PLUNC downregulates the expression of PD-L1 by inhibiting the interaction of DDX17/β-catenin in nasopharyngeal carcinoma by Ranran Feng, Yilin Guo, Meilin Chen, Ziying Tian, Yijun Liu, Su Jiang, Jieyu Zhou, Qingluan Liu, Xiayu Li, Wei Xiong, Lei Shi, Songqing Fan, Guiyuan Li, Wenling Zhang

“…Background Nasopharyngeal carcinoma (NPC) is characterized by high programmed death-ligand 1 (PD-L1) expression and abundant infiltration of non-malignant lymphocytes, which renders patients potentially suitable candidates for immune checkpoint blockade therapies. Palate, lung, and nasal epithelium clone (PLUNC) inhibit the growth of NPC cells and enhance cellular apoptosis and differentiation. …”
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Expression Profile of Genes Potentially Associated with Adequate Glycemic Control in Patients with Type 2 Diabetes Mellitus by Sâmia Cruz Tfaile Corbi, Alliny Souza Bastos, Rafael Nepomuceno, Thamiris Cirelli, Raquel Alves dos Santos, Catarina Satie Takahashi, Cristiane S. Rocha, Silvana Regina Perez Orrico, Claudia V. Maurer-Morelli, Raquel Mantuaneli Scarel-Caminaga

“…This demonstrated a systemic exacerbation of the gene expression related to immune response in T2D patients. Moreover, genes related to lipid metabolisms and DNA replication/repair were influenced by the glycemic control. …”
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Vitamin D Regulates the Expression of Glucocorticoid Receptors in Blood of Severe Asthmatic Patients by Bassam Mahboub, Saba Al Heialy, Mahmood Yaseen Hachim, Rakhee K. Ramakrishnan, Ashraf Alzaabi, Rania Medhat Seliem, Laila Ibraheem Salameh, Sameen Masooma Toor, Fathelrahman Salem Shendi, Ola Mohamed Al Ali, Basil Khalid Safarini, Wafa Taleb Erabia, Rabih Halwani, Qutayba Hamid

“…Vitamin D (VitD) deficiency is a significant public health concern in many areas around the globe and has been associated with many immune-mediated diseases, including asthma. Severe asthma has been linked to a decreased glucocorticoid receptor (GR) ratio (GR-α/GR-β ratio), indicating steroid hyporesponsiveness. …”
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Radiation-induced rescue effect on human breast carcinoma cells is regulated by macrophages by Spoorthy Pathikonda, Li Tian, Clement Manohar Arava, Shuk Han Cheng, Yun Wah Lam

“…This study shows a previously unappreciated role of the innate immune system in RIRE. Depending on polarised phenotypes, macrophages in the tumour microenvironment can interfere with the effectiveness of radiotherapy by adjusting the RIRE magnitudes.…”
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Enhancement of chemotherapy using oncolytic virotherapy: Mathematical and optimal control analysis by Joseph Malinzi, Rachid Ouifki, Amina Eladdadi, Delfim F. M. Torres, K. A. Jane White

“…To investigate how virotherapy could enhance chemotherapy, we propose an ODE based mathematical model describing the interactions between tumour cells, the immune response, and a treatment combination with chemotherapy and oncolytic viruses. …”
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Characterization of G2/M checkpoint classifier for personalized treatment in uterine corpus endometrial carcinoma by Yiming Liu, Yusi Wang, Shu Tan, Xiaochen Shi, Jinglin Wen, Dejia Chen, Yue Zhao, Wenjing Pan, Zhaoyang Jia, Chunru Lu, Ge Lou

“…The differences in biological and clinical features of different subtypes were compared through survival analysis, clinical characteristics, immune infiltration, tumor mutation burden, and drug sensitivity analysis. …”
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Genome analysis of Bifidobacterium adolescentis and investigation of its effects on inflammation and intestinal barrier function by Bo Li, Bo Li, Haoyu Wang, Haoyu Wang, Haoyu Wang, Mengmeng Wang, Mengmeng Wang, Hewei Liang, Hewei Liang, Hewei Liang, Tongyuan Hu, Tongyuan Hu, Tongyuan Hu, Jinlong Yang, Jinlong Yang, Jinlong Yang, Shangyong Li, Xinbi You, Xinbi You, Xinbi You, Binbin Xia, Binbin Xia, Binbin Xia, Yue Yuan, Yue Yuan, Yuanqiang Zou, Yuanqiang Zou, Yinglei Miao, Yinglei Miao, Yang Sun, Yang Sun, Yang Sun

