Metal‐based nanomaterials and nanocomposites as promising frontier in cancer chemotherapy by Sunil Kumar, Monu Kumar Shukla, Abhishek Kumar Sharma, Gururaj K. Jayaprakash, Rajiv K. Tonk, Dinesh K. Chellappan, Sachin Kumar Singh, Kamal Dua, Faheem Ahmed, Sanjib Bhattacharyya, Deepak Kumar

“…Several of NMs can also be used for photothermal therapy to destroy cancer cells or enhance immune response to cancer by delivering immune‐stimulating molecules to immune cells or modulating the tumor microenvironment. …”
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Growth Modeling of the Maternal Cytokine Milieu throughout Normal Pregnancy: Macrophage-Derived Chemokine Decreases as Inflammation/Counterregulation Increases by Shernan G. Holtan, Yiyi Chen, Rajani Kaimal, Douglas J. Creedon, Elizabeth Ann L. Enninga, Wendy K. Nevala, Svetomir N. Markovic

“…As pregnancy normally progresses, a maternal shift away from a type 2-biased immune response and toward an inflammatory/counterregulatory response is observed.…”
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COVID-19 vaccination: challenges in the pediatric population by Alice Nicoleta Azoicai, Ingrith Miron, Ancuta Lupu, Monica Mihaela Alexoae, Iuliana Magdalena Starcea, Mirabela Alecsa, Vasile Valeriu Lupu, Ciprian Danielescu, Alin Horatiu Nedelcu, Delia Lidia Salaru, Felicia Dragan, Ileana Ioniuc

“…An analysis of recent published studies reveals that the majority of clinical trials have reported a sustained immune response following COVID-19 vaccination in children across various age groups worldwide. …”
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Experimental Immunization Based on Plasmodium Antigens Isolated by Antibody Affinity by Ali N. Kamali, Patricia Marín-García, Isabel G. Azcárate, Antonio Puyet, Amalia Diez, José M. Bautista

“…The presence of specific antibodies in vaccinated mice serum was studied by immunoblot analysis at different days after vaccination and showed an intensive immune response to a wide range of antigens with molecular weight ranging between 22 and 250 kDa. …”
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Cytokine Levels in the Serum of Healthy Subjects by Giulio Kleiner, Annalisa Marcuzzi, Valentina Zanin, Lorenzo Monasta, Giorgio Zauli

“…Growing knowledge about the cytokine network response has led to a better comprehension of mechanisms of pathologies and to the development of new treatments with biological drugs, able to block specific molecules of the immune response. Indeed, when the cytokine production is deregulated, diseases often occur. …”
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Transcriptome-based insights into the calcium transport mechanism of chick chorioallantoic membrane by Qun Huang, Ran Yang, Qia Wang, Hui Teng, Hongbo Song, Fang Geng, Peng Luo

“…Functional enrichment analysis of DEGs showed that CAM DEGs were mainly involved in biological processes such as “ion transport regulation”, “immune response” and “cell cycle”. Time series analysis of the differential genes showed that the functional cells of CAM began to proliferate and differentiate at E9 and the calcium content of egg embryo increased significantly at E13. …”
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Autoserum: An Optimal Supplement for Bone Marrow Mesenchymal Stem Cells of Liver-Injured Rats by Qinglin Zhang, Xun Sun, Jianxun Ding, Ping He, Yujia Liu, Hongjing Cheng, Changlin Zhou, Xiangwei Meng

“…Although the use of adult serum, platelet lysate, or cord blood serum solves some of the problems caused by fetal bovine serum (FBS), the allogeneic immune response, contamination, and donor-to-donor and donor-to-receptor differences still obstruct the application of MSCs. …”
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The Microbiota Determines Susceptibility to Experimental Autoimmune Uveoretinitis by Jarmila Heissigerova, Petra Seidler Stangova, Aneta Klimova, Petra Svozilkova, Tomas Hrncir, Renata Stepankova, Miloslav Kverka, Helena Tlaskalova-Hogenova, John V. Forrester

“…These data suggest that the presence of microbiota during autoantigen recognition regulates the inflammatory response by influencing the adaptive immune response.…”
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Inflammatory cytokines in newborn infants by A. Sarandakou, G. Giannaki, A. Malamitsi-Puchner, D. Rizos, E. Hourdaki, E. Protonotariou, I. Phocas

“…In conclusion, the increased concentrations of IL-1 β, IL-6 and TNF-α during the perinatal period might suggest their involvement in an inflammation like process during normal parturition, and reflect also a newborn immune response to the stress of delivery and environmental changes.…”
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Genome-wide maps of highly-similar intrachromosomal repeats that can mediate ectopic recombination in three human genome assemblies by Luis Fernandez-Luna, Carlos Aguilar-Perez, Christopher M. Grochowski, Michele G. Mehaffey, Claudia M.B. Carvalho, Claudia Gonzaga-Jauregui

“…Olfactory receptors and immune response genes were enriched among those impacted.…”
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QTL mapping of human retina DNA methylation identifies 87 gene-epigenome interactions in age-related macular degeneration by Jayshree Advani, Puja A. Mehta, Andrew R. Hamel, Sudeep Mehrotra, Christina Kiel, Tobias Strunz, Ximena Corso-Díaz, Madeline Kwicklis, Freekje van Asten, Rinki Ratnapriya, Emily Y. Chew, Dena G. Hernandez, Sandra R. Montezuma, Deborah A. Ferrington, Bernhard H. F. Weber, Ayellet V. Segrè, Anand Swaroop

