Exploring Core Genes Associated with Sepsis and Systemic Inflammatory Response Syndrome Using Single-Cell Sequencing Technology by Shen Y, Leng L, Hu Y

“…The frequency of occurrence is on the rise, but there is a lack of certain indicators for the timely detection and recognition of illnesses.Methods: By virtue of scRNA-seq, this research has analyzed single-cell transcriptome data from samples taken from groups with septic death and systemic inflammatory response syndrome so as to identify the unique markers and patterns in immune response.Results: By revealing the status of twelve cell clusters of four major cell types in blood samples through UMAP cell clustering and the differences of major cell populations between the dead and SIRS patients, the results have elucidated the components of different cells and their marker genes in two disease states, and the response mechanism beneficial to disease diagnosis in blood samples.Conclusion: By establishing a theoretical framework centered on cellular and molecular regulation, the study has introduced a novel approach for diagnosing and treating sepsis death group and SIRS patients early, as well as differentiating and preventing these conditions.Keywords: sepsis, SIRS, single cell sequencing, biomarkers, single cell transcriptome…”
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Reevaluating the Concept of Treating Experimental Tumors with a Mixed Bacterial Vaccine: Coley’s Toxin by C. Maletzki, U. Klier, W. Obst, B. Kreikemeyer, M. Linnebacher

“…Antitumoral effects following local therapy were primarily accompanied by stimulation of innate immune mechanisms. Data presented herein prove that the historical approach of using killed bacteria as active immunotherapeutic agents still holds promise, and further careful preclinical analyses may pave the way back into clinical applications.…”
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CNS resident macrophages exhibit region-specific states and immunogenic responses during Rbpj-deficient brain arteriovenous malformation by Sera Nakisli, Kayleigh Fanelli, Julia LaComb, Lily J. Arnold, Corinne M. Nielsen

“…Abstract Microglia are heterogeneous macrophage cells that serve as the central nervous system’s resident immune cells. During neuro-related diseases, CNS resident macrophages change their molecular, cellular, and functional properties—that collectively define “states”—in response to specific neural perturbations. …”
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Major heavy metals and human gut microbiota composition: a systematic review with nutritional approach by Mahsa Rezazadegan, Bita Forootani, Yeganeh Hoveyda, Niloufar Rezazadegan, Reza Amani

“…Abstract Background The human gut microbiota has a critical role in several aspects of host homeostasis, such as immune development, metabolism, nutrition, and defense against pathogens during life. …”
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Monocyte Chemiluminescence Traits in Gastric Cancer by O. V. Smirnova, A. A. Sinyakov, V. V. Tsukanov

“…Maximal monocyte spontaneous chemiluminescence intensity diminished in stage IV gastric cancer compared to the control cohort. Immune activity reflected in monocyte chemiluminescence correlates with the stage of gastric adenocarcinoma.…”
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Advances in Ultrasound-Targeted Microbubble Destruction (UTMD) for Breast Cancer Therapy by Wu Y, Liu Y, Wu H, Tong M, Du L, Ren S, Che Y

“…This technique can enhance chemical, genetic, immune, and anti-vascular therapies through its physical and biological effects. …”
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Quality of life and well-being of dermatology patients: Influence of associated anxiety and depression in relation to satisfaction of care by Prasanta Mohapatra, Piyush Sahu, Ankita Mohapatra, Nilamadhab Kar

“…Results: The sample (n = 150) covered a range of dermatological diagnoses including allergy/eczema (53.3%), inflammatory/infective diseases (19.3%), sexually transmitted diseases (10.0%), psycho-somatic diseases (9.3%), and auto-immune diseases (7.3%). A clinically relevant level (moderate degree or above) of depression (12.7%) and anxiety (8.0%) was present in considerable proportions of patients, suggesting that overall 18.7% of patients had anxiety, depression, or both. …”
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Effects of macrolide antibiotics on blood inflammatory mediators and organ damage markers in lipopolysaccharide-induced pulmonary damage rats by Ayşe Er, Enver Yazar

“…<p> <b>Conclusion:</b> Macrolide antibiotics used in veterinary area may no shown depression on immune system. Hovewer, investigation is need that especially dose-depended manner effects of macrolide antibiotics on immunosystem.…”
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New treatment options for generalized myasthenia gravis by Antanas Vaitkus, J. Čiauškaitė, M. Malakauskaitė, M. Baublytė

“…Drugs are being developed that target specific links in the immune system to reduce the risk of systemic adverse effects. …”
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Gut–brain axis and neuropsychiatric health: recent advances by Ceymi Doenyas, Gerard Clarke, Renáta Cserjési

