Pretransplant Immune- and Apoptosis-Related Gene Expression Is Associated with Kidney Allograft Function by Dorota Kamińska, Katarzyna Kościelska-Kasprzak, Paweł Chudoba, Oktawia Mazanowska, Mirosław Banasik, Marcelina Żabinska, Maria Boratyńska, Agnieszka Lepiesza, Agnieszka Gomółkiewicz, Piotr Dzięgiel, Marian Klinger

“…Renal transplant candidates present immune dysregulation, caused by chronic uremia. The aim of the study was to investigate whether pretransplant peripheral blood gene expression of immune factors affects clinical outcome of renal allograft recipients. …”
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The gut microbiome, immune modulation, and cognitive decline: insights on the gut-brain axis by Ruyi Zhang, Ruyi Zhang, Ning Ding, Xicui Feng, Wenli Liao

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A pressure model of immune response to mycobacteriumtuberculosis infection in several space dimensions by Fabrizio Clarelli, Roberto Natalini

“…However, in general, the human immune system is able to contain it. In this work, we propose a mathematical model which describes the early immune response to the Mtb infection in the lungs, also including the possible evolution of the infection in the formation of a granuloma. …”
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Characterization of cellular immune system at different ages in water buffalo (Bubalus bubalis) by Maria C. Scata’, Giovanna De Matteis, Francesco Grandoni, Gabriele Di Vuolo, Giovanna Cappelli, Domenico Vecchio

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A telomere-related signature for predicting prognosis and assessing immune microenvironment in osteosarcoma by Shihao Li, Lina Zhang, Haiyang Zhang

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Macrophage-inherited exosome excise tumor immunosuppression to expedite immune-activated ferroptosis by Yan Liu, Junjie Liu, Qin Wang, Kun Zhang, Chunyan Zhu, Duo Wang, Guanhua Qiu, Xiaoqi Zhu, Chao Fang

“…The delivered RSL3 that serves as a common ferroptosis inducer can reduce the levels of ferroptosis hallmarkers (eg, glutathione and glutathione peroxidase 4), break the redox homeostasis to magnify oxidative stress accumulation, promote the expression of ferroptosis-related proteins, and induce robust ferroptosis of tumor cells, accompanied with which systematic immune response activation can bbe realized. M1 macrophage-derived exosomes can inherit more functions and genetic substances than nanovesicles since nanovesicles inevitably suffer from substance and function loss caused by extrusion-arised structural damage.Results Inspired by it, spontaneous homing to tumor and M2-like macrophage polarization into M1-like ones are attained, which not only significantly magnify oxidative stress but also mitigate ITM including M2-like macrophage polarization and regulatory T cell decrease, and regulate death pathways.Conclusions All these actions accomplish a synergistic antitumor enhancement against tumor progression, thus paving a general route to mitigate ITM, activate immune responses, and magnify ferroptosis.…”
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Immune Responses to Tissue-Restricted Nonmajor Histocompatibility Complex Antigens in Allograft Rejection by Ankit Bharat, T. Mohanakumar

“…Testing for preexisting and de novo immune responses to tissue-restricted SAgs and treatment based on immune responses after organ transplantation may improve short- and long-term outcomes after transplantation.…”
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Cross-Talk between Gut Microbiota and Heart via the Routes of Metabolite and Immunity by Jin Bu, Zhaohui Wang

“…Further, bacterial dysbiosis can disturb gut immunity, which increases the risk of acute arterial events. …”
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Proteomic profiling of the local and systemic immune response to pediatric respiratory viral infections by Emily Lydon, Christina M. Osborne, Brandie D. Wagner, Lilliam Ambroggio, J. Kirk Harris, Ron Reeder, Todd C. Carpenter, Aline B. Maddux, Matthew K. Leroue, Nadir Yehya, Joseph L. DeRisi, Mark W. Hall, Athena F. Zuppa, Joseph Carcillo, Kathleen Meert, Anil Sapru, Murray M. Pollack, Patrick McQuillen, Daniel A. Notterman, Charles R. Langelier, Peter M. Mourani

