Enhanced influenza vaccination for older adults in Europe: a review of the current situation and expert recommendations for the future by Gaëtan Gavazzi, Bertrand Fougère, Olivier Hanon, Isabel Leroux-Roels, Etienne Brochot, Elodie Blanchard, Colin A Russell, Marc Paccalin, Tino F Schwarz

“…Introduction Influenza causes considerable morbidity and mortality in Europe, particularly among older adults due to comorbidities, as well as immunosenescence and inflammaging, which contribute to a diminished immune response. …”
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Anti-Aging Potential of Avocado Oil via Its Antioxidant Effects by Olin Torres-Isidro, Marcela González-Montoya, Manuel Alejandro Vargas-Vargas, Ulises Florian-Rodriguez, Claudia Isabel García-Berumen, Rocío Montoya-Pérez, Alfredo Saavedra-Molina, Elizabeth Calderón-Cortés, Alain Raimundo Rodríguez-Orozco, Christian Cortés-Rojo

“…This phenomenon is the result of the convergence of multiple processes, including mitochondrial dysfunction, fibrosis, inflammation, dysregulation of cell death processes, and immunosenescence. These processes have as their point of convergence an increase in the production of ROS. …”
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GRSF1 loss in THP-1 macrophages promotes senescence-associated transcription in neighboring fibroblasts by Younggi Lee, Seokwoo Jo, Mi-Hee Lim, Sangik Hwang, Sohyeon Jang, Kyuseok Kim, Sung-Jin Yoon, Jian Sima, M. Laura Idda, Kyoung Mi Kim, Myriam Gorospe, Chungoo Park, Ji Heon Noh

“…Abstract Immunosenescence, the age-associated decline in immune function, is accompanied by altered macrophage phenotypes and increased chronic inflammation. …”
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Immunological characteristics in elderly COVID-19 patients: a post-COVID era analysis by Yunhui Li, Yuan Chen, Jing Liang, Yajie Wang

“…BackgroundAdvanced age is a primary risk factor for adverse COVID-19 outcomes, potentially attributed to immunosenescence and dysregulated inflammatory responses. …”
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Respiratory Vaccines in Older Adults: A Bibliometric Analysis and Future Research Agenda by Jose F. Parodi, Fernando Runzer-Colmenares, Carlos Cano-Gutiérrez, José Luis Dinamarca-Montecinos, Patricio Bendía-Gomez de La Torre, Paulo Fortes Villas Boas, Javier Flores-Cohaila, Diego Urrunaga-Pastor, Luis Miguel Gutiérrez-Robledo

“…Background/Objectives: Respiratory infections impact older adults due to immunosenescence and comorbidities, resulting in increased healthcare costs and mortality. …”
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Efficacy of the power centering for seniors intervention on physical functional performance in older community-dwelling adults: a secondary analysis of a randomised controlled tria... by Roland Rössler, Mathias Birrer, Aaron Haslbauer, Jay Goldfarb, Anton De Spiegeleer, Irene Härdi, Reto W. Kressig

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Glycemic control and associated factors in patients with type 2 diabetes in Southwest Ethiopia: a prospective observational study by Aster Wakjira Garedo, Gorfineh Teshome Tesfaye, Rahel Tamrat, Evelien Wynendaele

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A bibliometric and visual analysis of the impact of senescence on tumor immunotherapy by Zixu Liu, Zixu Liu, Zixu Liu, Yuchen Mao, Shukai Wang, Haoyu Zheng, Kangping Yang, Liang Yang, Peng Huang, Peng Huang

“…Vosviewer-based hierarchical clustering further categorized study characteristics into six clusters, including two major clusters of immunotherapy research, immunosenescence-related research factors, and timeline distributions suggesting that cellular senescence and tumor progression is a relatively new research cluster that warrants further exploration and development. …”
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Gut Microbiota Modulation by Lysozyme as a Key Regulator of Vascular Inflammatory Aging by Chenyang Zhang, Xin Zhao, Hang Zhang, Tongtong Wang, Zhenyu Zhang, Yilin Yin, Hui Wang, Xiao Tong, Yuzheng Xue, Yahong Zhou, Fenglai Yuan, Xiuwu Bian, Hong Wei, Yuan Huang, Tianhao Liu

