Efficacy of PD-1/PD-L1 Inhibitors versus Chemotherapy in Lung Cancer with Brain Metastases: A Systematic Review and Meta-Analysis by Xiaojun Yang, Yihong Zeng, Qinquan Tan, Zhihua Huang, Jun Jia, Guanming Jiang

“…Immune checkpoint inhibitors (ICIs) are widely used to treat local or metastatic lung cancer. …”
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THE BIOSYNTHESIS REGULATION OF POTATO STEROIDAL GLYCOALKALOIDS by K. A. Ivanova, S. V. Gerasimova, E. K. Khlestkina

“…Potato steroidal glycoalkaloids (SGAs) compose a part of plant immunity. Some of their modified variants are toxic to humans. …”
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Unravelling the transcriptomic symphony of muscle ageing: key pathways and hub genes altered by ageing and caloric restriction in rat muscle revealed by RNA sequencing by Gulam Altab, Brian J. Merry, Charles W. Beckett, Priyanka Raina, Inês Lopes, Katarzyna Goljanek-Whysall, João Pedro de Magalhães

“…Upregulated genes were commonly involved in protein folding and immune responses; meanwhile, downregulated genes were often related to developmental biology. …”
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Surveillance of SARS-CoV-2 variants in Henan, China from 2023 to 2024 by Yun Song, Bicong Wu, Hongxia Ma, Yafei Li, Su Yan, Jingjing Pan, Haifeng Wang, Ying Ye, Xueyong Huang, Wanshen Guo

“…As new SARS-CoV-2 variants continue to emerge, some have shown significant immune evasion, posing challenges to epidemic control efforts. …”
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Associations between Autoimmunity and Depression: Serum IL-6 and IL-17 Have Directly Impact on the HAMD Scores in Patients with First-Episode Depressive Disorder by Lijuan Mao, Xiajin Ren, Xin Wang, Feng Tian

“…The study is aimed at evaluating the immune-activation state before and after treatment in patients with first-episode depressive disorder (FDD) with evaluating the ILs and CRP levels and further clarifying the association between autoimmunity and the etiology and pathogenesis of FDD. …”
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Retrospective Analyses of Potential Risk Factors for Posterior Capsule Opacification after Cataract Surgery by Shuang Wu, Nianting Tong, Lin Pan, Xiaohui Jiang, Yanan Li, MeiLing Guo, Hehuan Li

“…Statistically significant associations with PCO were found for age at the time of surgery (χ2 = 78.504; p<0.001), diabetes (χ2 = 4.829; p=0.028), immune diseases (χ2 = 4.234; p=0.004), high myopia (χ2 = 5.753; p=0.016), lens nucleus hardness (χ2 = 11.046; p=0.026), surgery type (χ2 = 11.354; p=0.001), a history of vitrectomy (χ2 = 4.212; p=0.004), ocular inflammation (χ2 = 6.01; p=0.009), and the intraocular lens (IOL) type (χ2 = 8.696; p=0.003). …”
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The Role of CD40 in Allergic Rhinitis and Airway Remodelling by Ke-Jia Cheng, Min-Li Zhou, Yong-Cai Liu, Chen Wang, Ying-Ying Xu

“…CD40 is an important costimulatory molecule in immunity. However, few studies have focused on the role of CD40 in AR. …”
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Correlation of macronutrient and micronutrient intake with anemia status in pulmonary tuberculosis patients at namorambe community health center by Aritonang Evawany Yunita, Manalu Sarah Patumona, Manalu Samuel MH

“…Tuberculosis sufferers are at risk of experiencing abnormal body conditions due to a weakened immune system, so it is important for pulmonary tuberculosis sufferers to consume foods that meet their iron needs, such as meat, fish, cultivated vegetables and whole grains.…”
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Passive infusion of an S2-Stem broadly neutralizing antibody protects against SARS-CoV-2 infection and lower airway inflammation in rhesus macaques. by Christopher T Edwards, Kirti A Karunakaran, Elijah Garcia, Nathan Beutler, Matthew Gagne, Nadia Golden, Hadj Aoued, Kathryn L Pellegrini, Matthew R Burnett, Christopher Cole Honeycutt, Stacey A Lapp, Thang Ton, Mark C Lin, Amanda Metz, Andrei Bombin, Kelly Goff, Sarah E Scheuermann, Amelia Wilkes, Jennifer S Wood, Stephanie Ehnert, Stacey Weissman, Elizabeth H Curran, Melissa Roy, Evan Dessasau, Mirko Paiardini, Amit A Upadhyay, Ian N Moore, Nicholas J Maness, Daniel C Douek, Anne Piantadosi, Raiees Andrabi, Thomas R Rogers, Dennis R Burton, Steven E Bosinger

“…The continued evolution of SARS-CoV-2 variants capable of subverting vaccine and infection-induced immunity suggests the advantage of a broadly protective vaccine against betacoronaviruses (β-CoVs). …”
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Prevalence, Antimicrobial Resistance, and Associated Factors of Streptococcus pneumoniae Colonization Rate among Old-Age Patients with Respiratory Tract Infection Attending Sheik H... by Surafel Mekuria, Ayichew Seyoum, Zerihun Ataro, Tigist Abebe, Kedir Urgessa

“…It is the major cause of respiratory tract infection and frequent cause of physician visits, hospitalization, and death among old-aged patients because of their low immunity status. However, data on S. pneumoniae among old-aged patients in eastern Ethiopia are limited. …”
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Elevated Plasma Soluble Triggering Receptor Expressed on Myeloid Cells-1 Level in Patients with Acute Coronary Syndrome (ACS): A Biomarker of Disease Severity and Outcome by Shachaf Shiber, Vitaly Kliminski, Katia Orvin, Iftach Sagy, Mordehay Vaturi, Ran Kornowski, Michael Drescher, Yair Molad

