Expression and Secretion of CXCL-8 and CXCL-10 From Mycobacterium Bovis BCG-Infected Human Epithelial Cells: Role of IL-4 by Patricia Méndez-Samperio, Elena Miranda, Abraham Vázquez

“…Collectively, these data demonstrate that M. bovis BCG-infected human epithelial cells can have an active role in a local inflammatory immune response via the secretion of CXC chemokines which can be selectively regulated by Th2-derived cytokines.…”
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Burden of Acute Respiratory Infections Caused by Influenza Virus, Respiratory Syncytial Virus, and SARS-CoV-2 with Consideration of Older Adults: A Narrative Review by William P. Hanage, William Schaffner

“…In this narrative review, we summarize themes identified in the literature regarding the epidemiology, seasonality, immunity after infection, clinical presentation, and transmission for these ARIs, along with the impact of the COVID-19 pandemic on seasonal patterns of influenza and RSV infections, with consideration of data specific to older adults when available. …”
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Integrated analysis of single-cell and bulk-RNA sequencing for the cellular senescence in prognosis of lung adenocarcinoma by Fengqiang Yu, Liangyu Zhang, Xun Zhang, Jianshen Zeng, Fancai Lai

“…Different TRGS patient groups showed varying degrees of immune cell infiltration, frequency of gene missense mutation, sensitivity to different drugs, and tumor mutation burden (TMB). …”
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Wild-type bone marrow cells repopulate tissue resident macrophages and reverse the impacts of homozygous CSF1R mutation. by Dylan Carter-Cusack, Stephen Huang, Sahar Keshvari, Omkar Patkar, Anuj Sehgal, Rachel Allavena, Robert A J Byrne, B Paul Morgan, Stephen J Bush, Kim M Summers, Katharine M Irvine, David A Hume

“…These studies provide a model for the pathology and treatment of CSF1R mutations in humans and the innate immune deficiency associated with prematurity.…”
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The viral and cellular microRNA targetome in lymphoblastoid cell lines. by Rebecca L Skalsky, David L Corcoran, Eva Gottwein, Christopher L Frank, Dong Kang, Markus Hafner, Jeffrey D Nusbaum, Regina Feederle, Henri-Jacques Delecluse, Micah A Luftig, Thomas Tuschl, Uwe Ohler, Bryan R Cullen

“…Furthermore, targets of EBV miRNAs are involved in multiple cellular processes that are directly relevant to viral infection, including innate immunity, cell survival, and cell proliferation. Finally, we present evidence that myc-regulated host miRNAs from the miR-17/92 cluster can regulate latent viral gene expression. …”
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Glycemic Control in Type 2 Diabetes Mellitus Patients Could Affect NLRP3 Inflammasome Level by Refif Sabih Al-Shawk, Zainab Fadhel Ashoor, Wasan Abdul-elah Bakir, Intisar Manfi Ahmed

“…Objectives: This study was conducted to ensure that type 2 diabetes mellitus (T2DM) glycemic control could affect mitochondrial stress through NLRP3 inflammasome level leading to an aberrant immune response. Materials and Methods: A case–control study was conducted on 90 Iraqi subjects, 60 of them were T2DM who were subgrouped into 30 patients with good glycemic control (HbA1c ≤ 7%) and the second group with 30 patients with poor (bad) glycemic control (HbA1c > 7%). …”
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Effects of neutrophil granule proteins on sepsis-associated lymphopenia and their relationship with CD4+ T-cell pyroptosis by Jia-yu Mao, Ya-wen Xie, Xian-li Lei, Jia-hui Zhang, Wei Cheng, Na Cui

“…BackgroundNeutrophil acts as a double-edged sword in the immune system. We hypothesized that an elevated neutrophil granule protein level is associated with sepsis-associated lymphopenia (SAL).MethodsWe enrolled 61 patients with sepsis admitted to the Department of Critical Care Medicine of Peking Union Medical College Hospital between May 2022 and October 2023 in this study. …”
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Neuropathology-based approach reveals novel Alzheimer's Disease genes and highlights female-specific pathways and causal links to disrupted lipid metabolism: insights into a viciou... by Yin Jin, Apostolia Topaloudi, Sudhanshu Shekhar, Guangxin Chen, Alicia Nicole Scott, Bryce David Colon, Petros Drineas, Chris Rochet, Peristera Paschou

“…Finally, through PheWAS and Mendelian Randomization analysis, we identify causal links with AD neuropathology pointing to disrupted lipid metabolism, as well as impaired peripheral immune response and liver dysfunction as part of a vicious cycle that fuels neurodegeneration.…”
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Human induced pluripotent stem cell–derived therapies for regeneration after central nervous system injury by Stephen Vidman, Yee Hang Ethan Ma, Nolan Fullenkamp, Giles W. Plant