“…Despite this, no studies have employed proteomics to characterize host immune responses to severe pediatric vLRTI in both the lower airway and systemic circulation. …”
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Effector, Memory, and Dysfunctional CD8+ T Cell Fates in the Antitumor Immune Response by John Reiser, Arnob Banerjee

“…The adaptive immune system plays a pivotal role in the host’s ability to mount an effective, antigen-specific immune response against tumors. …”
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Editorial: Specific targeting of MHC antigens for T-cells and immune cells in human disease by Ali Afzal, Ali Afzal, Muhammad Babar Khawar, Muhammad Babar Khawar, Muhammad Babar Khawar, Weijuan Gong, Weijuan Gong, Weijuan Gong, Brian M. Baker, Brian M. Baker, Haibo Sun, Haibo Sun

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Azithromycin-Induced Thrombocytopenia: A Rare Etiology of Drug-Induced Immune Thrombocytopenia by Muhammad Umer Butt, Ahmad Jabri, Samy Claude Elayi

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Vascular Endothelial Growth Factor (VEGF) Family and the Immune System: Activators or Inhibitors? by Cristina Maria Failla, Maria Luigia Carbone, Carmela Ramondino, Emanuele Bruni, Angela Orecchia

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Tumour Necrosis Factor-α Production and Immune Cell Activation in Tuberculous Meningitis by C. M. Mastroianni, F. Paoletti, C. Valenti, A. P. Massetti, V. Vullo, S. Delia

“…The degree of intrathecal immune activation was also studied by assessing the CSF levels of β2-microglobulin (β2-M) and adenosine deaminase activity (ADA). …”
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Effect of Astaxanthin on Immune Function and Myocardial Injury in Mice with Chronic Sleep Deprivation by FENG Biyun, LI Lingyan, LI Ming, ZHANG Jiayuan, QI Huanyang, CHEN Pingping, XU Guanghui

Subjects: “…astaxanthin; chronic sleep deprivation; immune function; myocardial injury; network pharmacology…”
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The Mediation of Circulating Inflammatory Proteins in the Causal Pathway from Immune Cells to COPD by Yan K, Wang Y, Xin P

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Tryptophan as a biomarker of pregnancy-related immune expression and modulation: an integrative review by Stephanie Prescott, Stephanie Prescott, Natasa Billeci, Melissa Gotcher, Sapna Patel, Addison Almon, Hailey Morgan, Danielle Abukhalaf, Maureen Groer

“…The immunomodulatory role of TRP and its metabolites through the indoleamine 2,3-dioxygenase (IDO) pathway is particularly relevant to pregnancy due to its potential influence on maternal and fetal immune tolerance and the mother's health.MethodsA targeted literature search was conducted via PubMed, Web of Science, and Embase, focusing on maternal serum TRP levels in pregnancy. …”
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Bioinformatic Analysis of PTTG Family and Prognosis and Immune Cell Infiltration in Gastric Cancer by Xiao Li, Yanghao Tai, Shuying Liu, Yating Gao, Kaining Zhang, Jierong Yin, Huijuan Zhang, Xia Wang, Xiaofei Li, Dongfeng Zhang

“…In addition, the expression of PTTG1/2 was positively correlated with the molecular status of the immune checkpoint and negatively correlated with the infiltration of various immune cells. …”
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Enhancing precision in cancer treatment: the role of gene therapy and immune modulation in oncology by Emile Youssef, Brandon Fletcher, Dannelle Palmer

“…Despite significant breakthroughs, challenges such as tumor heterogeneity, immune evasion, and the immunosuppressive tumor microenvironment (TME) remain. …”
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Spatially mapping the tumour immune microenvironments of non-small cell lung cancer by Lysanne Desharnais, Mark Sorin, Morteza Rezanejad, Bridget Liu, Elham Karimi, Aline Atallah, Anikka M. Swaby, Miranda W. Yu, Samuel Doré, Saskia Hartner, Benoit Fiset, Yuhong Wei, Baharak Kadang, Roni Rayes, Philippe Joubert, Sophie Camilleri-Broët, Pierre-Olivier Fiset, Daniela F. Quail, Jonathan D. Spicer, Logan A. Walsh

“…An enhanced understanding of the immune microenvironments within these tumours may foster more precise and efficient treatment, particularly for immune-targeted therapies. …”
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