“…Plasma levels of soluble triggering receptor expressed on myeloid cells (sTREM-1) reflect innate immune cell activation. We sought to evaluate sTREM-1 levels in patients with acute coronary syndrome (ACS) and their predictive value for disease severity and outcome. …”
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Self-replicating recombinant virus-like particles of lentivirus proliferating in glioblastoma cells and normal human macrophages by Herman D. Moshkoff, Andrey E. Moshkoff, Dmitry A. Moshkoff

“…Inactivated vaccines are very diverse and include whole cell and acellular vaccines containing protein target antigens or nucleic acids encoding target antigens. Immunity induced by inactivated vaccines is not believed to be long-lasting. …”
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Safety, Tolerability and Pharmacokinetic-Pharmacodynamic Relationship of NX210c Peptide in Healthy Elderly Volunteers: Randomized, Placebo-Controlled, Double-Blind, Multiple Ascend... by Annette Janus, Daniël Dumas, Juliette Le Douce, Sébastien Marie, Giuseppe Pasculli, Pauline Bambury, Sighild Lemarchant, Philip Kremer, Yann Godfrin

“…Abstract Introduction Blood-brain barrier (BBB) integrity is fundamental to brain homeostasis, enabling control of substance exchange and safeguarding neurons against harmful toxins, pathogens, and immune cells that lead to dysregulation and inflammation involved in ageing and neurodegenerative diseases (NDD). …”
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Risk reduction in SARS-CoV-2 infection and reinfection conferred by humoral antibody levels among essential workers during Omicron predominance. by James Hollister, Cynthia Porter, Ryan Sprissler, Shawn C Beitel, James K Romine, Jennifer L Uhrlaub, Lauren Grant, Young M Yoo, Ashley Fowlkes, Amadea Britton, Lauren E W Olsho, Gabriella Newes-Adeyi, Sammantha Fuller, Pearl Q Zheng, Manjusha Gaglani, Spencer Rose, Kayan Dunnigan, Allison L Naleway, Lisa Gwynn, Alberto Caban-Martinez, Natasha Schaefer Solle, Harmony L Tyner, Andrew L Philips, Kurt T Hegmann, Sarang Yoon, Karen Lutrick, Jefferey L Burgess, Katherine D Ellingson

“…The extent to which semi-quantitative antibody levels confer protection against SARS-CoV-2 infection in populations with heterogenous immune histories is unclear. Two nested case-control studies were designed within the multisite HEROES/RECOVER prospective cohort of frontline workers to study the relationship between antibody levels and protection against first-time post-vaccination infection and reinfection with SARS-CoV-2 from December 2021 to January 2023. …”
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Pivotal roles of Plasmodium falciparum lysophospholipid acyltransferase 1 in cell cycle progression and cytostome internalization by Junpei Fukumoto, Minako Yoshida, Suzumi M. Tokuoka, Eri Saki H. Hayakawa, Shinya Miyazaki, Takaya Sakura, Daniel Ken Inaoka, Kiyoshi Kita, Jiro Usukura, Hideo Shindou, Fuyuki Tokumasu

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Sex differences of fall-risk-increasing drugs in the middle-aged and elderly: a descriptive, cross-sectional study of FDA adverse event reporting system by Ying Zhao, Yuke Zhong, Liuqing Wu, Jiao Yan, Weitao Lu

“…Signals showing significant sex differences were mainly concentrated on agents of the immune, nervous, musculo-skeletal, and cardiovascular systems. …”
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Under-nutrition and its associated factors among adult second-line antiretroviral treatment users in Northern Ethiopia by Seteamlak Adane Masresha, Atitegeb Abera Kidie, Getahun Fentaw Mulaw, Fentaw Wassie Feleke, Mesfin Wudu Kassaw, Tadesse Mamo Dejene, Aychew Kassie Gidafie, Fassikaw Kebede Bizuneh

“…Abstract Background Despite advancements in Human Immunodeficiency Virus (HIV) treatment and care, undernutrition remains a significant concern, accelerating disease progression and risk of Acquired Immune Deficiency Syndrome (AIDS)-related deaths. …”
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Exploring the Kidney-Brain Crosstalk: Biomarkers for Early Detection of Kidney Injury-Related Alzheimer&rsquo;s Disease by Cai Y, Huang G, Ren M, Chai Y, Fu Y, Yan T, Zhu L

“…Moreover, the relationship between hub biomarkers and immune infiltration was assessed using CIBERSORT, and the potential drugs or small molecules associated with the core biomarkers were identified via the DGIdb database.Results: MR analysis showed that KI may be a risk factor for AD. …”
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Golgi scaffold protein PAQR11 in pan-cancer landscape: A comprehensive bioinformatics exploration of expression patterns, prognostic significance, and potential immunological funct... by Zhu Liu, Zhi-Qiang Ling

“…This study aims to investigate the prognostic significance of PAQR11, its relevance to immune responses, and its association with drug sensitivity across various cancer types. …”
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Intensity of Nematode Infection in Children Aged 3 to 5 Years Living in Mukuru Kwa Njenga Slum Settlement, Nairobi, Kenya by Lynda Allan, Fiona N. Mbai, Dorcas S. Yole, Moses Owino

“…The burden of nematode infections is high mostly in children below 5 years old, with clinical manifestations ranging from mild to painful symptoms due to severe infections that end up suppressing the immune system of the infected children. The occurrence of these infections is highest in areas of extreme poverty. …”
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