“…Furthermore, successful transplantation requires innovative approaches to develop delivery vectors that can mitigate cell death and support integration. Lastly, host immune responses to allogeneic grafts must be thoroughly characterized and further developed to reduce the need for immunosuppression. …”
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Anemia in Children with Congenital Heart Disease: A Finding from Low-Resource Setting Hospitals by Henok Kumsa, Rediet Woldesenbet, Feven Mulugeta, Rajalakshmi Murugan, Tamirat Moges

“…Moreover, the findings of this study on illness profiles in children with CHD prompt further research into the cellular and molecular mechanisms underlying immune system dysfunction.…”
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COVID-19 Vaccine Acceptance Level in Ethiopia: A Systematic Review and Meta-Analysis by Addisu Tadesse Sahile, Girma Demissie Gizaw, Tennyson Mgutshini, Zewdu Minwuyelet Gebremariam, Getabalew Endazenaw Bekele

“…The level of COVID-19 vaccine acceptance in Ethiopia was at a lower rate than necessary to achieve herd immunity. The highest level of vaccine acceptance rate was reported via online or telephone surveys followed by the southern region of Ethiopia. …”
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Dual Role of Bacteria in Carcinoma: Stimulation and Inhibition by Suad A Al-Hilu, Wisam H Al-Shujairi

“…In this review, we discuss links between the bacterial species and cancer, with focus on immune responses for the stimulation of tumor cells such as induction of inflammation. …”
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Investigation of Antibiotic Resistance and Biofilm Formation in Clinical Isolates of Klebsiella pneumoniae by Kiana Karimi, Omid Zarei, Parinaz Sedighi, Mohammad Taheri, Amin Doosti-Irani, Leili Shokoohizadeh

“…The ability of biofilm formation in this bacterium decreases the host immune response and antibiotic efficacy. This may impose a huge impact on patients and healthcare settings. …”
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An Energy Modulation Interrogation Technique for Monitoring the Adhesive Joint Integrity Using the Full Spectral Response of Fiber Bragg Grating Sensors by Chow-Shing Shin, Tzu-Chieh Lin, Shun-Hsuan Huang

“…It has the advantages of being close to the damage and immune to environmental attack and electromagnetic interference. …”
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Comprehensive Analysis Reveals PTK6 as a Prognostic Biomarker Involved in the Immunosuppressive Microenvironment in Breast Cancer by Lili Wang, Shuimei Luo, Ziming Wang, Yiqiang Huang, Yang Luo, Xianhe Xie

“…After that, the Kaplan-Meier method, univariate analysis, and multivariate analysis were carried out in order to investigate the PTK6 gene’s potential prognostic significance in patients with BC. ssGSEA was utilized in order to conduct an investigation of the immune infiltration. In this study, we discovered that the expressions of PTK6 were significantly raised in the majority of different types of malignancies, including BC. …”
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Monitoring for respiratory viruses among wild canids, Texas by Lyudmyla V. Marushchak, Laura A. Pulscher, Judith U. Oguzie, Diego B. Silva, Kenneth A. Waldrup, Douglas M. Watts, Gregory C. Gray

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Rosuvastatin effects on the HDL proteome in hyperlipidemic patients by Vavlukis Ana, Mladenovska Kristina, Davalieva Katarina, Vavlukis Marija, Dimovski Aleksandar

“…Sixty-nine HDL proteins were identified, belonging to four main biological function clusters: lipid transport and metabolism; platelet activation, degranulation, and aggregation, wound response and wound healing; immune response; inflammatory and acute phase response. …”
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CRISPR/Cas9, a universal tool for genomic engineering by A. V. Smirnov, A. M. Yunusova, V. A. Lukyanchikova, N. R. Battulin

“…The CRISPR/Cas9 system was initially described as an element of archeal and bacterial immunity, but gained much attention recently for its outstanding ability to be programmed to target any genomic loci through a short 20-nucleotide sgRNA region. …”
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The Primate Habituation Programme, Dzanga Sangha Protected Areas, Central African Republic: An overview by Terence Fuh Neba, Anna Feistner, Angelique Todd

“…Added to potential emerging diseases, human contact may increase stress and expose gorillas to human-borne pathogens, to which they may have little immunity. A PHP priority is to develop the programme into a model of sustainable best-practice with reduced risk of negative impacts from tourism/research. …”
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Clinical manifestations in Egyptian Pompe disease patients: Molecular variability and enzyme replacement therapy (ERT) outcomes by Mohamed Abdelghafar Hussein, Heba ElTaher, Ranim Mahmoud, Donia Sobh, Mohammad Al-Haggar

“…The patient with a positive immune response had the most severe cardiac abnormalities, despite improvements in muscle weakness and motor skills from ERT. …”
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