Prescribing practices of corticosteroids in outpatient dermatology department of Injibara General Hospital, north-West Ethiopia, 2024 by Alemu Bezabih Tegegnie, Tamiru Alene, Workineh Tamir, Meaza Molla Sineshaw

“…BackgroundCorticosteroids are among the most frequently prescribed drugs in the world because they are extremely effective for the relief of symptoms of many inflammatory and immune disorders and other conditions. Corticosteroids have been a mainstay of pharmacotherapy in dermatological practice.ObjectiveThis study aimed to assess prescribing practices of corticosteroids in outpatient dermatology department of Injibara General Hospital, North-West Ethiopia, 2024.MethodA facility-based retrospective cross-sectional study was conducted from September 1 to September 10, 2024, with 422 patient prescriptions issued at the dermatology outpatient department of Injibara General Hospital containing at least one corticosteroid medicine. …”
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WNT3A promotes the cementogenic differentiation of dental pulp stem cells through the FOXO1 signaling pathway by Dongmei Cheng, Yang Bao, Xue Wang, Haidong Xiang, Tianyuan Guo, Yong Du, Zhiyong Zhang, Han Guo

“…CIBERSORT was utilized to analyze immune cell infiltration analysis. The comparative toxicogenomics database (CTD) was utilized for the validation of core targets. …”
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Effects of increasing levels of rubber seed cake on growth performance, nutrient digestion metabolism, serum biochemical parameters, and rumen microbiota of Hu sheep by Huwei Zhao, Jinling Hua, Wenwen Lu, Longfei Yan, Min Zhang, Chao Chen, Xiaokang Lv

“…Supplementing with 6% RSC enhanced the relative abundance of norank_Muribaculacea in the rumen fluid and the immune and antioxidant capabilities. However, supplementing with 12 and 18% RSC might have negatively impacted nutrient digestion and metabolism. …”
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High-Intensity Interval Training Improves Physical Function, Prevents Muscle Loss, and Modulates Macrophage-Mediated Inflammation in Skeletal Muscle of Cerebral Ischemic Mice by Lu Luo, Meixi Liu, Hongyu Xie, Yunhui Fan, Jingjun Zhang, Li Liu, Yun Li, Qiqi Zhang, Junfa Wu, Congyu Jiang, Yi Wu

“…Following the outcome, we further investigated the infiltrating immune cells abundant in paretic muscles. The results showed that HIIT modulated macrophage activation by downregulating CD86+ (M1 type) macrophages and upregulating CD163+ (M2 type) macrophages via inhibiting the TLR4/MyD88/NFκB signaling pathway and exerting an anti-inflammatory effect in paretic skeletal muscle. …”
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Genetic Background Strongly Influences the Bone Phenotype of P2X7 Receptor Knockout Mice by Susanne Syberg, Solveig Petersen, Jens-Erik Beck Jensen, Alison Gartland, Jenni Teilmann, Iain Chessell, Thomas H. Steinberg, Peter Schwarz, Niklas Rye Jørgensen

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A tendency towards leaf rust resistance decrease in common wheat introgression lines with genetic material from Aegilops speltoides Tausch by L. Ya. Plotnikova, L. V. Meshkova, E. I. Gultyaeva, O. Р. Mitrofanova, I. F. Lapochkina

“…The estimation of specimens in the field conditions on natural infectious background showed that the Ae. speltoides accessions were immune to leaf rust, however, а tendency towards increasing susceptibility of the introgressive lines and varieties was detected. …”
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Unveiling the nutritional and antioxidant properties of brown algae resources (Dictyota J.V. Lamouroux) from the Bay of Bengal and Arabian Sea, Indian coast by P. Chellamanimegalai, Geetanjali Deshmukhe, Amjad K. Balange, P. Layana

