Autoimmune Hepatitis in Children: The Current State of the Problem by G. V. Volynets, A. I. Khavkin, T. A. Skvortsova, V. V. Matkash

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Exhaustion of CD8pos central memory regulatory T cell differentiation is involved in renal allograft rejection by Florian Kälble, Jonas Leonhard, Jonas Leonhard, Martin Zeier, Oliver Zivanovic, Matthias Schaier, Andrea Steinborn

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Use of Cyclosporine in Uterine Transplantation by Srdjan Saso, Karl Logan, Yazan Abdallah, Louay S. Louis, Sadaf Ghaem-Maghami, J. Richard Smith, Giuseppe Del Priore

“…Cyclosporine A (CsA) is an immunosuppressant widely used by transplant recipients. …”
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Dermatological Disorders following Liver Transplantation: An Update by Dipesh Kumar Yadav, Xue li Bai, Tingbo Liang

“…Patients undergoing liver transplantation (LT) are at a high risk of dermatological complications compared to the general population as a result of long-term use of immunosuppressant. However, the risk is not as high as other solid organ transplantations (SOT), particularly for skin cancer. …”
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Efficacy and Safety of Sitagliptin for the Treatment of New-Onset Diabetes after Renal Transplantation by Brian P. Boerner, Clifford D. Miles, Vijay Shivaswamy

“…Renal function and immunosuppressant levels remained stable. Analysis of long-term followup (32.5 ± 17.8 months) revealed that 17/22 patients remained on sitagliptin (mean hemoglobin A1c < 7%) with 9/17 patients remaining on sitagliptin alone. …”
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Long-Term Follow-Up after Intravenous Immunoglobulin Therapy in Patients with Severe Ocular Mucous Membrane Pemphigoid Unresponsive to Conventional Therapy by Stefania Leuci, Massimo Amato, Elena Calabria, Raffaele Piscopo, Fausto Tranfa, Gianrico Spagnuolo, Michele Davide Mignogna

“…In its most severe forms, this disease needs systemic therapy, usually based on steroids and immunosuppressant agents. In unresponsive cases or in the presence of contraindications or severe side effects due to conventional systemic corticosteroid and/or immunosuppressant therapy, a therapy shift to high-dose intravenous immunoglobulins (IVIg) has been recommended in other reports. …”
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The hope as social commitment in the processing of tacrolimus by Alessandra Suzin Bertan, Marco Aurélio Cremasco

“… The 2020 year shows the fragility of the human been due to a virus that affects the people dependent of immunosuppressant agents. The aim of this paper it to contextualize the importance of the hope as essential element in chemical design to obtain tacrolimus, and to professionals involved in this research. …”
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Low regulatory T-cells frequency is associated with graft rejection after small bowel transplantation: Clinical and experimental evidence. by Rodrigo Papa-Gobbi, Pablo Stringa, Maria Virginia Gentilini, Ivana Ivanoff, Mariana Machuca, Nidia Monserrat Arreola, Javier Serradilla, Karla Estefanía-Fernández, Paloma Talayero, María Velayos, Elena Sánchez-Zapardiel, Gabriel Gondolesi, Ane Andrés-Moreno, Martin Rumbo, Francisco Hernández-Oliveros

“…Experimental allogenic-heterotopic small bowel transplantation was performed in rats and animals divided into 3 groups: non-immunosuppressant treatment, rapamycin (2 mg/kg), and tacrolimus (0.6 mg/kg) treatment. …”
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Polyoma BK Virus: An Oncogenic Virus? by Syed Hassan, Zaid Alirhayim, Syed Ahmed, Syed Amer

“…He subsequently developed BK virus nephropathy related to chronic immunosuppressant therapy. Three years later, misfortune struck again, and he developed adenocarcinoma of the bladder.…”
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A Case of Peripheral Ulcerative Keratitis Associated with Autoimmune Hepatitis by Hamoon Eshraghi, Aria Mahtabfar, Mohammad H. Dastjerdi

