Antiplasmodial and Cytotoxic Activities of Extracts of Selected Medicinal Plants Used to Treat Malaria in Embu County, Kenya by Bibianne Waiganjo, Gervason Moriasi, Jared Onyancha, Nelson Elias, Francis Muregi

“…It affects persons of all ages; however, pregnant mothers, young children, and the elderly suffer the most due to their dwindled immune state. The currently prescribed antimalarial drugs have been associated with adverse side effects ranging from intolerance to toxicity. …”
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Probabilistic nested model selection in pharmacokinetic analysis of DCE-MRI data in animal model of cerebral tumor by Hassan Bagher-Ebadian, Stephen L. Brown, Mohammad M. Ghassemi, Prabhu C. Acharya, Indrin J. Chetty, Benjamin Movsas, James R. Ewing, Kundan Thind

“…This study introduces an unsupervised feature engineering technique (Kohonen-Self-Organizing-Map (K-SOM)) to estimate the voxel-wise probability of each nested model. Sixty-six immune-compromised-RNU rats were implanted with human U-251 N cancer cells, and DCE-MRI data were acquired from all the rat brains. …”
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The search for a blood-based biomarker for Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome (ME/CFS): from biochemistry to electrophysiology by Krista S. P. Clarke, Caroline C. Kingdon, Michael Pycraft Hughes, Eliana Mattos Lacerda, Rebecca Lewis, Emily J. Kruchek, Robert A. Dorey, Fatima H. Labeed

“…This includes profiling immune cells using Raman spectroscopy, measuring the electrical impedance of blood samples during hyperosmotic challenge using a nano-electronic assay, use of metabolomic assays, and certain techniques which assess mitochondrial dysfunction. …”
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Plant-Based Antigen Production Strategy for SARS-CoV-2 Nucleoprotein and RBD and Its Application for Detection of Antibody Responses in COVID-19 Patients by Katerina Takova, Valeria Tonova, Ivan Minkov, Eugenia S. Mardanova, Nikolai V. Ravin, Stanislav Kotsev, Maria Pishmisheva, Gergana Zahmanova

“…During the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, the development of efficient serological tests for monitoring the dynamics of the disease as well as the immune response after illness or vaccination was critical. …”
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High-Density Lipoprotein Reduction Differentially Modulates to Classical and Nonclassical Monocyte Subpopulations in Metabolic Syndrome Patients and in LPS-Stimulated Primary Human... by Johanna L. Grün, Aaron N. Manjarrez-Reyna, Angélica Y. Gómez-Arauz, Sonia Leon-Cabrera, Felix Rückert, José M. Fragoso, Nallely Bueno-Hernández, Sergio Islas-Andrade, Guillermo Meléndez-Mier, Galileo Escobedo

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Possible linking and treatment between Parkinson’s disease and inflammatory bowel disease: a study of Mendelian randomization based on gut–brain axis by Beiming Wang, Xiaoyin Bai, Yingmai Yang, Hong Yang

“…Among 60 protein-coding druggable targets over tier 2, 18 overlapped with pleiotropic genes and enriched in mitochondria, antigen presentation, processing and immune cell regulation pathways. Three druggable genes (LRRK2, RAB29 and HLA-DQA2) passed colocalization analysis. …”
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Associations of Serum Urate and Cardiovascular Events in a Clinical Trial of Interleukin-1β Blockade by Nicholas H. Adamstein, MD, Jean G. MacFadyen, BA, Brittany N. Weber, MD, PhD, Peter Libby, MD, Daniel H. Solomon, MD, MPH, Paul M Ridker, MD, MPH

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Multilevel analysis of prevalence and determinants of diarrhea among under-five children in Somalia: insights from the Somalia demographic and health survey 2020 by Hamse Arab Ali, Abdulkadir Mohamed Nuh, Hamse Adam Abdi, Abdisalam Hassan Muse

“…Increasing the coverage and frequency of vitamin A supplementation could enhance children’s immune systems and reduce diarrhea incidence. Moreover, targeted economic support, health care programs for older mothers are essential to mitigate the adverse effects of socioeconomic factors on child health, ultimately leading to a substantial reduction in diarrheal diseases among young children.…”
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Platelet-derived HMGB1 induces NETosis, exacerbating brain damage in the photothrombotic stroke model by Sang-A. Oh, Song-I. Seol, Dashdulam Davaanyam, Seung-Woo Kim, Ja-Kyeong Lee

“…Abstract Following cerebral ischemia, neutrophil extracellular traps (NETs) contribute significantly to brain damage by exacerbating delayed immune cell infiltration and vascular injury. They are detected both in brain tissue and within blood vessels. …”
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<i>Artemia</i> Nauplii Enriched with Soybean Lecithin Enhances Growth Performance, Intestine Morphology, and Desiccation Stress Resistance in Yellow Drum (<i>Nibea albiflora</i>) L... by Zhenya Zhou, Pian Zhang, Peng Tan, Ruiyi Chen, Weihua Hu, Ligai Wang, Yuming Zhang, Dongdong Xu

