Alpinetin Attenuates Persistent Inflammation, Immune Suppression, and Catabolism Syndrome in a Septic Mouse Model by Yukun Liu, Kang Wang, Qaunrui Feng, Yongsheng Zhang, Chuntao Wang, Qinxin Liu, Xinghua Liu, Xiang Wang, Wei Gao, Xiangjun Bai, Zhanfei Li, Yuchang Wang

“…Patients who survive the acute phase of sepsis can progress to persistent inflammation, immunosuppression, and catabolism syndrome (PICS), which usually results in extended recovery periods and multiple complications. …”
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Usefulness of Adalimumab in the Treatment of Refractory Uveitis Associated with Juvenile Idiopathic Arthritis by Carmen García-De-Vicuña, Manuel Díaz-Llopis, David Salom, Rosa Bou, Jesus Díaz-Cascajosa, Miguel Cordero-Coma, Gabriela Ortega, Norberto Ortego-Centeno, Marta Suarez-De-Figueroa, Juan Cruz-Martínez, Alex Fonollosa, Ricardo Blanco, Ángel María García-Aparicio, Jose M. Benítez-Del-Castillo, Jordi Antón

“…Thirty-nine patients (mean [SD] age of 11.5 [7.9] years) with JIA-associated uveitis who were either not responsive to standard immunosuppressive therapy or intolerant to it were enrolled. …”
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Activatable Sulfur Dioxide Nanosonosensitizer Enables Precisely Controllable Sono‐Gaseous Checkpoint Trimodal Therapy for Orthotopic Hepatocellular Carcinoma by Jing Liang, Guangwen Cheng, Luping Qiu, Liyun Xue, Huning Xu, Xiaohui Qiao, Na Guo, Huijing Xiang, Yu Chen, Hong Ding

“…The activity of Aza‐DNBS NPs is initially silenced, and the sonodynamic, gaseous, and immunosuppressive TME reprogramming activities are precisely awakened under US irradiation. …”
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Malignant and Noninvasive Skin Tumours in Renal Transplant Recipients by Christopher D. Roche, Joelle S. Dobson, Sion K. Williams, Mara Quante, Joyce Popoola, Jade W. M. Chow

“…Transplant recipients require immunosuppression to prevent graft rejection. This conveys an increased risk of malignancy, particularly skin tumours. …”
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Renal Transplantation in Hepatitis C Positive Patients: A Single Centre Experience by P. R. Shah, A. V. Vanikar, M. R. Gumber, H. V. Patel, V. B. Kute, S. M. Godara, H. L. Trivedi

“…Hepatitis C virus (HCV) infection is an independent risk factor for renal transplantation (RTx). Immunosuppression minimization can render better quality of life to these patients. …”
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Hepatic Kaposi Sarcoma after Kidney Transplantation: A Case Report by Seunghyeon Roh, Myoung Seok Lee, Siwon Jang, Min Hoan Moon, Joon Koo Han

“…We report a rare case of de novo hepatic Kaposi’s sarcoma manifesting as an ill-defined infiltrative lesion in the left lobe of the liver in a patient who was immunosuppressed for 9 months after a kidney transplantation using ultrasonography, CT, MRI, and fluorodeoxyglucose-PET.…”
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Idiopathic CD4 lymphocytopenia: An uncommon but fatal cause of Pneumocystis pneumonia by Julia Schearer, Christopher Merrick

“…In those without previously identified risk factors, maintaining an index of suspicion for this diagnosis with search for underlying immunosuppressive cause is of utmost importance. Here, we present a case of fatal PCP in a patient without a known history of immunocompromise subsequently diagnosed with idiopathic CD4 lymphocytopenia (ICL) with an absolute CD4+ T-cell count of 7 cells/uL.…”
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Livedoid vasculopathy with mononeuritis multiplex associated with protein S deficiency mimicking systemic vasculitis by Vikramraj K Jain, Krishnamurthy Hegde, Renuka Panchagnula

“…The patient was treated with anticoagulation and immunosuppression after which her symptoms improved. LV can be associated with thrombophilias, fibrinolytic disorders, autoimmune diseases, and malignancy. …”
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Fatal Hepatocellular Carcinoma in a Patient with Occult Hepatitis B Virus Infection following the Administration of R-CHOP for Diffuse Large B-Cell Lymphoma by Vincenzo Pitini, Massimo Rizzo, Carmela Arrigo, Patrizia Mondello, Giuseppe Altavilla

