Integration of Metabolomics and Transcriptomics to Reveal the Antitumor Mechanism of <i>Dendrobium officinale</i> Polysaccharide-Based Nanocarriers in Enhancing Photodynamic Immuno... by Shengchang Tao, Huan Wang, Qiufeng Ji, Yushan Yang, Gang Wei, Ruiming Li, Benjie Zhou

“…The differentially regulated functional pathways were primally related to the antitumor immune response. The results of the pathological histology assay and qRT-PCR analysis verified the findings of the integrated metabolomics and transcriptomics analysis. …”
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Transcriptomic and metabolomic analyses reveal the spatial role of carnitine metabolism in the progression of hepatitis B virus cirrhosis to hepatocellular carcinoma by Pengxiang Gao, Qiuping Liu, Ziye Luo, Wenjun Pu, Wenjun Pu

“…The downregulated genes were linked to immune response and fatty acid metabolism. Metabolomic analysis showed major changes in lipid and choline metabolism. …”
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Oncostatin M [OSM] protein immuno-expression in oral squamous cell carcinoma – A prospective study by Sunil Prakash, Nandhini Gunasekaran, Ramya Mahalingam, Rajkumar Krishnan

“…When there is an upregulation of angiogenesis stimulators or a downregulation of angiogenesis inhibitors, the tumour may manifest its capacity for angiogenesis. Immune cells secrete a substance called Oncostatin M (OSM), which has been linked to cancer angiogenesis and subsequent pathogenesis. …”
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Comprehensive bioinformatics analysis reveals novel potential biomarkers associated with aging and mitochondria in osteoporosis by Ke Bi, Yuxi Chen, Yuhang Hu, Song Li, Weiming Li, Zhange Yu, Lei Yu

“…Cellular communication analysis showed that TSCs were active, with numerous signaling interactions with monocytes, macrophages and immune cells. Finally, the expression of key gene was verified by quantitative real-time PCR (qRT-PCR). …”
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The role of anti-inflammatory diets and supplementation in metabolic syndrome and symptom remission in adults with schizophrenia: a systematic review by Elizabeth Suschana, Thea Anderson, Catriona Hong, Arun Narikatte, Jillian Silverberg, Manu Suresh Sharma

“…IntroductionImmune dysregulation and chronic inflammation have been hypothesized as potential pathways in metabolic syndrome and schizophrenia. …”
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Ginger polysaccharide UGP1 suppressed human colon cancer growth via p53, Bax/Bcl-2, caspase-3 pathways and immunomodulation by Yanfang Qian, Chenying Shi, Chen Cheng, Dengwei Liao, Junping Liu, Gui-tang Chen

“…In conclusion, it indicated that the UGP1 could suppress human colon cancer growth by inducing apoptosis via the regulation of p53, caspase-3, and Bax/Bcl-2 ratio-dependent pathway and regulating immune system activity. This investigation provided basic theoretical mechanism of ginger polysaccharide-exerted antitumor activities, and contributed to develop a possible functional food or adjuvant agent for prevention or treatment of colon cancer.…”
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Seroprevalence of Herpes Simplex Virus Infection in HIV Coinfected Individuals in Eastern India with Risk Factor Analysis by Soumyabrata Nag, Soma Sarkar, Debprasad Chattopadhyay, Sanjoy Bhattacharya, Rahul Biswas, Manideepa SenGupta

“…In immunocompromised individuals, like HIV patients, impaired immunity leads to more frequent symptomatic and asymptomatic HSV infection. …”
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Previous Exercise Training Reduces Markers of Renal Oxidative Stress and Inflammation in Streptozotocin-Induced Diabetic Female Rats by Liliany Souza de Brito Amaral, Cláudia Silva Souza, Rildo Aparecido Volpini, Maria Heloisa Massola Shimizu, Ana Carolina de Bragança, Daniele Canale, Antonio Carlos Seguro, Terezila Machado Coimbra, Amélia Cristina Mendes de Magalhães, Telma de Jesus Soares

“…The results showed that exercise training reduced glycosuria, renal TBARS levels, and the number of immune cells in the renal tissue of the TD and PTD groups. …”
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Pregnancy Outcome in First 50 SARS-Cov-2 Positive Patients at Our Center by Madhusudan Dey, Sanjay Singh, Ravindu Tiwari, Vinod G Nair, Devendra Arora, Shyamji Tiwari

“… OBJECTIVES: Suppressed immune system and physiological changes in pregnancy put pregnant women vulnerable to various viral diseases. …”
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Sensory alterations and immunological changes during the chronification of postsurgical pain: a study protocol for a prospective observational cohort study by Leo Koenderman, Niels Eijkelkamp, Frank J P M Huygen, Roel J H Custers, Marjelle E C van Driel, Nadine van Veenendaal, Lisette Margaretha Vernooij, L Timmerman, Diyar Delawi, M Rijsdijk

“…It is hypothesised that surgery-induced tissue damage and the subsequent immune response cause sensory alterations in the early postoperative period, ultimately leading to a chronic neuropathic or nociplastic pain state. …”
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Pharmacological evidence supporting a role for IL-1, IL-2 and serotonin in the inflammation induced by Schistosoma mansoni Soluble Egg Antigen (SEA) in rat paws by C. M. F. Pacheco, C. A. P. Tavares, P. M. Z. Coelho, O. A. Rocha, J. M. M. Santos, F. R. M. Prado, J. N. Francischi

