VSIG4+ tumor-associated macrophages mediate neutrophil infiltration and impair antigen-specific immunity in aggressive cancers through epigenetic regulation of SPP1 by Zongfu Pan, Jinming Chen, Tong Xu, Anqi Cai, Bing Han, Ying Li, Ziwen Fang, Dingyi Yu, Shanshan Wang, Junyu Zhou, Yingying Gong, Yulu Che, Xiaozhou Zou, Lei Cheng, Zhuo Tan, Minghua Ge, Ping Huang

“…Abstract V-set and immunoglobulin domain-containing 4 (VSIG4) positive tumor-associated macrophage (VSIG4+ TAM) is an immunosuppressive subpopulation newly identified in aggressive cancers. …”
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Aggressive Cardiac Involvement in Systemic Lupus Erythematosus: A Case Report and a Comprehensive Literature Review by Reza Ashrafi, Pankaj Garg, Ewan McKay, John Gosney, Som Chuah, Gershan Davis

“…Treatment comprised of high-level immunosuppression.…”
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Susac Syndrome and Pregnancy by Yazan Al-Hasan, Justin L. Hoskin, John C. Wolf, Kamala Saha

“…We stress the importance of a multidisciplinary approach, involving both neurology and maternal-fetal medicine, and provide guidance in navigating the various options for immunosuppressive therapy during pregnancy.…”
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The Conundrum of Septic Shock Imitators in Patients with Hematologic Cancers: Case Presentation and Possible Differential Diagnoses by Giorgio Berlot, Giulia Moratelli, Martina Tarchini, Katiuscia Battaglia, Paolo Grassi, Nadia Zarrillo, Vincenzo Colella, Rossana Bussani

“…In this article, the mimickers of septic shock are reviewed and discussed, as some of them require an aggressive immunosuppression instead of the recommended treatment for septic shock.…”
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Topical Glucocorticoid Use and the Risk of Posttransplant Diabetes by Simon Bøtker, Henrik Birn, Lara Aygen Øzbay

“…Systemically administered glucocorticoids constitute an essential part of the immunosuppressive regimen for transplant recipients, yet their known risks of causing hyperglycemia or posttransplant diabetes require close monitoring and minimisation of use, when possible, to prevent detrimental effects on patient morbidity and graft survival. …”
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Resveratrol and its derivates improve inflammatory bowel disease by targeting gut microbiota and inflammatory signaling pathways by Ming Li, Ping Li, Rongxue Tang, Hui Lu

“…Conventional treatments for IBD include antibiotics, immunosuppressive agents, 5-aminosalicylic acid, steroids and surgery, which have high toxic side effects. …”
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A Challenging Case of Multifocal Mycobacterium marinum Osteoarticular Infection in a Patient with Anorexia Nervosa by Katie Sharff, Zaw Min, Nitin Bhanot

“…Disseminated infection due to Mycobacterium marinum is rare but has been described in immunosuppressed and transplant recipients. We describe a case of multifocal osteoarticular involvement by this pathogen in a patient with anorexia nervosa. …”
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Bartonella Infection in Immunocompromised Hosts: Immunology of Vascular Infection and Vasoproliferation by Mosepele Mosepele, Dana Mazo, Jennifer Cohn

“…This paper will discuss Bartonella's manifestations in immunosuppressed patients and will examine Bartonella's interaction with the immune system including its mechanisms of establishing infection and immune escape. …”
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Paroxysmal Amnesia Attacks due to Hashimoto’s Encephalopathy by Pelin Nar Senol, Aylin Bican Demir, Ibrahim Bora, Mustafa Bakar

“…Although symptoms suggest a nonlesional encephalopathy in most of the cases, sometimes the clinical appearance can be subtle and may not respond to immunosuppressants or immunomodulatory agents. Here we report a case who presented with drowsiness and amnestic complaints associated with paroxysmal electroencephalography (EEG) abnormalities which could be treated only with an antiepileptic drug.…”
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Efficacy of Anti-Cancer Immune Responses Elicited Using Tumor-Targeted IL-2 Cytokine and Its Derivatives in Combined Preclinical Therapies by Sahar Balkhi, Giorgia Bilato, Andrea De Lerma Barbaro, Paola Orecchia, Alessandro Poggi, Lorenzo Mortara

“…Also, the use of IL-2 immunocytokines in “in situ” vaccination to relieve the immunosuppression of the TME is discussed.…”
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Serum glutathione peroxidase-3 concentration at diagnosis as a biomarker for assessing disease activity and damage of antineutrophil cytoplasmic antibody-associated vasculitis at d... by Jihye Chung, Jang Woo Ha, Yong-Beom Park, Yong-Beom Park, Sang-Won Lee, Sang-Won Lee