“…Vascular inflammatory aging is strongly associated with multimorbidity, including immunosenescence. Here, bioinformatic analysis indicated elevated expression of the lysozyme (LYZ) gene in age-dependent vascular diseases. …”
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Harnessing TAGAP to improve immunotherapy for lung squamous carcinoma treatment by targeting c-Rel in CD4+ T cells by Peian Cai, Haibo Sun, Tongmeng Jiang, Huawei Li, Dejing Huang, Xiaopei Hao, Wei Wang, Wenqun Xing, Guanghui Liang

“…Abstract Revealing the immunosenescence, particularly in CD4+ T cell function in lung squamous carcinoma (LUSC) assists in devising individual treatment strategies. …”
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RETRACTED ARTICLE: Efficacy and immunogenicity of MultiTEP-based DNA vaccines targeting human α-synuclein: prelude for IND enabling studies by Changyoun Kim, Armine Hovakimyan, Karen Zagorski, Tatevik Antonyan, Irina Petrushina, Hayk Davtyan, Gor Chailyan, Jonathan Hasselmann, Michiyo Iba, Anthony Adame, Edward Rockenstein, Marcell Szabo, Mathew Blurton-Jones, David H. Cribbs, Anahit Ghochikyan, Eliezer Masliah, Michael G. Agadjanyan

“…To ensure sufficient therapeutic concentrations of anti-α-Syn antibodies in the periphery and CNS, we developed four α-Syn DNA vaccines based on the universal MultiTEP platform technology designed especially for the elderly with immunosenescence. Here, we are reporting on the efficacy and immunogenicity of these vaccines targeting three B-cell epitopes of hα-Syn aa85–99 (PV-1947D), aa109–126 (PV-1948D), aa126–140 (PV-1949D) separately or simultaneously (PV-1950D) in a mouse model of synucleinopathies mimicking PD/DLB. …”
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Thymic hyperplasia after autologous hematopoietic stem cell transplantation in multiple sclerosis: a case series by Alice Mariottini, Alice Mariottini, Riccardo Boncompagni, Diletta Cozzi, Edoardo Simonetti, Anna Maria Repice, Valentina Damato, Valentina Damato, Mirella Giordano, Vittorio Miele, Chiara Nozzoli, Luca Massacesi, Luca Massacesi

“…Radiological evidence of thymic hyperplasia after AHSCT was previously reported in patients with systemic sclerosis, but, to our knowledge, it has not been described in multiple sclerosis (MS), where premature thymic involution has been observed and immunosenescence might be accelerated by disease-modifying treatments (DMTs).Participants and methodsmonocentric case series including MS patients who performed a chest CT scan for clinical purposes after having received AHSCT (BEAM/ATG regimen) for aggressive MS failing DMTs. …”
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Viral infections and immune modulation in bladder cancer: implications for immunotherapy by Lívia Bitencourt Pascoal, Mehrsa Jalalizadeh, Gabriela Barbosa, Andrea Nazare Monteiro Rangel da Silva, Maria Alice Freitas Queiroz, Ekaterina Laukhtina, Shahrokh F. Shariat, Alessandra Gambero, Leonardo O. Reis

“…Despite its success, variability in response rates suggests that host immune status, influenced by persistent infections, immunosenescence, and antigenic overload, may play a crucial role in therapeutic effectiveness. …”
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Aging‐related biomarkers in testicular cancer survivors after different oncologic treatments by A. Carballo‐Muñoz, G. Lima, L. Llorente, Y. A. Remolina‐Bonilla, S. Jaime‐Casas, A. Otamendi‐Lopez, R. A. Ortiz‐Guerra, Hugo E. Velazquez, Y. Atisha‐Fregoso, M. T. Bourlon

“…Abstract Purpose Testicular cancer survivors (TCS) exposed to chemotherapy have an increased expression of CDKN2A/p16INK4a and a lymphocyte phenotype associated with immunosenescence. We seek to define whether the immunosenescent phenotype is associated with chemotherapy. …”
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Exploring the Association Between <i>Torquetenovirus</i> Viral Load and Immunosuppressive Drug Exposure in Lung Transplantation by Victor M. Mora, Emilio Rodrigo, David Iturbe-Fernández, Sheila Izquierdo, Sandra Tello, Adalberto Benito-Hernández, Maria Mar García-Saiz, David San Segundo, María Victoria Francia, Jose M. Cifrián

