Leveraging radiotherapy to improve immunotherapy outcomes: rationale, progress and research priorities by Faith Hartley, Martin Ebert, Alistair M Cook

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A hypomorphic Il2rb mutant mouse model recapitulates and reveals mechanisms of human T cell immune dysregulation in IL-2Rβ deficiency by Berenice Cabrera-Martinez, Josselyn E. Garcia-Perez, Ryan M. Baxter, Victor G. Lui, Tusharkanti Ghosh, Ahmet Eken, Zander Kostka-Newman, John Rhey Mhar Garcia, Jeremy Rahkola, Rachel L. Gessner, Cullen M. Dutmer, Jared Klarquist, Eric M. Pietras, Debashis Ghosh, Sara A. Johnson, Ross M. Kedl, Elena W.Y. Hsieh

Subjects: “…CP: Immunology…”
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Early precursor-derived pituitary gland tissue-resident macrophages play a pivotal role in modulating hormonal balance by Henna Lehtonen, Heli Jokela, Julian Hofmann, Lauriina Tola, Arfa Mehmood, Florent Ginhoux, Burkhard Becher, Melanie Greter, Gennady G. Yegutkin, Marko Salmi, Heidi Gerke, Pia Rantakari

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Satb1 directs the differentiation of TH17 cells through suppression of IL-2 expression by Maren Köhne, Mehrnoush Hadaddzadeh Shakiba, Lisa Schmidleithner, Jonas Schulte-Schrepping, Rebekka Scholz, Tarek Elmzzahi, Daniel Sommer, Yuanfang Li, Caterina Carraro, Elena De Domenico, Jannis Wißfeld, Kristian Händler, Doaa Hamada, Aleksej Frolov, Xiaoxiao Cheng, Ann-Kathrin Baumgart, Lisa Holsten, Collins Osei-Sarpong, Svenja Bourry, Yasser Thabet, Hannes Renken, Stefan Paulusch, Timothy Sadlon, Thorsten Buch, F. Thomas Wunderlich, Claudia Wickenhauser, Judith Alferink, Tanja Kuhlmann, Matthias Geyer, Lorenzo Bonaguro, Simon C. Barry, Joachim L. Schultze, Marc D. Beyer

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Activation of the endoplasmic reticulum stress regulator IRE1α compromises pulmonary host defenses by Amit Sharma, Linda M. Heffernan, Ky Hoang, Samithamby Jeyaseelan, William N. Beavers, Basel H. Abuaita

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Unveiling IRF4-steered regulation of context-dependent effector programs in CD4+ T cells under Th17- and Treg-skewing conditions by Anna Gabele, Maximilian Sprang, Mert Cihan, Mareen Welzel, Assel Nurbekova, Karolina Romaniuk, Sarah Dietzen, Matthias Klein, Georg Bündgen, Maxim Emelianov, Gregory Harms, Krishnaraj Rajalingam, Tanja Ziesmann, Katrin Pape, Beatrice Wasser, David Gomez-Zepeda, Kathrin Braband, Michael Delacher, Niels Lemmermann, Stefan Bittner, Miguel A. Andrade-Navarro, Stefan Tenzer, Katja Luck, Tobias Bopp, Ute Distler

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Granulysin-high decidual NK cells in macaques and humans share signatures of immune defense by Nina Salinger Prasanphanich, Giulia Protti, Monica Cappelletti, Feiyang Ma, Neema Pithia, Angel Dasenbrock, Jerzy Stanek, Claire A. Chougnet, Suhas G. Kallapur, Matteo Pellegrini, Tamara Tilburgs, Pietro Presicce

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Sca-1 expression depicts pro-inflammatory murine neutrophils under steady-state and pathological conditions by Milind Nahiyera, Supriya Sinha, Priyanka Dhankani, Apurwa Singhal, Abhinav Singh, Rakesh Kumar Sharma, Ambalika Gond, Prayrna Atter, Kanchan Gupta, Kalyan Mitra, Amit Lahiri, Kumarvelu Jagavelu, Marie-Dominique Filippi, Madhu Dikshit, Sachin Kumar

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SaaS sRNA promotes the interfering effect of Salmonella on hepatic iron metabolism via modulating ferroportin 1 by Linlin Cai, Yunting Xie, Haijing Hu, Chongyang Lv, Liangting Shao, Huhu Wang, Xinglian Xu, Guanghong Zhou

