Challenges in the Diagnosis and Management of Patients with Fibrosing Interstitial Lung Disease by Leslie B. Tolle

“…Patients with some fibrosing ILDs may respond well to immunosuppressants, but even patients who respond well to immunosuppressants initially may later show deterioration despite appropriate management. …”
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Research progress of HIF-1a on immunotherapy outcomes in immune vascular microenvironment by Shaoyan Shi, Xuehai Ou, Chao Liu, Hao Wen, Jiang Ke

“…This review explores the molecular mechanisms of action of HIF-1α in IVM, its impact on immunotherapy resistance, as well as potential interventions, emphasizing the need for innovative approaches to circumvent hypoxia-driven immunosuppression in cancer therapy.…”
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Free Radical Scavenging Capacities and Alleviating Actions of Polysaccharides Extract of Termitomyces le-testui on Methylprednisolone-Induced Immunodepression in Rats by Foncham Evans Ngwenah, Kada Sanda Antoine, Salah Martin, Tume Christopher, Oumar Mahamat

“…Hot water extract of polysaccharide extract of T. le-testui was prepared and tested in white albino Wister rats for its immunomodulatory activities effect on methylprednisolone-immunosuppressed animals. In addition, the radical scavenging activity of the polysaccharide was evaluated using nitrite and hydrogen peroxide. …”
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Biology of extracellular vesicles and the potential of tumor-derived vesicles for subverting immunotherapy of cancer by Theresa L Whiteside

“…Immunosuppressive molecular profiles and abilities to signal, enter and functionally reprogram a variety of recipient cells enable TEX to exert pro-tumor effects that promote tumor resistance to immunotherapy. …”
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Immunological Remission as a Basis for Dose Reduction of Immunosuppressors in Autoimmune Hepatitis: Results of Monocenter Surveillance Study by A. O. Bueverov, S. V. Koblov, P. O. Bogomolov

“…The data of 47 patients with AIH who received immunosuppressive therapy from April 2001 to August 2023 were analyzed: 10 men (21 %), 37 women (79 %); the average age was 37 (17–66) years. …”
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YAP1 as a Novel Negative Biomarker of Immune Checkpoint Inhibitors for EGFR-Mutant Non-Small-Cell Lung Cancer by Ling-Chen Li, Xie-Wan Chen, Ling Fang, Chun-Li Jian, Yong-Xin Yu, Xing-Yun Liao, Jian-Guo Sun

“…Conclusions. YAP1 mediates immunosuppressive microenvironment and poor prognosis in EGFR-mutant NSCLC population. …”
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Pulmonary Nocardiosis in the Immunocompetent Host: Case Series by Inderjit Singh, Frances Mae West, Abraham Sanders, Barry Hartman, Dana Zappetti

“…Pulmonary nocardiosis is commonly recognized as an opportunistic infection in patients with predisposing immunosuppressive conditions. However, reports of pulmonary nocardiosis in the immunocompetent host are rare. …”
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Wickerhamomyces anomalous: A Rare Cause of Fungemia Causing Febrile Neutropenia in Acute Lymphoblastic Leukemia by Vibha Mehta, Aroop Mohanty, Suneeta Meena, J. S. Rahul, Nath Uttam Kumar, Debranjani Chattopadhyay, Anamika Bakliwal, Ranjana Choudhary, Pratima Gupta

“…Here, we report a case of catheter-related bloodstream infection (CRBSI) caused by W. anomalus in a leukemic immunosuppressed patient who was successfully treated by early detection and treatment of this emerging fungus.…”
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Divergent Effects of <i>Circoviridae</i> Capsid Proteins on Type I Interferon Signaling by Anon H. Kosaka, Chen-Yu Huang, Zih-Ying Lu, Hua-Zhen Hsing, Amonrat Choonnasard, Rissar Siringo Ringo, Kuo Pin Chuang, Akatsuki Saito

“…Additionally, beak and feather disease virus in parrots, canine circovirus in dogs, and columbid circovirus (pigeon circovirus) in racing pigeons induce immunosuppression, followed by secondary infections in these hosts. …”
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ACSL4 promotes the formation of the proliferative subtype in hepatoblastoma by Wei Dang, Qin Li, Xiaoying Wang

