Opioid System and Epithelial–Mesenchymal Transition by Marzena Łazarczyk, Dominik Skiba, Michel-Edwar Mickael, Kinga Jaskuła, Agata Nawrocka, Piotr Religa, Mariusz Sacharczuk

“…Clinicians’ vigilance considering treatment with opioids is necessary, bearing in mind extensive data accumulated over decades that have reported the contribution of opioids to immunosuppression, tumour progression, or impaired tissue regeneration, either following opioid use during surgical tumour resection and post-surgical pain treatment, or as a result of other diseases like diabetes, where chronic wounds healing constitutes a challenge. …”
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Mouse Mesenchymal Progenitor Cells Expressing Adipogenic and Osteogenic Transcription Factors Suppress the Macrophage Inflammatory Response by Natalie Fernandez, Heather Renna, Lauren McHugh, Katie Mazolkova, William Crugnola, Jodi F. Evans

“…We have determined that immune-supportive mesenchymal progenitors highly express chondrogenic and tenogenic transcription factors while immunosuppressive mesenchymal progenitors highly express adipogenic and osteogenic transcription factors. …”
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Reprogramming the tumor immune microenvironment using engineered dual-drug loaded Salmonella by Dinh-Huy Nguyen, Sung-Hwan You, Hien Thi-Thu Ngo, Khuynh Van Nguyen, Khang Vuong Tran, Tan-Huy Chu, So-young Kim, Sang-Jun Ha, Yeongjin Hong, Jung-Joon Min

“…Both primary and metastatic tumors from bacteria-treated female mice are characterized by massive infiltration of anti-tumorigenic innate immune cells and activated tumor-specific effector/memory T cells; however, the percentage of immunosuppressive cells is low. Here, we show that SAM-FC induces functional reprogramming of the tumor immune microenvironment by activating both the innate and adaptive arms of the immune system and can be used for targeted delivery of multiple immunotherapeutic payloads for the establishment of potent and long-lasting antitumor immunity.…”
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Improvement of Liver Transplantation Outcome by Heme Oxygenase-1-Transduced Bone Marrow Mesenchymal Stem Cells in Rats by Bin Wu, Hong-Li Song, Yang Yang, Ming-Li Yin, Bo-Ya Zhang, Yi Cao, Chong Dong, Zhong-Yang Shen

“…Bone marrow mesenchymal stem cells (BMMSCs) exert immunosuppressive activity in transplantation, and heme oxygenase-1 (HO-1) enhances their immunomodulatory effects. …”
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ANKRD22 participates in the proinflammatory activities of macrophages in the colon cancer tumor microenvironment by Xiaoying Wang, Keqing Yang, Bin Yang, Rui Wang, Yongliang Zhu, Tianhui Pan

“…Reprogramming M2-type TAMs with immunosuppressive functions into M1-type TAMs with proinflammatory functions is a novel strategy for reshaping the tumor microenvironment (TME) and enhancing the efficacy of immunotherapy in colon cancer. …”
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Prevalence of Anti-JC Virus (JCV) Antibodies in the Multiple Sclerosis (MS) Population in Cyprus: A Retrospective Study by Sakis Lambrianides, Christiana A. Demetriou, Andis Tillyris, Elena Kkolou, Eftychia Gaglia, Eleni Agkastinioti, Eleni Leonidou, Yiolanda-Panayiota Christou, Savvas S. Papacostas, Kleopas A. Kleopa, Theodoros Kyriakides, Marios Pantzaris

“…In recent years, a new subpopulation of patients at risk for PML has emerged, due to the growing use of immunomodulatory or immunosuppressive therapies in autoimmune diseases such as multiple sclerosis (MS). …”
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Immunological differences between monophasic and biphasic synovial sarcoma with implications for immunotherapy by S. J. Luk, M. E. IJsselsteijn, A. Somarakis, I. Acem, I. Briaire de Bruijn, K. Szuhai, J. V. M. G. Bovee, N. F. C. C. de Miranda, J. H. F. Falkenburg, M. H. M. Heemskerk

“…The immune composition of synovial sarcoma was dominated by CD68+ myeloid cells of which a substantial part was of the CD163+ immunosuppressive phenotype, which increased after chemotherapy or radiotherapy. …”
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The Effectiveness of Pre- and Postoperative Infliximab in Controlling Behçet’s Disease Posterior Uveitis in Patients Undergoing Vitrectomy: A Preliminary Study by Hossam El Din Mohamed Khalil, Heba A. El Gendy, Hala Ahmed Raafat, Hazem Effat Haroun, Tamer Atef Gheita, Hossam Mahmoud Bakir

“…Patients and Methods. 30 eyes of 27 adult male BD patients with a mean age of 35.56 yrs presented with refractory posterior uveitis not responding to immunosuppressive drugs and candidate for vitrectomy were included. …”
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Cryo-thermal therapy reshaped the tumor immune microenvironment to enhance the efficacy of adoptive T cell therapy by Shicheng Wang, Peng Peng, Junjun Wang, Zelu Zhang, Ping Liu, Lisa X. Xu

