Evaluation of naturally occurring IgG anti-Vi antibody titers as predictors and correlates of typhoid fever in Dhaka, Bangladesh by Farhana Khanam, Natasha Y. Rickett, Faisal Ahmmed, Md Taufiqul Islam, Cecilia Kathure Mbae, Justin Im, Asma Binte Aziz, Beatrice Ongadi, Fahima Chowdhury, Ashraful Islam Khan, Afroza Akter, Md Golam Firoj, Sadia Isfat Ara Rahman, Kassa Haile, Se Eun Park, Martin Bundi Mwebia, Moses Mwangi, Benjamin Ngugi, Meseret Gebre Behute, Kelvin Kering, Suneth Agampodi, Suman Kanungo, Xinxue Liu, Andrew J. Pollard, K. Zaman, Deok Ryun Kim, Samuel Kariuki, Firdausi Qadri, John D. Clemens

“…Conclusions In typhoid-endemic populations, IgG anti-Vi antibodies may indicate natural immunity to typhoid. The increasing seroprevalence with age suggests that these antibodies could serve as markers of cumulative past typhoid infections. …”
Get full text

Effects of dietary Spirulina platensis supplementation on growth performance, whole body composition, antioxidant activity, histological alterations, and resistance to Vibrio parah... by Ragaa A. Ahmed, Samyah D. Jastaniah, Bothaina A. Alaidaroos, Manal E. Shafi, Ehab El-Haroun, Yasmin M. Abd El-Aziz, Ola Hasan Abd El Megeed, Mada M. AL-Qurashi, Safia M.A. Bahshwan, Mohammad Bodrul Munir, Zulhisyam Abdul Kari, Roshmon Thomas Mathew, Moaheda E.H. Eissa, El-Sayed Hemdan Eissa, Amal Elfeky

“…It is also used as a feed additive in aquafeeds, where it serves as a growth promoter and immune stimulant. The genus S. platensis recognize for its high protein content, carotenoid, phycocyanin and phytochemicals content, which can help mitigate challenges in the aquaculture industry challenges such as disease outbreaks, pathogen infection and ultimately contributing to aquaculture sustainability. …”
Get full text

Research Progress on Animal Models of Sepsis-Related Organ Injury by YANG Jiahao, DING Chunlei, QIAN Fenghua, SUN Qi, JIANG Xusheng, CHEN Wen, SHEN Mengwen

“…Sepsis is a multi-organ dysfunction syndrome caused by infection and immune dysfunction, with a high mortality rate. It affects multiple important organs such as the heart, lungs, kidneys, liver, and brain. …”
Get full text

Bisphenol S exposure interrupted human embryonic stem cell derived cardiomyocytes differentiation through ER-NF-κB/ERK signaling pathway by Yongru Zhou, Lin Tian, Liang Wang, Wenjing Wu, Baofang Liang, Wei Xiong, Lishi Zhang, Xiaomeng Li, Jinyao Chen

“…However, exposure to BPS throughout the differentiation stage may disrupt the immune response and cell differentiation, which in turn interrupts heart function. …”
Get full text

Cytosolic phospholipase A2 in infiltrating monocyte derived macrophages does not impair recovery after spinal cord injury in female mice by Ethan P. Glaser, Timothy J. Kopper, William M. Bailey, Hassan K. Kashif, Reena Kumari, Andrew N. Stewart, John C. Gensel

“…Cytosolic phospholipase A2 (cPLA2) frees arachidonic acid from phospholipids, generating eicosanoids that play an important role in inflammation, immunity, and host defense. cPLA2 is expressed in macrophages along with multiple other cell types after SCI, and cPLA2 inhibition has been reported to both reduce and exacerbate secondary injury pathology recovery. …”
Get full text

Antiganglioside Antibodies and Inflammatory Response in Cutaneous Melanoma by Corina Daniela Ene, Mircea Tampa, Ilinca Nicolae, Cristina Iulia Mitran, Madalina Irina Mitran, Clara Matei, Ana Caruntu, Constantin Caruntu, Simona Roxana Georgescu

“…Tumour ganglioside antigens generate an immune response in patients with primary melanomas. …”
Get full text

DEPDC1B, CDCA2, APOBEC3B, and TYMS are potential hub genes and therapeutic targets for diagnosing dialysis patients with heart failure by Wenwu Tang, Wenwu Tang, Zhixin Wang, Xinzhu Yuan, Liping Chen, Haiyang Guo, Zhirui Qi, Ying Zhang, Xisheng Xie

“…In addition, we further explored potential mechanism and function of hub genes in HF of patients with MHD through GSEA, immune cell infiltration analysis, drug analysis and establishment of molecular regulatory network.ResultsTotally 23 candidate genes were screened out by overlapping 673 differentially expressed genes (DEGs) and 147 key module genes, of which four hub genes (DEPDC1B, CDCA2, APOBEC3B and TYMS) were obtained by two machine learning algorithms. …”
Get full text

