Sex differences in the neuroinflammatory signaling pathway: effect of miRNAs on fatty acid synthesis in microglia by Haolin Zheng, Akiko Mizokami, Sergio Romera-Giner, Jaime Llera-Oyola, Yosuke Yamawaki, Tomomi Sano, Eijiro Jimi, Francisco García-García, Takashi Kanematsu

“…Recent studies have demonstrated that microglia, the primary innate immune cells in the brain, play a crucial role in AD development. …”
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Interleukin-10 Polymorphisms in Association with Prognosis in Patients with B-Cell Lymphoma Treated by R-CHOP by Min Kyeong Kim, Kyong-Ah Yoon, Eun Young Park, Jungnam Joo, Eun Young Lee, Hyeon-Seok Eom, Sun-Young Kong

“…Interleukin-10 (IL10) plays an important role in initiating and maintaining an appropriate immune response to non-Hodgkin lymphoma (NHL). Previous studies have revealed that the transcription of IL10 mRNA and its protein expression may be infl uenced by several single-nucleotide polymorphisms in the promoter and intron regions, including rs1800896, rs1800871, and rs1800872. …”
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Cell-free DNA: a metabolic byproduct with diagnostic and prognostic potential in rheumatic disorders by Fancheng Liu, Fancheng Liu, Yazhen Su, Yazhen Su, Xinling Liu, Li Zhao, Li Zhao, Zewen Wu, Zewen Wu, Yang Liu, Yang Liu, Liyun Zhang, Liyun Zhang

“…Elevated concentrations of cfDNA are recognized by DNA receptors, initiating immune-inflammatory reactions which subsequently accelerate the progression of disease. …”
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Preclinical evaluation and preliminary clinical study of 68Ga-NODAGA-NM-01 for PET imaging of PD-L1 expression by Lingzhou Zhao, Jiali Gong, Sisi Liao, Wenhua Huang, Jinhua Zhao, Yan Xing

“…Abstract Background Programmed cell death 1/programmed death ligand-1 (PD-L1)-based immune checkpoint blockade is an effective treatment approach for non-small-cell lung cancer (NSCLC). …”
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Differential Production of Midkine and Pleiotrophin by Innate APCs upon Stimulation through Nucleic Acid-Sensing TLRs by Elias A. Said, Sumaya Al-Dughaishi, Wadha Al-Hatmi, Iman Al-Reesi, Mohammed S. Al-Balushi, Atika Al-Bimani, Juma Z. Al-Busaidi, Marwa Al-Riyami, Murtadha Al-Khabori, Salam Al-Kindi, Francesco A. Procopio, Shadia Al-Sinawi, Aliyaa Al-Ansari, Crystal Y. Koh, Khalid Al-Naamani, Ali A. Al-Jabri

“…They regulate and are expressed by some immune cells. We have recently demonstrated MK production by some human innate antigen-presenting cells (iAPCs), i.e., monocyte-derived dendritic cells (MDDCs) and macrophages stimulated through Toll-like receptor (TLR)-4, and plasmacytoid dendritic cells (pDCs) stimulated through TLR 7. …”
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Effects of Elemental Mercury Vapor Inhalation on Arterial Blood Gases, Lung Histology, and Interleukin-1 Expression in Pulmonary Tissues of Rats by Liqaa A. Raffee, Khaled Z. Alawneh, Ruba A. Alassaf, Abdallah Alzoubi, Musa A. Alshehabat, Nadeem Alabdallah, Abdel-Hameed Al-Mistarehi

“…Lung tissue sections were prepared for histology evaluation and immune-stained to detect IL-1 expression. There was a significant decrease in body weight in both STG (15%) and LTG (22%) compared with the CG. …”
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The emergence of DNAM-1 as the facilitator of NK cell-mediated killing in ovarian cancer by Rachel Pounds, Rachel Pounds, Wayne Croft, Hayden Pearce, Tasnia Hossain, Kavita Singh, Janos Balega, David N. Jeevan, Sudha Sundar, Sudha Sundar, Sean Kehoe, Jason Yap, Jason Yap, Paul Moss, Jianmin Zuo