“…These antioxidants can help reduce the risk of chronic diseases, improve immune function, and promote overall well-being. The findings of this study provide comprehensive insights into the nutritional and antioxidant potentials of Dictyota, facilitating future applications in nutrition and health promotion.…”
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Antimicrobial photodynamic inactivation of Pseudomonas aeruginosa persister cells and biofilms by Mona Mahmoud, Peter Richter, Philipp Arnold, Michael Lebert, Andreas Burkovski

“…P. aeruginosa is known for forming biofilms, a complex aggregate of bacteria embedded in a self-generated protective matrix that enhance its resistance to antibiotics and the immune system. Within the biofilm, persister cells, sub-populations of slow-growing or growth-arrested cells, are associated with recalcitrance of infections and antibiotic treatment failure. …”
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Increased Serum Interleukin-2 Levels Are Associated with Abnormal Peripheral Blood Natural Killer Cell Levels in Patients with Active Rheumatoid Arthritis by Baochen Li, Qiaoling Guo, Yanyan Wang, Rui Su, Chong Gao, Jinfang Zhao, Xiaofeng Li, Caihong Wang

“…In RA patients, serum IL-2 levels were not only correlated with patients’ disease activity and autoantibody levels but were also involved in their Th17/Treg immune imbalance. In addition, in patients with active RA, NK cell levels were abnormally elevated, possibly due to high serum levels of IL-2.…”
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Progress in the Study of Intratumoral Microorganisms in Hepatocellular Carcinoma by Song Y, Tian S, Li Z, Miao J, Wu M, Xu T, Wu X, Qiao J, Zhang X, Zhao H, Kang L, Cao L, Zhu P, Miao M

“…Through the analysis, it is proposed that intratumor organisms can be used as markers for liver cancer diagnosis and treatment, drug carrier materials for targeting liver cancer tissues, and the research prospects of developing new combination therapies based on the in-depth understanding of the interactions between intratumor microorganisms and the tumor microenvironment, immune cells, liver cancer cells, etc. as well as exploring the prospects of developing new combination therapies based on these interactions. …”
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Chitinase-3-like-1: a multifaceted player in neuroinflammation and degenerative pathologies with therapeutic implications by Pharaoh Fellow Mwale, Cheng-Ta Hsieh, Ting-Lin Yen, Jing-Shiun Jan, Rajeev Taliyan, Chih-Hao Yang, Wen-Bin Yang

“…This review explores the role of CHI3L1 in the pathogenesis of these disorders, with a focus on its contributions to neuroinflammation, immune cell infiltration, and neuronal degeneration. …”
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The Prognostic Value of Peripheral Blood Inflammatory Markers in Hepatocellular Carcinoma Treated with Lenvatinib Combined with PD-1 Inhibitors by Xin Y, Liu N, Peng G, Huang X, Cao X, Zhou X

“…The AUC value of nomogram based on baseline SIRI, PNI, and tumor distribution in predicting the 6-,12- and 18-month PFS of patients was significantly higher than that of traditional BCLC stage, and its prediction performance was substantially better than that of BCLC stage system (C-index, 0.730 vs 0.535).Conclusion: The baseline SIRI could be used as a potential non-invasive biomarker to predict the efficacy and survival benefit of immune combination therapy for HCC. The nomogram based on inflammation indexes could achieve better prediction performance and help clinicians to identify high-risk patients and formulate treatment plans.Keywords: lenvatinib, PD-1 inhibitor, inflammatory indexes, hepatocellular carcinoma…”
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In Vitro Free Radical Scavenging Properties and Anti-Inflammatory Activity of Ilex paraguariensis (Maté) and the Ability of Its Major Chemical Markers to Inhibit the Production of... by Ingrid Vicente Farias, Eduarda Fratoni, Lais Cristina Theindl, Angela Machado de Campos, Eduardo Monguilhott Dalmarco, Flavio Henrique Reginatto

