Rituximab-Associated Inflammatory Progressive Multifocal Leukoencephalopathy by Chandra Punch, Christina Schofield, Penelope Harris

“…Progressive multifocal leukoencephalopathy (PML) is a rare disease of the immunosuppression that results from neurotropic invasion of the JC virus which leads to demyelination of oligodendrocytes. …”
Get full text

A Case of Systemic Lupus Erythematosus Presenting as Guillain-Barré Syndrome by Helen Chioma Okoh, Sandeep Singh Lubana, Spencer Langevin, Susan Sanelli-Russo, Adriana Abrudescu

“…We are reporting a rare case of Miller-Fisher (MFS) variant of Guillain-Barré syndrome (GBS) as the first manifestation of SLE in a 41-year-old female who progressed to flaccid paralysis with no neurological improvement with initial immunosuppressive therapy, plasmapheresis, and first cycle of intravenous immunoglobulin (IVIG) but with remarkable and complete recovery after the second 5-day course of IVIG.…”
Get full text

An Interesting Case of Bilateral Facial Palsy due to Granulomatosis with Polyangiitis by Rajish Sanjit Kumar Shil, Jamal Ali Teir

“…We are reporting a case of granulomatosis with polyangiitis, complicated by bilateral facial palsy due to lower motor neuron involvement of the facial nerve, which has responded well to immunosuppressive treatment, particularly rituximab. It is prudent to be vigilant in investigating patients with atypical presentation for systemic autoimmune diseases, as this approach would affect the patient morbidity and mortality with early initiation of treatment for the disease.…”
Get full text

CMV Ileitis: To Treat or Not to Treat? Implications of Initiating Biologic Therapy for Concurrent Crohn’s Disease by Kendra T. Stilwell, Jason Estes, Maria T. Kurtz, James M. Francis, David T. Lynch, Anish A. Patel

“…Conversely, recent data suggests that spontaneous resolution occurs less frequently than previously believed; furthermore, mortality rate in immunocompetent individuals is similar to that of the immunosuppressed. We present a case of a 43-year-old male who was simultaneously diagnosed with CMV ileitis and Crohn’s Disease. …”
Get full text

Blocking the CD39/CD73 pathway synergizes with anti-CD20 bispecific antibody in nodal B-cell lymphoma by Carsten Müller-Tidow, Peter Dreger, Joseph Kauer, Wolfgang Huber, Clara Kolbe, Berit Brinkmann, Sascha Dietrich, Tobias Roider

“…CD39 catalyzes—together with CD73—the hydrolysis of immunogenic ATP into immunosuppressive adenosine and thus actively promotes an immunosuppressive micromilieu. …”
Get full text

Impact of Herpesvirus Detection via Metagenomic Next-Generation Sequencing in Patients with Lower Respiratory Tract Infections by Zhang H, Zhang X, Zheng Y, Gu X, Fu Z, Gai W, Wang H

“…Additionally, the HD group tended to have longer hospital stays compared to non-HD group, especially in immunosuppressed patients. Furthermore, in immunocompetent patients, there were significant differences in α diversity and β diversity between the HD group and non-HD group, but such differences were not observed in immunosuppressed patients.Conclusion: The presence of herpesvirus in patients with non-critical LRTI is associated with longer hospital stays and alterations in the lung’s microbial composition. …”
Get full text

Physician characteristics associated with the referral from general practitioners to dental surgeons and proposal for a referral letter template endorsed by dental surgeons in Fran... by Matthias Lamauviniere, Jan Chrusciel, Cassandre Finot, Adrien Basset, Maximillien Graftieaux, Aline Ohl-Hurtaud, Stéphane Sanchez

“…Standardized referral letters could include the list of items for which interest was confirmed by dental surgeons (including presence of diabetes, immunosuppressants and anticoagulants or antiplatelet agents).…”
Get full text

The effect of conditioned media on the cellular proliferation of pancreatic cancer cells, pancreatic stellate cells, and myeloid-derived suppressor cells by Y. Chong, S. Samsudin, D. Bahrani, C. Chang, A. Masamune, S. Ng, N. Ismail, K. Ho

“…Objective: Pancreatic cancer has remained one of the most devastating diseases over the past two decades, with minimal improvements in survival rates. Its highly immunosuppressive tumour microenvironment is driven by secreted proteins, such as cytokines and growth factors, which promote the differentiation of immunosuppressive cells and influence cellular proliferation and migration. …”
Get full text

A first evaluation of the efficacy of minibeam radiation therapy combined with an immune check point inhibitor in a model of glioma-bearing rats by Lorea Iturri, Emmanuel Jouglar, Cristèle Gilbert, Julie Espenon, Marjorie Juchaux, Yolanda Prezado

“…GBM is widely recognized to induce local and systemic immunosuppression, which is a hindrance to the use of immune-modulating therapies. …”
Get full text

Changes in PD-1 expression on T lymphocyte subsets and related immune indicators before and after definitive chemoradiotherapy for esophageal squamous cell carcinoma by Xueling Shi, Hongyu Zhao, Jiaqi Yu, Peng Cai, Shixiang Zhou, Ning Yang, Duojie Li