“…Like overt HBV infection, OBI can be associated with the integration of HBV sequences into the host genome and has a substantial clinical relevance for patients who are severely immunosuppressed for long durations. We present the case of a patient with a diffuse large B-cell non-Hodgkin lymphoma and OBI who developed a hepatocellular carcinoma with a fulminant clinical course following the administration of rituximab plus CHOP.…”
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Successful Therapy of Refractory Erythema Nodosum Associated with Crohn's Disease Using Potassium Iodide by John K Marshall, E Jan Irvine

“…While mild skin involvement often responds to conservative management, severe or refractory cases may require systemic corticosteroid or immunosuppressive therapy. …”
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Strongyloides stercoralis and Organ Transplantation by Bhalaghuru Chokkalingam Mani, Moses Mathur, Heather Clauss, Rene Alvarez, Eman Hamad, Yoshiya Toyoda, Mark Birkenbach, Mustafa Ahmed

“…Infection in the immunocompetent host is usually associated with mild gastrointestinal symptoms. However, in immunosuppressed individuals it has been known to cause a “hyperinfection syndrome” with fatal complications. …”
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Epididymo-Orchitis as a Presenting Feature of Relapsing Polychondritis: A Case Report by Kuljeet Bhamra, Rachel Weerasinghe, Alan Steuer

“…Corticosteroids are the mainstay of treatment but other immunosuppressive drugs can be used in combination with steroids. …”
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Urinary System Manifestation of IgG4-Related Disease: Clinical, Laboratory, Radiological, and Pathological Spectra of a Chinese Single-Centre Study by Fei Teng, Hui Lu, Ke Zheng, Gang Chen, Yubing Wen, Zheng Liu, Linyi Peng, Li Huo, Xiaofeng Zeng, Wen Zhang, Xuemei Li

“…Patients showed good initial response to immunosuppressive treatment but relapses could occur at the maintenance period.…”
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Transplantation and Pregnancy by Pinar Erkan Uc, Sermet Sagol

“…Specific criteria such as pre-pregnancy serum creatinine levels and blood pressure control, as well as adherence to immunosuppressive therapy, significantly influence pregnancy success in transplant patients. …”
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Cancer in ANCA-Associated Glomerulonephritis: A Registry-Based Cohort Study by Sanjeevan Sriskandarajah, Leif Bostad, Tor Åge Myklebust, Bjørn Møller, Steinar Skrede, Rune Bjørneklett

“…Background. Immunosuppressive therapy for antineutrophil cytoplasmic antibody-associated vasculitis has been associated with increased malignancy risk. …”
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A fulminant case of JC virus encephalopathy supporting a novel syndrome associated with JC virus infection of cortical neurons by Matteo Ciocca, Marta Pirovano, Monica Lodi, Antonino Romeo, Vincenza Fetoni

“…PML almost exclusively affects immunosuppressed patients, whereas it is rare in immunocompetent subjects. …”
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Mesenchymal Stromal Cells Mediate Clinically Unpromising but Favourable Immune Responses in Kidney Transplant Patients by Urvashi Kaundal, Raja Ramachandran, Amit Arora, Deepesh B. Kenwar, Ratti Ram Sharma, Ritambhra Nada, Mukut Minz, Vivekanand Jha, Aruna Rakha

“…Allograft rejection postkidney transplantation (KTx) is a major clinical challenge despite increased access to a healthcare system and improvement in immunosuppressive (IS) drugs. In recent years, mesenchymal stromal cells (MSCs) have aroused considerable interest in field of transplantation due to their immunomodulatory and regenerative properties. …”
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The road ahead: emerging therapies for primary IgA nephropathy by Edward J. Filippone, Rakesh Gulati, John L. Farber

“…Sparsentan is indicated for persisting proteinuria. Immunosuppression should be considered for all patients at risk for progression (persisting proteinuria and/or declining eGFR). …”
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Organ donation in the paediatric intensive care unit: Time for change? by Kristy Xinghan Fu, Sze Lyn Jasmin Jeanette Tan, Ne-Hooi Will Loh

“…To our knowledge, the first solid organ transplantation performed in Singapore in July 1970 involved a kidney from a deceased donor.1 Since then, rapid advancements in both transplant surgery and immunosuppressive medical therapy have enabled solid organ transplantation to better meet the increasing demands of a growing Singapore population with end-organ diseases. …”
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Evaluation of Protocol Biopsy Utility 12 Months after Renal Transplantation: A Multicenter Observational Analysis by Bruno Moulin, Pierre Merville, Karine Renaudin, David Buob, Sophie Ferlicot, Michel Delahousse, Jacques Dantal, Laetitia Albano, Christelle Barbet, Georges Mourad, Laure-Hélène Noel

“…SB at 12 months posttransplant did not prompt significant modification of immunosuppression, and no renal benefit was observed.…”
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