Composition of peripheral blood immune cell compartment in stage 5 chronic kidney disease is affected by smoking and other risk factors associated with systemic inflammatory respon... by Ivan Zahradka, Filip Tichanek, Lucia Majercikova, Jana Duskova, Mathias Streitz, Stephan Schlickeiser, Stephan Schlickeiser, Klara Osickova, Vojtech Petr, Petra Hruba, Petra Reinke, Ondrej Viklicky, Ondrej Viklicky

“…Variables that significantly affected immune cell composition were then included in a subsequent series of Poisson regression models, assessing predictors influence on the counts of individual immune cell subpopulations.ResultsCompared to healthy controls, CKD5 patients presented with B cell lymphopenia across all measured subsets except for plasmablasts, T cell lymphopenia with an immunosenescent phenotype predominantly in the CD4+ compartment, and significantly higher counts of LIN-HLA-DR+ antigen-presenting cells, mainly due to an increase in myeloid dendritic cell subpopulations. …”
Get full text

Comparison of circulating immune signatures across different consensus molecular subtypes (CMS) and between left- and right-sided lesions in stage II colorectal cancer using single... by Pin Gao, Chuanyong Zhou, Hong Yang, Shunyu Deng, Beihai Jiang, Zaozao Wang, Jiabo Di, Xiangqian Su

“…Patients with right-sided CRC had significantly higher frequencies of circulating CD8+CD27-CD28- immunosenescent T cell subsets compared to patients with left-sided CRC. …”
Get full text