“…Immunotherapeutic approaches that overcome local immune suppression and enhance DNAM-1-targeted lysis of OC offer the potential to improve disease control.…”
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Th1/Th2 Cells and Associated Cytokines in Acute Hepatitis E and Related Acute Liver Failure by Jian Wu, Yurong Guo, Xuan Lu, Fen Huang, Feifei Lv, Daqiao Wei, Anquan Shang, Jinfeng Yang, Qiaoling Pan, Bin Jiang, Jiong Yu, Hongcui Cao, Lanjuan Li

“…The involvement of cellular immunity in the development of hepatitis E virus (HEV) infection is rare. …”
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Achilles Tendon Repair by Decellularized and Engineered Xenografts in a Rabbit Model by Marta Bottagisio, Daniele D’Arrigo, Giuseppe Talò, Matilde Bongio, Marco Ferroni, Federica Boschetti, Matteo Moretti, Arianna B. Lovati

“…The use of auto- or allografts is notoriously limited due to the scarce supply and the high risks of immune adverse reactions. To overcome these limitations, tissue engineering (TE) has been considered a promising approach. …”
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<i>In vitro</i> and <i>in vivo</i> tropism and biodistribution of recombinant simian adenovirus type 25 by Irina V. Vavilova, Tatiana A. Ozharovskaia, Olga V. Zubkova, Olga Popova, Daria V. Voronina, Polina P. Goldovskaya, Denis I. Zrelkin, Alina Sh. Dzharullaeva, Inna V. Dolzhikova, Dmitry V. Shcheblyakov, Denis Yu. Logunov, Alexander L. Gintsburg

“…Different types of adenoviruses vary in their cellular tropism, which plays a key role in their ability to elicit an immune response. The aim of this study was to investigate the cellular tropism of the simian adenovirus type 25 in vitro and its biodistribution in vivo in comparison with human adenoviruses types 5 and 26. …”
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Neoadjuvant atezolizumab + chemotherapy for resectable NSCLC: 3-year clinical update of phase II clinical trial results and translational findings by Benjamin Izar, Justin F Gainor, Mark M Awad, Codruta Chiuzan, Anjali Saqi, Catherine A Shu, Katja Schulze, Brian S Henick, Naiyer A Rizvi, Samyukta Mallick, Yohanna Georgis, Peter D Koch, Stephanie Izard, Robert F Garofano, Cheryl V Wong, Jessica Grindheim, Joshua R Sonett, Alison M Taylor

“…Major pathological response (MPR, primary endpoint) was previously reported; here, we report 3-year disease-free survival (DFS), OS, and clinical characteristics of patients developing brain metastases (BM) with integrated data from tumor genomics, gene expression, and quantitative immunofluorescent measurement of immune markers.Results Of 30 enrolled patients, 29 were taken to the operating room. 26 underwent R0 resection, with 17 experiencing MPR (10 pCR). …”
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Trends and advances in Leptospira, a bibliometric analysis by Wei Wang, Wei Wang, Wei Wang, Yamin Gao, Yamin Gao, Yamin Gao, Jianyu Ji, Jianyu Ji, Jianyu Ji, Zhai Huang, Zhai Huang, Bin Xiong, Bin Xiong, Shulin Xiang, Shulin Xiang

“…“PLOS Neglected Tropical Diseases” published the highest number of articles (166), while “Infection and Immunity” garnered the most citations (6,591). Prominent research areas included restriction endonucleases, monoclonal antibodies, outer membrane proteins, water environments, detection methods, and antimicrobial agents. …”
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Adaptability of clams to prolonged heatwaves: Influences on gene expression, antioxidant capacity, and histology of Chinese cyclina Cyclina sinensis by Meimei Liu, Zhichao Wang, Hongwei Ni, Wenqing Zhuo, Gaoyuan Yuan, Zhiguo Dong

“…Acute heat stress alters the expression of immune-related genes in the hepatopancreas, including LSZ1, DPP1, SRB1, Casp3, BIRC2, Arf, CLEC4M, CLEC10A and Gadd45β. …”
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Expert consensus on the benefits of neuraminidase in conventional influenza vaccines: a Delphi study by John Youhanna, Joan Puig-Barberà, Matthew S. Miller, Deborah Molrine, Monica Hadi, Shweta Bapat, Ike Iheanacho, Sophie Dodman, Tsion Fikre, Paul Swinburn, ADD-NA (Adding Neuraminidase) Delphi panel

