Modulatory Effects of Astragalus Polysaccharides on T-Cell Polarization in Mice with Polymicrobial Sepsis by Yu-Chen Hou, Jin-Ming Wu, Ming-Yang Wang, Ming-Hsun Wu, Kuen-Yuan Chen, Sung-Ling Yeh, Ming-Tsan Lin

“…Treatments with 100 and 200 mg APS/kg BW reduced Treg populations and elicited a more-balanced Th1/Th2 response that consequently attenuated immunosuppression in polymicrobial sepsis. High-dose APS administration led to excessive responses of Th17 cells which may have adverse effects in sepsis-induced organ injury.…”
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Triptolide Inhibits Osteoclast Differentiation and Bone Resorption In Vitro via Enhancing the Production of IL-10 and TGF-β1 by Regulatory T Cells by Huihui Xu, Hongyan Zhao, Cheng Lu, Qi Qiu, Gui Wang, Jing Huang, Minghui Guo, Baosheng Guo, Yong Tan, Cheng Xiao

“…Triptolide, a purified component of Tripterygiumwilfordii Hook F, has been shown to have immunosuppressive and anti-inflammatory properties in rheumatoid arthritis (RA). …”
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Rare Encounter Behind the Ear: Unveiling Kimura Disease in the Postaural Region by Divya Nayani, Siddhartha Nyathani, Rahul Kumar Pitale Ashok

“…Treatment options encompass systemic steroids, antihistamines, immunosuppressants, chemotherapy, radiotherapy, and surgical excision. …”
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Severe Disabling Myalgia as an Initial Presentation of Polyarteritis Nodosa by H. M. Senarathna, C. L. Fonseka, H. A. S. Perera, P. U. T. De Silva, T. P. Weerarathna

“…With continuation of aggressive immunosuppression and rehabilitation for five months, the patient improved and was able to walk without support. …”
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Attempted Depletion of Passenger Leukocytes by Irradiation in Pigs by Hao-Chih Tai, Xiaocheng Zhu, Yih Jyh Lin, Hidetaka Hara, Mohamed Ezzelarab, Michael Epperley, Mubina A. Quader, David K. C. Cooper

“…Study 2 was aimed at providing an indication of whether near-complete depletion of leukocytes had any major impact on kidney allograft survival. In non-immunosuppressed recipient pigs, survival of a kidney from a donor that received high-dose irradiation was compared with that of a kidney taken from a non-irradiated donor. …”
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Thiopurines Induce Oxidative Stress in T-Lymphocytes: A Proteomic Approach by Misbah Misdaq, Sonia Ziegler, Nicolas von Ahsen, Michael Oellerich, Abdul R. Asif

“…Thiopurines are extensively used immunosuppressants for the treatment of inflammatory bowel disease (IBD). …”
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Silver nanoparticle induced immunogenic cell death can improve immunotherapy by Ara Sargsian, Xanthippi Koutsoumpou, Hermon Girmatsion, Can Egil, Kiana Buttiens, Carla Rios Luci, Stefaan J. Soenen, Bella B. Manshian

“…Abstract Cancer immunotherapy is often hindered by an immunosuppressive tumor microenvironment (TME). Various strategies are being evaluated to shift the TME from an immunologically ‘cold’ to ‘hot’ tumor and hereby improve current immune checkpoint blockades (ICB). …”
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Concomitant of Pulmonary Hydatid Cyst and Aspergilloma: A Rare Coinfection by Zahra Zareshahrabadi, Bahador Sarkari, Nadereh Shamsolvaezin, Bizhan Ziaian, Alireza Tootoonchi, Reza Shahriarirad, Kamiar Zomorodian

“…Infection by Aspergillus is often occurring in immunosuppressed patients. However, coinfection of aspergilloma with pulmonary hydatid cyst is very unusual, especially in an immunocompetent patient with unruptured cyst. …”
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The crosstalk between senescence, tumor, and immunity: molecular mechanism and therapeutic opportunities by Zehua Wang, Chen Chen, Jiaoyu Ai, Yaping Gao, Lei Wang, Shurui Xia, Yongxu Jia, Yanru Qin

“…Senescent immune cells create an immunosuppressive TME favoring tumor progression. In contrast, senescent tumor cells could promote a transition from immune evasion to clearance. …”
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Update on the Progress of Musashi-2 in Malignant Tumors by Yiting Niu, Tao Zhou, Yanjun Li

“…This review summarizes the research progress related to MSI2 in recent years, including its occurrence, migration mechanism, and drug resistance, as well as the prospect of developing tumor immunosuppressants and biomarkers.…”
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Vitamin D Deficiency Contributes to the Reduction and Impaired Function of Naïve CD45RA+ Regulatory T Cell in Chronic Heart Failure by Yan-hui Ma, Yun-lan Zhou, Chao-yan Yue, Guang-hui Zhang, Lin Deng, Guo-hua Xie, Wei-ping Xu, Li-song Shen