Clinically relevant orthotopic pancreatic cancer models for adoptive T cell transfer therapy by Gregory B. Lesinski, Chrystal M. Paulos, Maggie Phillips, Jacklyn Hammons, Isaac Karpovsky, Zaid Mahdi, Natalie K. Horvat, Megan M. Wyatt, Margaret A. Hall, Cameron J. Herting, Richard A. Moffitt

“…In contrast, far more host immune cells infiltrate the KPC-Luc tumors, which have less stroma, although CD4+ and CD8+ T cells were similarly detected in the MT-5 tumors compared with KPC-GEMM in mice. …”
Get full text

Neurological syndromes associated with COVID-19: a multicenter study in Brazil by Aline de Moura Brasil Matos, Andre Borges Ferreira Gomes, Fernanda Martins Maia Carvalho, Francisco Tomaz Meneses de Oliveira, Lohana Santana Almeida da Silva, Flavia Esper Dahy, Joao Victor Luisi de Moura, Marcela Vieira Freire, Jose Ernesto Vidal, Rosa Maria Nascimento Marcusso, Jerusa Smid, Victor Rebelo Procaci, Rodrigo Meireles Massaud, Felipe Von Glehn, Jorge Casseb, Camila Malta Romano, Augusto Cesar Penalva de Oliveira, on behalf of NeurocovBR study group

“…The median time from COVID-19 to onset of neurological symptoms was 14 days, suggesting a post-infectious immune-mediated mechanism. Patients were 10 times more likely to die (χ2 (1) = 356.55, p < 0.01, OR = 10.89) and 38 times more likely to be hospitalized than other COVID-19 patients (χ2 (1) = 1167.9, p < 0.01, OR = 38.22). …”
Get full text

Exendin-4 Exacerbates Burn-Induced Morbidity in Mice by Activation of the Sympathetic Nervous System by Xiao-Jing Ji, Ji-Wei Hao, Guang-Lei Li, Ning Dong, Xin-Qi Wang, Min Zhou, Qing-Hong Zhang, Yong-Ming Yao

“…We hypothesize that exendin-4, a GLP-1 analogue, might affect the immune response via the activation of the sympathetic nervous system in burn injury. …”
Get full text

Computational pathology assessments of cardiac stromal remodeling: Clinical correlates and prognostic implications in heart transplantation by Eliot G. Peyster, MD, MSc, Cai Yuan, PhD, Sara Arabyarmohammadi, PhD, Priti Lal, MD, Michael D. Feldman, MD, PhD, Pingfu Fu, PhD, Kenneth B. Margulies, MD, MS, Anant Madabhushi, PhD, FAIMBE, FIEEE, FNAI

“…Background: The hostile immune environment created by allotransplantation can accelerate pathologic tissue remodeling. …”
Get full text

Peptide-based vaccine targeting IL17A attenuates experimental spondyloarthritis in HLA-B27 transgenic rats by Tetsuya Tomita, Hiromi Rakugi, Hiroki Hayashi, Ryuichi Morishita, Jiao Sun, Yuka Yanagida, Shota Yoshida, Satoshi Baba, Akiko Tenma, Masayoshi Toyoura, Sotaro Kawabata, Takako Ehara, Ryoko Asaki, Makoto Sakaguchi, Hideki Tomioka, Munehisa Shimamura, Hironori Nakagami

“…Objectives Spondyloarthritis (SpA) is known as series of immune-mediated inflammatory disease of the axial and peripheral joints. …”
Get full text

Population genetic analysis of clinical Mycobacterium abscessus complex strains in China by Xiangchen Li, Xiangchen Li, Yelei Zhu, Yewei Lu, Kunyang Wu, Yang Che, Xiaomeng Wang, Weixin Wang, Junli Gao, Junshun Gao, Zhengwei Liu, Zhengwei Liu, Zhuxian Zhou

“…Mobile genetic elements (MGEs), such as prophages and genomic islands, were prevalent across all genomes. 139 to 151 virulence factors (VFs) were identified per genome, with distinct accessory VFs in MabA and MabM affecting immune modulation and metabolism. Resistance gene profiling revealed ubiquitous mtrA, RbpA, and blaMAB, with MabA-specific erm(41) conferring resistance to macrolides and β-lactams. …”
Get full text

Granulocyte-Macrophage Colony-Stimulating Factor-Activated Neutrophils Express B7-H4 That Correlates with Gastric Cancer Progression and Poor Patient Survival by Zhi-guo Shan, Zong-bao Yan, Liu-sheng Peng, Ping Cheng, Yong-sheng Teng, Fang-yuan Mao, Kun Fan, Yuan Zhuang, Yong-liang Zhao