“…Among them, the proliferative subtype, characterized by enhanced proliferative capacity, poor prognosis, and an immunosuppressive tumor microenvironment, was particularly notable. …”
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Basic Molecular Biology, Metabolic and Immunological Mechanisms of Fecal Microbiota Transplantation by O. V. Goloshchapov, A. V. Beynarovich, A. B. Chukhlovin, R. V. Klementeva, A. A. Shcherbakov, E. A. Bakin, I. K. Golubovskaya, N. D. Ventslovayte, O. S. Yudintseva, M. V. Gorchakova, V. E. Karev, M. A. Kucher, M. A. Suvorova, E. V. Svetkina, G. G. Rodionov, V. V. Gostev, S. V. Sidorenko, I. S. Moiseev, A. D. Kulagin

“…This complication required resumption and subsequent intensification of immunosuppressive therapy with complete resolution of GVHD symptoms. …”
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Transverse Myelitis Associated with Cryptococcus neoformans in an Immunocompetent Patient by David B. Villafuerte, Marco F. Passeri, Rayan Qazi, Moulika Baireddy, Fernando L. Sanchez

“…Cryptococcal infections are known to cause significant morbidity and mortality in immunosuppressed patients as it is difficult to eradicate even with adequate antifungal treatment. …”
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Hepatitis C Virus, Cryoglobulinemia, and Kidney: Novel Evidence by Fabrizio Fabrizi

“…Various approaches have been tried for the treatment of HCV-related glomerulonephritis, including immunosuppressive therapy (corticosteroids and cytotoxic agents), plasma exchange and antiviral agents. …”
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Targeted therapy for pancreatic ductal adenocarcinoma: Mechanisms and clinical study by Heng‐Chung Kung, Jun Yu

“…Contributing to the poor prognosis of PDAC is the lack of early detection, a complex network of signaling pathways and molecular mechanisms, a dense and desmoplastic stroma, and an immunosuppressive tumor microenvironment. A recent shift toward a neoadjuvant approach to treating PDAC has been sparked by the numerous benefits neoadjuvant therapy (NAT) has to offer compared with upfront surgery. …”
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Glioblastoma Multiforme Stem Cells by Irena Dimov, Deasanka Tasic-Dimov, Irena Conic, Vladisav Stefanovic

“…Therefore, a comprehensive understanding of the mechanisms underlying the GBM-induced immunosuppression is indispensable. This review presents a summary of the present knowledge both on GBMSCs and the GBM, and/or GBMSC-related mechanisms of developing both local and systemic immunosuppression, of which an understanding may lead to the development of the novel and effective therapeutic strategies.…”
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Pancreatitis in systemic lupus erythematosus: Clinical characterization and outcome analysis in concurrent pancreatitis and lupus by Sheba Charles, Benzeeta Pinto, Vineeta Shobha

“…All our patients were treated with high-dose steroids and other immunosuppression as indicated for concomitant disease activity. …”
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Coinfections increase the risk of HIV acquisition, AIDS progression, and therapy and prophylaxis failure: a review by Robert Root-Bernstein

“…The primary drivers of preexisting immunosuppression and inflammation are non-HIV infections and possibly alloantigen and drug exposures. …”
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Lymphatic-derived oxysterols promote anti-tumor immunity and response to immunotherapy in melanoma by Mengzhu Sun, Laure Garnier, Romane Chevalier, Martin Roumain, Chen Wang, Julien Angelillo, Julien Montorfani, Robert Pick, Dale Brighouse, Nadine Fournier, David Tarussio, Stéphanie Tissot, Jean-Marc Lobaccaro, Tatiana V. Petrova, Camilla Jandus, Daniel E. Speiser, Manfred Kopf, Caroline Pot, Christoph Scheiermann, Krisztian Homicsko, Giulio G. Muccioli, Abhishek D. Garg, Stéphanie Hugues

“…Abstract In melanoma, lymphangiogenesis correlates with metastasis and poor prognosis and promotes immunosuppression. However, it also potentiates immunotherapy by supporting immune cell trafficking. …”
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Tacrolimus toxicity management in a pregnant kidney transplant recipient with newly diagnosed human immunodeficiency virus: A case report by Ahmad Matarneh, Ravi chokshi, Sundus Sardar, Dinia Salmeron, James O’brien, Fareeha Khalil, Naman Trivedi, Nasrollah Ghahramani, Vaqar Shah

“…Managing kidney transplant recipients during pregnancy presents significant challenges, particularly in balancing the interactions and safety concerns of immunosuppressive medications such as mycophenolate mofetil and tacrolimus. …”
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SLE and Non-Hodgkin’s Lymphoma: A Case Series and Review of the Literature by Prajwal Boddu, Abdul S. Mohammed, Chandrahasa Annem, Winston Sequeira

“…We will also review and discuss the implications of immunosuppressives in SLE-related lymphoma and the role of mycophenolate mofetil in SLE-related primary CNS lymphoma development.…”
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