“…These data suggested that SEA-challenge was immune-derived and dependent of IL-2 release. It is discussed the association between cytokine release and the resistance of rats to S. mans o ni infe ction.…”
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Interaction of human neutrophils with Trichomonas vaginalis protozoan highlights lactoferrin secretion by Wei-Hung Cheng, Ruei-Min Chen, Seow-Chin Ong, Yuan-Ming Yeh, Po-Jung Huang, Chi-Ching Lee

“…Background: Neutrophils are vital constituents of the immune response in the vaginal environment, playing a pivotal role in the defense against trichomoniasis. …”
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Gut microbiota dysfunction in Crohn’s disease by Sylvie Buffet-Bataillon, Sylvie Buffet-Bataillon, Gabriela Durão, Isabelle Le Huërou-Luron, Olivier Rué, Olivier Rué, Yann Le Cunff, Vincent Cattoir, Guillaume Bouguen

“…IntroductionCrohn’s disease (CD) results from alterations in the gut microbiota and the immune system. However, the exact metabolic dysfunctions of the gut microbiota during CD are still unclear. …”
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Increased Death of Peripheral Blood Mononuclear Cells after TLR4 Inhibition in Sepsis Is Not via TNF/TNF Receptor-Mediated Apoptotic Pathway by Chien-Ming Chu, Li-Chung Chiu, Chung-Chieh Yu, Li-Pang Chuang, Kuo-Chin Kao, Li-Fu Li, Huang-Pin Wu

“…Apoptosis is one of the causes of immune depression in sepsis. Pyroptosis also occurs in sepsis. …”
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Platycodon grandiflorum-derived extracellular vesicles suppress triple-negative breast cancer growth by reversing the immunosuppressive tumor microenvironment and modulating the gu... by Min Yang, Jia Guo, Jinxian Li, Shuyue Wang, Yuan Sun, Ying Liu, Yinghua Peng

“…Further in vivo investigations revealed that PGEVs efficiently accumulated in 4T1 tumors and exerted significant therapeutic effects through boosting systemic anti-tumor immune responses and modulating the gut microbiota whether administered orally or intravenously (i.v.). …”
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Stabilizing milk-derived extracellular vesicles (mEVs) through lyophilization: a novel trehalose and tryptophan formulation for maintaining structure and Bioactivity during long-te... by Alan B. Dogan, Spencer R. Marsh, Rachel J. Tschetter, Claire E. Beard, Md R. Amin, L. Jane Jourdan, Robert G. Gourdie

“…Abstract Extracellular vesicles (EVs) are widely investigated for their implications in cell-cell signaling, immune modulation, disease pathogenesis, cancer, regenerative medicine, and as a potential drug delivery vector. …”
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PfCSP-ferritin nanoparticle malaria vaccine antigen formulated with aluminum-salt and CpG 1018® adjuvants: Preformulation characterization, antigen-adjuvant interactions, and mouse... by John M. Hickey, Nitya Sharma, Max Fairlamb, Jennifer Doering, Yetunde Adewunmi, Katherine Prieto, Giulia Costa, Benjamin Wizel, Elena A. Levashina, Nicholas J. Mantis, Jean-Philippe Julien, Sangeeta B. Joshi, David B. Volkin

“…In addition, two N-linked glycans were engineered to mitigate possible anti-apoferritin immune responses, and a universal T-cell epitope was included to further enhance immunogenicity. …”
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Protection Conferred by Gallid Alphaherpesvirus 2 Vaccines Against Immunosuppression Induced by Very Virulent Plus (vv+) Marek’s Disease Virus Strains in Commercial Meat Type Chick... by Nagwa Khaled, Carissa Gaghan, Abdelhamid M. Fares, Christa Goodell, William Stanley, Raveendra R. Kulkarni, Isabel M. Gimeno

“…In this study, we evaluated how three Gallid alphaherpesvirus 2 (GaHV-2) vaccines (CVI-988, rMd5-BAC∆Meq, and CVI-LTR) protected against two negative outcomes of vv+MDV infection: (1) reduced viability and frequency of immune cells in the spleen and (2) decreased efficacy of the CEO (chicken embryo origin) vaccine against infectious laryngotracheitis challenge. …”
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Cities as parasitic amplifiers? Malaria prevalence and diversity in great tits along an urbanization gradient by Caizergues, Aude E., Robira, Benjamin, Perrier, Charles, Jeanneau, Mélanie, Berthomieu, Arnaud, Perret, Samuel, Gandon, Sylvain, Charmantier, Anne

“…By affecting the reservoirs of pathogens and the body and immune conditions of hosts, urbanization alters the epidemiological dynamics and diversity of diseases. …”
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Eupalinolide B inhibits periodontitis development by targeting ubiquitin conjugating enzyme UBE2D3 by Wenhua Kuang, Ruishen Zhuge, Ping Song, Letai Yi, Shujie Zhang, Ying Zhang, Yin Kwan Wong, Ruixing Chen, Junzhe Zhang, Yuanbo Wang, Dandan Liu, Zipeng Gong, Peili Wang, Xiangying Ouyang, Jigang Wang

“…Eupalinolide B (EB) is a sesquiterpenoid natural product extracted from Eupatorium lindleyanum and has been reported as a potential drug for cancers and immune disorders. Here, we explored the ameliorative effects and underlying molecular mechanism of EB on periodontitis for the first time. …”
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