“…PD-1 expression in T lymphocyte subsets can predict short-term outcomes in patients and provide a theoretical basis for the sequential application of PD-1 immunosuppressants after radiotherapy and chemotherapy.…”
Get full text

The clinical significance of T cell infiltration and immune checkpoint expression in central nervous system germ cell tumors by Jiajun Zhou, Jiajun Zhou, Wenhao An, Lei Guan, Lei Guan, Jinyu Shi, Qiaozhen Qin, Shuai Zhong, Zheng Huang, Rui Liu, Chenxing Wu, Zhong Ma, Xueling Qi, Xiaoxia Jiang, Yan Wang, Shouwei Li

“…The results also highlighted the strong immunosuppressive nature of the CNS GCTs’ tumor microenvironment. …”
Get full text

Invasive Aspergillosis in the Intensive Care Unit by Anna Zubovskaia, Jose A. Vazquez

“…Invasive aspergillosis (IA) is a fungal infection, which has traditionally been associated with neutropenia and immunosuppressive therapies. Our understanding of invasive aspergillosis has been evolving and, in the past few decades, IA among ICU patients has been recognized as a common infection and has become more widely recognized. …”
Get full text

Critical Care Management for Novel 2019 SARS-CoV-2 and HCoV-NL63 Coinfection in a Young Immunocompromised Patient: A Chicago Experience by Alejandro Sanchez-Nadales, Miguel Treminio-Quezada, Hasan Abad, Jessica Navarro-Motta, Pamela Contreras-Chavez, Anil Kachru, Chae Chu

“…We describe the case of a young, immunosuppressed and critically ill patient with previous Influenza B infection, requiring extracorporeal membrane oxygenation, which was then followed, in the succeeding months, by SARS-CoV-2 infection complicated by severe adult respiratory distress syndrome. …”
Get full text

Extensive Morphea Following Adjuvant Radiotherapy for Breast Carcinoma—Case Report by Alexandru Panaitescu, Hannah Nguyen, Laurence Masson-Côté, Carolina Lucena Fernandes

“…., topical tacrolimus or topical corticosteroids), phototherapy, and systemic therapy (i.e., systemic immunosuppressants). We present a case of extensive morphea post RT for breast cancer with 2 years of favorable evolution under systemic therapy.…”
Get full text

Two Case Presentations Infected by Trichosporon asahii and Treated with Voriconazole Successfully by Hikmet Gulsah Tanyildiz, Sule Yesil, Sule Toprak, Mehmet Onur Candir, Gurses Sahin

“…Trichosporon asahii is an opportunistic fungus that causes infections in immunosuppressed patients. Neutropenia developing due to malignancies is an important risk factor for fungal infection. …”
Get full text

Atypical Kaposi Sarcoma of the Tongue in HIV Positive Tanzanian Female by Elichilia Shao, Flora Ruhangisa, Neema Minja, Kanankira Nnko, Denis Katundu, George Semango, Eva Mbwilo, Amos Mwasamwaja, Kajiru Kilonzo, Isaack Lyaruu

“…This patient was newly diagnosed and had no history of antiretroviral therapy (ART), radiotherapy, or immunosuppressive drugs prior to this admission. Clinically, there were no dermatological features of KS lesions which are purple, red, or brown and which may be flat, raised (plaques), or bumpy (nodules) except for fungating and protruding enlarged tongue which was necrotic. …”
Get full text

Simultaneous Penile and Signet Ring Cell Bladder Carcinoma in Renal Transplant Recipient: A First Case by Francesca Manassero, Gianluca Giannarini, Davide Paperini, Andrea Mogorovich, Greta Alí, Ugo Boggi, Cesare Selli

“…This provides the opportunity to initiate appropriate immunosuppressive regimens depending on the tumor type and stage of development. …”
Get full text

Low viral persistence of an immunological model by Suqi Ma

“…Hepatitis B virus can persist at very low levels in the body in the face of host immunity, and reactive during immunosuppression and sustain the immunological memory to lead to the possible state of 'infection immunity'. …”
Get full text

A Case Report of Purtscher-Like Retinopathy Secondary to Pneumocystis jirovecii Pneumonia in an Immunocompromised Patient by Alastair David Bezzina, Isaac Bertuello

“…To the best of our knowledge, we present the first case of a young adult male, on long-term immunosuppressive therapy following a live-donor kidney transplant, with Purtscher-like retinopathy (PLR) secondary to Pneumocystis jirovecii pneumonia (PCP). …”
Get full text

A Case Series of Gastrointestinal Tuberculosis in Renal Transplant Patients by Pedro Azevedo, Cristina Freitas, Hugo Silva, Pedro Aguiar, Pedro Farrajota, Manuela Almeida, Sofia Pedroso, La Salete Martins, Leonídio Dias, José Ramón Vizcaíno, António Castro Henriques, António Cabrita

“…Therapeutic options may be a problem in the context of an immunosuppressed patient, requiring adjustment of maintenance therapy. …”
Get full text