“…BackgroundIn this study, we investigated whether serum glutathione peroxidase-1 (GPX-3) concentration at diagnosis could be used to assess vasculitis activity and damage at diagnosis in immunosuppressive drug-naïve patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV).MethodsWe included 71 immunosuppressive drug-naïve patients newly diagnosed with AAV. …”
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A Randomized Multicenter Study Comparing a Tacrolimus-Based Protocol with and without Steroids in HCV-Positive Liver Allograft Recipients by Ulf Neumann, Didier Samuel, Pavel Trunečka, Jean Gugenheim, Giorgio Enrico Gerunda, Styrbjörn Friman

“…This randomized study evaluated HCV recurrence in HCV-positive liver allograft recipients using steroid-free immunosuppression. All patients received tacrolimus (TAC) at an initial dose of 0.10–0.15 mg/kg. …”
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Long-term Results in Children with Henoch-Schönlein Nephritis by Caner ASLAN, Nilufer GOKNAR, Emre KELESOGLU, Diana UCKARDES, Cengiz CANDAN

“…The severe group had higher histopathologic stages compared to the mild group (p=0.022). Immunosuppressive treatments were used in 44.4% of mild cases and 100% of severe cases (p<0.01). …”
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Masquerade Syndrome of Multicentre Primary Central Nervous System Lymphoma by Silvana Guerriero, Ermete Giancipoli, Lorenza Ciracì, Giuseppe Ingravallo, Marcella Prete, Elisabetta Di Leo, Antonietta Cimmino, Nicola Cardascia

“…After one year of steroidal and immunosuppressive therapy, a vitrectomy, and a trabeculectomy for unresponsive bilateral vitreitis and glaucoma, MRI showed a multicentre primary central nervous system lymphoma, which was the underlying cause of the masquerade syndrome. …”
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Herpes Simplex Virus-2 Hepatitis: A Case Report and Review of the Literature by Amna Ahmed, Alejandro Granillo, Ethan Burns, Kerri Glassner, Nishath Naseem, Christopher Force, Suzanne M. Crumley, Ashley Drews

“…Herpes simplex virus (HSV) is a rare cause of hepatitis in pregnancy and the chronically immunosuppressed, with a high propensity to progress to acute liver failure (ALF) and death. …”
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Chronic Infection with Hidden Malignancy Mimicking the Clinical Presentation of an Autoimmune Disease by Ammar Bakhsh, Khalil Miyajan, Abdulghani Sadaqa, Amer Eisa, Ghali Faidah, Hani Almoallim

“…Clinicians should look carefully for hidden infections and/or malignancies in patients lacking response while on immunosuppressive therapy for autoimmune disease.…”
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A case of mitral valve plastics in the early postoperative period after orthotopic heart transplantation by B.M. Todurov, G.I. Kovtun, O.O. Samchuk, S.O. Sheludko, I.M. Kuzmich, O.M. Druzhyna, H.Yu. Melnyk

“…Despite the constant improvement of the technique of this operation and the emergence of new protocols of immunosuppressive therapy, one of the main problems in the development of heart transplantation in Ukraine is a limited donor pool. …”
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Experimental Porcine Toxoplasma gondii Infection as a Representative Model for Human Toxoplasmosis by Julia Nau, Silvia Kathrin Eller, Johannes Wenning, Katrin Henrike Spekker-Bosker, Horst Schroten, Christian Schwerk, Andrea Hotop, Uwe Groß, Walter Däubener

“…In addition, the severe immunosuppression during acute infection described in mice does not occur in the experimentally infected ones. …”
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Posttransplant Lymphoproliferative Disease Presenting as an Extracranial Mass by Reuben J. Arasaratnam, Alejandro Restrepo

“…The patient was treated successfully with immunosuppression reduction, anti-CD20 monoclonal antibody therapy, and cytotoxic chemotherapy. …”
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Features of pregnancy after simultaneous pancreas-kidney transplantation in patient with type 1 diabetes mellitus. Case report by Madina I. Yevloyeva, Darya U. Savitskaya, Anastasia S. Severina, Minara S. Shamkhalova, Natalia P. Trubitsyna, Marina V. Shestakova

“…These risks are significantly reduced with pregnancy planning, regular monitoring of the woman and fetus with timely correction of immunosuppressive therapy, maintenance of target blood pressure and glycemia, selection of optimal timing and method of delivery. …”
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