Teaching an old dog new tricks: re-engineering IL-2 for immuno-oncology applications by Mario Sznol, Naiyer Rizvi

“…Interleukin-2 has become a prominent focus of preclinical and clinical investigation, because of its known clinical activity, the important role of this cytokine in immune biology, and the ability to engineer variant proteins with potentially improved antitumor immunomodulatory activity and reduced toxicity. Bempegaldesleukin, the first of the modified IL-2 agents to reach phase 3 evaluation in combination with an anti-PD-1, did not improve outcome for patients with metastatic melanoma and renal carcinoma. …”
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Role of Leukotrienes on Protozoan and Helminth Infections by Alexandre P. Rogerio, Fernanda F. Anibal

“…Herein, in this paper, we showed the immunomodulatory and pathogenic roles of LTs during the helminth and protozoan infections.…”
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A Comprehensive Review on the Chemical Composition and Pharmacological Activities of Acacia catechu (L.f.) Willd. by Bikash Adhikari, Babita Aryal, Bibek Raj Bhattarai

“…On preliminary assessments, A. catechu is demonstrated as a significant wellspring of bioactive compounds with a wide range of biological and pharmaceutical applications such as antidiabetic, antioxidant, antimicrobial, anticancer, antidiarrheal, anti-inflammatory, antiviral, hepatoprotective, immunomodulatory, and so on. Although the metabolites from the plant are reported with diverse pharmacological applications, there is little information in regards to toxicity and clinical trials on bioactive compounds of this plant. …”
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A new paradigm for cancer immunotherapy: targeting immunogenic cell death-related noncoding RNA by Guojuan Sun, Ling He

“…Accordingly, ICD-related ncRNAs hold promise as novel therapeutic targets for optimizing the efficacy of cancer immunotherapy. However, the immunomodulatory properties of ICD-related ncRNAs have not yet been comprehensively summarized. …”
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Limosilactobacillus reuteri - a probiotic gut commensal with contextual impact on immunity by Amanda H. Lee, Daphne Michelle Rodriguez Jimenez, Marlies Meisel

“…Modern probiotics have been extensively studied for their immunomodulatory effects. Limosilactobacillus reuteri (L. reuteri), a widely used probiotic, has garnered significant attention for its systemic immune-regulatory properties, particularly in relation to autoimmunity and cancer. …”
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Inflammatory Bowel Disease and Statins by V. V. Genkel, I. I. Shaposhnik

“…Statins exhibit immunomodulatory effects, which are of particular importance with regard to IBD treatment. …”
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Extracellular vesicles from fifth-stage larval Angiostrongylus cantonensis upregulate cholesterol biosynthesis and suppress NLRP2-associated inflammatory responses in mouse astrocy... by Chien-Ju Cheng, Lian-Chen Wang, Lichieh Julie Chu, Kuang-Yao Chen, Ching-Yun Huang, Kuo-Lun Lan, Kuo-Yang Huang

“…The highly abundant proteins in L5 EVs that have immunomodulatory or pathogenic potential in the host deserve further investigation. …”
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Effects of Macrofungal Polysaccharides Combined with Vemurafenib on Melanoma and Its Associated Mechanism by Wenya Wu, Zhigang Su, Shasha Fan

“…In addition, the combination of MFPS1 and Vemurafenib can enhance the immunomodulatory activity of melanoma-bearing mice as well as elicit the activation and proliferation of B cells and T cells.…”
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The Role of TGFβ Signaling in Squamous Cell Cancer: Lessons from Mouse Models by Adam B. Glick

“…TGFβ1 is a member of a large growth factor family including activins/inhibins and bone morphogenic proteins (BMPs) that have a potent growth regulatory and immunomodulatory functions in normal skin homeostasis, regulation of epidermal stem cells, extracellular matrix production, angiogenesis, and inflammation. …”
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Mesenchymal Stromal Cells and Tissue-Specific Progenitor Cells: Their Role in Tissue Homeostasis by Aleksandra Klimczak, Urszula Kozlowska

