Therapeutic Activity of Lenalidomide in Mantle Cell Lymphoma and Indolent Non-Hodgkin’s Lymphomas by Marco Gunnellini, Lorenzo Falchi

“…Lenalidomide is an immunomodulatory drug with activity in multiple myeloma, myelodisplastic syndrome and chronic lymphoproliferative disorders. …”
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Perspectives for Clinical Translation of Adipose Stromal/Stem Cells by Mimmi Patrikoski, Bettina Mannerström, Susanna Miettinen

“…Great interest and investment have been placed in efforts to exploit the allogeneic use and immunomodulatory and anti-inflammatory effects of ASCs. …”
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Are Systematic Screening for Vitamin D Deficiency and Vitamin D Supplementation Currently Feasible for Ankylosing Spondylitis Patients? by Mickael Essouma, Jean Jacques N. Noubiap

“…We will review the immunomodulatory role of vitamin D and its contribution in initiation and progression of AS, as well as how they would determine the occurrence of comorbid conditions. …”
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The Role of T Helper (TH)17 Cells as a Double-Edged Sword in the Interplay of Infection and Autoimmunity with a Focus on Xenobiotic-Induced Immunomodulation by Nasr Y. A. Hemdan, Ahmed M. Abu El-Saad, Ulrich Sack

“…This perception is learned from experimental models of infection and epidemiologic studies and clearly underscores the interplay of exposure to such immunomodulatory elements with pre- or postexposure infectious events. …”
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Desensitization: Overcoming the Immunologic Barriers to Transplantation by Supreet Sethi, Jua Choi, Mieko Toyoda, Ashley Vo, Alice Peng, Stanley C. Jordan

“…Over the last decade, several immunomodulatory therapies have emerged allowing for increased access to kidney transplantation for the immunologically disadvantaged group of HLA sensitized end stage kidney disease patients. …”
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Mesenchymal Stem Cells and Cardiovascular Disease: A Bench to Bedside Roadmap by Manuel Mazo, Miriam Araña, Beatriz Pelacho, Felipe Prosper

“…Moreover, their immunomodulatory capacity has opened up their allogenic use, consequently broadening the possibilities for their application. …”
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Oxidative Stress in Patients With Nongenital Warts by Sezai Sasmaz, Ozer Arican, Ergul Belge Kurutas

“…Therefore, we propose an argument for the appropriateness to give priority to immunomodulatory treatment alternatives instead of destructive methods in patients with demonstrated oxidative stress.…”
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Therapeutic implications for the PD-1 axis in cerebrovascular injury by James Feghali, Christopher M. Jackson

“…The therapeutic potential of PD-1 agonism in ischemic stroke, intracerebral hemorrhage, subarachnoid hemorrhage-related vasospasm, and traumatic brain injury rests on the notion of harnessing the immunomodulatory function of immune checkpoint pathways to temper the harmful effects of immune overactivation and secondary injury while promoting repair and recovery. …”
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Contribution of Gut Microbiota to Immune Tolerance in Infants by Constanza S. Méndez, Susan M. Bueno, Alexis M. Kalergis

“…The microbiota features may be shaped by a plethora of immunomodulatory mechanisms, including a predominant role of Tregs and the transcription factor FOXP3. …”
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MSCs: Delivery Routes and Engraftment, Cell-Targeting Strategies, and Immune Modulation by Thomas J. Kean, Paul Lin, Arnold I. Caplan, James E. Dennis

“…The differentiation, trophic, and immunomodulatory characteristics of MSCs contribute to their therapeutic effects. …”
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Phytochemical constituents and biological activities of longan (Dimocarpus longan Lour.) fruit: a review by Xiaofang Zhang, Sen Guo, Chi-Tang Ho, Naisheng Bai

