Highest Recorded Serum Creatinine by Christine Persaud, Uttsav Sandesara, Victor Hoang, Joshua Tate, Wayne Latack, David Dado

“…This was the patient’s fourth episode of late acute rejection and emphasizes the need for education of immunosuppressant adherence and periodic monitoring of renal function in high-risk patients. …”
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Bullous Lupus: An Atypical Case of Refractory Disease in a Patient with Sulfa Allergy by Maria Salgado Guerrero, Oscar Mena Miranda, Ana B. Arevalo, Nevena Barjaktarovic, Barbara Mendez

“…This case highlights the importance of the prompt recognition of BSLE as the initial manifestations of SLE and illustrates the association of BSLE with severe disease and the benefit of concomitant use of dapsone with corticosteroids and other immunosuppressant drugs, even in patients with a history of sulfa allergy.…”
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Exploring the interactions of rapamycin with target receptors in A549 cancer cells: insights from molecular docking analysis by Sanjeev K. Ganesh, C. Subathra Devi

“…Abstract Rapamycin, a macrocyclic antibiotic derived from the actinomycetes Streptomyces hygroscopicus, is a widely used immunosuppressant and anticancer drug. Even though rapamycin is regarded as a multipotent drug acting against a broad array of anomalies and diseases, the mechanism of action of rapamycin and associated pathways have not been studied and reported clearly. …”
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Oxford-AstraZeneca Coronavirus Disease-2019 Vaccine-Induced Immune Thrombocytopenia on Day Two by Azhar Kareem Razzaq, Ameer Al-Jasim

“…ITP is treated with immunosuppression. Case Presentation. A 26-year-old Iraqi male laboratory analyst with an unremarkable medical history presented with severe thrombocytopenia 2 days after receiving the Oxford-AstraZeneca coronavirus disease-2019 vaccine. …”
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Listeria Rhombencephalitis Complicating Anti-TNF Treatment during an Acute Flare of Crohn’s Colitis by L. Stratton, G. R. Caddy

“…Patients with Crohn’s disease often require the use of immunosuppressant drugs to control disease activity. Such medication includes steroids, azathioprine, and biologic therapy. …”
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High on Cannabis and Calcineurin Inhibitors: A Word of Warning in an Era of Legalized Marijuana by Naomi Hauser, Tanmay Sahai, Rocco Richards, Todd Roberts

“…Tacrolimus, a potent immunosuppressant medication, acts by inhibiting calcineurin, which eventually leads to inhibition of T-cell activation. …”
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Polymyositis-Dermatomyositis and Interstitial Lung Disease in Pregnant Woman Successfully Treated with Cyclosporine and Tapered Steroid Therapy by Saito Mayu, Sakiko Isojima, Yoko Miura, Shinichiro Nishimi, Mika Hatano, Takahiro Tokunaga, Ryo Takahashi, Keiko Koide, Yusuke Miwa

“…Polymyositis-dermatomyositis is extremely rare during pregnancy, and immunosuppressive therapy should be administered after carefully considering the effects on both the mother and fetus. …”
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Challenges in Treating Statin-Associated Necrotizing Myopathy by Patrick Webster, Nicholas Wiemer, Abdalhamid Al Harash, Cody Marshall, Nazia Khatoon, Michael Lucke

“…Multiple patients required several immunosuppressant medications as well as intravenous immunoglobulin (IVIG) to achieve disease control. …”
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The Incidence and Risk Factors for Lower Limb Skin Graft Failure by Sumeet Reddy, Falah El-Haddawi, Michael Fancourt, Glenn Farrant, William Gilkison, Nigel Henderson, Stephen Kyle, Damien Mosquera

“…One-third of lower limb skin grafts went on to fail with increased BMI, peripheral vascular disease, and immunosuppressant medication use identified as significant risk factors.…”
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Mycophenolate Mofetil and Clostridium difficile-associated Colitis by A. I. Dolgushina, A. A. Selyanina, E. A. Mezenceva, A. G. Vasilenko, L. I. Pozdeeva, L. Yu. Zhuravleva, E. R. Olevskaya, E. A. Fedorova

“…Mycophenolate mofetil (MMF) is an active immunosuppressant with side effects affecting gastrointestinal tract (GIT). …”
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Cyclosporine and Herbal Supplement Interactions by D. Colombo, L. Lunardon, G. Bellia