“…Integrated pathway analysis reveals epigenetic regulation of immune response and metabolism including the glutathione pathway and glycolysis. …”
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Precise HER2 Protein Degradation via Peptide‐Conjugated Photodynamic Therapy for Enhanced Breast Cancer Immunotherapy by Changyong Guo, Fei Gao, Guoyuan Wu, Jinqiu Li, Chunquan Sheng, Shipeng He, Honggang Hu

“…The Pha‐PLG molecules self‐assemble into nanofibers, prolonging circulation, boosting immune induction, and activating CD8+ T cells, thus promoting a robust anti‐tumor immune response. In vivo, studies confirm superior biosafety, tumor targeting, and HER2 degradation, with increased cytotoxic T cell activity and improved antitumor immunity. …”
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Molecular characterization of mixed-histology endometrial carcinoma provides prognostic and therapeutic value over morphologic findings by Paulina J. Haight, Ashwini Esnakula, Courtney J. Riedinger, Adrian A. Suarez, Jessica Gillespie, Ashley Patton, Alexis Chassen, David E. Cohn, Casey M. Cosgrove

“…Transcriptional analysis demonstrated 93 differentially expressed genes between p53abnl and NSMP tumors, including many associated with the innate immune response and DNA damage repair. While p53abnl and NSMP tumors have similarly poor outcomes, transcriptome analysis revealed biologic differences that could impact targeted therapeutics in this high-risk group.…”
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Evaluation of Lymphocyte Response to the Induced Oxidative Stress in a Cohort of Ageing Subjects, including Semisupercentenarians and Their Offspring by Federico Sizzano, Sebastiano Collino, Ornella Cominetti, Daniela Monti, Paolo Garagnani, Rita Ostan, Chiara Pirazzini, Maria Giulia Bacalini, Daniela Mari, Giuseppe Passarino, Claudio Franceschi, Alessio Palini

“…This process could lead to an impairment of the immune response. However, little is known about the capability of the immune cells of elderly individuals to dynamically counteract the oxidative stress. …”
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The Role of Genetic and Immune Factors for the Pathogenesis of Primary Sclerosing Cholangitis in Childhood by Priscila Menezes Ferri, Ana Cristina Simões e Silva, Soraya Luiza Campos Silva, Diego Junior Queiroga de Aquino, Eleonora Druve Tavares Fagundes, Débora Marques de Miranda, Alexandre Rodrigues Ferreira

“…In addition, the literature supports a role for an altered immune response to pathogens in the pathogenesis of PSC. …”
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Immunology and Oxidative Stress in Multiple Sclerosis: Clinical and Basic Approach by Genaro G. Ortiz, Fermín P. Pacheco-Moisés, Oscar K. Bitzer-Quintero, Ana C. Ramírez-Anguiano, Luis J. Flores-Alvarado, Viridiana Ramírez-Ramírez, Miguel A. Macias-Islas, Erandis D. Torres-Sánchez

“…Lymphocytes activated in the periphery infiltrate the central nervous system to trigger a local immune response that ultimately damages myelin and axons. …”
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Assessing spacer acquisition rates in E. coli type I-E CRISPR arrays by Luke J. Peach, Haoyun Zhang, Brian P. Weaver, James Q. Boedicker, James Q. Boedicker

“…Through an adaptation process, short “spacer” sequences, captured from these elements and incorporated into a CRISPR array, provide target specificity for the immune response. CRISPR arrays and array expansion are also central to many emerging biotechnologies. …”
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OCH Ameliorates Bone Marrow Failure in Mice via Downregulation of T-Bet Expression by Xiaohong Qiao, Xiaotian Xie, Wei Shi, Jinqing Tang, Yuexia Shao, Fuxing Li

“…In conclusion, treatment of OCH prior to the induction of BMF could prevent the incidence of BMF possibly through downregulating T-bet expression leading to the transition of immune response from Th1 to Th2, suggesting OCH might be a new therapeutic approach in the treatment of BMF or AA.…”
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Biologic Agents in Crohn’s Patients Reduce CD4+ T Cells Activation and Are Inversely Related to Treg Cells by Eliane Aparecida Rosseto-Welter, Leticia D’argenio-Garcia, Filipa Blasco Tavares Pereira Lopes, Ana Eduarda Zulim Carvalho, Fernando Flaquer, Vanessa Severo-Lemos, Claudia Concer Viero Nora, Flavio Steinwurz, Lucas Pires Garcia Oliveria, Thiago Aloia, Luiz Vicente Rizzo, Cristóvão Luis Pitangueira Mangueira, Karina Inacio Carvalho

“…This approach prolongs the subsequent clinical relapse; however, this procedure could be implicated in the immune response and enhance disease severity. Our purpose was to assess the effects of different treatments on CD4+ T cells in a cohort of patients with Crohn’s disease compared with healthy individuals. …”
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Microenvironmental β-TrCP negates amino acid transport to trigger CD8+ T cell exhaustion in human non-small cell lung cancer by Ge Li, Zhenke Wen, Sidong Xiong

“…Consequently, inhibiting cancer-associated β-TrCP effectively restores the anti-tumor immune response of CD8+ T cells and curtails tumor growth in NSCLC patient-derived organoids. …”
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