“…Conclusions Our results suggest that CTT can significantly reshape the tumor immunosuppressive microenvironment and convert “cold tumors” into “hot tumors,” thereby enhancing ACT-induced immune responses and maximizing the therapeutic effect of ACT.…”
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Tacrolimus Protects Podocytes from Apoptosis via Downregulation of TRPC6 in Diabetic Nephropathy by Ruixia Ma, Ying Wang, Yan Xu, Rui Wang, Xianghua Wang, Ning Yu, Minghui Li, Yan Zhou

“…Tacrolimus is a novel immunosuppressive agent that is reported to play an important role in podocyte protection. …”
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Long-term antibody responses to COVAXIN and COVISHIELD vaccines in rheumatoid arthritis patients and healthy control population – A cross-sectional study by Vijaya Prasanna Parimi, Anand Pyati, Madhavi Eerike

“…Nonetheless, there was no discernible difference in the antispike antibody concentration between the COVISHIELD and COVAXIN vaccination groups. Additionally, immunosuppressive medications significantly impact serological responses to these vaccines.…”
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An atypical presentation of autoimmune hepatitis with delayed menarche in a Nigerian adolescent: a case report by Promise Udoka Asogwa, Bruno Basil, Winifred Njideka Adiri, Nelson Ugwu, Gideon Ekene Anigbo, Evaristus Offia, Casmir Orjioke

“…Early intervention with immunosuppressive therapy is essential, even in the absence of classic liver-related symptoms, to prevent progression to advanced liver disease.…”
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A Case Report of Membranoproliferative Glomerulonephritis: Infection‐Related or Immune‐Related? by Ayman Azhary, Mohammed Taha, Nooh Mohamed Hajhamed, Salahaldeen Ismail Mohammed, Nouh Saad Mohamed, Waleed Azhary Sir Alkhatim

“…Following the modification of our diagnosis to lupus nephritis, the patient responded fairly well once we started him on an immunosuppressive drug. The patient was released from the hospital in a stable condition.…”
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COVID-19 and renal allograft rejection: insight from controlled and non-controlled studies by Ahmed Daoud, Karim Soliman, Maria Aurora Posadas Salas, Genta Uehara, Sakshi Vaishnav, Wisit Cheungpasitporn, Michael J. Casey

“…Aim Kidney transplant recipients (KTRs), due to their immunosuppressed status, are potentially more susceptible to both the severe effects of COVID-19 and complications in their transplanted organ. …”
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Conditioned Medium from Adipose-Derived Stem Cell Inhibits Jurkat Cell Proliferation through TGF-β1 and p38/MAPK Pathway by Xiuxia Wang, Yinmin Wang, Xianyu Zhou, Fei Liu

“…Since the first report on the immunomodulatory and immunosuppressive properties of Adipose-Derived Stem Cells (ADSCs), many studies have elucidated the underlying molecular mechanism of their suppressive activity on mixed lymphocyte reaction (MLR). …”
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Recurrent Herpes Zoster Ophthalmicus Preceded by Anabolic Steroids and High-Dose L-Arginine by Stephen A. LoBue, Adam Goldman, Richard A. Giovane, Stacy M. Carlson, Michael Bivona, Sinan Albear, Thomas D. LoBue

“…The patient had no significant past medical or past ocular history, including systemic immunosuppressive agents or HIV. However, prior to the onset of his symptoms the patient had completed a 6-week course of anabolic steroids including trenbolone, deca-durabolin, and testosterone as well as high-dose arginine supplementation averaging more than 40 grams a day. …”
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Clinical Factors of Blood Transfusion-Related Acute Lung Injury and Changes in Levels of Treg-Related Cytokines by Lifang Sun, Yu Liu

“…Elevated HLA antibody II and CD4 + CD25 + Treg are the main clinical risk factors for TRALI, and CD4 + CD25 + Treg may be involved in immunosuppression by increasing the expression levels of IL-10 and TGF-β. …”
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The effect of maintenance therapy on Crohn’s disease clinical outcomes by O. B. Schukina, E. A. Kondrashina, A. M. Kharitidis, Ye. G. Vepreva, A. G. Kharitonov, A. Yu. Baranovsky

“…In complicated cases the combination of systemic steroids and immunosuppressants is ineffective. Biological therapy should be considered as disease-modifying treatment in patients with inflammatory forms of CD. …”
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Mucosal Epithelial Jak Kinases in Health and Diseases by Narendra Kumar, Longxiang Kuang, Ryan Villa, Priyam Kumar, Jayshree Mishra

“…A selective Jak3 inhibitor CP-690550 (Xeljanz) approved by the FDA for certain chronic inflammatory conditions demonstrates immunosuppressive activity in rheumatoid arthritis, psoriasis, and organ transplant rejection. …”
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The effects of lymphocele formation after living donor kidney transplantation on mid-term allograft function by Christian Kuhn, Bernd Jänigen, Laura Matuschik, Max J. Rieger, Daniel Sidler, Stefan Zschiedrich

“…Abstract Background Despite advances in kidney transplant surgery and immunosuppression, lymphoceles remain a frequent complication in the early postoperative period following kidney transplantation, often requiring reintervention. …”
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