Steroid Avoidance in Liver Transplantation by José Oberholzer, Mohammed Al-Saghier, Norman M Kneteman

“…Steroids may also exacerbate problems that existed before surgery, including malignancy, hepatitis B and hepatitis C. New, powerful immunosuppressants have allowed steroid use to be reduced or avoided altogether, but use of these regimens is not simple and may be associated with late acute rejection and recurrence of autoimmune disease. …”
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Sclerosing Mesenteritis as a Cause of Abdominal Mass and Discomfort in an Elderly Patient: A Case Report and Literature Review by Farzana Nawaz Ali, Sidra Ishaque, Bushra Jamil, Nasir-Ud-Din, Muhammad Idris

“…The patient's symptoms responded to a combination of immunosuppressive drugs, with no interval change in the size of the mass on radiological examination after fifteen months.…”
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Treatment of Immunocompromised, Critically Ill Patients with Influenza A H1N1 Infection with a Combination of Oseltamivir, Amantadine, and Zanamivir by Wouter J. Meijer, Wiete Kromdijk, Marcel P. H. van den Broek, Pieter-Jan A. Haas, Monique C. Minnema, Charles A. Boucher, Dylan W. de Lange, Annemarie M. J. Wensing

“…We report on two critically ill patients on immunosuppressive medication with influenza pneumonia. …”
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Polyarteritis Nodosa Presenting as Digital Gangrene and Breast Lesion following Exposure to Silicone Breast Implants by Yamen Homsi, John Andrew Carlson, Samer Homsi

“…While the pathogenesis of idiopathic PAN is not known yet, responsiveness to immunosuppressive therapy may suggest an immunologic mechanism. …”
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Review of Current First-Line Pharmacotherapy Strategies for Thyroid Eye Disease by Julia Ryniecka, Maciej Wojszczyk, Damian Zys, Piotr Pasek, Julia Kulbacka, Michalina Wójcikiewicz, Marta Chuncia-Ileczko, Julia Kacperczyk, Filip Arczewski, Karol Dziedzic

“…Glucocorticoids (GCs), particularly in intravenous (IV) regimens, remain the first-line treatment due to their strong anti-inflammatory and immunosuppressive effects. This paper focuses on the efficacy, protocols, and safety profiles of selenium supplementation and glucocorticoid therapy, emphasizing its central role in TED management. …”
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Refractory Epistaxis due to Severe Factor V Deficiency with Inhibitor by Elizabeth S. John, Minesh D. Patel, Julio Hajdenberg

“…We describe a complicated case of an elderly patient with severe factor V deficiency with high inhibitor titer refractory to FEIBA (anti-inhibitor coagulation complex) treated with NovoSeven concurrently with cyclosporine immunosuppression and Rituxan. Given that there are no consensus guidelines on treatment, this case offers important insight into the therapeutic approaches that can be used to treat such patients.…”
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New Coronavirus Infection (COVID-19) and Digestive System by V. T. Ivashkin, A. A. Sheptulin, O. Yu. Zolnikova, A. V. Okhlobystin, E. A. Poluektova, A. S. Trukhmanov, E. N. Shirokova, M. I. Gonik, N. I. Trofimivskaya

“…Patients with chronic inflammatory bowel diseases receiving immunosuppressive therapy are at elevated risk of severe COVID-19 progression. …”
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Pharmacological Modulation of the Unfolded Protein Response as a Therapeutic Approach in Cutaneous T-Cell Lymphoma by Nadia St. Thomas, Benjamin N. Christopher, Leticia Reyes, Reeder M. Robinson, Lena Golick, Xiaoyi Zhu, Eli Chapman, Nathan G. Dolloff

“…Conditioned media (CM) from CTCL were immunosuppressive to normal T cells through an IL-10-dependent mechanism. …”
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Allogenic Cultured Limbal Epithelial Transplantation and Cultivated Oral Mucosal Epithelial Transplantation in Limbal Stem Cells Deficiency: A Comparative Study by Mohamed Elalfy, Kareem Elsawah, Sundas Maqsood, Nigel Jordan, Mansour Hassan, Ahmed Zaki, Zisis Gatzioufas, Samer Hamada, Damian Lake

“…Although COMET has lower graft survival rate than ACLET, it does not mandate systemic immunosuppression therapy to protect against potential graft rejection.…”
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Dynamic changes in peripheral blood lymphocyte trajectory predict the clinical outcomes of sepsis by Dongkai Li, Jiahui Zhang, Wei Cheng, Guoyu Zhao, Xianli Lei, Yawen Xie, Na Cui, Hao Wang