“…Low level of vitamin D receptor (VDR) was detected in CD4+CD45RA+T cell of CHF than control, while 1,25(OH)2D treatment increased the VDR expression to exert its immunosuppression on T cell. The results of this study might provide tangible evidence to our knowledge of the impact of vitamin D supplementation on naïve Tregs, which may offer new means of preventing and treating CHF.…”
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Regressing Multiple Viral Plaques and Skin Fragility Syndrome in a Cat Coinfected with FcaPV2 and FcaPV3 by Alberto Alberti, Gessica Tore, Alessandra Scagliarini, Laura Gallina, Federica Savini, Chiara Caporali, Francesca Abramo

“…Numerous reports suggest that papillomaviruses (PVs) are involved in their development. Immunosuppressed and immunocompetent cats are both affected, the biological behavior is variable, and the regression is possible but rarely documented. …”
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Late Onset Graft Plasmacytoma-Like PTLD Presenting as Acute Hyperglycemia in a Kidney-Pancreas Transplant Recipient by P. Ventura-Aguiar, M. T. Cibeira, A. Martinez, M. Cuatrecasas, M. Aymerich, J. Ferrer, J. Blade, F. Diekmann, M. J. Ricart

“…We report the case of a 54-year-old simultaneous pancreas-kidney transplant recipient (immunosuppression: OKT3, methylprednisolone, cyclosporine, and azathioprine), diagnosed with an IgG-kappa monoclonal gammopathy of undetermined significance eighteen years after transplant. …”
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Determination of anti-COVID-19 IgG and IgM seroprevalence among pregnant women at Pietersburg Hospital, Limpopo Province, South Africa by I Rukasha, S T S Pheeha, M R Lekalakala, P Malope

“…COVID-19 has been a major public health concern globally, leading to a higher mortality rate, especially among immunosuppressed individuals, who include pregnant women, people with HIV and people living with other comorbidities. …”
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Intratympanic administration of dexamethasone attenuates radiation induced damage to middle ear mucosa by Hyuk Chan Kwon, Sup Kim, Sheng Jin, Sun-Ae Shin, Jeong Han Lee, Min Jung Park, Soo Jeong Kim, Yong-Ho Park

“…Dexamethasone (DEX) is widely used in clinical practice because of its immunosuppressive and anti-inflammatory properties. The present study investigated the effects and underlying mechanisms of DEX delivered via intratympanic administration on RTx-induced damage to the middle ear and human middle ear epithelial (HMEE) cells. …”
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Brincidofovir Use after Foscarnet Crystal Nephropathy in a Kidney Transplant Recipient with Multiresistant Cytomegalovirus Infection by Romain Vial, Christine Zandotti, Sophie Alain, Alexandre Decourt, Noémie Jourde-Chiche, Raj Purgus, Charleric Bornet, Laurent Daniel, Valérie Moal, Tristan Legris

“…Despite a large decrease in immunosuppression, CMV disease was not controlled and a salvage therapy with Brincidofovir (BCV), which is an oral lipid conjugate of cidofovir with limited nephrotoxicity, was attempted. …”
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Time in therapeutic range of tacrolimus in allogeneic hematopoietic stem cell transplant recipients is associated with acute graft-versus-host disease prophylaxis by Naoki Yoshikawa, Yukina Ehara, Yusei Yamada, Yuki Matsusaki, Kazuya Shimoda, Ryuji Ikeda

“…Abstract Intra-patient variability in immunosuppressive blood drug concentrations is a potential biomarker in managing organ transplant patients. …”
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Retroperitoneal Soft Tissue Sarcoma and Kidney Autotransplantation: A Case Report by S. N. Hakkesteegt, C. A. J. Oudmaijer, L. J. Jeletich, J. Sprakel, H. J. A. N. Kimenai, D. J. Grünhagen

“…Kidney autotransplantation offers a unique solution by preserving renal function in these cases, avoiding the need for dialysis and immunosuppressive therapy. This case report presents a 61‐year‐old female with a large RPS encasing her only functioning kidney. …”
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Gastrointestinal Bleeding and Diffuse Skin Thickening as Kaposi Sarcoma Clinical Presentation by Sara Querido, Henrique Silva Sousa, Tiago Assis Pereira, Rita Birne, Patrícia Matias, Cristina Jorge, André Weigert, Teresa Adragão, Margarida Bruges, Domingos Machado

“…A 56-year-old African patient received a kidney from a deceased donor with 4 HLA mismatches in April 2013. He received immunosuppression with basiliximab, tacrolimus, mycophenolate mofetil, and prednisone. …”
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Cardiovascular disease risk in Korean patients with systemic lupus erythematosus compared to diabetes mellitus and the general population by Jung-Yong Han, Soo-Kyung Cho, Yena Jeon, Gaeun Kang, Sun-Young Jung, Eun Jin Jang, Yoon-Kyoung Sung

“…Advanced age, male gender, and current use of glucocorticoids, immunosuppressive, and anti-platelet agents were associated with increased CVD risk in SLE patients. …”
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