“…It effectively modulated the immune response by reducing the levels of pro-inflammatory cytokines such as IL-6, IL-1β, IL-17A, IFN-γ, and TNF-α, while promoting the secretion of anti-inflammatory cytokines like IL-4, IL-10, and TGF-β1. …”
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Risk factors and outcomes of vitamin D deficiency in very preterm infants by Hannah Cho, Yoon Lee, Saelin Oh, Ju Sun Heo

“…Background: Vitamin D is essential for bone health and immune system. Vitamin D deficiency (VDD) poses a high-risk to very preterm (VP) infants. …”
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Machine learning based on blood test biomarkers predicts fast progression in advanced NSCLC patients treated with immunotherapy by Jie Yang, Jian-Guo Zhou, Benjamin Frey, Hu Ma, Haitao Wang, Markus Hecht, Rainer Fietkau, Udo Gaipl, Xiaofei Chen, Ada Hang-Heng Wong, Fangya Tan, Si-Si He, Gang Shen, Yun-Jia Wang, Wenzhao Zhong

“…Objective Fast progression (FP) represents a desperate situation for advanced non-small cell lung cancer (NSCLC) patients undergoing immune checkpoint inhibitor therapy. We aimed to develop a predictive framework based on machine learning (ML) methods to identify FP in advanced NSCLC patients using blood test biomarkers.Methods and analysis We extracted data of 1546 atezolizumab-treated patients from four multicentre clinical trials. …”
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In vivo production of engineered ACE2 decoy protects lungs from SARS-CoV-2 infection by Yuta Suzuki, Takayuki Miyazaki, Yoko Ida, Tatsuya Suzuki, Yumi Itoh, Shuto Nakao, Keita Kondo, Kenji Kubara, Keisuke Nishioka, Hiroki Muto, Ryuji Watari, Toshifumi Hirayama, Dai Kakiuchi, Shinya Sato, Satoshi Inoue, Yoshifumi Uemoto, Yohei Mukai, Atsushi Hoshino, Toru Okamoto, Junji Matsui

“…Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) variants repeatedly evade the immune system within short periods. Thus, next-generation therapeutics that are resistant to mutations and can be rapidly supplied to individuals in an emergency are required. …”
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Systematic evaluation of intratumoral and peripheral BCR repertoires in three cancers by Sofia V Krasik, Ekaterina A Bryushkova, George V Sharonov, Daria S Myalik, Elizaveta V Shurganova, Dmitry V Komarov, Irina A Shagina, Polina S Shpudeiko, Maria A Turchaninova, Maria T Vakhitova, Igor V Samoylenko, Dimitr T Marinov, Lev V Demidov, Vladimir E Zagaynov, Dmitriy M Chudakov, Ekaterina O Serebrovskaya

“…The current understanding of humoral immune response in cancer patients suggests that tumors may be infiltrated with diffuse B cells of extra-tumoral origin or may develop organized lymphoid structures, where somatic hypermutation and antigen-driven selection occur locally. …”
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Eosinophilic esophagitis in children: A multicenter study evaluating current practices in Mexico by Victor Gonzalez-Uribe, MD, MSc, Luis A. Hernandez-Zarate, MD, Cesar F. Pozo Beltran, MD, Christian R. Alcocer-Arreguin, MD, Paola de Baro Alvarez, MD, MEd, Natalia Coello-Niembro, MD, Pablo Jimenez-Feria, MD, Zaira S. Mojica Gonzalez, MD, Carlos Andres Gomez-Nuñez, MD, Ricardo Martinez-Tenopala, MD, Martín R. Basile-Alvarez, MD, Berenice Velasco-Benhumea, MD, Roberto Fernandez-Soto, MD, Daniela E. García-Fajardo, MD, Herberth Perez-Avilés, MD, Cesar Pinto-Solis, MD, Luis A. Rios-Villalobos, MD, Roberto Ureña-Ortiz, MD, Leticia Lezama-Vazquez, MD, Patricio Acosta-Rodriguez-Bueno, MD, MSc, Blanca Estela Del Rio-Navarro, MD

