrointestinal disturbance, alopecia, skin toxicity, and hepatotoxicity. …”
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Oral Cancer Stem Cell-Derived Small Extracellular Vesicles Promote M2 Macrophage Polarization and Suppress CD4+ T-Cell Activity by Transferring UCA1 and Targeting LAMC2 by Lan Wu, Sai Ye, Yilin Yao, Chenping Zhang, Wei Liu

“…In conclusion, our results indicated that OSCC-CSC-sEV transfer of UCA1 promotes M2 macrophage polarization via a LAMC2-mediated PI3K/AKT axis, thus facilitating tumor progression and immunosuppression. Our findings provide a new understanding of OSCC-CSC molecular mechanisms and suggest a potential therapeutic strategy for OSCC through targeting CSC-sEVs and M2-TAMs.…”
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Amelioration of liver fibrosis with autologous macrophages induced by IL-34-based condition by Yuichi Igarashi, Haruka Wada, Masato Muto, Ryohei Sone, Yoshinori Hasegawa, Ken-ichiro Seino

“…As a mechanism analysis, we have examined liver inflammation and damage, the status of stellate cells, and the immunosuppressive capacity of the macrophages. Human macrophages were differentiated from CD14+ monocytes and analyzed. …”
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Liver transplantation in glycogen storage disease type III: A case‐series by Simon Gay, Adrien Bigot, Louis d'Alteroche, Fanny Dujardin, Gaëlle Fromont‐Hankard, Nathalie Tressel, Ephrem Salame, François Maillot

“…Post‐LT outcome was positive for all three GSD III patients, with significant improvement in liver function and no complications related to immunosuppression. Long‐term hepatic monitoring is essential for early detection of complications such as cirrhosis and HCC. …”
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