Mesenchymal Stromal Cells Support Endometriotic Stromal Cells In Vitro by Fawaz Abomaray, Sebastian Gidlöf, Bartosz Bezubik, Mikael Engman, Cecilia Götherström

“…Mesenchymal stromal cells (MSC) have immunosuppressive properties that have been suggested as a treatment for inflammatory diseases. …”
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The relationship between Helicobacter pylori and pityriasis versicolor by May H. El Samahy, Raafat Z. Abdelrahman, Hossam O. Ibrahim, Azza E. Mostafa

“…Accordingly, its role as a systemic immunosuppressive cytokine predisposing for PVC was unverified in this study.…”
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Mucor and Aspergillus Maxillary Bone and Sinuses coinfection in a woman with Systemic Lupus Erythematosus: A Case Report by Hassan Mir Mohammad Sadeghi, Azin Kheradmand, Simin Dokht Shoaei

“…She had a history of immunosuppressive therapy and steroid-induced hyperglycemia for SLE. …”
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Identification of Molecular Subtypes and Prognostic Features of Breast Cancer Based on TGF-β Signaling-related Genes by Jia Qu, Mei-Huan Wang, Yue-Hua Gao, Hua-Wei Zhang

“…Objectives: The TGF-β signaling pathway is widely acknowledged for its role in various aspects of cancer progression, including cellular invasion, epithelial-mesenchymal transition, and immunosuppression. Immune checkpoint inhibitors (ICIs) and pharmacological agents that target TGF-β offer significant potential as therapeutic options for cancer. …”
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Management of Bladder Cancer following Solid Organ Transplantation by Jeffrey J. Tomaszewski, Jeffrey A. Larson, Marc C. Smaldone, Matthew H. Hayn, Stephen V. Jackman

“…The use of intravesical BCG is possible in select immunosuppressed patients.…”
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Machine Learning-Devised Immune-Related lncRNA Signature Panel Predicts the Prognosis and Immune Landscape in Breast Cancer Novel IRLP Signature in BRCA by Jun-Yu Zhu, An-Qi Lyu, Zhang-Ting Wang, Wai-Yee Chan, Tao Qin, Kai-Kei Miu, He-Rui Yao

“…Immune infiltrating analyses found that the low-risk group has a lower expression level of macrophage M2 and a higher expression level of immunosuppressed biomarkers than the high-risk group. DEirlncRNAs were further proven to be significantly related to the MAPK signaling, Jak-STAT signaling, and ErbB signaling pathways in BRCA. …”
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Asymptomatic Lymphocytic Interstitial Pneumonia with Extensive HRCT Changes Preceding Sjogren’s Syndrome by Hazlyna Baharuddin, Mohammad Hanafiah, Syazatul Syakirin Sirol Aflah, Mohd Arif Mohd Zim, Shereen Suyin Ch’Ng

“…The lessons from this case are (i) patients with LIP can be asymptomatic, (ii) LIP can precede symptoms of SS, and (iii) treatment decision for asymptomatic patients with abnormal imaging or patients with mild severity should be weighed between the risk of immunosuppression and risk of active disease.…”
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HER2 Negative Mammary Paget’s Disease or In Situ Melanoma? A Case Report and Review of the Literature by Luana-Andreea Boșoteanu, Mariana Așchie, Cristian Ionuţ Orǎșanu, Mădălina Boșoteanu

“…Bowen’s disease was invalidated by its rare presentation in the breast cutaneous tissue and the absence of individual risk factors suggestive of an existing immunosuppressive status. In the case of similar morphoimmunohistochemical aspects, significant expression of Ki-67 signals MPD, an immunoreactivity that helped distinguish the cellular population from Toker cells. …”
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Effect of Shogaol on the Expression of Intestinal Stem Cell Markers in Experimentally Induced Colitis in BALB/c Mice by Snur M. A. Hassan, Ali Hussein Hassan

“…The results of this study indicated that oral treatment with the ginger-derived substance Shogaol could be better than the conventional immunosuppressive chemotherapeutic remedy 6-TG in treatment of DSS-induced UC.…”
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Silent Human Trypanosoma brucei gambiense Infections around the Old Gboko Sleeping Sickness Focus in Nigeria by Karshima Solomon Ngutor, Lawal A. Idris, Okubanjo Oluseyi Oluyinka

“…We isolated 7 (33.3%) trypanosomes from the 21 seropositive samples using immunosuppressed mice which were identified as T. b. gambiense group 1 by TgsGP-PCR. …”
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CAR T cells for treating autoimmune diseases by Dimitrios Mougiakakos, Ulrike Koehl, Stephan Fricke, Ulrich Blache, Sandy Tretbar

“…Currently, autoimmune disorders are largely treated by broad immunosuppressive agents and blocking antibodies, which can manage the diseases but often are not curative. …”
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The Burden of Cost in Bronchiolitis Obliterans Syndrome: Predictions for the Next Decade by Christopher A. Jones, David G. Chapman, Peter Weimersheimer, Luca Fernandez, Oscar Alejandro Mesa, Christian Peters, Bart M. Vanaudenaerde, Mitchell C. Norotsky, Robin Vos