“…Background: Eosinophilic esophagitis (EoE) is a chronic immune-mediated condition characterized by eosinophil infiltration in the esophagus, leading to symptoms such as food impaction and growth delays. …”
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Systematic review: e-cigarettes vs. conventional cigarettes by Mateusz Janik, Barbara Ufnalska, Joanna Rychlewska-Duda, Justyna Lisiecka, Artur Fabijański, Anna Konarska, Anna Machowiak, Michał Nowak, Wojciech Firlej, Adrianna Dukacz

“…Keywords included "e-cigarettes", "vaping", "health effects", "conventional cigarettes", "tobacco", "respiratory system", "cardiovascular system", "immune system", "oral health", and "cellular effects". …”
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aPD-L1-facilitated theranostic and tumor microenvironment remodeling of pancreatic cancer via docetaxel-loaded phase-transformation nanoparticles triggered by low-intensity pulsed... by Yi Tang, Qingling Shen, Peng Lin, Zhixin Chen, Denghui Fan, Minling Zhuo, Yajiao Gan, Yixi Su, Qingfu Qian, Liwu Lin, Ensheng Xue, Zhikui Chen

“…Additionally, hypoxia and immune suppression within the tumor contribute to poor responses to radiotherapy and chemotherapy, ultimately leading to an unfavorable prognosis. …”
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Biosafety Management Practices Among Clinical Laboratory Professionals in Debre Berhan Town Governmental Hospitals, Ethiopia: A Cross‐Sectional Study by Mahlet Tewodros Tadesse, Libse Lemma Ayalke, Beza Fitiwi Tedla, Fikrite Adefris Weldemeskel, Ahmed Seid Yirdaw, Tsegahun Asfaw Abebe

“…Only 35 (43.2%) of participants received appropriate immunizations, and access to biosafety equipment like biological safety cabinets was limited 15 (18.5%). …”
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Real-world outdoor air exposure effects in a model of the human airway epithelium – A comparison of healthy and asthmatic individuals using a mobile laboratory setting by Pavel Rossner, Helena Libalova, Tereza Cervena, Michal Sima, Zuzana Simova, Kristyna Vrbova, Antonin Ambroz, Zuzana Novakova, Fatima Elzeinova, Anezka Vimrova, Lubos Dittrich, Michal Vojtisek, Martin Pechout, Michal Vojtisek-Lom

“…In samples originating from healthy and asthmatic individuals, we assessed the parameters of toxicity, lipid peroxidation and immune response; we further performed comprehensive monitoring of air pollutants at sampling sites. …”
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Effects of GABA Supplementation on Intestinal SIgA Secretion and Gut Microbiota in the Healthy and ETEC-Infected Weanling Piglets by Yuanyuan Zhao, Jing Wang, Hao Wang, Yonggang Huang, Ming Qi, Simeng Liao, Peng Bin, Yulong Yin

“…In conclusion, GABA supplementation can enhance intestinal mucosal immunity by promoting jejunal SIgA secretion, which might be related with the T-cell-dependent pathway and altered gut microbiota structure and metabolism.…”
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Peripheral Expression of IL-6, TNF-α and TGF-β1 in Alzheimer's Disease Patients by Gamze Güven, Pınar Köseoğlu, Ebba Lohmann, Bedia Samancı, Erdi Şahin, Başar Bilgiç, Haşmet Ayhan Hanağası, Hakan Gürvit, Nihan Erginel-Ünaltuna

“…Conclusion: The outcomes of this study suggest a disruption in the peripheral immune response in individuals with AD. The observed decreased expression of cytokine genes in peripheral leukocytes may indicate a contributory mechanism through which peripheral cytokines influence AD pathogenesis.…”
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RAGE and its ligands in breast cancer progression and metastasis by Madalina Coser, Bogdan Mihai Neamtu, Bogdan Mihai Neamtu, Bogdan Pop, Bogdan Pop, Calin Remus Cipaian, Calin Remus Cipaian, Maria Crisan, Maria Crisan

“…In addition, studies have shown that RAGE and its ligands influence the way breast cancer cells interact with immune cells present in the tumor microenvironment (macrophages, fibroblasts), thus regulating it to promote tumor growth and metastasis.ConclusionBreast cancers with a high expression of RAGE are associated with poor prognosis. …”
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Bronchoalveolar Lavage Fluid IFN-γ+ Th17 Cells and Regulatory T Cells in Pulmonary Sarcoidosis by Anders Tøndell, Torolf Moen, Magne Børset, Øyvind Salvesen, Anne Dorthea Rø, Malcolm Sue-Chu

“…Our results indicate a possible immune cell imbalance in sarcoidosis.…”
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