“…The patient was treated with topical and systemic steroids, immunosuppressant drugs (azathioprine and mycophenolate mofetil), a biologic (rituximab), and surgery (conjunctival resection), and the peripheral ulcerative keratitis epithelialized but ultimately led to corneal perforation. …”
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Successful Treatment of Disseminated Subcutaneous Panniculitis-Like T-Cell Lymphoma with Single Agent Oral Cyclosporine as a First Line Therapy by Nida Iqbal, Vinod Raina

“…Cyclosporine, an immunosuppressant, has shown good responses in relapsed/refractory SPTL; however its use in first line setting is not well established. …”
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Epidermodysplasia Verruciformis: A Clinicopathologic Review of Two Cases by Tummidi Santosh, Tanya Sharma, Deepti Joshi, Dinesh Prasad Asati, Sanjeev Vijay Choudhary, Neelkamal Kapoor

“…It can also occur as an acquired entity in patients with immunocompromised status, human immunodeficiency virus (HIV) infection, and immunosuppressant therapy. Hereby, we report two cases of EV, histologically diagnosed on skin punch biopsy, both presented with a clinical history of macular/verrucous lesions in various sun-exposed body regions. …”
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Diagnosis and Management of Interstitial Lung Disease in Patients with Connective Tissue Diseases by Matthew Koslow, Mehrnaz Maleki-Fischbach, Rebecca C. Keith

“…In the absence of guidelines regarding how CTD-ILDs should be treated, clinicians face difficult decisions on when to use immunosuppressant and anti-fibrotic therapies. The importance of a multidisciplinary and individualized approach to the diagnosis and management of CTD-ILD is highlighted in the three case studies that we describe in this article.…”
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Medication-related hospitalisations in patients with SLE by Arielle Mendel, Évelyne Vinet, Sasha Bernatsky, Christian A Pineau, Fares Kalache, Louis-Pierre Grenier, Emily G McDonald, Michèle Stanciu, Joo-Young Esther Lee, Gregory Clark

“…Renal involvement, polypharmacy, prednisone and immunosuppressant use were associated with hospitalisation related to an ADE, highlighting a vulnerable group.…”
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The Safety of Systemic Treatments That Can Be Used for Geriatric Psoriasis Patients: A Review by Jillian W. Wong, John Y. M. Koo

“…Patients with moderate-to-severe psoriasis are often treated with systemic immunosuppressant agents that decrease immune system function. …”
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Dermatomyositis following resection of thyroid and breast cancer: a case report and literature review by Miaomiao Yang, Jiannan Liu

“…This patient subsequently received systemic immunosuppressant therapy and thus dermatomyositis gradually resolved.ConclusionsA combination of thyroid cancer and breast cancer is thought to be very rare, especially in patients who develop dermatomyositis after thyroidectomy and mastectomy. …”
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Atypical Presentation of Kimura’s Disease in a Male Patient: A Case Report and Review of Literature by Zahra A. Natsha, Islam A. Hamarsheh, Rawan S. Utt, Bassam Abu Alrob, Adnan A. Wahdan

“…The patient was managed with steroids and an immunosuppressant (Azathioprine) with a moderate response for two years. …”
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Clinical Implications for the Timely Diagnosis of Mycobacterium marinum in the Age of Biologic Therapy: A Case Report and Review of the Literature by Chris J. Lata, Kelle Edgar, Stephen Vaughan

“…The natural history of this infection can be altered if the host is immunosuppressed, leading to disseminated presentations. …”
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Long-Term Clinical Behavior of Jejunoileal Involvement in Crohn’s Disease by Hugh J Freeman

“…Moreover, pharmacological therapies with corticosteroids and immunosuppressant drugs were rarely successful, with virtually all patients requiring at least one, and usually multiple, intestinal resections. …”
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Tacrolimus Toxicity due to Biliary Obstruction in a Combined Kidney and Liver Transplant Recipient by Samuel Chan, Michael T. Burke, David W. Johnson, Ross S. Francis, David W. Mudge

“…The immunosuppressant tacrolimus has a narrow therapeutic window, necessitating therapeutic drug monitoring to maintain efficacy and minimise toxicity. …”
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