“…Other variables, such as inflammation, immunosenescence, and frailty, may influence the overall level of immunosuppression and TTV load.…”
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Expansion of CD57+ CD8 T cells in common variable immunodeficiency with hepatopathy and CMV infection by Patrick Bez, Patrick Bez, Patrick Bez, Enrico Santangeli, Enrico Santangeli, Sigune Goldacker, Sigune Goldacker, Ulrich Salzer, Ulrich Salzer, Klaus Warnatz, Klaus Warnatz

“…The loss of significant association with increasing age might corroborate the suggestion of premature immunosenescence in CVID. Significantly higher values of CD57+ CD8 T cells were seen in patients with a complicated clinical phenotype, and especially associated with the presence of splenomegaly, status post-splenectomy, and hepatic disease. …”
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Outer retina micro-inflammation is driven by T cell responses prior to retinal degeneration in early age-related macular degeneration by Lucas Stürzbecher, Lucas Stürzbecher, Lucas Stürzbecher, Lucas Stürzbecher, Hendrik Bartolomaeus, Hendrik Bartolomaeus, Hendrik Bartolomaeus, Hendrik Bartolomaeus, Theda U. P. Bartolomaeus, Theda U. P. Bartolomaeus, Theda U. P. Bartolomaeus, Theda U. P. Bartolomaeus, Sylvia Bolz, Andjela Sekulic, Marius Ueffing, Marius Ueffing, Simon J. Clark, Simon J. Clark, Simon J. Clark, Nadine Reichhart, Sergio Crespo-Garcia, Nicola Wilck, Nicola Wilck, Nicola Wilck, Nicola Wilck, Olaf Strauß

“…T cells were intimately associated with the RPE, suggesting transmigration and participating in local micro-inflammation.DiscussionOur data support that activation and accumulation of memory T cells can be considered as a hallmark of early AMD, and that adaptive immunosenescence likely to contribute to the chronic inflammation associated with RPE damage and the progression to large lesions as seen in GA.…”
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Time-restricted eating reveals a “younger” immune system and reshapes the intestinal microbiome in human by Yiran Chen, Xi Li, Ming Yang, Chen Jia, Zhenghao He, Suqing Zhou, Pinglang Ruan, Yikun Wang, Congli Tang, Wenjing Pan, Hai Long, Ming Zhao, Liwei Lu, Weijun Peng, Arne Akbar, Irene XY. Wu, Song Li, Haijing Wu, Qianjin Lu

“…However, the effect of TRE on the human immune system, especially on immunosenescence, intestinal microbiome, and metabolism remains unclear. …”
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Decoupled dynamics of absolute and relative lymphocyte counts and age−polarized CD4+/CD8+ ratio in infants versus older adults by Ting Ge, Ting Ge, Ting Ge, Guixin He, Guixin He, Guixin He, Qian Cui, Qian Cui, Qian Cui, Shuangcui Wang, Shuangcui Wang, Shuangcui Wang, Zekun Wang, Yingying Xie, Yingying Xie, Yingying Xie, Yuanyuan Tian, Yuanyuan Tian, Yuanyuan Tian, Juyue Zhou, Juyue Zhou, Juyue Zhou, Wentao Li, Wentao Li, Baohui Wang, Keming Zhang, Jianchun Yu, Jianchun Yu

“…The age-dependent polarization of the CD4+/CD8+ ratio may serve as a potential biomarker of immunosenescence, offering valuable reference points for age-tailored vaccination strategies and immune risk stratification in the elderly.…”
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Oxidative stress, microparticles, and E-selectin do not depend on HIV suppression by Katerina Havlickova, Svatava Snopkova, Miroslav Pohanka, Radek Svacinka, David Vydrar, Petr Husa, Jirina Zavrelova, Filip Zlamal, Lenka Fabianova, Miroslav Penka, Petr Husa

“…Markers of oxidative stress, inflammation, and endothelial activation were investigated in people with HIV on antiretroviral treatment to determine whether they had an immunosenescent phenotype that might predispose to the development of premature age-related diseases. …”
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