PD-L1 Expression and CD8+ T Cell Infiltration Predict a Favorable Prognosis in Advanced Gastric Cancer by Yangyang Wang, Chunchao Zhu, Wei Song, Jun Li, Gang Zhao, Hui Cao

“…Taken together, this study further highlights targets for immune checkpoint-based therapy in AGC.…”
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Thymus Hyperplasia and Thymoma Type B in Patients with Myasthenia Gravis: Two case reports and Literature Review by Selman Dumani, Altin Kuqo, Ermal Likaj, Saimir Kuci, Majlinda Ikonomi, Laureta Dibra, Alessia Mehmeti, Ejona Celiku, Altin Veshti

“… Introduction: The thymus gland plays a pivotal role in immune system regulation, but conditions such as thymic hyperplasia (TH) and thymoma pose distinct clinical challenges due to their rarity and complex presentation in surgical practice. …”
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Genomic characterization and evolutionary analysis of a Getah virus variant from piglets in central China by Zhenhua Guo, Yao Jiang, Peng Li, Gaiping Zhang, Gaiping Zhang, Gaiping Zhang, Gaiping Zhang

“…Most of these special sites were distributed in domain A, B, and C of E2 protein, which are usually associated with the GETV infection and immune response.DiscussionOur study expands knowledge of GETV pathogenicity and deepens understanding of GETV genetic and adaptive evolution, which would be valuable for the development of diagnosis and prevention for GETV.…”
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Cell therapy for scleroderma: progress in mesenchymal stem cells and CAR-T treatment by Liting Chen, Rongshan Huang, Chaoshuo Huang, Guiming Nong, Yuanyuan Mo, Lvyin Ye, Kunhong Lin, Anping Chen, Anping Chen

“…CAR-T cell therapy ca specifically target and eliminate autoreactive immune cells, exhibiting enhanced specificity and personalized potential. …”
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A distinct metabolomic pattern revealed intestinal microenvironment factor-mediated food allergy in a BALB/c mouse model by Qiang Xie, Chenglong Liu, Wenhui Fu, Chen Chen, Dan Luo, Shimin Gu, Wentong Xue

“…Intestinal immune homeostasis plays a critical role in the pathogenesis of food allergy. …”
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Adjuvant Autologous Melanoma Vaccine for Macroscopic Stage III Disease: Survival, Biomarkers, and Improved Response to CTLA-4 Blockade by Michal Lotem, Sharon Merims, Stephen Frank, Tamar Hamburger, Aviram Nissan, Luna Kadouri, Jonathan Cohen, Ravid Straussman, Galit Eisenberg, Shoshana Frankenburg, Einat Carmon, Bilal Alaiyan, Shlomo Shneibaum, Zeynep Ozge Ayyildiz, Murat Isbilen, Kerem Mert Senses, Ilan Ron, Hanna Steinberg, Yoav Smith, Eitan Shiloni, Ali Osmay Gure, Tamar Peretz

“…Improved survival in patients attaining a strong DTH and increased response rate with subsequent ipilimumab suggests that the autologous vaccine confers protective immunity.…”
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Generation of Mature Nα-Terminal Acetylated Thymosin α1 by Cleavage of Recombinant Prothymosin α by Bo Liu, Xin Gong, Shaohong Chang, Peng Sun, Jun Wu

“…Nα-terminal acetylated thymosin α1 (Tα1), a 28-amino-acid peptide, is an immune modifier that has been used in the clinic to treat hepatitis B and C virus (HBV/HCV) infections. …”
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Transcriptional profiles analysis of effects of Toxoplasma gondii rhoptry protein 16 on THP-1 macrophages by Ningai Yang, Ningai Yang, Ningai Yang, Mingyang Li, Hong Yang, Jiaming Li, Tiantian Dang, Guangqi Li, Zhijun Zhao, Zhijun Zhao, Zhijun Zhao

“…IntroductionToxoplasma gondii, an intracellular parasitic protozoan, is globally recognized for its ability to cause parasitic diseases and has developed diverse strategies to evade immune-mediated elimination. The protein ROP16 of T.gondii plays a crucial role in this evasion process by specifically targeting macrophages and mononuclear phagocytes in vivo. …”
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Autoimmune Hepatitis in Brazilian Children: IgE and Genetic Polymorphisms in Associated Genes by Léa Campos de Oliveira, Anna Carla Goldberg, Maria Lucia Carnevale Marin, Karina Rosa Schneidwind, Amanda Farage Frade, Jorge Kalil, Irene Kasue Miura, Renata Pereira Sustovich Pugliese, Vera Lucia Baggio Danesi, Gilda Porta

“…The novel association suggests an additional role for IgE-linked immune response genes in the pathogenesis of AIH.…”
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Identification and Characterization of the <i>ROP GTPase</i> Gene Family in Strawberry and the Positive Role of <i>FveROP4</i> in Fruit Resistance to Gray Mold by Shuai Zhao, Baode Zhu, Zhijun Zou, Yushan Zhai, Sufeng Liao, Ming Xu, Kunyang Li, Nasir Mehmood, Xiong Liao

“…The study findings may provide valuable insights for investigating the mechanisms of ROP signaling in regulating the immune response in strawberries and could significantly contribute to strawberry breeding programs aimed at developing new cultivars with enhanced fruit shelf life.…”
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The Gut Microbiome Regulates the Psychomotor Effects and Context-Dependent Rewarding Responses to Cocaine in Germ-Free and Antibiotic-Treated Animal Models by Andrew D. Winters, Dina M. Francescutti, David J. Kracht, Diptaraj S. Chaudhari, Branislava Zagorac, Mariana Angoa-Perez

