Involvement of a 1-Cys peroxiredoxin in bacterial virulence. by Gilberto Hideo Kaihami, José Roberto Fogaça de Almeida, Suelen Silvana dos Santos, Luis Eduardo Soares Netto, Sandro Rogério de Almeida, Regina Lúcia Baldini

“…LsfA is the first bacterial 1-Cys Prx shown to modulate host immune responses and its characterization will allow a better understanding of the role of redox signaling in host-pathogen interactions.…”
Get full text

IL-8, IL-10, TGF-β, and GCSF Levels Were Increased in Severe Persistent Allergic Asthma Patients with the Anti-IgE Treatment by Arzu D. Yalcin, Atil Bisgin, Reginald M. Gorczynski

“…In this study, we compare the anti-IgE treatment modality in the dynamics of immune system cytokine levels in severe persistent asthma (SPA) patients who had no other any allergic disease, newly diagnosed allergic asthma patients and healthy volunteers. …”
Get full text

Phylostratigraphic analysis of gene networks of human diseases by Z. S. Mustafin, S. A. Lashin, Yu. G. Matushkin

“…It was also shown that among the gene networks analyzed, the highest proportion of evolutionarily young genes was found in the networks associated with diseases of the immune system (65 %), and the highest proportion of evolutionarily ancient genes was found in the networks responsible for the formation of human dependence on substances that cause addiction to chemical compounds (88 %); gene networks responsible for the development of infectious diseases caused by parasites are signif icantly enriched for evolutionarily young genes, and gene networks responsible for the development of specif ic types of cancer are signif icantly enriched for evolutionarily ancient genes.…”
Get full text

Phase I Study of Anti-CD3 x Anti-Her2 Bispecific Antibody in Metastatic Castrate Resistant Prostate Cancer Patients by Ulka Vaishampayan, Archana Thakur, Ritesh Rathore, Nicola Kouttab, Lawrence G. Lum

“…There were no dose limiting toxicities, and there was 1 partial responder and 3 of 7 patients had significant decreases in their PSA levels and pain scores. Immune evaluations of peripheral blood mononuclear cells in 2 patients before and after immunotherapy showed increases in IFN-γ EliSpot responses and Th1 serum cytokines. …”
Get full text

Multiomic machine learning on lactylation for molecular typing and prognosis of lung adenocarcinoma by Mengmeng Hua, Tao Li

“…The tumor microenvironment analysis illustrated that immune activity was notably elevated in low-risk patients, indicating they might more strongly respond to immunotherapy than high-risk patients. …”
Get full text

Efficacy and safety of immunotherapy for head and neck squamous cell carcinoma: a meta-analysis of randomized clinical trials by Cailing Jiang, Shuqin Wang, Lijun Zhu

“…BackgroundHead and neck squamous cell carcinoma (HNSCC) is one of the most common types of cancer worldwide and immune checkpoint inhibitors have shown favorable therapeutic effects in recurrent or metastatic or locally advanced head and neck squamous cell carcinoma (R/M/LA HNSCC). …”
Get full text

Narcolepsy treatment: from exorcism and bloodletting to modern therapy with histamine receptor inverse agonists by E. Sakalauskaitė-Juodeikienė, R. Masaitienė

“…In this article, we also review future perspectives for narcolepsy treatment including novel versions of sodium oxybate, the noradrenaline reuptake inhibitor reboxetine, the combination of modafinil and the astroglial connexins inhibitor flecainide, selective hypocretin-2 receptor agonists, and immune-based therapies. …”
Get full text

Characterization of Positive and Suspected COVID-19 Cases with Comorbidities by Yoenny Peña García, Annia Suárez Padilla, Niuva Milagro Arruebarrena Blanco

“…<strong>Background:</strong> factors associated with the severity and worse prognosis in SARS-CoV-2 infection have been described, such as age, the presence of chronic diseases such as diabetes, arterial hypertension and those that compromise the immune system. <br /><strong>Objective:</strong> to characterize positive and suspected COVID-19 cases with comorbidities in the Puerto Padre municipality between March and May 2020. …”
Get full text

The Effect of Erythritol Injection in Decreasing of Abortion Rate in Local Breed Ewes by Maher Saber Owain, Mustafa Salah Hasan, Ali Ghazi Atiyah

“…In conclusion, Erythritol alone can decrease the rate of abortion by making the bacteria extracellular far from placenta and evading of infection by immunity and/or gentamicin injection. Also, erythritol can be used as elicit diagnosis of brucellosis in latent infected animals.…”
Get full text

Metabolite-Sensing Receptors: Emerging Targets for Modulating Chronic Pain Pathways by Ciprian Pușcașu, Corina Andrei, Octavian Tudorel Olaru, Anca Zanfirescu