“…They agreed that anti-NA responses acquired via natural infection or vaccination are associated with protective immunity independently of haemagglutinin and that NA provided additional advantages including improving disease severity metrics. …”
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Infections, autoimmunity and immunodeficiencies are the leading etiologies of non-cystic fibrosis bronchiectasis in adults from the southwest of Colombia. by Andrés F. Zea-Vera, Carlos Andrés Rodríguez, Sebastián Giraldo, Mario Alejandro Chacón, Luis Fernando Guerrero, Ricardo Mosquera, Raúl Andrés Vallejo, Fabio Samir Vargas, María Andrea García, María A. Rengifo, Anilza Bonelo, Maximiliano Parra

“…Postinfectious (34.6%) and immune disorders (25.3%), represented by autoimmunity (13.6%) and immunodeficiency (11.7%), were the leading causes. …”
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Mortality causes and health spending by gender and health conditions in octogenarians, nonagenarians and centenarians in Colombia by Oscar Espinosa, Valeria Bejarano, Isabella Franky, Sandeep Pagali, Michael Drummond, Oscar H. Franco

“…Our analysis found that centenarians survived COVID-19 more than octogenarians and nonagenarians, with several hypotheses attributing this to their immune profiles. We found high expenditure on HIV/AIDS among older males suggesting the need for further study on sexually transmitted diseases prevention in this population. …”
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The association of single nucleotide polymorphisms in tumor necrosis factor 3 with susceptibility/resistance of Magallana gigas to Halomonas sp. 7T by Hongmei Fan, Qingyu Peng, Tianbao Liu, Lei Fang, Chuanyan Yang, Ning Kong, Lingling Wang, Linsheng Song

“…Tumor necrosis factors (TNFs) are a group of multifunctional inflammatory cytokines involved in various pathological and immune processes. In the present study, a TNF-3 was characterized in Pacific oyster Magallana gigas (MgTNF-3), and its association of single nucleotide polymorphisms with susceptibility/resistance of oyster to Halomonas sp. 7T were investigated. …”
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CD94-driven in vitro expansion of highly functional adaptive NKG2C+ NKG2A- CD57+ NK cells from CMV+ healthy donors by Chiara Giordano, Simona Carlomagno, Simona Carlomagno, Michela Falco, Claudia Cantoni, Claudia Cantoni, Massimo Vitale, Ignazio Caruana, Johannes Dirks, Alberto Serio, Letizia Muccio, Giulia Bartalucci, Alessandra Bo, Franco Locatelli, Franco Locatelli, Cristina Bottino, Cristina Bottino, Simona Sivori, Simona Sivori, Mariella Della Chiesa, Mariella Della Chiesa

“…Importantly, mAb-expanded adaptive NK cells did not upregulate PD-1 or other regulatory immune checkpoints that could dampen their function.ConclusionsBy this study we provide hints to improve previous expansion methods, by eliminating the use of genetically modified cells as stimulators, and obtaining effectors not expressing unwanted inhibitory receptors. …”
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The preoperative neutrophil‐to‐lymphocyte ratio is not a marker of prostate cancer characteristics but is an independent predictor of biochemical recurrence in patients receiving r... by Zhi Cao, Jin Ji, Chao Zhang, Fubo Wang, Huan Xu, Yongwei Yu, Yinghao Sun

“…In conclusion, NLR cannot reflect prostate cancer characteristics or the local immune microenvironment, but a high NLR can serve as an independent predictor of better BCR.…”
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MyD88 inhibitor TJ-M2010-5 alleviates spleen impairment and inflammation by inhibiting the PI3K/miR-136-5p/AKT3 pathway in the early infection of Trichinella spiralis by Huifang Bai, Qianqian Dang, Guoliang Chen, Lingfeng Xie, Saining Wang, Ning Jiang, Xiaoxia Wu, Shuyan Zhang, Xuelin Wang

“…Abstract Trichinella spiralis (T. spiralis) has been reported to induce inflammation, which can cause immune system dysregulation. Myeloid differentiation primary response gene 88 (MyD88) is implicated in inflammation signalling pathways. …”
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