T Cell Subsets and the Expression of Related MicroRNAs in Patients with Recurrent Early Pregnancy Loss by Ya-ni Yan, Jian Zhang, Na Yang, Chaochao Chen, Weiwei Li

“…The cell frequencies of T helper 17 (Th17) cells and exhausted Treg cells in the EPL group were significantly higher than those in the control group (P<0.05). In conclusion, immune cells and associated miRNA profiles can be used as prognostic biomarkers for the treatment of human reproductive disorders, such as EPL.…”
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Efficacy and safety of dual-targeted therapy for inflammatory bowel disease: a retrospective multicenter study in China by Xiuxiu Jin, Kefang Sun, Liying Wang, Haiyan Shen, Dan Ma, Tejia Shen, Chunxiao Chen, Lan Li

“…Objective: This study aimed to examine the efficacy and safety of combining biologics or small molecules in patients with refractory IBD, active EIM, or active immune-mediated inflammatory disease (IMID). Design: This was a retrospective and multicenter study. …”
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Association between Helicobacter pylori Infection and Risk of Osteoporosis in Elderly Taiwanese Women with Upper Gastrointestinal Diseases: A Retrospective Patient Record Review by Shih-Chun Lin, Malcolm Koo, Kun-Wei Tsai

“…Helicobacter pylori (H. pylori) infection could lead to chronic local and systemic immune response. The resulting increase in proinflammatory cytokines could affect bone resorption and might increase the risk of osteoporosis. …”
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Identification of Psychological Crisis Signals of College Students Based on the Dufferin Equation by Jianping Zhao, Haitao Song

“…To address the shortcomings of the classical Dufferin equation with limited noise immunity, the use of a higher-order double-coupled Dufferin system was further improved. …”
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The Role of Ubiquitin-Like Interferon (IFN)-Stimulated 15 and IFN Gamma Genes Polymorphism with the Severity and Serum Biochemical Markers in COVID-19 Patients by Khadijah Gatfan Hosseien, Parisa Tahmasebi, Hayder Obayes Hashim, Alaa Tareq Shakir, Zahra Bozorgi Moghadam

“…IFN-gamma (IFN-γ) is a kind of cytokine that plays a significant role in both the induction and regulation of a wide variety of immune responses. Objectives: This study examined the relationships between rs1921 and rs1861494 single nucleotide polymorphisms with the manifestation of coronavirus disease 2019 (COVID-19) symptoms in patients and the status of biochemical markers in previously diagnosed cases. …”
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Asymptotic analysis of mathematical model describing a new treatment of breast cancer using AZD9496 and palbociclib by Ophir Nave, Ophir Nave

“…The mathematical model that described the interaction between the cancer cells, the treatment, and the immune system cells includes a system of nonlinear ordinary differential equations of the firs order. …”
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Vitamin D and Tinospora cordifolia modulate TLR3 and TLR4 pathways, reduce inflammation, and maintain antimicrobial peptide levels in infected mice by Jamil Ahmad Shobrun, Widyarti Sri, Setiawan Meddy, Rifa’i Muhaimin

“…The activation of Toll-Like Receptor-3 (TLR3) and Toll-Like Receptor-4 (TLR4) signalling pathways is a regular pathway for immune system activation during infection. This study aimed to investigate the effects of vitamin D (VD) and Tinospora cordifolia ethanol extract (TC) on TLR3 and TLR4 receptor protein expression, proinflammatory cytokine (IL1 and IL-6) production, and antimicrobial peptide cathelicidin (CAP) production in CD11b+ cells of mice infected with Escherichia coli. …”
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Workplace violence, psychopathological symptoms, and deviant workplace behavior among nursing interns in China: a network analysis by Simeng Dong, Xinshu Shen, Tong Zhao, Rui Zeng, Min Chen

“…Abstract Background Workplace violence in healthcare has become a global concern, and nursing interns are not immune to it in clinical settings. It is critical to understand the impact of workplace violence on the psychological and work status of nursing interns. …”
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Geospatial Analysis of COVID-19 Death Rate and Influencing Factors in the MENA Region by MUSTAFA SHEBANI ABOALYEM, Mohd Tahir Ismail

“…The research suggests that hospital bed allocation, unemployment rate, and overall immunizations could be key factors influencing the death rate. …”
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Systemic inflammatory indices as a non-invasive grading modality for endometriosis: a comparative study versus exploratory laparoscopy by Ahmed Sabra Ibrahim Mohammed Sabra, Shreen Naguib Aboelezz Moselhy, Ahmed Kasem Mohamed Zain Eldin

“…Abstract Objective: Included evaluation of the possibility of using the systemic inflammatory indices for preoperative screening for the presence and severity of endometriosis (EM) in comparison to the findings of the exploratory laparoscopy Methods: 88 women with clinical manifestations suggestive of EM were evaluated clinically and by US and gave blood samples for estimation of serum cancer antigen-125 (CA125), platelet and total and differential leucocytic counts for calculation of inflammatory indices; the Systemic Immune-Inflammation index, the Systemic Inflammation Response Index (SIRI), the Neutrophil-Lymphocyte ratio (NLR), the Neutrophil-Monocyte ratio, the Neutrophil-Platelet ratio and the Platelet-Lymphocyte ratio. …”
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Comparing Cisplatin Dosing Schedules in Concurrent Chemoradiotherapy for Locally Advanced Head-and-Neck Cancer: A Comprehensive Review of Weekly Versus 3-Weekly Regimens by Oscar Chi-Yu Yang, Nai-Wen Su, Yi-Shing Leu, Yi-Fang Chang