“…<b>Conclusions</b>: This study highlights that feeding soybean lecithin-enriched <i>Artemia</i> nauplii enhances growth performance and desiccation stress in yellow drum larvae by promoting lipid catabolism, improving intestinal structure, and regulating immune responses.…”
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A new method for detecting mixed Mycobacterium tuberculosis infection and reconstructing constituent strains provides insights into transmission by Benjamin Sobkowiak, Patrick Cudahy, Melanie H. Chitwood, Taane G. Clark, Caroline Colijn, Louis Grandjean, Katharine S. Walter, Valeriu Crudu, Ted Cohen

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Breeding results for Echinacea purpurea (L.) Moench in Moscow Province by I. N. Korotkikh, E. Yu. Babaeva, A. E. Burova

“…Preparations from crude herbal materials of E. purpurea have a widerange effect against pathologies of the immune system, infectious and inflammatory diseases of the respiratory tract, genitourinary system and musculoskeletal system. …”
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Protocol for a systematic review and individual participant data meta-analysis for risk factors for lung cancer in individuals with lung nodules identified by low-dose CT screening by Matthew Callister, Harry J de Koning, Robert C Rintoul, Carolyn Horst, Arjun Nair, John K Field, Christine D Berg, Samantha Quaife, Rhian Gabe, Stephen Duffy, Sam Janes, Philip AJ Crosbie, Mark M Hammer, Panos Alexandris, Michael PA Davies

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Assessment of Clinical Analgesic Levels and Serum Biomarkers in Patients with Rheumatoid Arthritis: A Randomized Controlled Trial Comparing the Efficacy of Diclofenac and Methotrex... by Mei Zhang, Zhongyuan Ma, Rinkiko Suguro, Menglin Zhu, Esther Xinyi Chen, Xin Dong, Meixiu Chen, Linling Cheng, Bolun Su, Yizhun Zhu

“…Furthermore, ESWT produced a more immediate and noteworthy anti-inflammatory impact by regulating NRP-1 expression, a trophic factor receptor that facilitates vascular endothelial cell migration and tissue repair through angiogenesis, and regulating RGS-1 to limit inflammatory signal transmission and immune cell activation.…”
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Cell-specific transcriptional signatures of vascular cells in Alzheimer’s disease: perspectives, pathways, and therapeutic directions by Soumilee Chaudhuri, Minyoung Cho, Julia C. Stumpff, Paula J. Bice, Özkan İş, Nilüfer Ertekin-Taner, Andrew J. Saykin, Kwangsik Nho

“…Dysregulated transcriptional pathways in AD involve multiple pathways, notably immune responses, and angiogenesis common to both endothelial and mural cells. …”
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Constitutive expression of Cas9 and rapamycin-inducible Cre recombinase facilitates conditional genome editing in Plasmodium berghei by Samhita Das, Tanaya Unhale, Carine Marinach, Belsy del Carmen Valeriano Alegria, Camille Roux, Hélène Madry, Badreddine Mohand Oumoussa, Rogerio Amino, Shiroh Iwanaga, Sylvie Briquet, Olivier Silvie

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Exploring the potential benefits of areca nut extract in animal production: a review by Zhuying Liu, Zhuying Liu, Xiaolong Wang, Lixin Wen, Lixin Wen

“…This review focuses on the biological activities of areca nut extract, particularly its antioxidant, anti-inflammatory, antiparasitic, antibacterial, and microbiota-modulating effects, which collectively contribute to its potential role as a feed additive for enhancing animal health and performance.Key findings indicate that areca nut extract can promote livestock productivity by accelerating growth, enhancing immune responses, and reducing disease incidence. …”
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Whole-transcriptome analysis reveals the profiles and roles of coding and non-coding RNAs during hair follicle cycling in Rex rabbits by Jie Wu, Jiamin Zhai, Haofan Jia, Ifeanyi Solomon Ahamba, Xianggui Dong, Zhanjun Ren

“…Numerous studies have confirmed the crucial roles of mRNAs and non-coding RNAs (ncRNAs) in regulating key cellular processes such as cell proliferation, differentiation, apoptosis and immunity. However, their involvement in the regulation of the hair cycle in Rex rabbits remains unknown. …”
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Concurrent versus sequential immunotherapy with chemoradiotherapy for unresectable stage III non-small-cell lung cancer: a retrospective study by Zhou Meng-Xi, Fan Wen-Jie, Zhang Ning, Zhu Li-Yang, Wang Hong-Yan

“…This study aimed to compare the efficacy and safety of immune checkpoint inhibitors (ICIs) administered concurrently or sequentially with chemoradiotherapy in unresectable stage III NSCLC.MethodsA retrospective analysis of 98 patients with unresectable stage III NSCLC, treated between January 1, 2019, and June 30, 2023, was conducted. …”
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Spectrum and trends of cancer among HIV patients in Southwestern Uganda. by Raymond Atwine, Mitala Yekosani, Abraham Birungi, Brian Ssenkumba, Barbra Tuhamize, Richard Ezinga, Keneth Male, Taseera Kabanda

“…<h4>Background</h4>Antiretroviral therapy (ART) restores cellular immunity, significantly reducing AIDS-related mortality and morbidity thus improving the quality of life among People living with HIV (PLHIV). …”
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