“…Our results illuminate a novel regulating mechanism of B7-H4 expression on tumor-activated neutrophils in GC, suggesting that functional inhibition of these novel GM-CSF-B7-H4 pathways may be a suitable therapeutic strategy to treat the immune tolerance feature of GC.…”
Get full text

Geriatric nutritional risk index and newly developed scoring system as prognosis prediction for unresectable hepatocellular carcinoma patients treated with lenvatinib by Hideko Ohama, Atsushi Hiraoka, Toshifumi Tada, Masashi Hirooka, Kazuya Kariyama, Joji Tani, Masanori Atsukawa, Koichi Takaguchi, Ei Itobayashi, Shinya Fukunishi, Kunihiko Tsuji, Toru Ishikawa, Kazuto Tajiri, Hironori Ochi, Satoshi Yasuda, Hidenori Toyoda, Chikara Ogawa, Takashi Nishimura, Takeshi Hatanaka, Satoru Kakizaki, Noritomo Shimada, Kazuhito Kawata, Atsushi Naganuma, Hisashi Kosaka, Tomomitsu Matono, Hidekatsu Kuroda, Yutaka Yata, Hironori Tanaka, Hiroki Nishikawa, Hiroshi Shibata, Fujimasa Tada, Kazuhiro Nouso, Asahiro Morishita, Akemi Tsutsui, Takuya Nagano, Norio Itokawa, Tomomi Okubo, Taeang Arai, Michitaka Imai, Yohei Koizumi, Shinichiro Nakamura, Hiroko Iijima, Masaki Kaibori, Yoichi Hiasa, Takashi Kumada

“…Abstract In the current era of immune therapy, lenvatinib (LEN) continues to be vital for treating unresectable hepatocellular carcinoma (uHCC) patients. …”
Get full text

PARP-1 Is Critical for Recruitment of Dendritic Cells to the Lung in a Mouse Model of Asthma but Dispensable for Their Differentiation and Function by Laura C. Echeverri Tirado, Mohamed A. Ghonim, Jeffrey Wang, Amir A. Al-Khami, Dorota Wyczechowska, Hanh H. Luu, Hogyoung Kim, Maria Dulfary Sanchez-Pino, José Yélamos, Lina M. Yassin, A. Hamid Boulares

“…Dendritic cells (DCs) are critical in asthma and many other immune diseases. We previously demonstrated a role for PARP-1 in asthma. …”
Get full text

Targeted Delivery of BMS-1166 for Enhanced Breast Cancer Immunotherapy by Yu Z, Zhou Z, Zhao Y

“…The Programmed Death-1 (PD-1) /Programmed Death-Ligand 1 (PD-L1) immune checkpoint pathway is among the most studied. …”
Get full text

Rescue of in vitro models of CSF1R-related adult-onset leukodystrophy by iluzanebart: mechanisms and therapeutic implications of TREM2 agonism by Kelley C. Larson, Frederick W. Gergits, Abigail J. Renoux, Elizabeth J. Weisman, Borislav Dejanovic, Liyue Huang, Bhaumik Pandya, Donald G. McLaren, Berkley A. Lynch, Richard Fisher, Evan Thackaberry, David Gray, Francois Gaudreault, Christian Mirescu

“…Differentially expressed genes identified in the hippocampus of mice treated with iluzanebart were exemplary of TREM2 activation and were related to cell proliferation, regulation of inflammatory processes, and innate immune response pathways. Proliferation of microglia, changes in protein levels of specific chemokines identified by gene expression analysis, and increased CSF1R levels were also confirmed in vivo. …”
Get full text

Assessment of MPOX infection-related knowledge levels, concerns, and associated factors: a community-based cross-sectional study by Mehmet Emin Arayici, Suleyman Dolu, Hasan Ozdek Sayilir, Hatice Simsek, Sükran Kose

“…Multivariable logistic regression confirmed that being in non-medical fields (OR = 2.858, 95% CI: 1.809–4.515, p < 0.001), lower income (OR = 3.141, 95% CI: 2.015–4.896, p < 0.001), and perceived low immunity (OR = 2.264, 95% CI: 1.350–3.797, p = 0.002) independently predicted lower knowledge. …”
Get full text

Dual Role of &alpha;-MSH in Colitis Progression: Mediating Neutrophil Differentiation via Bone Marrow by Liao X, Liu H, Li Y, Zhang W, Dai Q, Wei H, Zhou J, Xie X, Zhou H

“…Recent studies on the brain-gut axis suggest that the central nervous system (CNS), particularly the hypothalamic-pituitary axis (HPA), may play a crucial role in modulating the immune system and influencing disease progression. …”
Get full text