“…Chronic pain is a debilitating condition affecting millions worldwide, often resulting from complex interactions between the nervous and immune systems. Recent advances highlight the critical role of metabolite-sensing G protein-coupled receptors (GPCRs) in various chronic pain types. …”
Get full text

“POLONIZATION AND “SOVIETIZATION” OF WESTERN BYELORUSSIA: A COMPARATIVE STUDY OF ASSIMILATION AND INTEGRATION POLICIES by N. A. Markelov

“…As a result, such an ambiguity led to the development of a stronger local identity immune to the stronger oppression in the concerned period. …”
Get full text

TRIM28 is an essential regulator of three-dimensional chromatin state underpinning CD8+ T cell activation by Kun Wei, Ruifeng Li, Xiaohong Zhao, Bowen Xie, Tian Xie, Qinli Sun, Yongzhen Chen, Peng Wei, Wei Xu, Xinyi Guo, Zixuan Zhao, Han Feng, Ling Ni, Chen Dong

Get full text

Hemoglobin, albumin, lymphocyte and platelet (HALP) score for predicting early and late mortality in elderly patients with proximal femur fractures. by Abdussamed Vural, Turgut Dolanbay, Hilal Yagar

“…Among these, the hemoglobin, albumin, lymphocyte and platelet (HALP) score evaluates a patient's nutritional and immune status. The primary aim of this study was to determine the predictive effect of the HALP score on 30-day and 1-year mortality in elderly patients with proximal femoral fractures (PFFs).…”
Get full text

National Surveillance of Occupational Exposure to the Human Immunodeficiency Virus by Maura Ricketts, Linda Deschamps, Kimberly Elmslie, Michael O’Shaughnessy

“…This program was coordinated by the Federal Centre for acquired immune deficiency syndrome (AIDS) (now the Division of HIV/AIDS Epidemiology at the Laboratory Centre for Disease Control). …”
Get full text

Prevalence and Antimicrobial Resistance of Bacteria Isolated from Marine and Freshwater Fish in Tanzania by Esther Marijani

“…These results suggest that the presence of these bacteria might cause a health risk/hazard to human beings and may cause disease to susceptible individuals, especially immune-compromised consumers.…”
Get full text

To describe the subsets of malignant epithelial cells in gastric cancer, their developmental trajectories and drug resistance characteristics by Tingting Xu, Tianying Zhang, Yan Sun, Sijia Wu

“…This study employed single-cell RNA sequencing, using the 10 × Genomics platform, to analyze 262,532 cells from gastric cancer samples, identifying 32 distinct clusters and 10 major cell types, including immune cells (e.g., T cells, monocytes) and epithelial subpopulations. …”
Get full text

Occurrence of Bordetella Infection in Pigs in Northern India by Sandeep Kumar, Bhoj R. Singh, Monika Bhardwaj, Vidya Singh

“…In the present study, occurrence of Bordetella infection in apparently healthy pigs was determined in 392 pigs sampled to collect 358 serum samples and 316 nasal swabs from Northern India by conventional bacterioscopy, detection of antigen with multiplex polymerase chain reaction (mPCR), and detection of antibodies with microagglutination test (MAT) and enzyme linked immune-sorbent assay (ELISA). Bordetella bronchiseptica could be isolated from six (1.92%) nasal swabs. …”
Get full text

Using fecal microbiota transplantation for animal health (review) by H. Yu. Drobot, S. K. Shebeko, A. M. Ermakov

“…Fecal microbiota transplantation is a procedure when fecal matter from a healthy donor is administered into the intestinal tract of a recipient in order to restore microbial balance and strengthen immune responses. Mainly, fecal microbiota transplantation increases bacterial diversity and facilitates a growth in beneficial microorganisms. …”
Get full text

METTL3 Attenuates LPS-Induced Inflammatory Response in Macrophages via NF-κB Signaling Pathway by Jinghua Wang, Shushan Yan, Hongying Lu, Shufeng Wang, Donghua Xu

“…As a key enzyme of m6A methylation modification, METTL3 has been implicated in immune and inflammation regulation. However, little is known of the role and underlying mechanism of METTL3 in rheumatoid arthritis (RA). …”
Get full text

Metabolic engineering of Priestia megaterium for 2’-fucosyllactose production by Bu-Soo Park, Jihee Yoon, Jun-Min Lee, Sang-Hyeok Cho, Yoojeong Choi, Byung-Kwan Cho, Min-Kyu Oh

“…Abstract Background 2′-Fucosyllactose (2′-FL) is a predominant human milk oligosaccharide that significantly enhances infant nutrition and immune health. This study addresses the need for a safe and economical production of 2’-FL by employing Generally Recognized As Safe (GRAS) microbial strain, Priestia megaterium ATCC 14581. …”
Get full text