“…BackgroundSepsis induces profound derangements in the immune system, including lymphopenia, which correlates with immunosuppression and poor prognosis. However, most evaluations of immunosuppression in sepsis patients rely on static, sporadic lymphocyte counts, lacking dynamic modeling over the disease course. …”
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Combination of rapamycin and adipose-derived mesenchymal stromal cells enhances therapeutic potential for osteoarthritis by Damien Veret, Gautier Tejedor, Esther Perez, Alison Chomette, Maylis Farno, Rosanna Ferreira-Lopez, Louis Dagneaux, Yves-Marie Pers, Christian Jorgsensen, Claire Gondeau, Jean-Marc Brondello

“…In addition, rapamycin improved AD-MSC immunoregulatory functions by promoting the expression of immunosuppressive factors, such as IDO1, PTGS2 and also CD274 (encoding PD-L1). …”
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Beta-Blocker Therapy Preserves Normal Splenic T-Lymphocyte Numbers Reduced in Proportion to Sepsis Severity in a Sepsis Model by Takeshi Suzuki, Kei Inoue, Toru Igarashi, Jungo Kato, Hiromasa Nagata, Takashige Yamada, Shizuka Minamishima, Hiroshi Morisaki

“…Beta-blocker therapy might improve sepsis-induced immunosuppression via normal splenic T-lymphocyte preservation.…”
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Transfusion-transmitted hepatitis E by LI Baixun, LIU Tianxu, HUANG Liqin, DANG Yingnan, WANG Lin

“…It has a higher mortality rate among immunosuppressed patients and pregnant women infected with HEV. …”
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Review on the Relationship between Human Polyomaviruses-Associated Tumors and Host Immune System by Serena Delbue, Manola Comar, Pasquale Ferrante

“…To date, at least nine members of the Polyomaviridae family have been identified, some of them playing an etiological role in malignancies in immunosuppressed patients. Here, we describe the biology of human polyomaviruses, their nonmalignant and malignant potentials ability, and their relationship with the host immune response.…”
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Iatrogenic T-Cell Lymphoma with Associated Hemophagocytic Lymphohistiocyotsis in a Patient with Long-Standing Rheumatoid Arthritis by X. A. Andrade, H. E. Fuentes, D. M. Oramas, H. Mann, P. Kovarik

“…Patients with rheumatoid arthritis are at increased risk of hematological malignancies, especially when exposed to immunosuppressive therapy. The mechanisms of lymphomagenesis remain poorly understood but factors implicated include high disease activity, exposure to antitumoral necrosis factor medications, and Epstein–Barr virus infection. …”
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Bullous pemphigoid as a diagnostic and therapeutic challenge with a wide spectrum of dermatological symptoms by Przemysław Borowy, Olga Wcisłek, Julia Płonczyńska, Mateusz Heba, Bogdan Batko

“…The treatment involves the use of topical or systemic glucocorticosteroids (GCS) and, in challenging cases, immunosuppressive drugs. In a 74-year-old patient with internistic and psychiatric burdens, and oral lesions present for the several past months. …”
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Updates in the management of connective tissue disease-associated interstitial lung disease by Chengappa Kavadichanda, G S R S N K Naidu

“…Insights into the pathology of these diseases and the associated lung involvement have resulted in the emergence of several immunosuppressive, antifibrotic, and small molecules as alternatives in CTD-ILD. …”
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Pulmonary hypertension associated with connective tissue disease by Srinivas Rajagopala, Molly Mary Thabah

“…PH-specific therapy in addition to immunosuppression is the most common treatment used though data are scant. …”
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Improving the Safety of Tolerance Induction: Chimerism and Cellular Co-Treatment Strategies Applied to Vascularized Composite Allografts by Wei-Chao Huang, Jeng-Yee Lin, Christopher Glenn Wallace, Fu-Chan Wei, Shuen-Kuei Liao

“…Although vascularized composite allografts (VCAs) have been performed clinically for a variety of indications, potential complications from long-term immunosuppression and graft-versus-host disease remain important barriers to widespread applications. …”
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A Rare Case of Meningitis Caused by Alcaligenes faecalis in an Immunocompetent Patient by Kevin Cantillo García, Oscar Calderón Duran, Tomás Acosta Pérez, Ángel Vásquez Jiménez, Emerson Madrid Pérez, María Cristina Martínez-Ávila, Tomás Rodríguez Yánez, Amilkar Almanza-Hurtado

“…The first cases of infections caused by this microorganism, such as pneumonia, soft tissue infections, urinary tract infections, bacteremia, and meningitis, date back more than 40 years and are almost entirely in newborns and immunosuppressed hosts. Optimal antibiotic therapy for A. faecalis has not been well established in the literature. …”
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