Pregnancy after kidney and liver transplantation by A Wise, N E Diana, B Bobat, R T Saggers, S Bhoora, S Budhram, L Chauke, V G Lala, A Mahomed, D Mokgoko, M Seabi, B Moore, S Naidoo, R B Nyakoe, N Odell, G Paget, L Wium, J Zamparini

“…This article examines the management of pregnancy in kidney and liver transplant recipients, focusing on pre-pregnancy counselling, trimester-specific care, the teratogenic effects of immunosuppressive drugs, and the role of the multidisciplinary team. …”
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Artificial intelligence in kidney transplantation: a 30-year bibliometric analysis of research trends, innovations, and future directions by Ying Jia He, Pin Lin Liu, Tao Wei, Tao Liu, Yi Fei Li, Jing Yang, Wen Xing Fan

“…Key research themes include AI-driven advancements in donor matching, deep learning for post-transplant monitoring, and machine learning algorithms for personalized immunosuppressive therapies. The findings underscore a rapid expansion in AI applications since 2017, with emerging trends in personalized medicine, multimodal data fusion, and telehealth. …”
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Mechanisms and Mediators of Inflammation: Potential Models for Skin Rejection and Targeted Therapy in Vascularized Composite Allotransplantation by Theresa Hautz, Dolores Wolfram, Johanna Grahammer, Ravi Starzl, Christoph Krapf, Johann Pratschke, W. P. Andrew Lee, Gerald Brandacher, Stefan Schneeberger

“…However, postoperative courses of VCA recipients have been complicated by skin rejection, and long-term immunosuppression remains a necessity for allograft survival. …”
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Culture and Use of Mesenchymal Stromal Cells in Phase I and II Clinical Trials by Bourin Philippe, Sensebé Luc, Planat-Bénard Valérie, Roncalli Jérôme, Bura-Rivière Alessandra, Casteilla Louis

“…Moreover, MSCs have immunosuppressive properties related to non-HLA restricted immunosuppressive capacities. …”
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Enhancement of Cytomegalovirus-Specific Cytokine Production after Modulation of the Costimulation in Kidney Transplant Patients by Theresa Dornieden, Benjamin Wilde, Johannes Korth, Kai Werner, Peter A. Horn, Oliver Witzke, Monika Lindemann

“…Kidney transplantation is the therapy of choice for patients with end stage renal disease. Due to immunosuppressive treatment, patients are at risk for opportunistic infections. …”
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The Role of mTOR Inhibitors in Liver Transplantation: Reviewing the Evidence by Goran B. Klintmalm, Björn Nashan

“…Clearly there is a need for better immunosuppressive agents that maintain similar rates of efficacy and renal function whilst minimizing adverse effects. …”
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Giant Cell Myocarditis in a Patient With Crohn's Disease, Treated with Etanercept – A Tumour Necrosis Factor-Alpha Antagonist by C Nash, R Panaccione, LR Sutherland, JB Meddings

“…Little clinical improvement occurred with immunosuppressive therapy. Only after the addition of etanercept, a TNF- α p75 receptor antagonist, did complete clinical resolution occur. …”
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Sorafenib enhanced the function of myeloid-derived suppressor cells in hepatocellular carcinoma by facilitating PPARα-mediated fatty acid oxidation by Chunxiao Li, Liting Xiong, Yuhan Yang, Ping Jiang, Junjie Wang, Mengyuan Li, Shuhua Wei, Suqing Tian, Yuexuan Wang, Mi Zhang, Jie Tang

“…MDSCs were analyzed for chemotaxis, immunosuppressive functions, fatty acid oxidation (FAO), and PPARα expression. …”
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IGF2BP2 Shapes the Tumor Microenvironment by Regulating Monocyte and Macrophage Recruitment in Bladder Cancer by Jianpeng Li, Yunzhong Jiang, Minghai Ma, Lu Wang, Minxuan Jing, Zezhong Yang, Lizhao Wang, Quanpeng Qiu, Rundong Song, Yuanchun Pu, Yuanquan Zhang, Nan Mei, Mengzhao Zhang, Jinhai Fan

“…Furthermore, IGF2BP2 expression was linked to immunosuppressive M2‐like and SPP1+ macrophages, contributing to an angiogenesis‐promoting and immunosuppressive TME. …”
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Mesenchymal Stem Cell-Based Immunomodulation: Properties and Clinical Application by Mengyuan Wang, Quan Yuan, Liang Xie

“…In particular, their extensive immunosuppressive properties are being explored for promising therapeutic application in immune disorders. …”
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Macrophages in Tumor Microenvironments and the Progression of Tumors by Ning-Bo Hao, Mu-Han Lü, Ya-Han Fan, Ya-Ling Cao, Zhi-Ren Zhang, Shi-Ming Yang