“…Abstract The gut–brain axis, a bidirectional communication pathway, permits the central nervous system (CNS) to exert influence over gastrointestinal function in response to stress, while the gut microbiota regulates the CNS via immune, neuroendocrine, and vagal pathways. Current research highlights the importance of the gut microbiota in stress-related disorders and the need for further research into the mechanisms of gut–brain communication, with potential therapeutic implications for a wide range of health conditions. …”
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Assessment of Some Biochemical Parameters in Iraqi Women with Recurrent Miscarriage by Ruqaya K. Abbas, Amani M. Jasim, Qater Al-nada A. Al-Ibady

“…There are a number of things that can cause a miscarriage, such as inflammatory and immune system diseases. This study aims to compare the levels of calcium, Zinc, lipid peroxidation (Malondialdehyde), and superoxide dismutase (SOD) in the serum of women who have experienced a miscarriage with those of women who are pregnant and healthy. …”
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GGT5 Is an Independent Prognostic Biomarker in Stomach Adenocarcinoma by Yong Huang, HaiLang Zhou, Junwei Zou, Dong Wang

“…The results showed that the ESTIMATEScore, ImmuneScore, and StromalScore of the high-expression GGT5 group were higher than those of the low-expression GGT5 group. …”
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Therapeutic Implications of a Polymethoxylated Flavone, Tangeretin, in the Management of Cancer via Modulation of Different Molecular Pathways by El-Shaimaa A. Arafa, Noura T. Shurrab, Manal A. Buabeid

“…Furthermore, tangeretin works through mitigating levels of inflammatory mediators in the immune system. Using tangeretin in combination with clinically applied anticancer drugs could be a good strategy for increasing the efficiency of these agents and protecting noncancerous cells from damage caused by chemotherapy. …”
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How to Translate Basic Knowledge into Clinical Application of Biologic Therapy in Spondyloarthritis by Chung-Tei Chou

“…The increased Toll-like receptors (TCR) 2 and 4 in the serum, peripheral blood mononuclear cells, or synovial tissues of ankylosing spondyloarthritis (AS) or SpA patients suggest that SpA is highly associated with innate immunity. Any drug including anti-TNFα blocker which can downregulate the TCR, infiltrated neutrophils, or CD163+ macrophages in the synovial tissue is the rationale for the management of SpA. …”
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Immature granulocytes predict severe acute pancreatitis independently of systemic inflammatory response syndrome by Michał Lipiński, Grażyna Rydzewska

“…Introduction : Early prediction of severity of acute pancreatitis (AP) by a simple parameter that positively correlates with the activation stage of the immune system would be very helpful because it could influence the management and improve the outcome. …”
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Immunomodulatory Effects of Taiwanese Neolitsea Species on Th1 and Th2 Functionality by Yin-Hua Cheng, Ying-Chi Lin, Ih-Sheng Chen, Sian-De Liu, Jih-Heng Li, Chia-Chi Wang

“…However, species differences in the immunomodulatory effects and evidence pertaining to the effects of Neolitsea species on adaptive immunity are scarce. This study aimed to evaluate the immunomodulatory properties of ten Taiwanese Neolitsea plants on T helper (Th) cell functionality, especially Th1 and Th2. …”
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Infeksi Cacing dan Alergi by Selfi Renita Rusdji

“…This disease is frequently occurred in poor personal hygiene and environmental sanitation. The human immune response to helminth infections is similar with response to allergic disease. …”
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Effect of attenueted parapoxvirus ovis on levels of some serum cytokines and antibody response in sheep by Kamil Atlı, Atilla Şimşek

“…<p> <b>Conclusion:</b> It was concluded that the vaccines against ORFV infection considered to be used in the future should be applied after the effects on the immune system have been clearly demonstrated.…”
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Mycobacterium avium Complex Infection in a Patient with Sickle Cell Disease and Severe Iron Overload by Kamal Shemisa, Nasima Jafferjee, David Thomas, Gretta Jacobs, Howard J. Meyerson

“…An appreciable number of mycobacterial infection cases have been reported in sickle cell disease patients without immune dysfunction. It has been reported that iron overload is known to increase the risk for mycobacterial infection in vitro and in vivo studies. …”
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Atypical HPV Typing: Detection of Genital-Associated HPV Type 6 in Verruca Vulgaris of the Hands and Feet in an HIV-Positive Patient by Achdiat PA, Larasati R, Hidayah RMN, Avriyanti E, Usman HA, Maharani RH

“…This atypical result may suggest a failure of the immune defense system of the body. Therefore, accurately identifying HPV types through PCR testing in immunocompromised patients is essential for appropriate clinical management and monitoring.Keywords: verruca vulgaris, human papillomavirus type 6, human immunodeficiency virus, genotyping, polymerase chain reaction…”
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