“…Longan pulp has abundant nutritional phytochemicals such as protein, carbohydrate, vitamin C, polysaccharides, polyphenols, which shows multiple biological activities including antioxidant, immunomodulatory and antitumor effects. Longan pericarp also demonstrates biological activities because of its rich content of polysaccharides and polyphenols. …”
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Immunomodulation as the main characteristic of vegetable oils: a review by D.P. Tres, S.T. Nicolau, T.S. Ayala, R.A. Menolli

“…Most of these benefits come from the immunomodulatory effects of vegetable oils, mainly the anti-inflammatory activities triggered by the unsaturated fatty acids present in these oils. …”
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Side effects of retinoid therapy on the quality of vision by Bergler-Czop Beata, Bilewicz-Stebel Monika, Stańkowska Anna, Bilewicz-Wyrozumska Teresa

“…They have anti-seborrhoeic, immunomodulatory and anti-inflammatory effects (1, 2). …”
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Compliant immune response of silk-based biomaterials broadens application in wound treatment by Zhiqiang Tian, Hong Chen, Ping Zhao

“…The immune response directly influences wound healing cycle, and the extensive immunomodulatory functions of silk-based nanoparticles and hydrogels have attracted wide attention. …”
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Traditional Chinese Medicine Protects against Cytokine Production as the Potential Immunosuppressive Agents in Atherosclerosis by Yan Ren, Wei Qiao, Dongliang Fu, Zhiwei Han, Wei Liu, Weijie Ye, Zunjing Liu

“…This review focuses on plants that have immunomodulatory effects on the production of inflammatory cytokine burst and are used in Chinese traditional medicine for the prevention and therapy of atherosclerosis.…”
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Myelodysplastic Syndrome with Transfusion Dependence Treated with Venetoclax by Waqas Jehangir, Alexander Karabachev, Taimoor Jahangir, Elvira Umyarova

“…Hypomethylating agents, azacitidine and decitabine, and the immunomodulatory agent, lenalidomide, are the only FDA approved medications for the treatment of MDS, all of which are noncurative. …”
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Mesenchymal Stem Cell-derived Exosomes: Novel Therapeutic Approach for Inflammatory Bowel Diseases by Cheng-mei Tian, Mei-feng Yang, Hao-ming Xu, Min-zheng Zhu, Yuan Zhang, Jun Yao, Li-sheng Wang, Yu-jie Liang, De-feng Li

“…The anti-inflammatory and immunomodulatory activities of mesenchymal stem cell (MSC)-derived Exos (MSC-Exos) provide a rationale for novel cell-free therapies for inflammatory bowel disease (IBD). …”
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Role of the Microenvironment in Mesenchymal Stem Cell-Based Strategies for Treating Human Liver Diseases by Shan-jing Xu, Li-ping Ye, Wei Wang, Ya-hong Chen, Jian Dong, Xin-li Mao, Shao-wei Li

“…Mesenchymal stem cell (MSC) therapy is a novel treatment for patients with different liver diseases due to its vast expansion potential and distinctive immunomodulatory properties. Despite several preclinical trials having confirmed the considerable efficacy of MSC therapy in liver diseases, the questionable safety and efficacy still limit its application. …”
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Vitiligo in a Patient Treated with Interferon Alpha-2a for Behçet’s Disease by Esra Guney, Gulunay Akcali, Betul Ilkay Akcay, Cihan Unlu, Gurkan Erdogan, Tahir Kansu Bozkurt, Huseyin Bayramlar

“…Interferon treatment in various diseases have also been observed causing certain autoimmune diseases such as vitiligo because of its immunomodulatory activity. The association between IFN therapy and vitiligo has been reported in the literature. …”
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Strategies to Enhance Mesenchymal Stem Cell-Based Therapies for Acute Respiratory Distress Syndrome by Jibin Han, Yanmin Li, Yuanyuan Li

“…MSC-based therapies have the advantage of targeting nearly all pathophysiological components of ARDS by means of a variety of secreted trophic factors, exerting anti-inflammatory, antioxidative, immunomodulatory, antiapoptotic, and proangiogenic effects, resulting in significant structural and functional recovery following ARDS in various preclinical models. …”
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