“…Our results suggest that I. paraguariensis and its major chemical markers have strong free radical scavenging properties as well as showed important anti-inflammatory activity and that these compounds in a plant extract may work based on several different mechanisms synergistically, resulting in moderating the immune system.…”
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Review: Application of Protein-Based Raw Materials in Health Foods in China by Hao Duan, Gaigai Liu, Jiaqi Liu, Zhuoye Wang, Shuyuan Bao, Xinyue Chang, Wenjie Yan

“…The results show the following for health foods containing raw protein materials: in terms of the dosage form, they are mainly solid preparations; according to their functional claims, they mainly help to enhance immunity, help improve bone density, help improve skin moisture, and relieve physical fatigue; and in the application of raw materials, it is found that the use of raw materials such as casein phosphopeptide, soybean protein isolate, whey protein, collagen, spirulina, and other raw materials in products is relatively high. …”
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Analysis of the behaviour of the Tukad Buluk Poh flood water at the Gilimanuk - Denpasar National Road Crossing by Hidayat Acep, Suprapti, Isradi Muhammad, Dwi Praptoyo Riska

“…Access to Gilimanuk to Denpasar via the national road was not immune to the flood overflow at the time in Tukad Biluk Poh. …”
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Efficacy and safety of left bundle branch area pacing versus biventricular pacing in heart failure patients with left bundle branch block: study protocol for a randomised controlle... by Lin Zhao, Liting Cheng, Junmeng Zhang, Zefeng Wang, Mengge Zhou, Zhuo Liang, Jieruo Chen, Yongquan Wu

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Methylsulfonylmethane (MSM) Supplementation in Adult Horses Supports Improved Skeletal Muscle Inflammatory Gene Expression Following Exercise by Madison R. Barshick, Kristine M. Ely, Keely C. Mogge, Lara M. Chance, Sally E. Johnson

“…A comparison of the exercise by diet contrasts revealed that horses supplemented with MSM contained a greater number of exercise-responsive genes (630; logFC > 0.2; q < 0.05) by comparison to the CON (237), with many of these mapping to the immune response (71) and cytokine signal transduction (60) pathways. …”
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Functional effects of natural silicate, yeast and saponins based product on the growth and health status of the Pacific white shrimp Litopenaeus vannamei by Romi Novriadi, Djumbuh Rukmono, Benny Shapira, Arik Farzeli

“…Therefore, NSY and SBP can be regarded as the functional ingredients in shrimp diet to improve the growth and non-specific immune function of shrimp. Keywords: Silicates and yeast, saponins, growth, health status, shrimp Litopenaeus vannamei ABSTRAK Pada kajian ini, produk komersial yang berbasiskan kepada komponen alamiah silikat dan ragi (NSY) dan saponins yang berasal dari tumbuhan Yucca schidigera dan Quillaja saponaria (SBP) digunakan untuk mengevaluasi pengaruhu nutrisi yang dimiliki terhadap pertumbuhan dan status kesehatan dari udang putih Litopenaeus vannamei. …”
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Examining the impact of probiotic Lactiplantibacillus pentosus 6MMI on inhibiting biofilm formation, adhesion, and virulence gene expression in Listeria monocytogenes ATCC 19115 by Behrooz Alizadeh Behbahani, Mostafa Rahmati-Joneidabad, Morteza Taki

“…Probiotic bacteria improve human health by secreting pro-microbial substances, balancing intestinal flora, binding to the mucous membrane and epithelium, strengthening the intestinal epithelial barrier, and creating interactions between the gastrointestinal microbiota and the immune system. This study aimed to investigate the probiotic potential, biofilm-related gene expression and anti-biofilm capabilities of Lactiplantibacillus pentosus 6MMI. …”
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Proteome‐Wide Mendelian Randomization Identifies Therapeutic Targets for Abdominal Aortic Aneurysm by Ka Zhang, Yuan Liu, Aiqin Mao, Changzhu Li, Li Geng, Hao Kan

“…Several causal proteins are involved in pathways regulating lipid metabolism, immune responses, and extracellular matrix organization. …”
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