Immune checkpoint inhibitor-induced diabetes mellitus: clinical characteristics and risk factors by Mei Zhan, Mei Zhan, Qinran Long, Qinran Long, Jinhan He, Jinhan He, Jinhan He, Litao Huang, Bin Wu, Bin Wu, Haixia Xu, Li Mo, Ting Xu

“…By excluding patients influenced by glucocorticoids or immunosuppressants, ICI-DM was observed in 713 of 8,199 (8.70%) patients. …”
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Drug-Induced Hematological Cytopenia in Kidney Transplantation and the Challenges It Poses for Kidney Transplant Physicians by Muhammad Abdul Mabood Khalil, Muhammad Ashhad Ullah Khalil, Taqi F. Taufeeq Khan, Jackson Tan

“…On the contrary, reducing or stopping immunosuppressive medications in these events can provoke a rejection. …”
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TGFβ-specific T cells induced by a TGFβ-derived immune modulatory vaccine both directly and indirectly modulate the phenotype of tumor-associated macrophages and fibroblasts by Mads Hald Andersen, Inés Lecoq, Evelina Martinenaite, Maria Perez-Penco, Lucia Lara de la Torre

“…The tumor microenvironment (TME) of pancreatic cancer is highly immunosuppressive. We recently developed a transforming growth factor (TGF)β-based immune modulatory vaccine that controlled tumor growth in a murine model of pancreatic cancer by targeting immunosuppression and desmoplasia in the TME. …”
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Monomorphic Ventricular Tachycardia as a Presentation of Giant Cell Myocarditis by Michael H. Chiu, Cvetan Trpkov, Saman Rezazedeh, Derek S. Chew

“…She was treated with combined immunosuppressive therapy as well as guideline-directed medical therapy. …”
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Anaesthesia affects immune function and impact on long-term cancer prognosis: A review by Kisdyanti Yuniar Melissa, Suandika Made, Rahmawati Arni Nur

“…Anti-tumour immunity is compromised by local and systemic immunosuppression, which may ultimately contribute to tumor survival and the long-term prognosis of cancer patients. …”
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Effect of innate and induced immunity on infectious bursal disease pathogenesis by A. N. Semina

“…In case of IBD, the immunosuppression is both direct consequence of specific target-cell infection and indirect consequence of the interactions occurring in the bird’s immune network. …”
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Potentially paraneoplastic glomerulopathies in a Brazilian cohort: a retrospective analysis by Marcella Soares Laferreira, Gianna Mastroianni Kirsztajn

“…The dose of the immunosuppressive agents among patients with neoplasms before or after immunosuppression was not statistically different. …”
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Use of High-Flow Nasal Cannula Oxygen Therapy in a Pregnant Woman with Dermatomyositis-Related Interstitial Pneumonia by Tomohiro Shoji, Takeshi Umegaki, Kota Nishimoto, Natsuki Anada, Akiko Ando, Takeo Uba, Munenori Kusunoki, Kanako Oku, Takahiko Kamibayashi

“…In order to save the life of the patient, the use of combination therapy with immunosuppressants was necessary. The patient underwent emergency cesarean section and was immediately treated with immunosuppressants while continuing HFNC oxygen therapy. …”
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Insights into the Roles of B Cells in Patients with Sepsis by Xijie Dong, Hao Tu, Shuang Qin, Xiangjun Bai, Fan Yang, Zhanfei Li

“…Dysfunction of B cells, along with aggravated immunosuppression, are closely related to poor prognosis. …”
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The changing landscape of treatment for acquired hemophilia A by Massimo Franchini, Daniele Focosi

“…Recent studies have renewed the interest towards the immunosuppressive agent rituximab for FVIII inhibitor eradication and have suggested a potential role for emicizumab for the prevention of bleeding in AHA patients. …”
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Homeostatic T Cell Proliferation after Islet Transplantation by Paolo Monti, Lorenzo Piemonti

“…Pancreatic islet transplantation in patients with type 1 diabetes mellitus is performed under immunosuppression to avoid alloreactive T cell responses and to control the reactivation of autoreactive memory T cells. …”
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Adjuvant Ciprofloxacin for Persistent BK Polyomavirus Infection in Kidney Transplant Recipients by David Arroyo, Sindhu Chandran, Parsia A. Vagefi, David Wojciechowski