“…The lost workforce resulting from BOS-related infirmity will cost society more than $3.7 Billion over the next decade, a figure that is more than double the estimated 10-year cost of treating BOS ($1.4B), including diagnostics, immunosuppressives, and additional complications. As such, BOS is estimated to present a burden of cost that must be evaluated in a new light to include the wider societal perspective.…”
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Mechanistic insights into the role of traditional Chinese medicine in treating gastric cancer by Ziqiang Chen, Ting Yu, Yunhe Wang, Jiaxin Li, Bo Zhang, Liya Zhou

“…Furthermore, TCM modulates the immune microenvironment by enhancing the activity of effector immune cells such as CD4+ and CD8+ T cells and natural killer (NK) cells while reducing immunosuppressive cells like regulatory T cells (Tregs) and myeloid-derived suppressor cells (MDSCs). …”
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Staphylococcus aureus-specific TIGIT+ Treg are present in the blood of healthy subjects – a hurdle for vaccination? by Jonah Clegg, Jonah Clegg, Malgorzata E. Mnich, Malgorzata E. Mnich, Alberto Carignano, Giovanni Cova, Simona Tavarini, Chiara Sammicheli, Bruna Clemente, Megan Smith, Megan Smith, Emilio Siena, Monia Bardelli, Michela Brazzoli, Fabio Bagnoli, Rachel M. McLoughlin, Elisabetta Soldaini

“…Therefore, these results uncover the presence of S. aureus-specific TIGIT+ Treg in the blood of healthy subjects that could blunt responses to vaccination and indicate TIGIT as a potential targetable biomarker to overcome pre-exposure-induced immunosuppression.…”
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A Comprehensive Review of the Diversity of Fungal Secondary Metabolites and Their Emerging Applications in Healthcare and Environment by Khushbu Wadhwa, Neha Kapoor, Hardeep Kaur, Eman A. Abu-Seer, Mohd. Tariq, Sazada Siddiqui, Virendra Kumar Yadav, Parwiz Niazi, Pankaj Kumar, Saad Alghamdi

“…In healthcare, it is being used as an antimicrobial, anticancer, anti-inflammatory, and immunosuppressive drug. The usage of modern tools of biotechnology can achieve an increase in demand for these SMs and large-scale production. …”
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Sintilimab for treating progressive multifocal leukoencephalopathy caused by human polyomavirus 2 virus infection following allogeneic hematopoietic cell transplantation: a case re... by Xuelian Jin, Xushu Zhong, Qinyu Liu, Xinchuan Chen

“…Therapeutic strategies involve restoring immune function and/or discontinuing immunosuppressive treatment. Immune checkpoint inhibitors such as those targeting programmed death receptor-1 (PD-1) can alleviate PML by restoring T cell function. …”
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Engineered macrophage nanoparticles enhance microwave ablation efficacy in osteosarcoma via targeting the CD47-SIRPα Axis: A novel Biomimetic immunotherapeutic approach by Xiongfa Ji, Xin Qian, Guowen Luo, Wenjie Yang, Wenhan Huang, Zehua Lei, Jiaqi Zhou, Guoqing Zhong, Jielong Zhou, Nan Liu, Limin Ma, Mei Li, Xiangmei Liu, Shuilin Wu, Yu Zhang

“…It is of critical importance to note that the enhancement of SIRPα on the nanoparticle surface actively targets and binds CD47 of tumor cells, thereby disrupting the ''don't-eat-me'' signal and effectively countering the immunosuppressive tumor environment. This action restores macrophage phagocytosis with M1 polarization, triggering potent immune responses. …”
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Feasibility and Safety of Bariatric Surgery in High-Risk Patients: A Single-Center Experience by Yusef Moulla, Orestis Lyros, Matthias Blüher, Philipp Simon, Arne Dietrich

“…., 2016) at least one of the following risk factors was met: age ≥ 70 years, body mass index (BMI) > 70 kg/m2, liver cirrhosis, end-organ failure, or immunosuppression by status after organ transplantation along with (Birkmeyer et al., 2010) at least two comorbidities associated with obesity. …”
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Sarcoidosis: molecular mechanisms and therapeutic strategies by Danfeng Xu, Xiaohua Tao, Yibin Fan, Yan Teng

“…The efficacy of traditional treatments, such as glucocorticoids and immunosuppressants, has been confirmed in the management of sarcoidosis. …”
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Glioblastoma drives protease-independent extracellular matrix invasion of microglia by Chia-Wen Chang, Ashwin Bale, Rohit Bhargava, Brendan A.C. Harley

“…Microglia infiltration into the tumor microenvironment is associated with immunosuppression and poor prognosis. Improved physicochemical understanding of microglia activation and invasion may provide novel GBM therapeutic strategies essential for improving long-term treatment efficacy. …”
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