“…Novel agents including immune checkpoint inhibitors, xevinapant, and berzosertib are being actively investigated as combinational therapies with cisplatin-based CCRT. …”
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Defense strategy of industrial control worm based on SEIPQR model by Jie PAN, Lan YE, He ZHAO, Xinlei ZHANG

“…Computer viruses keep evolving with the development of society and progress of technologies, and they become more complex and hidden.The worm virus is the earliest computer virus, which has evolved to an industrial control worm virus and caused a great impact on the safety of the industrial system.Neither the single network isolation nor the patching immunity is unable to keep up with the spreading of the worm virus.The propagation mode and characteristics of the worm virus in the industrial control system were analyzed.Based on the related works of network isolation and patching, a defense strategy against the worm virus was proposed.This strategy was originated from the fundamental infectious disease model, and then a mathematics model (SEIPQR) was proposed to simulate the trend of worm virus propagation.The model included six situations: Susceptible, Exposed, Infected, Quarantine and Recovered.The state transition diagrams of the model was created, and the calculus equations were obtained from the state transition diagrams.Under the condition that the number of system equipment is fixed, the equations were transformed.The equations were solved by solving the basic regeneration number R0, and six equation expressions of the model ware analyzed when the number of exposed hosts and infected hosts is zero.According to the principle of the Routh-Hurwitz, the system is asymptotically stable when R₀＜1, and unstable if R₀＞1.Then the dynamic characteristics of the SEIPQR model under different patching probability, different isolation rate and different infection rate were compared by numerical simulation.Furthermore, the disease-free equilibrium point and endemic equilibrium point of the model were obtained.The simulation results showed that, when the whole system is infected with worm virus, timely patching the susceptible devices and isolating the network can effectively inhibit the spread of industrial control worm virus.…”
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Green Strategy–Based Synthesis of Silver Nanoparticles for Antibacterial Applications by Keneth Iceland, Kasozi

“…They are routinely used to treat bacterial infections and to prevent infections in patients with compromised immune systems and enhancing growth in livestock. …”
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Effects of B-Blockers on the Sympathetic and Cytokines Storms in Covid-19. by Al-kuraishy, Hayder M., Al-Gareeb, Ali Ismail, Mostafa-Hedeab, Gomaa, Keneth Iceland, Kasozi, Zirintunda, Gerald, Aslam, Akhmed, Allahyani, Mamdouh, Welburn, Susan Christina, Batiha, Gaber El-Saber

“…On the other hand, an exaggerated immune response to the SARS-CoV-2 invasion may lead to uncontrolled release of pro-inflammatory cytokine development of cytokine storm (CS). …”
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Advances in CAR T cell therapy: antigen selection, modifications, and current trials for solid tumors by Safwaan H. Khan, Safwaan H. Khan, Yeonjoo Choi, Mysore Veena, Mysore Veena, John K. Lee, John K. Lee, Daniel Sanghoon Shin, Daniel Sanghoon Shin

“…Finally, we address critical therapeutic limitations, including cytokine release syndrome (CRS), immune effector cell-associated neurotoxicity syndrome (ICANS), and suboptimal persistence of CAR T cells. …”
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Proteomic analysis of murine norovirus-infected Raw 264.7 cells reveals the induction of Ras GTPases by Sung Ho Yun, Md Arif-Ur Rahman, Soo-Bin Nam, Soo Hyeon Kim, Gyuri Kim, Kun Cho, Jong-Soon Choi

“…Consequently, the recognition of Ras-related proteins can lead to a better understanding of how noroviral infection affects the immune system of the host cell.…”
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Diagnosing and Treating ANCA-Associated Vasculitis within the COVID-19 Era: A Challenging Case Report by Erjola Likaj, Larisa Shehaj, Deniona Nunci, Lordian Nunci, Irda Rrugeja, Merita Rroji, Saimir Seferi, Nertila Gjonaj, Alma Idrizi, Arjana Strakosha

“…Renal manifestations often present as pauci-immune focal and segmental necrotizing crescentic glomerulonephritis (PI-NCGN), which can progress to acute or chronic kidney failure and multiorgan involvement. …”
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The Role of Gut Microbiota in Hypertension Management - A Review by Alicja Kot, Marta Wojtczak, Natalia Myśliwiec, Adrian Różycki, Michał Pniak, Paweł Miklis, Maciej Mawlichanów, Aleksandra Ciesielska, Aleksandra Sieradzka, Krzysztof Szerej

“…The state of knowledge: Key mechanisms involved into regulation of blood pressure include the production of short- chain fatty acids (SCFAs), modulation of the renin-angiotensin system (RAS), immune system regulation, and metabolite production such as trimethylamine-N-oxide (TMAO). …”
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Factors affecting hematological abnormality in HIV-infected patients at Dr. Wahidin Sudirohusodo Hospital Makassar, Indonesia by I. Nyoman Yogi Wiraguna, Andi Fachruddin Benyamin, Risna Halim, Syakib Bakri, Sahyuddin Saleh, Hasyim Kasim, Andi Alfian Zainuddin

“…Introduction Human immunodeficiency virus (HIV) is characterized by a progressive damage of immune system, resulting in a number of opportunistic infections and hematological abnormalities, and become more severe in late stages. …”
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Insights into microbial compositions of the respiratory tract of neonatal dairy calves in a longitudinal probiotic trial through 16S rRNA sequencing by Jia W. Tan, Susan D. Eicher, Janice E. Kritchevsky, Keith A. Bryan, Aaron Dickey, Carol G. Chitko-McKown, Tara G. McDaneld

“…IntroductionProbiotics are a promising intervention for modulating the microbiome and the immune system, promoting health benefits in cattle. …”
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