“…Cyclosporine (CyA) is a well-known immunosuppressant with a narrow therapeutic window. Its bioavailability is affected by many other traditional drugs and herbal extracts. …”
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Manic-Like Psychosis Associated with Elevated Trough Tacrolimus Blood Concentrations 17 Years after Kidney Transplant by Giuseppe Bersani, Pietropaolo Marino, Giuseppe Valeriani, Valentina Cuoco, Claudia Zitelli, Claudia Melcore, Francesco Saverio Bersani

“…The use of antipsychotics may improve the severity of symptoms; but in order to obtain a complete remission, the reduction in the dose of tacrolimus, or its replacement with alternative immunosuppressant therapies, is recommended.…”
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Evaluation of the Effects of systemic Therapy on Inflammatory Markers and Disease Severity in Patients With Pemphigus by Mehmet Enes Güner, Perihan Ozturk, Mine müjde Kuş

“…Objective: In this study, our objective was to investigate changes in the inflammatory markers NLR, PLR, MPV, LMR, CRP and ESR, which are inflammatory markers, before treatment and during follow-up, and the correlation of disease severity with these markers in patients with pemphigus receiving IVIG and/or systemic immunosuppressant agents. Method: 76 pemphigus patients who received systemic treatment, and used these treatments for at least 6 months were included. …”
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Cost-Effectiveness of Extracorporeal Photopheresis in Patients With Chronic Graft-vs-Host Disease by Adrian Peacock, Frances C. Dehle, Oscar A. Mesa Zapata, Francesca Gennari, Maro R.I. Williams, Nada Hamad, Stephen Larsen, Simon J. Harrison, Colman Taylor

“…The analysis considered costs of second-line treatment and disease management including immunosuppressants, hospitalizations and subsequent therapy. …”
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Acknowledging and addressing real-world challenges to treating immune-related adverse events by Bonnie L Bermas, Mitchell S von Itzstein, David E Gerber, Alexa Meara

“…Currently, irAE treatment remains suboptimal in many areas, as many expert guidelines remain vague on the optimal selection, dosing, and duration of steroids and the use of other immunosuppressive agents. This coupled with delays in diagnosis and difficulties for patients accessing effective irAE treatment results in barriers to effective irAE care. …”
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Immunoprotective Effect of Seabuckthorn (Hippophae rhamnoides) and Glucomannan on T-2 Toxin-Induced Immunodepression in Poultry by T. Ramasamy, C. Varshneya, V. C. Katoch

“…The present investigation revealed that the seabuckthorn alone protected the immunosuppressant action of T-2 toxin, but seabuckthorn and glucomannan in combination provided an additive protection against T-2 toxicity.…”
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Effects of Storage Temperature and Time on Stability of Serum Tacrolimus and Cyclosporine A Levels in Whole Blood by LC-MS/MS by İbrahim Kaplan, Hatice Yüksel, Osman Evliyaoğlu, M. Kemal Basarali, Gülten Toprak, Leyla Çolpan, Velat Şen

“…Tacrolimus and cyclosporine A are immunosuppressant drugs with narrow therapeutic windows. …”
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Novel methotrexate long-acting system using ambroxol coating and hydroxypropyl methylcellulose encapsulation for preferential and enhanced lung cancer efficiency. by Samaa Abdullah, Najla Altwaijry, Meaad Alnakhli, Ghezlan ALenezi, Alaa A Al-Masud, Hanan Henidi, Yahya F Jamous

“…It's commonly used to treat lung cancer. MTX is an immunosuppressant following the above-mentioned mechanism of action due to its poor selectivity. …”
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Ruxolitinib Associated Tuberculosis Presenting as a Neck Lump by Eamon Shamil, David Cunningham, Billy L. K. Wong, Piyush Jani

“…It was hypothesized that use of Ruxolitinib through its selective inhibition of Janus-activated kinases 1 and 2 resulted in immunosuppression and miliary tuberculosis in this patient. …”
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Pneumocystis jirovecii Pneumonia in Patients with Nephrotic Syndrome: Application of Lymphocyte Subset Analysis in Predicting Clinical Outcomes by Yang Liu, Ke Zheng, Yecheng Liu, Huadong Zhu

“…Purpose. With immunosuppressants being widely used, Pneumocystis jirovecii pneumonia (PCP) has been increasing and could be life-threatening among HIV-negative patients. …”
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