Subjects: “…immunology…”
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BLIMP1 controls GC B cell expansion and exit through regulating cell cycle progression and key transcription factors BCL6 and IRF4 by Laura Conter, Shuchi Smita, Derrick Callahan, Shuxian Wu, Aiden Brown, Kevin M. Nickerson, Rebecca A. Elsner, Wenzhao Meng, Ayelet Peres, Gur Yaari, Steven H. Kleinstein, Eline T. Luning Prak, Wei Luo, Mark Shlomchik

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Designed miniproteins potently inhibit and protect against MERS-CoV by Robert J. Ragotte, M. Alejandra Tortorici, Nicholas J. Catanzaro, Amin Addetia, Brian Coventry, Heather M. Froggatt, Jimin Lee, Cameron Stewart, Jack T. Brown, Inna Goreshnik, Jeremiah N. Sims, Lukas F. Milles, Basile I.M. Wicky, Matthias Glögl, Stacey Gerben, Alex Kang, Asim K. Bera, William Sharkey, Alexandra Schäfer, Jack R. Harkema, Ralph S. Baric, David Baker, David Veesler

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Overcoming NK-mediated rejection by anti-3rd-party central memory veto CD8 T cells through downregulation of DNAM-1 on alloreactive NK cells by Wei-Hsin Liu, Aloukick Kumar Singh, Christa Blagdon, Sandeep Kumar Yadav, Einav Shoshan, Esther Bachar-Lustig, Yair Reisner

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BCG-trained macrophages couple LDLR upregulation to type I IFN responses and antiviral immunity by Yangdian Lai, Xiaoxu Yang, Dong Wei, Xin Wang, Ruiming Sun, Yunfei Li, Ping Ji, Yujie Bao, Tiancheng Chu, Chenxing Zhang, Qiming Liang, Jie Xu, Xinxin Zhang, Yingying Chen, Ying Wang

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Early host defense against virus infections by Søren R. Paludan, Thomas Pradeu, Andreas Pichlmair, K. Brad Wray, Jacob Giehm Mikkelsen, David Olagnier, Trine H. Mogensen

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Ocular immune privilege in action: The living eye imposes unique regulatory and anergic gene signatures on uveitogenic T cells by Zixuan Peng, Vijayaraj Nagarajan, Reiko Horai, Yingyos Jittayasothorn, Mary J. Mattapallil, Rachel R. Caspi

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Clonal expansion and diversification of germinal center and memory B cell responses to booster immunization in primates by Lachlan P. Deimel, Yoshiaki Nishimura, Gabriela S. Silva Santos, Viren A. Baharani, Brianna Hernandez, Thiago Y. Oliveira, Andrew J. MacLean, Marie Canis, Sadman Shawraz, Anna Gazumyan, Harald Hartweger, Paul D. Bieniasz, Theodora Hatziioannou, Malcolm A. Martin, Michel C. Nussenzweig

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TRIM65 regulates innate immune signaling by enhancing K6-linked ubiquitination of IRF3 and its chromatin recruitment by Danae Fonseca, Giuseppe Pisanelli, Rocío Seoane, Lisa Miorin, Adolfo García-Sastre

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Aberrant zonal recycling of germinal center B cells impairs appropriate selection in lupus by Gina M. Sanchez, Eden S. Hirsch, Arthur VanValkenburg, Daniel P. Mayer, Komi Gbedande, Rebecca L. Francis, Wenzhi Song, Olivia Q. Antao, Kyleigh E. Brimmer, Alexander Lemenze, Robin Stephens, W. Evan Johnson, Jason S. Weinstein

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Modulation of B cell receptor activation by antibody competition by Yuanyuan He, Zijian Guo, Michael D. Vahey

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Desuccinylation of TBK1 by SIRT5 regulates inflammatory response of macrophages in sepsis by Xuedi Zhang, Chunxiu Ling, Ziying Xiong, Ting Gong, Shuhua Luo, Xiaolei Liu, Lina Zhang, Chaoxiong Liao, Yue Lu, Xiao Huang, Wending Zhou, Shuangnan Zhou, Youtan Liu, Jing Tang

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