“…However, MSCs do not only contribute to structurally tissue repair but also MSC possess strong immunomodulatory and anti-inflammatory properties and may influence in tissue repair by modulation of local environment. …”
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Therapeutic potential of mesenchymal stem cells for fungal infections: mechanisms, applications, and challenges by Yangjie Gao, Zhe Ji, Jingyu Zhao, Julin Gu

“…Mesenchymal stem cells (MSCs), characterized by multilineage differentiation potential and immunomodulatory properties, are considered an emerging strategy for the treatment of FIs. …”
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Inflammatory Bowel Diseases: When Natural Friends Turn into Enemies—The Importance of CpG Motifs of Bacterial DNA in Intestinal Homeostasis and Chronic Intestinal Inflammation by Florian Obermeier, Claudia Hofmann, Werner Falk

“…In this review we focus on the role of bacterial DNA which is a potent immunomodulatory component of the bacterial flora. Bacterial DNA has been shown to be protective against experimental colitis. …”
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Modern Approaches to Vaccination of Patients with Chronic Liver Diseases and Inflammatory Bowel Diseases against a Novel Coronavirus Infection by A. A. Sheptulin, V. T. Ivashkin

“…IBD patients are also subject to vaccination, although the immunomodulatory drugs which they take may reduce its effectiveness. …”
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Challenges and limitations in using bacterial metabolites as immunomodulators by Chinnashanmugam Saravanan, Nandana Karrath Gopinath, Raja Ganesan, Durairaj Thirumurugan

“…Harnessing the immunomodulatory potential of bacterial metabolites opens up exciting possibilities for treating various immune-related disorders. …”
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Anticytotoxic T-Lymphocyte Antigen-4 Induced Autoimmune Hypophysitis: A Case Report and Literature Review by Deborah Majchel, Mary T. Korytkowski

“…Autoimmune hypophysitis, a previously described rare disorder, is being recognized more frequently as a side effect of novel immunomodulatory agents used in the treatment of malignancies such as melanoma. …”
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Effect of Methylation on Storage Properties of Lacticaseibacillus paracasei as Analyzed by Untargeted Metabolomics by YOU Mingkun, ZHANG Wenyi

“…Lacticaseibacillus paracasei Zhang is an excellent strain with probiotic properties such as immunomodulatory and antioxidant activities. DNA methylation is an important epigenetic mechanism that plays a key role in many physiological processes in bacteria. …”
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Promising Markers in the Context of Mesenchymal Stem/Stromal Cells Subpopulations with Unique Properties by Agnieszka Smolinska, Aleksandra Bzinkowska, Paulina Rybkowska, Magdalena Chodkowska, Anna Sarnowska

“…Such populations differ in specialization degree, proliferation, and immunomodulatory properties or exhibit other additional properties such as increased angiogenesis capacity. …”
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Current Development of Mesenchymal Stem Cell-Derived Extracellular Vesicles by Bingyi Zheng, Xueting Wang, Meizhai Guo, Chi-Meng Tzeng

“…They play a critical role in cell therapy due to their powerful immunomodulatory and regenerative effects. Recent studies suggest that one of the key therapeutic mechanisms of MSCs seems to derive from their paracrine product, called extracellular vesicles (EVs). …”
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Glutamate Receptors in Neuroinflammatory Demyelinating Disease

“…However, over the past decade, a group of compounds that suppress EAE but have no apparent immunomodulatory activity have emerged. These drugs interact with the N-methyl-D-aspartate (NMDA) and <mml:math alttext="$alpha$"><mml:mi>&#x03B1;</mml:mi> </mml:math>-amino-3-hydroxy-5-isoxazolepropionic acid (AMPA)/kainate family of glutamate receptors reported to control neurovascular permeability, inflammatory mediator synthesis, and resident glial cell functions including CNS myelination. …”
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Mesenchymal Stem Cells and Inflammatory Cardiomyopathy: Cardiac Homing and Beyond by S. Van Linthout, Ch. Stamm, H.-P. Schultheiss, C. Tschöpe

“…Mesenchymal stem cells (MSCs) have the advantage over other stem cells that they possess immunomodulatory features, making them attractive candidates for the treatment of inflammatory cardiomyopathy. …”
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