“…In most tumors, the infiltrated macrophages are considered to be of the M2 phenotype, which provides an immunosuppressive microenvironment for tumor growth. Furthermore, tumor-associated macrophages secrete many cytokines, chemokines, and proteases, which promote tumor angiogenesis, growth, metastasis, and immunosuppression. …”
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Burkholderia Gladioli – A Predictor of Poor Outcome in Cystic Fibrosis Patients Who Receive Lung Transplants? A Case of Locally Invasive Rhinosinusitis and Persistent Bacteremia in... by Bradley S Quon, James D Reid, Patrick Wong, Pearce G Wilcox, Amin Javer, Jennifer M Wilson, Robert D Levy

“…A case involving a lung transplant recipient with cystic fibrosis who ultimately died as a result of severe rhinosinusitis due to B gladioli infection in the context of postlung transplant immunosuppression is reported.…”
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Campylobacter fetus Bacteremia Revealed by Cellulitis without Gastrointestinal Symptoms in the Context of Acquired Hypogammaglobulinemia: A Report of Three Cases by Souleymane Brah, Laurent Chiche, Marion Brun, Nicolas Schleinitz, Jean-Robert Harle, Jean-Marc Durand

“…Campylobacter fetus bacteremia is rare and occurs mainly in patients with immunosuppression. This infection, which often involves secondary localizations has already been reported in some primary humoral immune deficiencies. …”
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LBP-CD155 Liposome Nanovaccine Efficiently Resist Colorectal Cancer and Enhance ICB Therapy by Yan Y, Duan T, Xue X, Yang X, Liu M, Ma B, Duan X, Su C

“…Prophylactic and therapeutic combination regimens with anti-PD-1 treatment demonstrate synergism that stimulates T-cell infiltration into tumors and counteracts immunosuppression, leading to remarkable tumor remission and enhancing the efficacy of immune checkpoint therapy in solid tumors.Conclusion: Our work provided that LBP-CD155L NVs may serve as a promising tool for reversing tumor immunosuppressive microenvironment and enhancing ICB therapy in CRC.Keywords: Lycium barbarum polysaccharides, nanovaccines, nanovaccine codelivery, CD155, tumor immunotherapy…”
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A Behcet’s Disease Patient with Right Ventricular Thrombus, Pulmonary Artery Aneurysms, and Deep Vein Thrombosis Complicating Recurrent Pulmonary Thromboembolism by Selvi Aşker, Müntecep Aşker, Özgür Gürsu, Rıdvan Mercan, Özgür Bülent Timuçin

“…At the controls after three months of immunosuppressive and anticoagulant therapies, some clinical and radiological improvements were recognized. …”
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Immune Modulation as Adjunctive Therapy for Pneumocystis pneumonia by Jing Wang, Terry W. Wright, Francis Gigliotti

“…Pneumocystis is an opportunistic fungal respiratory pathogen that causes life-threatening pneumonia (Pcp) in patients suffering from defects in cell-mediated immunity, including those with acquired immunodeficiency syndrome (AIDS) and immunosuppression secondary to chemotherapy or organ transplantation. …”
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Prior Exposure to Immunosuppressors Sensitizes Retinal Microglia and Accelerates Optic Nerve Regeneration in Zebrafish by Ilse Bollaerts, Jessie Van houcke, An Beckers, Kim Lemmens, Sophie Vanhunsel, Lies De Groef, Lieve Moons

“…We first demonstrated that systemic immunosuppression with dexamethasone (dex) impedes regeneration after optic nerve injury. …”
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Immunomodulatory Effects of Hemagglutinin- (HA-) Modified A20 B-Cell Lymphoma Expanded as a Brain Tumor on Adoptively Transferred HA-Specific CD4+ T Cells by Valentin P. Shichkin, Roman M. Moriev

“…Our data support an idea about sufficient role of both the tumor-specific and -nonspecific mechanisms inducing immunosuppression in cancer patients.…”
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Role of Myokines in Myositis Pathogenesis and Their Potential to be New Therapeutic Targets in Idiopathic Inflammatory Myopathies by Vlad Mageriu, Emilia Manole, Alexandra E. Bastian, Florica Staniceanu

“…Many patients, even after immunosuppressive therapy, do not respond to treatment, so new alternatives have been sought for this. …”
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Actinomyces Acute Rhinosinusitis Complicated by Subperiosteal Abscess in an Immunocompromised 12-Year-Old: Case Report and Literature Review by Sai V. Nimmagadda, Li-Xing Man, Margo K. McKenna, John J. Faria, Isaac L. Schmale

“…Our case is the first reported in a pediatric patient and the first taking immunosuppressive medication. Overall, only 3 cases of actinomyces rhinosinusitis in immunosuppressed individuals have been reported, each with uncontrolled diabetes and each also responded well to surgery and appropriate antibiotics. …”
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