“…BK virus (BKV) infection is a common complication following kidney transplantation. Immunosuppression reduction is the cornerstone of treatment while adjuvant drugs have been tried in small uncontrolled studies. …”
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Absence of Rejection in a Facial Allograft Recipient with a Positive Flow Crossmatch 24 Months after Induction with Rabbit Anti-Thymocyte Globulin and Anti-CD20 Monoclonal Antibody by Bruce E. Gelb, J. Rodrigo Diaz-Siso, Natalie M. Plana, Adam Jacoby, William J. Rifkin, Kimberly S. Khouri, Daniel J. Ceradini, Eduardo D. Rodriguez

“…To our knowledge, this is the first report of targeted B cell agents used for induction immunosuppression in skin-containing vascularized composite tissue allotransplantation. …”
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Fever, Haematuria, and Acute Graft Dysfunction in Renal Transplant Recipients Secondary to Adenovirus Infection: Two Case Reports by J. Ramírez, I. C. Bostock, A. Martin-Onraët, S. Calleja, A. Sánchez-Cedillo, L. A. Navarro-Vargas, A. L. Noriega-Salas, O. Martínez-Mijangos, N. O. Uribe-Uribe, M. Vilatoba, B. Gabilondo, L. E. Morales-Buenrostro, J. Alberú

“…The viral real-time PCR became negative upon immunosuppression reduction and administration of IVIG; graft function normalized. …”
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Molecular Mechanisms of Immunomodulation Properties of Mesenchymal Stromal Cells: A New Insight into the Role of ICAM-1 by Yury Rubtsov, Кirill Goryunov, Аndrey Romanov, Yulia Suzdaltseva, George Sharonov, Vsevolod Tkachuk

“…ICAM-1 is involved in the control of T cell activation leading to immunosuppression or modest stimulation depending on the T cell status. …”
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Modulation of Acid Sphingomyelinase in Melanoma Reprogrammes the Tumour Immune Microenvironment by Emma Assi, Davide Cervia, Laura Bizzozero, Annalisa Capobianco, Sarah Pambianco, Federica Morisi, Clara De Palma, Claudia Moscheni, Paolo Pellegrino, Emilio Clementi, Cristiana Perrotta

“…In contrast, the restoration of A-SMase in melanoma cells not only reduced tumour growth and immunosuppression, but also induced a high recruitment at tumour site of effector immune cells with an antitumoural function. …”
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Methotrexate-Associated Lymphoproliferative Disorder in a Patient with Psoriasis: A Case Report and Review of the Literature by Carolina Afonso, Adriana Roque, Cátia Almeida, Maria Beatriz Pimentão, Maria José Julião, Rodolfo Silva, Catarina Geraldes, Marília Gomes

“…Iatrogenic immunodeficiency-associated lymphoproliferative disorders (LPDs) are heterogeneous clinicopathological entities developing in patients receiving immunosuppression. Outside the posttransplant setting, methotrexate (MTX), a drug commonly used for the treatment of autoimmune diseases, is an immunosuppressive agent frequently reported to be associated with LPD. …”
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The Need for Inducing Tolerance in Vascularized Composite Allotransplantation by Kadiyala V. Ravindra, Hong Xu, Larry D. Bozulic, David D. Song, Suzanne T. Ildstad

“…In order to optimize VCA outcomes, translational studies are needed to develop less toxic immunosuppression and possibly achieve donor-specific tolerance. …”
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Ehrlichiosis in a Recent Liver Transplant Recipient Leading to Multiorgan Failure by Fawwaz Almajali, Catherine Oleary, Taylor Hallcox, Justin Lok, Daniela Hermelin, Alexis Guenette, Mustafa Nazzal

“…While Ehrlichia often presents as a mild form of the disease in immunocompetent patients, immunosuppressed patients are at increased risk for a more virulent and potentially fatal infection. …”
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Effective Administration of Rituximab in Anti-MDA5 Antibody–Positive Dermatomyositis with Rapidly Progressive Interstitial Lung Disease and Refractory Cutaneous Involvement: A Case... by Yuka Ogawa, Dai Kishida, Yasuhiro Shimojima, Koichi Hayashi, Yoshiki Sekijima

“…Even after combination immunosuppressive therapy including a corticosteroid, cyclosporine A, and intravenous cyclophosphamide, his respiratory insufficiency and cutaneous involvement progressively worsened. …”
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