“…ABX-treated mice also showed significant declines in microbial diversity, shifts in bacterial structure, and dysregulation in metabolic, immune, and neurotransmitter pathways (<i>p</i> ≤ 0.0001), including alterations in short-chain fatty acids and gamma-aminobutyric acid metabolism. …”
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Assessing in-vitro models for microglial development and fetal programming: a critical review by Steven Schepanski, Steven Schepanski, Gonza B. Ngoumou, Gonza B. Ngoumou, Claudia Buss, Claudia Buss, Claudia Buss, Claudia Buss, Georg Seifert, Georg Seifert

“…This review evaluates in-vitro models for studying how maternal influences during pregnancy impact the development of offspring microglia, the immune cells of the central nervous system. The models examined include primary microglia cultures, microglia cell lines, iPSC-derived microglia, PBMC-induced microglia-like cells, 3D brain organoids derived from iPSCs, and Hofbauer cells. …”
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Application of Nucleic Acid Reference Material for Rapid Detection of Cronobacter sakazakii (Cronobacter spp.) in Flammulina velutipes by Huandie Yang, Danyang Guo, Leilei Chen, Alexander Suvorov, Qingxin Zhou, Junhua Wang, Xiaofeng Gao, Jinyu Yang, Xiangyan Chen

“…It can cause meningitis, bacteremia, and necrotizing enterocolitis in infants and elderly people with low immunity. Therefore, the development of the rapid detection method for foodborne pathogen C. sakazakii is very important for food safety control. …”
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Regulation of fibronectin and collagens type I, III and VI by TNF-α, TGF-β, IL-13, and tofacitinib by Frederik S. Gillesberg, Martin Pehrsson, Anne-Christine Bay-Jensen, Peder Frederiksen, Morten Karsdal, Bent W. Deleuran, Tue W. Kragstrup, Satoshi Kubo, Yoshiya Tanaka, Joachim H. Mortensen

“…TNF-α and IL-13 are key cytokines in Th1 and Th2 immune responses, respectively, while TGF-β1 is the principal pro-fibrotic mediator. …”
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Lysosome and Cytoskeleton Pathways Are Robustly Enriched in the Blood of Septic Patients: A Meta-Analysis of Transcriptomic Data by Jie Ma, Chuanxi Chen, Andreas S. Barth, Chris Cheadle, Xiangdong Guan, Li Gao

“…In contrast, pathways related to “Ribosome”, “Spliceosome” and “Cell adhesion molecules” were found to be downregulated, along with known pathways for immune dysfunction. Overall, our study revealed distinct mRNA activation profiles and protein-protein interaction networks in blood of human sepsis. …”
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Studying dynamic changes in body mass and mass of internal organs in laboratory rats experimentally infected with bovine leukosis virus by E. S. Krasnikova, R. V. Radionov, A. V. Krasnikov, A. Yu. Svetozarova

“…Preliminary studies have established that BLV infection of laboratory rats is accompanied by clinical, morphological and biochemical changes in the blood, signs of immune suppression, impaired immunological reactivity of the body, and morphofunctional changes in the immunocompetent cells that correlate with bovine leukosis. …”
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Loss-of-function variant in MAGT1 leading to XMEN disease in a Colombian patient with a common variable immunodeficiency by Sebastián Gutiérrez-Hincapié, Julio César Orrego, José Luis Franco, Claudia M. Trujillo-Vargas

“…To elucidate the genetic defect conferring impaired immunity in a patient diagnosed with common variable immunodeficiency. …”
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Multiepitope Subunit Vaccine Design against COVID-19 Based on the Spike Protein of SARS-CoV-2: An In Silico Analysis by Hamza Arshad Dar, Yasir Waheed, Muzammil Hasan Najmi, Saba Ismail, Helal F. Hetta, Amjad Ali, Khalid Muhammad

“…In conclusion, our data supports the proposition that a multiepitope vaccine will provide protective immunity against COVID-19. However, further in vivo and in vitro experiments are needed to validate the immunogenicity and safety of the candidate vaccine.…”
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Targeting natural antioxidant polyphenols to protect neuroinflammation and neurodegenerative diseases: a comprehensive review by Maroua Jalouli, Md Ataur Rahman, Partha Biswas, Hasanur Rahman, Abdel Halim Harrath, In-Seon Lee, In-Seon Lee, Sojin Kang, Jinwon Choi, Moon Nyeo Park, Bonglee Kim, Bonglee Kim

“…Furthermore, polyphenols have demonstrated their therapeutic potential through the regulation of key signaling pathways such as Akt, Nrf2, STAT, and MAPK, which play critical roles in neuroprotection and the body’s immune response. This review emphasizes the growing body of evidence supporting the therapeutic potential of polyphenols in combating neurodegeneration and neuroinflammation, as well as enhancing brain health. …”
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SILAC-based quantification reveals modulation of the immunopeptidome in BRAF and MEK inhibitor sensitive and resistant melanoma cells by Melissa Bernhardt, Anne Rech, Marion Berthold, Melina Lappe, Jan-Niklas Herbel, Florian Erhard, Annette Paschen, Bastian Schilling, Bastian Schilling, Andreas Schlosser

“…It is highly dynamic and reflects the current cellular state, enabling the immune system to recognize abnormal cellular conditions, such as those present in cancer cells. …”
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